DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp52F and Ptprh

DIOPT Version :9

Sequence 1:	NP_611093.2	Gene:	Ptp52F / 36790	FlyBaseID:	FBgn0034085	Length:	1433	Species:	Drosophila melanogaster
Sequence 2:	XP_011248936.1	Gene:	Ptprh / 545902	MGIID:	3026877	Length:	1153	Species:	Mus musculus

Alignment Length:	1280	Identity:	296/1280 - (23%)
Similarity:	469/1280 - (36%)	Gaps:	404/1280 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   310 GKLREYLLTDLQGCDL------------------YTFQVFINENSTAKASQTFTSAEKLVSAVYE 356
            |..|..:|..|.||.:                  |.|.:::.::..:.:.|.
Mouse     9 GVWRSLVLLGLYGCSVVRAAGTSVTVDRHAPASSYEFSMWVEKDGVSSSPQI------------- 60

  Fly   357 PSPTAYPTQLHWTWFSPQNHPKCVANYSVTLT--GPIQRS---------------ENKTMNVITE 404
            |..||.|..:.......||      |.|::|:  .|.|.|               :.:|.|  |.
Mouse    61 PVTTAAPNPVRNLRVEGQN------NISISLSWEPPDQSSLQGLTYWTQCSRHGGQTETRN--TT 117

  Fly   405 ETFAIFDDLDP-----CGIYLVEIVPNQLNGSAGTKYQEQSTVG-EDQPSVIQDPVVEAE-AYSM 462
            :|....|.|||     |.:::      :.:|    .|.:..|:. ...|:.:::..||.: ..|:
Mouse   118 DTSVTVDGLDPGSSYECSVWV------EKDG----LYSKNETLNTSTAPNPVRNLRVEGQNNISI 172

  Fly   463 EVSWKTPEYADL--------C------------------IDG------YRLSGWMEDDKLVEV-E 494
            .:||:.|:.:.|        |                  :||      |..|.|:|.|.:... |
Mouse   173 SLSWEPPDQSSLQGLTYWAQCSRHGGQTETRNTTDTSVTVDGLDPGSSYECSVWVEKDGVYSTNE 237

  Fly   495 ALSITT-----QNTTVVFDKNL---LACQVYIIQIIPYTKENLDG-----QLRQVGVETKAAIVD 546
            .||.||     :|..|....|:   |:.:       |..:.:|.|     |..:.|.:|:.....
Mouse   238 TLSNTTAPNPVRNLRVEGQNNISISLSWE-------PPDQPSLQGLTYWAQCSRHGGQTETRNTT 295

  Fly   547 YTKVKLEMKNAGSEFIDLIAFNADYNNSCPTIFALFTCNAT---TQVRNPYAERYVEGHSKQGFN 608
            .|.:.::..:.||.:...:....|         .:::.|.|   |...||.....|||.:....:
Mouse   296 DTSITVDGLDPGSSYECSVWVEKD---------GVYSTNETLSNTTAPNPVRNLRVEGQNNISIS 351

  Fly   609 ASLSP------------------------------------LSPYATYVCKVI-----LYNVAGP 632
            .|..|                                    |.|.::|.|.|.     :|:
Mouse   352 LSWEPPDQPSLQGLTYWAQCSRHGGQTETRNTADTSVTVDGLDPGSSYECSVWVEKDGVYS---- 412

  Fly   633 SEPVVDADMHTTTY---FPEQPESVMLEKSTVSSLLFNWQPPTYTNGPIKYYQAFLMRHEASYFV 694
                .:..::|:|.   .|....::.:|.....|:..:|:||...:.....|.|...||..
Mouse   413 ----TNETLNTSTVPISAPNPVRNLRVEGQNNISISLSWEPPDQPSLQGLTYWAQCSRHGG---- 469

  Fly   695 PADCAIVEQDTKSETKGDPSVNFTGLAPAVRYMMQVAAQNDFGMGVYT--EPVIGITLPAVSDSV 757
                   :.:|::.|  |.|:...||.|...|...|..:.|   |||:  |.:...|.|
Mouse   470 -------QTETRNTT--DTSITVDGLDPGSSYECSVWVEKD---GVYSTNETLSNTTAP------ 516

  Fly   758 TQLTVLTQGPVNNNAVYEAN---VTITWKVPCKSN--GDIEYFQLAFNGTRNNFAPVSFERRVEL 817
                    .||.|..|...|   ::::|:.|.:.:  |.|.:.|.:.:|.:.       |.|...
Mouse   517 --------NPVRNLRVKSQNNFSISLSWEPPDQPSLQGLIYWAQCSRHGGQT-------ETRNTT 566

  Fly   818 DTGNKQGRMSYTETEMQPQFDYTVEVSVKNRDV----EQLSSSVPGSWQSPAGLPTIPSDELIKQ 878
            ||       |.|...:.|.|.|...|.|:...|    |.|::|            |:|.
Mouse   567 DT-------SVTVDGLDPGFLYKCSVWVEKDGVYSTNETLNTS------------TVPI------ 606

  Fly   879 MRANVEETSNPTKTAIVRLPADIMTSASGDIKWMALMISQKNCAGVPHLKYDVSSDW--PKVLSY 941
                  ..|||.:.                     |.:..:|       .:.:|..|  |...|.
Mouse   607 ------SASNPVRN---------------------LRVEGQN-------NFSISLSWEPPDQSSL 637

  Fly   942 QEAGADGTGDCSLEYQTTEER----------------------WHPEPVQRQRRDGEVTSDE--- 981
            |  |......||.....||.|                      |       ..:||..:::|
Mouse   638 Q--GLTYWAQCSRHGGQTETRNTADTSVTVDGLDPGSSYECSVW-------VEKDGVYSTNETLN 693

  Fly   982 --EIVFTIGLDKCSEVQKTYCNGPLL----PDTDYN----------------------VVVRLFT 1018
              .:...:.:..|......|  |.||    |...|.                      .|..|..
Mouse   694 TSTVPAAVNITSCISTSGGY--GVLLTWSCPSGGYESFEVKVGRKWRSENGSLCGKGVTVSDLEP 756

  Fly  1019 ASGYSDAAVLNFKTKAAIKVT---------LILVSVCSCLLLAFVLGLTVLWVRKRLAWKRDSGQ 1074
            |..|:......||...|..::         :|..::...|||..::||.::::::|    |...|
Mouse   757 AQSYTATVTTVFKDLKAQSLSTTCHTESAAIIAGAIVGILLLFILVGLLIVFLKRR----RKKRQ 817

  Fly  1075 GIEDPF-------GNVIAKNFAIFYTEVAKPEK--LAREFKEITVVALE------LSYSASELGC 1124
            ..|.|.       |:::||:||....|..|...  .|.|::::   |||      ::.||.| ..
Mouse   818 PKEVPKDLVCSCPGDILAKDFADHVRENEKDSNCGFAEEYQQL---ALEGQGQSQITASALE-NR 878

  Fly  1125 HKNRYADIFPYDKNRVILD--IDAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQY 1187
            .||||.::.|||.:||.|.  .:..|||||||||:.|....||:||||||.|.:|.|||||:.:.
Mouse   879 SKNRYRNVLPYDWSRVPLQPLQEEPGSDYINASFMPGLWSPKEFIATQGPLPNTVGDFWRMVWEQ 943

  Fly  1188 NVRVIVQVTQFREGNTIKCHEYYPYN----VRG-LTVTIKSKEVLELYDRTELTVVHDKYGLKEK 1247
            ....:|.:|...|...:||..|:|.:    :.| |.|.:.|:|..|.:....|.:.|.|......
Mouse   944 QSHTLVMLTNCMESGRVKCEHYWPLDAQPCIHGQLQVMLISEEASENWTVRHLQLFHMKEQQTLS 1008

  Fly  1248 VIHYYFKKWPDHGVPEDPMHLIMFVKKVK--AEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRL 1310
            :..:::..|||||||..|..|:.|.|.::  .::.....|.:||||||||||||.|.||:::::|
Mouse  1009 LRQFHYLAWPDHGVPYSPDPLLAFRKMLRQWMDQTTDGGPPIVHCSAGVGRTGTLIALDVLLRQL 1073

  Fly  1311 KSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVKHKIP 1355
            :.|..:..|..|||:|..|..||||:.||.||:.|..:.::...|
Mouse  1074 ECEGLVGPFSFVKKMRESRPLMVQTEAQYVFLHQCILKSLQKPAP 1118

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020	24/102 (24%)
		PTPc	1100..1345	CDD:214550	102/261 (39%)
		PTPc	1125..1348	CDD:238006	95/231 (41%)
Ptprh	XP_011248936.1	FN3	67..146	CDD:238020	20/96 (21%)
		FN3	156..234	CDD:238020	16/77 (21%)
		FN3	245..323	CDD:238020	14/93 (15%)
		FN3	334..412	CDD:214495	12/77 (16%)
		FN3	427..505	CDD:238020	22/93 (24%)
		FN3	516..594	CDD:238020	24/105 (23%)
		FN3	611..687	CDD:214495	17/112 (15%)
		PTP_DSP_cys	881..1113	CDD:391942	94/231 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0791
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900