DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp52F and Ptpro

DIOPT Version :9

Sequence 1:	NP_611093.2	Gene:	Ptp52F / 36790	FlyBaseID:	FBgn0034085	Length:	1433	Species:	Drosophila melanogaster
Sequence 2:	NP_059032.1	Gene:	Ptpro / 50677	RGDID:	62068	Length:	1216	Species:	Rattus norvegicus

Alignment Length:	1475	Identity:	326/1475 - (22%)
Similarity:	523/1475 - (35%)	Gaps:	515/1475 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 HALILILWIAGVQGQTVGSLVAVSESQELAEKVEVTVVSTVYTLGFSISNEADYSIDKVICRNGS 78
            |.|..|:.:..|.|.     |....|:.:....:...|::|....:..|.|.....:
  Rat    89 HGLYYIISLVVVSGN-----VVTKPSRSITVLTKPLPVTSVSIYDYKPSPETGVLFE-------- 140

  Fly    79 GSETEANAAHVCENLNPCTFYTSVVSFRSNVS---GKPPPSDQTIYAYTEYKQPKTTVTSVVATA 140
                    .|..|..|        |..|.|:|   ||    |.....|.::.:.||.....:...
  Rat   141 --------IHYPEKYN--------VFSRVNISYWEGK----DFRTMLYKDFLKGKTVFNHWLPGI 185

  Fly   141 NTIKVTWQT------NDRACVESFGITAKATDY-TKSFQLLNDKSSQTFVNLSACLTHTITLDTR 198
            ....:|:|.      |....||..|::.:...: |..:...|  .|..||||:           :
  Rat   186 CYSNITFQLVSEATFNKSTLVECSGVSHEPKQHRTAPYPPRN--ISVRFVNLN-----------K 237

  Fly   199 NN----------ASVVVDTDATDVDTQYAEPGDLVMN-VTNLASGITMITWGDPSEKNCISNYVF 252
            ||          .|.:...||...|..:..|.:.... .:|.:||     |.||:
  Rat   238 NNWEEPSGSFPEDSFIKPQDAIGRDRPFHFPEETPETPASNASSG-----WPDPN---------- 287

  Fly   253 KWQRNDCGTD---QNQDTTTDVPSTETTNEIDYVTTTPMETTPDTPSDEVKCEWTDVSSDGKLRE 314
                   ||:   .:|....|..|....||.|:|:..|                .|..::..|..
  Rat   288 -------GTEYESTSQPYWWDSASAAPENEEDFVSVLP----------------ADYDTEATLGR 329

  Fly   315 YLLTDLQGCDLYTFQVFINENSTAKASQTFTSAEKLVSAVYEPSPTAYPTQLHWTWFSPQNHPKC 379
                              .|..||                 :|. :|:|.|:..:|..|: .|..
  Rat   330 ------------------TEKPTA-----------------DPF-SAFPVQMTLSWLPPK-PPTA 357

  Fly   380 VANYSVTLTGPIQRSENKT-MNVITEETFAIFDDLDPCGIYLVEIVPNQLNGSAGTKYQEQSTVG 443
            ...:::.    |:|..|.| ...:.||......:|...|.|.:.:.....:|:..|: :.||
  Rat   358 FDGFNIL----IEREGNFTDYLTVDEEAHEFVAELKEPGKYRLSVTTFSSSGACETR-KSQS--- 414

  Fly   444 EDQPSVIQDPVVEAEAYSMEVSWKTPEYADLCIDGYRLSGWMED----DKLVEVEALSITTQNTT 504
                         |::.|..:| .|.|             |:|:    .:.|.|..||.||
  Rat   415 -------------AKSLSFYIS-PTGE-------------WIEELTEKPQHVSVHVLSSTT---- 448

  Fly   505 VVFDKNLLACQVYIIQIIPYTKENLDGQLRQVGVETKAAIVDYTKVKLEMKNAGSEFIDLIAFNA 569
                                                  |::.:|                 :...
  Rat   449 --------------------------------------ALLSWT-----------------SSQE 458

  Fly   570 DYNNSCPTIFALFTCNATTQVRNPYAERYVEGHSKQGFNAS---LSPLSPYATYVCKVILYNVAG 631
            :||::..::.:| ||.     :...::|..:.:..| .|:|   :..|.|.|.|  :|::|...|
  Rat   459 NYNSTIVSVVSL-TCQ-----KQKESQRLEKQYCTQ-VNSSKPVIENLVPGAQY--QVVMYLRKG 514

  Fly   632 -----PSEPVVDADMHT----TTYFPEQPESVML----------EKSTVSSLLFNWQPPTYTNGP 677
                 ||:||..|.:.|    ...:|..|.:|:|          .|..|....||  |.|.|:..
  Rat   515 PLIGPPSDPVTFAIVPTGIKDLMLYPLGPTAVVLSWTRPYLGVFRKYVVEMFYFN--PTTMTSEW 577

  Fly   678 IKYYQAFLMRHEASYFVPADCAIVEQDTKSETKGDPSVNFTGLAPAVRYMMQVAAQNDFGMGVYT 742
            ..||:           :.|..::..           ||....|.||..|..:|.      |..:.
  Rat   578 TTYYE-----------IAATVSLTS-----------SVRIANLLPAWYYNFRVT------MVTWG 614

  Fly   743 EPVIG---------ITLPAVSDSVTQLTVLTQGPVNNNAVYEANVTITWKVPCKSNGDIEYFQLA 798
            :|.:.         ||.| |:..:|.:...      |:.:|     |:|     :.||..
  Rat   615 DPELSCCDSSTISFITAP-VAPEITSVEYF------NSLLY-----ISW-----TYGDAT----- 657

  Fly   799 FNGTRNNFAPVSFERRVE---LDTGNKQGRMSYTETEMQPQFDYTVEVSVKNRDVEQLSSSVPGS 860
                    ..:|..|.:.   :..|.::.:.|.|...|      |..:|:...|:..||
  Rat   658 --------TDLSHSRMLHWMVVAEGRRKIKKSVTRNVM------TAILSLPPGDIYNLS------ 702

  Fly   861 WQSPAGLPTIPSDELIKQMRANVEETSNPTKTAIVRL----PADIM----TSASGDIKWMALMIS 917
                              :.|..|..||.:...:|:|    |..:.    |..|..:.|:.
  Rat   703 ------------------VTACTERGSNTSMLRLVKLEPAPPKSLFAVNKTQTSVTLLWVE---- 745

  Fly   918 QKNCAGVPHLKYDVSSDWPKVLSYQEAGADGTGDCSLEYQTTEERWHPEPVQRQRRDGEVTSDEE 982
                .||        :|:.:||. |:.|:...|...            |||       .|:|.
  Rat   746 ----EGV--------ADFFEVLC-QKLGSGHDGKLQ------------EPV-------AVSSH-- 776

  Fly   983 IVFTIGLDKCSEVQKTYCNGPLLPDTDYNVVVRLFTASGYS---DAAVLNFKTKAAIKVTLI-LV 1043
             |.||              ..|||.|.||..|..|:....|   ..||....|:....|.:| ::
  Rat   777 -VVTI--------------SSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEVNPNVVVISVL 826

  Fly  1044 SVCSCLLLAFVLGLTVLWVRKRLAWKRDSGQGIEDPFG--------------------------- 1081
            ::.|.||:..:|...|:..:|.|...|:.|.|....|.
  Rat   827 AILSILLIGLLLVTLVILRKKHLQMARECGAGTFVNFASLEREGKLPYSWRRSVFTFLTLLPSCL 891

  Fly  1082 ----------NVIAKN---------------FAIFYTEVAKPE--KLAREFKEITVVALELSYSA 1119
                      |..:||               |..:..::||..  |.:.:|:|:.::.|::.:.|
  Rat   892 WTDYLLAFYINPWSKNGLKKRKLTNPVQLDDFDSYIKDMAKDSDYKFSLQFEELKLIGLDIPHFA 956

  Fly  1120 SELGCH--KNRYADIFPYDKNRVILDI--DAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDF 1180
            ::|..:  ||||.:|.|||.:||.|..  :.||:|||||::|.|:...:||||||||.||:..||
  Rat   957 ADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDF 1021

  Fly  1181 WRMILQYNVRVIVQVTQFREGNTIKCHEYYPYNVR-----GLTVTIKSKEVLELYDRTELTVVH- 1239
            |:|:||...|:||.:||..|...:||..|:|:...     .:||.:.|:|..|.:......:.:
  Rat  1022 WKMVLQQKSRIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMVSEEEQEDWASRHFRINYA 1086

  Fly  1240 DKYGLKEKVIHYYFKKWPDHGVPEDPMH----LIMFVKKVKAEKRPSYSPIVVHCSAGVGRTGTF 1300
            |:   .:.|:|:.:..|||||||  |.:    ::.||..|:.:...|..|:::||||||||||||
  Rat  1087 DE---AQDVMHFNYTAWPDHGVP--PANAAESILQFVYTVRQQATKSKGPMIIHCSAGVGRTGTF 1146

  Fly  1301 IGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYAC 1345
            |.||.::|.::....::|...|.::|..||.||||::||.|::.|
  Rat  1147 IALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQC 1191

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020	23/119 (19%)
		PTPc	1100..1345	CDD:214550	101/258 (39%)
		PTPc	1125..1348	CDD:238006	96/235 (41%)
Ptpro	NP_059032.1	FN3	434..526	CDD:238020	28/159 (18%)
		FN3	530..630	CDD:238020	24/129 (19%)
		fn3	725..805	CDD:278470	29/132 (22%)
		PTPc	937..1192	CDD:214550	102/260 (39%)
		PTPc	965..1193	CDD:238006	96/232 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0791
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810