Protein Alignment Ptp52F and Ptpn13

DIOPT Version :10

• Sequence 1: NP_611093.2
• Gene: Ptp52F / 36790
• FlyBaseID: FBgn0034085
• Length: 1433
• Species: Drosophila melanogaster
• Sequence 2: XP_038948202.1
• Gene: Ptpn13 / 498331
• RGDID: 1563360
• Length: 2465
• Species: Rattus norvegicus
• Alignment Length: 1769
• Identity: 346/1769 - (19%)
• Similarity: 555/1769 - (31%)
• Gaps: 635/1769 - (35%)

  Fly    18 LILWIAGVQGQTVGSLV-----AVSESQELAEK---VEVTVVSTV----YTLGFSISNEADYSID 70
            |.|....|:|..||..:     |.|...:||.:   |:..::..:    ::|...:.|.:....|
  Rat   884 LNLQAESVRGFNVGRAISTGSLASSTFNKLAVRPLSVQAEILKRLSCSEWSLYQPLQNSSKEKND 948

  Fly    71 KVIC----RNGSGSETEANAAHVCENLNPCTFYTSVVSFRSNVSGKP----PPSDQTIYAYTEYK 127
            |...    |..|.|..:.:.|.:|.:........|:....:.:.|||    ..||....|    .
  Rat   949 KASWEEKPRGMSKSYHDLSQASLCPHRKQVINMESLPQAFAELVGKPLYPMARSDTESLA----G 1009

  Fly   128 QPKTTVTSVVATANTIKVTWQTNDRACVES------------FGITAKATDYTKSFQLLNDKSSQ 180
            .|:...:..||:.|      ::.:|...||            .|::..::..:.|.....|..|.
  Rat  1010 LPQLNNSKSVASLN------RSPERRSHESDSSVEDPGQAYVVGMSLPSSGKSSSQVPFKDNDSL 1068

  Fly   181 --------------TFVNLSACLTHTI-----------TLDTRNNASVVVDTDATDVDTQYAEPG 220
                          |.|||...|.|.:           .||.....|.|......|:| ...:||
  Rat  1069 HKRWSTVSSPEREITLVNLKKDLKHGLGFQIVGGGKMGRLDLGVFISAVTPGGPADLD-GCLKPG 1132

  Fly   221 DLVMNVT-----------------NLASGITMITWGDPSEK------------NCISNYVFK--- 253
            |.:::|.                 |....:|::. ..|.||            |.:.||..|
  Rat  1133 DRLISVNSVSLEGVSHHAAVDILQNAPEDVTLVI-SQPKEKPTKVPSTPVHFANGMKNYTKKPSS 1196

  Fly   254 -------------WQRNDC----------------GTDQNQDTTTDVPSTETTNEIDYVTT---- 285
                         |.|...                |:..:||:.|:..|...::...:.|:
  Rat  1197 MQDSAMDPSEDQPWPRGPLRHVPESPFGLSSGLREGSLSSQDSRTESASLSQSHVNGFFTSHLGD 1261

  Fly   286 ----TPMETTPDTPSDEVKCEWTDVSSDGKLREYL-------LTDLQGC---DLYTFQVFINENS 336
                .|..::|..|   |..:.|:.:.....|...       :|:|.||   |:
  Rat  1262 RGWQEPQHSSPSPP---VTSKITEKTFSDSYRSPARRQGTCDVTELPGCADSDI----------- 1312

  Fly   337 TAKASQTFTSAEKLVSAVYEP-SPTAYPTQLHWTWFSPQNHPKCVANYSVTLTGPIQRSENKTMN 400
               ...|::|::...:...|| ||.....::.:..| |...|:....:.|.|.        ||..
  Rat  1313 ---DDPTYSSSQDRQAPKQEPSSPLKASDKMSFAAF-PGPSPEPGDAFEVELA--------KTDG 1365

  Fly   401 VITEETFAIFD------DLDPCGIYLVEIVPN----------------QLNG------------- 430
            .:......:||      .:...|||:..::||                .:||
  Rat  1366 SLGISVTVLFDKGGVNTSVRHGGIYVKAVIPNGAAETDGRIHKGDRVLAVNGVSLEGATHKQAVE 1430

  Fly   431 ----------------------------------------SAGTKYQEQSTVGEDQPSVIQDPVV 455
                                                    .|..|.::|:...:|...|.:|...
  Rat  1431 TLRNTGQVVHLLLEKGQSPTSRERDPASPRCPTPDQDAQSQAPEKMEKQTAHVKDYSFVTEDNTF 1495

  Fly   456 EAE----------AYSMEVSWKTPEYAD---------------------------LCIDGYRLSG 483
            |.:          ::|.|.: .|||..:                           |.::|..|.|
  Rat  1496 EVKLFKNSSGLGFSFSREDN-LTPELINGSIVRVKKLFPGQPAAESGKINVGDVILKVNGAPLKG 1559

  Fly   484 WMEDDKLVEVEALSITTQNTTVVFDKNLLACQVYIIQIIPYTKENLDGQLRQVGVETKAAIVDYT 548
            ..:.|   .:.||..|..      :.:||.|:            ...|.|.:|.          |
  Rat  1560 LSQQD---VISALRGTAP------EVSLLLCR------------PAPGVLPEVN----------T 1593

  Fly   549 KVKLEMKNAGSEFIDLIAFNADYNNSCPTIFALFTC----------NATTQVRNPYAERYVEGHS 603
            .:...:.:....|:     |:...:|.|:..::..|          .:..|.:.|........||
  Rat  1594 ALLTPLHSPAHAFL-----NSRKEHSQPSPLSVEQCASSDENGLSGQSKRQCKPPSRRESYSDHS 1653

  Fly   604 KQGFNASLS---------PLSPYATYVCKVILYNVAGPSEPVVDADMHTTTYF-----PEQPESV 654
            ..|...|:.         |||.:|....:       ...||.      :|.::     |.:|||
  Rat  1654 DSGEEESVRAAAKMPNVIPLSAFAPEALR-------SQGEPA------STMFYLPRKIPGKPES- 1704

  Fly   655 MLEKSTVSSLLFNWQPPTYTNGPIKYYQAFLMRHEASYFVPADCAIVEQDTKSETKGDPSVNFTG 719
              |.|.:.      .|...:.|.|:.             .||:||         ....|..:.|.
  Rat  1705 --ESSRLP------HPLDVSPGQIRQ-------------PPAECA---------PSDSPGKHLTH 1739

  Fly   720 LAPAV-RYMMQVAAQNDFG----------------------------------MGVYTEPVI--- 746
            ||..: :.....|.:||.|                                  :|.|...||
  Rat  1740 LASQLHKEENMTALKNDLGNHLEDSELEVELLITLVKSEKGSLGFTVTKGSQSIGCYVHDVIQDP 1804

  Fly   747 ---------GITLPAVSDS-VTQLT------VLTQGPVNNNAVYE---------------ANVTI 780
                     |..|..|:|: ||.:|      :|...|.....|..               .::|:
  Rat  1805 AKGDGRLRPGDRLVKVNDADVTNMTHTDAVNLLRAAPKTVRLVIGRILELPRMPVFPHLLPDITV 1869

  Fly   781 TWKVPCKSNGDIEYFQLAFN-----GTRNNFAPVSFERRVELDTGNKQGRMSYTETEMQPQFDYT 840
            |    |  :|:    :|.|:     |:.:....:|       |...:.........::.....|.
  Rat  1870 T----C--HGE----ELGFSLSGGRGSPHGVVYIS-------DINPRSAAAVDCSLQLLDIIHYV 1917

  Fly   841 VEVSVKNRDVEQLSSSVPGSWQSPA------GLPTIPSD-----ELIKQMRAN----VEETSNPT 890
            ..||.....:|:.:.::..|..|..      |.|.:|..     ..::.:.||    :|....|.
  Rat  1918 NGVSTHGMTLEEANRALDLSLPSVVLKVTRDGCPVVPCSTRSAISALRPLEANGLSSMEPYGQPA 1982

  Fly   891 KTAIVRLPADIMTSASGDIKWMALMISQKNCAGVPHLKYDVSSDWPKV--LSYQEAGA--DGTGD 951
            .|     |....:..:||....|:....|..:. |..|   |:|..:.  .|:||:.:  |...|
  Rat  1983 LT-----PKKSFSKVNGDGASGAMCPGGKGLSS-PRKK---SADLMEARDFSFQESDSRDDDVYD 2038

  Fly   952 -------------------CSLEYQTTEER--WHPEPVQRQRRDGEVTSDEEIVFTIGLDKCSEV 995
                               .:|..||...|  ..|:|:   |.:||.:.|.|
  Rat  2039 DPQEAEVIQSLLDVVDEEAQNLLNQTKASRRACSPDPL---RTNGEASEDGE------------- 2087

  Fly   996 QKTYCNG-PLLPDTDYNV--------VVRLFTAS--------------------------GYSDA 1025
             .|.|:| ||..|...:|        ...|..||                          ...|.
  Rat  2088 -DTDCDGSPLPEDVPESVNGGGGKACFASLIQASQEEKPVKEEATQESRESTTETTDREDSSKDP 2151

  Fly  1026 AVLNFKTKAAIKVTLILVS--VCSCLLLAFVLGLTVLWVRKRLAWKRDSGQGIEDPFGNVIAKNF 1088
            ..|..:..||:.|..:..|  .....|.|.:..|                ||:.|.
  Rat  2152 LFLTNEELAALPVVRVPPSGKYTGTQLQATIRTL----------------QGLLDQ--------- 2191

  Fly  1089 AIFYTEVAKPEKLAREFKEITVVALELSYSASELGCHKNRYADIFPYDKNRVILDIDAEGSDYIN 1153
                   ..|.|.....:|:..:...|.....| ...||||.:|.|||..||.|   .:...|||
  Rat  2192 -------GIPSKELENLQELKPLDQCLIGQTKE-NRRKNRYKNILPYDTTRVPL---GDEGGYIN 2245

  Fly  1154 ASF--IDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYNVRG 1216
            |||  |...|::..|||.|||.|.:|.|||:|:.:.|..||..:||..||..|||..|:| ::.|
  Rat  2246 ASFIRIPVGTQEFVYIACQGPLPTTVGDFWQMVWEQNSTVIAMMTQEVEGEKIKCQRYWP-SILG 2309

  Fly  1217 LTVTIKSKEVLELYDRTEL-------TVVHD-KYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVK 1273
            .|.....:..|.|....:|       ..:.| :.|....:.|..|..||||..|..|..|:.|:.
  Rat  2310 TTTMANERLRLALLRMQQLKGFVVRVMALEDIQTGEVRHISHLNFTAWPDHDTPSHPEDLLTFIS 2374

  Fly  1274 KVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQ 1338
            .::..:|.  .|::.|||||:||:||.|.:|:::..:..:.:.:|.:.|:.:|.||..||||:.|
  Rat  2375 YMRHIRRS--GPVITHCSAGIGRSGTLICIDVVLGLISQDLEFDISDLVRCMRLQRHGMVQTEGQ 2437

  Fly  1339 YTFLYACTYELVKH 1352
            |.|.|.....::.|
  Rat  2438 YVFCYQVVLYVLTH 2451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020	26/147 (18%)
		PTPc	1100..1345	CDD:214550	90/254 (35%)
Ptpn13	XP_038948202.1	KIND	3..190	CDD:214801
		FERM_F1_PTPN13	564..659	CDD:340715
		B41	566..774	CDD:214604
		PH-like	770..870	CDD:473070
		PDZ1_PTPN13-like	1081..1172	CDD:467285	19/92 (21%)
		PTN13_u3	1168..1356	CDD:465189	35/205 (17%)
		PDZ2-PTPN13_FRMPD2-like	1354..1445	CDD:467254	13/98 (13%)
		PDZ3_PTPN13_FRMPD2-like	1494..1583	CDD:467181	17/110 (15%)
		PDZ4_PTPN13-like	1767..1851	CDD:467182	14/83 (17%)
		PDZ5_PTPN13-like	1862..1948	CDD:467183	15/102 (15%)
		PTPc-N13	2216..2449	CDD:350445	87/239 (36%)