DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp52F and csw

DIOPT Version :9

Sequence 1:	NP_611093.2	Gene:	Ptp52F / 36790	FlyBaseID:	FBgn0034085	Length:	1433	Species:	Drosophila melanogaster
Sequence 2:	NP_477131.1	Gene:	csw / 45278	FlyBaseID:	FBgn0000382	Length:	945	Species:	Drosophila melanogaster

Alignment Length:	973	Identity:	193/973 - (19%)
Similarity:	309/973 - (31%)	Gaps:	420/973 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   753 VSDSVTQLTVLTQGPVNNNAVYEANVTITWKVPCKSNGDIEYFQLAFNGTRNNFAPVSFERRVEL 817
            |:..:.:..|.....:|||    .|.|:       :|.:      |:|..||    ..:||.::.
  Fly    18 VNHKLQEKQVYNNNNINNN----NNNTL-------NNNN------AYNNQRN----FEYERAIQA 61

  Fly   818 DTGNKQGRMSYTETEMQPQF------------------------------DYTVEV--------- 843
            ..|:| ||.| .|.|...:|                              |...::
  Fly    62 HYGSK-GRRS-EERERSGKFKASKGRKAKVTPPTETPEAQEPACKNCMTHDELAQIIKGVAKGAD 124

  Fly   844 SVKNRDVEQLSSSVPGSWQSPAGLPTIPSDELIKQMRANVEETSNPTKTAIVRLPADIMTSASG- 907
            :.:|||........|.|.|..|......|.|.:.::..:.:.:...|.|:....|.....:..|
  Fly   125 AQRNRDNRLQRRRRPLSAQPSAAASASTSTESLHRLTPSPQASYPATPTSWTATPPQFPAAFGGA 189

  Fly   908 -----DIKWMALMISQKNCAGVPHLKYDVSSDWPKVLSYQEAGADGT----------GDCSLEYQ 957
                 .:..:|.|..|.:  |......::|....:.| ..|.|.:|:          ||..|..:
  Fly   190 SCSNSTLSLLATMRVQLH--GYTWFHGNLSGKEAEKL-ILERGKNGSFLVRESQSKPGDFVLSVR 251

  Fly   958 TTEE------RWHPEPVQRQRRDGEVTSDEEIVFTIGLDKCSEVQKTYCNGPLLPDTDYNVVVRL 1016
            |.::      ||       |.:..:|...|      .....||:...|...|
  Fly   252 TDDKVTHVMIRW-------QDKKYDVGGGE------SFGTLSELIDHYKRNP------------- 290

  Fly  1017 FTASGYSDAAVLNFKTKAAIKVTLILVSVCSCLLLAFVLGLTVLWVRKRLAWKRDSGQGIEDPFG 1081
                                     :|..|.          ||:.:|:.....|.:..||.
  Fly   291 -------------------------MVETCG----------TVVHLRQPFNATRITAAGIN---- 316

  Fly  1082 NVIAKNFAIFYTEVAKPEKLAR-----EFKEITVVALELSYSASELGCH-----KNRYADIFPYD 1136
                          |:.|:|.:     ||:.:...:.: ::|.:| |..     ||||.:|.|||
  Fly   317 --------------ARVEQLVKGGFWEEFESLQQDSRD-TFSRNE-GYKQENRLKNRYRNILPYD 365

  Fly  1137 KNRV-ILDID--AEGSDYINASFI----DG----------------------------------- 1159
            ..|| :||::  ..|::||||::|    ||
  Fly   366 HTRVKLLDVEHSVAGAEYINANYIRLPTDGDLYNMSSSSESLNSSVPSCPACTAAQTQRNCSNCQ 430

  Fly  1160 ---------------------------------HTRK---------------------------- 1163
                                             |.|.
  Fly   431 LQNKTCVQCAVKSAILPYSNCATCSRKSDSLSKHKRSESSASSSPSSGSGSGPGSSGTSGVSSVN 495

  Fly  1164 -----------------------------------------------KEYIATQG----PKPESV 1177
                                                           |.||||||    .:..:|
  Fly   496 GPGTPTNLTSGTAGCLVGLLKRHSNDSSGAVSISMAEREREREREMFKTYIATQGCLLTQQVNTV 560

  Fly  1178 MDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYNVRGLTVTIKSKEVLELYDRTELTVVHDK- 1241
            .|||.|:.|.|.||||..|:..|....||..|:|...|.           |.:....:..|.:.
  Fly   561 TDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRS-----------EQFGHARIQCVSENS 614

  Fly  1242 ---YGLKE-----------KVIHYYFKKWPDHGVPEDPMHLIMFVKKV--------KAEKRPSYS 1284
               |.|:|           ::.||:|:.|||||||.||..::.|::.|        :|.::|  .
  Fly   615 TSDYTLREFLVSWRDQPARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAGEKP--G 677

  Fly  1285 PIVVHCSAGVGRTGTFIGLDLIMQRLKS---ESKINIFETVKKLRFQRMKMVQTQQQYTFLYACT 1346
            ||.||||||:|||||||.:|:|:.::..   :::|:|..|::.:|.||..:|||:.||.|:|...
  Fly   678 PICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAV 742

  Fly  1347 YELVKHKIPR--------------AALKMDGR-----------PKSVTVPAIPSPKKVSFPDVD- 1385
            ...::..|.|              ..:|..|.           |...::..:||...::....|
  Fly   743 QHYIQTLIARKRAEEQSLQVGREYTNIKYTGEIGNDSQRSPLPPAISSISLVPSKTPLTPTSADL 807

  Fly  1386 -------------VGSEYVS--SAPITDLDDGRPIVQLPSRFSGLRRNS-PPGENDNPTSSSN 1432
                         ||:::.|  ..|:       |:|...:..:|:..:. ..|...:.|||||
  Fly   808 GTGMGLSMGVGMGVGNKHASKQQPPL-------PVVNCNNNNNGIGNSGCSNGGGSSTTSSSN 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020
		PTPc	1100..1345	CDD:214550	104/434 (24%)
		PTPc	1125..1348	CDD:238006	98/407 (24%)
csw	NP_477131.1	SH2_C-SH2_SHP_like	211..307	CDD:198185	23/157 (15%)
		PTPc	326..744	CDD:214550	103/432 (24%)
		PTPc	543..743	CDD:238006	76/212 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443564
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840