Protein Alignment Ptp52F and PTPRQ

DIOPT Version :9

• Sequence 1: NP_611093.2
• Gene: Ptp52F / 36790
• FlyBaseID: FBgn0034085
• Length: 1433
• Species: Drosophila melanogaster
• Sequence 2: XP_016874762.1
• Gene: PTPRQ / 374462
• HGNCID: 9679
• Length: 2536
• Species: Homo sapiens
• Alignment Length: 1725
• Identity: 373/1725 - (21%)
• Similarity: 594/1725 - (34%)
• Gaps: 560/1725 - (32%)

  Fly    27 GQTVGSLVAVSESQELAEKVEVTVV-----STVYTLGFSISNEADYSIDK---VICRNGSGSETE 83
            |..|.||::|..|:.:.:.....:.     |....|.|...:..:..|.|   .:.|:....|..
Human   965 GNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEERT 1029

  Fly    84 ANAAHVCENLNPCTFYTSVV--SFRSNVSGK-----------------PPPSDQTIYAYTEYKQP 129
            .|...:.:|:.....||..:  ...|.:.|:                 .||.|.::      ||
Human  1030 INTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSV------KQ- 1087

  Fly   130 KTTVTSVVATANTIKVTWQTNDRACVESFGITAKATDYTKSFQLLNDKSSQTFVNLSACLTHTIT 194
                    .:..|:|::||..    :|..||....|.|      :.::||...:|::........
Human  1088 --------LSGVTVKLSWQPP----LEPNGIILYYTVY------VWNRSSLKTINVTETSLELSD 1134

  Fly   195 LD--TRNNASVVVDTDATD---------VDTQYAEPGDLVMNV--TNLASGITMITWGDPSEKNC 246
            ||  ...:|.|...|...|         ..|....|.|...:|  .||:|...::.|..||:.|.
Human  1135 LDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPNG 1199

  Fly   247 ISNYVFKWQRNDCGTDQNQDTTTDVPSTETTNEIDYVTTT------------------------- 286
            |..|...:.||..||.....|..:|     ||:.|.:|.:
Human  1200 IIQYYSVYYRNTSGTFMQNFTLHEV-----TNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNG 1259

  Fly   287 -------PMETTPDTP-------------SDEVKCEWTDVSSDG--------------------- 310
                   .:.|..|.|             |..:...|...:...
Human  1260 NKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLILQQTPRHVRPP 1324

  Fly   311 --------------KLREYLL-----TDLQGCDLYTFQVFI-NENSTAKASQTFTSAEKLVSAVY 355
                          |..:|:|     |:....|.||.|::| .|....:.|....:.:.|.|
Human  1325 LVTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLSS--- 1386

  Fly   356 EPSPTAYPTQLHWTWFSPQNHPKCVANYSVTLTGPIQRSENKTMNVITEETFAIFDDLDPCGIY- 419
                    |.:..:|..|......:.:|.:||.||     |:..:.||.:.:.|.::|.|..:|
Human  1387 --------TSVLLSWDPPVKPNGAIISYDLTLQGP-----NENYSFITSDNYIILEELSPFTLYS 1438

  Fly   420 -----------------------LVEIVPNQ----LNGSAGTKYQEQSTVGEDQPSVIQDPVVEA 457
                                   .|.:.|.|    :|.::...:.:.|      ||.:...:|:.
Human  1439 FFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVWLKWS------PSPLPGGIVKV 1497

  Fly   458 EAYSMEVSWKTPEYADLCIDGYRLSGWMEDDKLVEVEALSITTQNTTVVFDKNLLACQVYIIQII 522
                  .|:|..|:....|....:||:..:.|||.:|.:|                  .|.|::.
Human  1498 ------YSFKIHEHETDTIYYKNISGFKTEAKLVGLEPVS------------------TYSIRVS 1538

  Fly   523 PYTKENLDGQLRQVGVETKAAIVDYTKVKLEMKNAGSEFIDLIAFNADYNNSCPTIFALFTCNAT 587
            .:||         ||                   .|::|.:::.|..  ..|.|.:.....|.||
Human  1539 AFTK---------VG-------------------NGNQFSNVVKFTT--QESVPDVVQNMQCMAT 1573

  Fly   588 T-----------QVRNPYAERY---VEGHSKQGFNASLSP---------LSPYATYVCKVILYNV 629
            :           :..|....:|   ||.:|     ..:||         |....:||.||.....
Human  1574 SWQSVLVKWDPPKKANGIITQYMVTVERNS-----TKVSPQDHMYTFIKLLANTSYVFKVRASTS 1633

  Fly   630 AGPSEPVVDADMHTTTY---FPEQPESVMLEKSTVSSLLFNWQPPTYTNGPIKYYQAF-----LM 686
            ||..:   ::..|.:|.   .|..|.::.......:|....|..|....|   |:|.:     |.
Human  1634 AGEGD---ESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTWIRPDTILG---YFQNYKITTQLR 1692

  Fly   687 RHEASYFVPADCA-------IVEQDTKSETKGDPSVNFTGLAPAVRYMMQVAAQNDFGMGVYTEP 744
            ..:...:...:|.       :.|.....||       ..||.....|..||||..:.|.|..:..
Human  1693 AQKCKEWESEECVEYQKIQYLYEAHLTEET-------VYGLKKFRWYRFQVAASTNAGYGNASNW 1750

  Fly   745 VIGITLPAVSDSVTQLTVLTQGPVNNNAVYEA---NVTITWKVPCKSNG-----------DIEYF 795
            :...|||...|          ||..|..|...   :::|:|..|....|           |.:.|
Human  1751 ISTKTLPGPPD----------GPPENVHVVATSPFSISISWSEPAVITGPTCYLIDVKSVDNDEF 1805

  Fly   796 QLAFNGTRNNFAPVSFE-RRVELDT-------------------GNKQGRMSYTETEMQP----- 835
            .::|  .::|....:.| :.:|:.|                   |.....|..|..|..|
Human  1806 NISF--IKSNEENKTIEIKDLEIFTRYSVVITAFTGNISAAYVEGKSSAEMIVTTLESAPKDPPN 1868

  Fly   836 ------------QFDYT------------------------VEVSVKNRDVEQLSS--------- 855
                        :|..|                        ..|.:.|..:.|.::
Human  1869 NMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQALVYREDDPTAVQIHNLSIIQKTNTFVIAMLEG 1933

  Fly   856 ---------SVPGSWQSPAGLPTIPSDELIKQMRANVEETSNPT-------------KTAIVRLP 898
                     ||.....:.|| |.:|. .:...::|.....:.||             .|..:|:|
Human  1934 LKGGHTYNISVYAVNSAGAG-PKVPM-RITMDIKAPARPKTKPTPIYDATGKLLVTSTTITIRMP 1996

  Fly   899 ADIMTSASGDIKWMALMISQKNCAGVPHLKYDVSSDWPKVLSYQEAGADGTGDCSLEYQT----- 958
            ....:...|.||.:.::::                         |.||...|:.:..|..
Human  1997 ICYYSDDHGPIKNVQVLVT-------------------------ETGAQHDGNVTKWYDAYFNKA 2036

  Fly   959 ----TEERWHPEPVQRQRRDGEVTSDEEIVFTIGLDKCSEV---QKTYCNGPLLPDTDY------ 1010
                |.|.: |.|...:.:. :.:.:||| :.||.|....:   :...|||||.|...|
Human  2037 RPYFTNEGF-PNPPCTEGKT-KFSGNEEI-YIIGADNACMIPGNEDKICNGPLKPKKQYLFKFRA 2098

  Fly  1011 -NVVVRLFTASGYSDAAVLNFKTKAAIKVTLILVSVCSCLLLAFVLGLTVLWVRKRLAWKRDSGQ 1074
             |::.: ||.|.||| .|.......:.:...|::||..|:|...:|| |.::...|:..|:..|
Human  2099 TNIMGQ-FTDSDYSD-PVKTLGEGLSERTVEIILSVTLCILSIILLG-TAIFAFARIRQKQKEG- 2159

  Fly  1075 GIEDP------------------------------FGNVIAKNFAIF------YTEVAKP----- 1098
            |...|                              :.:...:...||      |.:..||
Human  2160 GTYSPQDAEIIDTKLKLDQLITVADLELKDERLTRYSSFFFRRKEIFVIQLLSYRKSIKPISKKS 2224

  Fly  1099 -------------EKLAREFKEITVVALELSYSASELGCH--KNRYADIFPYDKNRV--ILDIDA 1146
                         .|...||.|:.....:||.:.::|..:  |||:.:|.||:.|||  |.|...
Human  2225 FLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASV 2289

  Fly  1147 EGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYP 1211
            .||||||||:|.|:....|:||||||.|.:|.|||||:.:...:.:|.:||..|...|:||:|:|
Human  2290 PGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWP 2354

  Fly  1212 YNVRGLT-----VTIKSKEVLELYDRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMF 1271
            .:.:.:|     |..|..|.::: |.|...:..:::|....|....|..||:|||||:...||.|
Human  2355 EDNKPVTVFGDIVITKLMEDVQI-DWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSAPLIHF 2418

  Fly  1272 VKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQ 1336
            ||.|:|.:....:|::|||||||||||.||.||.:.|.:.....::|:..|.:||.:||.|||..
Human  2419 VKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNL 2483

  Fly  1337 QQYTFLYACTYELVKHK--------IPRAAL-KMD 1362
            .||.||:.|..:|:.:|        :..:|| |||
Human  2484 AQYIFLHQCILDLLSNKGSNQPICFVNYSALQKMD 2518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020	22/112 (20%)
		PTPc	1100..1345	CDD:214550	104/253 (41%)
		PTPc	1125..1348	CDD:238006	98/231 (42%)
PTPRQ	XP_016874762.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910