Protein Alignment Ptp52F and Ptp4E

DIOPT Version :10

• Sequence 1: NP_611093.2
• Gene: Ptp52F / 36790
• FlyBaseID: FBgn0034085
• Length: 1433
• Species: Drosophila melanogaster
• Sequence 2: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Alignment Length: 1537
• Identity: 347/1537 - (22%)
• Similarity: 570/1537 - (37%)
• Gaps: 342/1537 - (22%)

  Fly    58 GFSISNEADYSIDKVICRNGSGSETEANAAHVCENLNPCTF---YTSVVSFRSNVSGKPPPS--- 116
            |.....|.:.|:..|.....|...|.|....|.|.:...||   ||:..|||  |..:||.:
  Fly   308 GLVPGREYNISVQTVSEDETSSVPTTARYLTVPERVLNVTFDEAYTTSSSFR--VRWEPPRTYSE 370

  Fly   117 -----------------------DQTIYAYTEYKQPKTTVTSVVAT------------------- 139
                                   |...:.|.:..:|..|...||.|
  Fly   371 FDAYQVMLSTSRRIFNVPRAANGDSVYFDYPDILEPGRTYEVVVKTIADNVNSWPASGEVTLRPR 435

  Fly   140 ------------ANTIKVTWQTNDRACVESFGIT----AKATDYTKSF------QLLNDKSSQTF 182
                        :|.:.::|:..:....:|:.|:    ..|::....|      |:..:.:..|.
  Fly   436 PVRSLGGFLDDRSNALHISWEPAETGRQDSYRISYHEQTNASEVPAPFPVAAESQITTNLTEYTL 500

  Fly   183 VNLSACLTHTITLDTRNNASVVVDTDATDVDTQYAEP-GDLVMNVTNLASGITMITW-GDPSEKN 245
            .:|.|...:.|.:...:..   |.::|:|: |:|..| ..|:..:.::..|: |::| .|.:.:.
  Fly   501 DSLLAGRRYLIAVQALSKG---VASNASDI-TRYTRPAAPLIQELRSIDQGL-MLSWRSDVNSRQ 560

  Fly   246 CISNYVFKWQRNDCGTDQNQDTTTDVPSTETTNEIDYVTTTPMETTPDTPSD--EVKCEWTDVSS 308
              ..|...:|||  ||.:.:...|:    ||:..|.|:          .|..  |||........
  Fly   561 --DRYEVHYQRN--GTREERTMATN----ETSLTIHYL----------HPGSGYEVKVHAISHGV 607

  Fly   309 DGKLREYLLTDLQGCDLYTFQVFINENSTAKASQTFTSAEKLVSAVYEPSPTAYPTQ-------- 365
            ..:...|            ||                       ||:...|.....|
  Fly   608 RSEPHSY------------FQ-----------------------AVFPKPPQNLTLQTVHTNLVV 637

  Fly   366 LHWTWFSPQNHPKCVANYSVTLTGPIQRSENKTMNVITEETFAIFDDLDPCGIYLVEIVPNQLN- 429
            |||......:..:.|..|. |...|.||...      ..|..|...|:.....|||::  |.::
  Fly   638 LHWQAPEGSDFSEYVVRYR-TDASPWQRISG------LHENEARIKDMHYGERYLVQV--NTVSF 693

  Fly   430 GSAGTKYQEQSTVGEDQPSVIQDPVVEAEAYSMEVSWKTPEYADLCIDGYRLSGWMEDDKLVEVE 494
            |.......|.:.....||.....|:|::...::|  |..|   |..:|.|.|..|..|      |
  Fly   694 GVESPHPLELNVTMPPQPVSNVVPLVDSRNLTLE--WPRP---DGHVDFYTLKWWPTD------E 747

  Fly   495 ALSITTQNTTVVFDKNLLACQVYIIQIIPYTKENLDGQLRQVGVETKAAIVDYTKVKL-----EM 554
            ...:..:|.|.:.|.:..:.::.|..:.|..:...:.|....|:.:....:....:.|     .:
  Fly   748 EDRVEFKNVTQLEDLSSPSVRIPIEDLSPGRQYRFEVQASSNGIRSGTTHLSTRTMPLIQSDVFI 812

  Fly   555 KNAGSEFIDLIAFNADYNNSCPT--------IFALFTCNATTQVRNPYA---ERYVEGHSKQGFN 608
            .|||.|..........|.   ||        |:.....:.|.:.:...|   ||          .
  Fly   813 ANAGHEQGQDETITLSYT---PTPADSTRFDIYRFSMGDPTIKDKEKLANDTER----------K 864

  Fly   609 ASLSPLSPYATYVCKVILYNVAG--PSEPVVDADMHTTTYFPEQPESVMLEKSTVSSLLFNWQPP 671
            .|.|.|:|...|  .|.::.|:|  .|.||    .......|.....:...:.....:..:|..|
  Fly   865 LSFSGLTPGKLY--NVTVWTVSGGVASLPV----QRLYRLHPLPISDLKAIQVAAREITLHWTAP 923

  Fly   672 T--YTNGPIKYYQAFLMRHEASYFVPADCAIVEQDTKSETKGDPSVNFTGLAPAVRYMMQVAAQN 734
            .  ||:..::|..|   ..||.       .:::..||     :..:...||.|...|...|..::
  Fly   924 AGEYTDFELQYLSA---DEEAP-------QLLQNVTK-----NTEITLQGLRPYHNYTFTVVVRS 973

  Fly   735 DFGMGVYTEPVIGITL----PAVSDSVTQLTVLTQGPVN---NNAVYEANVTITWKV-PCKSNGD 791
            ....|.....|...||    ..:|.|...||. ..|.|:   .:.|....||..|.: |.:.:|.
  Fly   974 GSIQGTDFADVSVSTLMRSSAPISASYQTLTA-PPGKVDYFQPSDVQPGEVTFEWSLEPAEQHGP 1037

  Fly   792 IEYFQLAFNGTRNNFAPVSFERRVELDTGNKQGRMSYTETEMQPQFDYTVEVSVKN-----RDVE 851
            |:||::......:.....|:|..|....|...|        :.|...|...:..|:     .:.|
  Fly  1038 IDYFRITCQNADDAADVSSYEFPVNATQGKIDG--------LVPGNHYIFRIQAKSALGYGAERE 1094

  Fly   852 QLSSSVPGSWQSPAGLPTIPSDELIKQMRANVEETSNPTKTAIVRLPADIMTSASGDIKWMALMI 916
            .:.:       .|...|.:|...:...      |.|..:.|..:.......::|.|.::...::|
  Fly  1095 HIQT-------MPILAPPVPEPSVTPL------EVSRTSSTIEISFRQGYFSNAHGMVRSYTIII 1146

  Fly   917 SQ---KNCAGVPHLKYDVSSDWPKVLSYQEAGADGTGDCSLEYQTTEERWHPEPVQRQRRDGEVT 978
            ::   ||.:|:.      ...|..|.:|         ...|.||..|. ::|.......|...:.
  Fly  1147 AEDVGKNASGLE------MPSWQDVQAY---------TVWLPYQAIEP-YNPFLTSNGSRKSSLE 1195

  Fly   979 SDEEIVFTIGLDKCSEVQKTYCNGPLLPDTDYNVVVRLFT-ASGYSDAAVLNFKTKAAIKVTLIL 1042
            ::.   ||||...|.:.|..||||||...|.|.:.:|.|| ...::|....:..|.......::.
  Fly  1196 AEH---FTIGTANCDKHQAGYCNGPLRAGTTYRIKIRAFTDEDKFTDTVYSSPITTERSDTVIVA 1257

  Fly  1043 VSVCSCLLLAFVLGLTVLWVRKR---------LAWKRDS----GQGIEDPFGNVIAKNFAIFYTE 1094
            .:|.:.||:|.|  |.|::.:.|         ||..:|.    .:|...|...|..|:|:..|..
  Fly  1258 ATVSAVLLVAMV--LVVVYCQHRCQLIRRASKLARMQDELAALPEGYITPNRPVHVKDFSEHYRI 1320

  Fly  1095 VAKPE--KLAREFKEITVVALELSYSASELGCH--KNRYADIFPYDKNRVILD--IDAEGSDYIN 1153
            ::...  :.:.||:|:..|..:.:.|.:.|.|:  |||:.:|.|||.:|..|.  .|.:||||||
  Fly  1321 MSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYIN 1385

  Fly  1154 ASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYN-VRGL 1217
            |:::.||...:|:|.||||...:..:||||..:.|.|.||.:|:..|....||.:|:|.: |...
  Fly  1386 ANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMF 1450

  Fly  1218 TVTIKSKEVLELYDRTELTVVHDKYGLKEKVI----------HYYFKKWPDHGVPEDPMHLIMFV 1272
            ...||.:.:::       |..|| :.:.|.::          |::|..|||.||||.|..|:.||
  Fly  1451 YGDIKVQLIID-------THYHD-WSISEFMVSRNCESRIMRHFHFTTWPDFGVPEPPQSLVRFV 1507

  Fly  1273 KKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQ 1337
            :..:........||:|||||||||:||||.||.|:|.:.....::||..|..:|.:|:.||||:|
  Fly  1508 RAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQ 1572

  Fly  1338 QYTFLYACTYELVK-----------------HKIPRAALKMDGRPKSVTVPAIPSPKKVSFPDVD 1385
            ||..::.|...:::                 :::.:..|:...:.|..|:|...|.......|.|
  Fly  1573 QYVCIHQCLLAVLEGKEHLLADSLELHANDGYEVTKIYLERQPQTKMGTLPIRASLAMAEKLDAD 1637

  Fly  1386 VGSEYVSSAPITDLDDGRPIVQLPSRFSGLRRN-SPPGENDN 1426
            :         :|:.|:.....|...:...|... .|.|.||:
  Fly  1638 L---------MTNKDEDEDQEQQQQQQLQLATEVKPKGSNDD 1670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020	18/102 (18%)
		PTPc	1100..1345	CDD:214550	97/259 (37%)
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628	6/25 (24%)
		fn3	247..328	CDD:394996	4/19 (21%)
		FN3	319..>749	CDD:442628	99/509 (19%)
		fn3	708..796	CDD:394996	21/98 (21%)
		fn3	902..978	CDD:394996	15/90 (17%)
		fn3	1013..1092	CDD:394996	17/86 (20%)
		PTP_tm	1127..1247	CDD:465889	33/138 (24%)
		R3-PTPc	1358..1579	CDD:350396	88/228 (39%)