DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp52F and Ptprd

DIOPT Version :9

Sequence 1:	NP_611093.2	Gene:	Ptp52F / 36790	FlyBaseID:	FBgn0034085	Length:	1433	Species:	Drosophila melanogaster
Sequence 2:	XP_038967340.1	Gene:	Ptprd / 313278	RGDID:	1561090	Length:	1940	Species:	Rattus norvegicus

Alignment Length:	1451	Identity:	327/1451 - (22%)
Similarity:	545/1451 - (37%)	Gaps:	369/1451 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 PKTTVTSVV--ATANTIKVTWQTNDRACVESFGITAKATDYTKSFQLLNDKSSQTF--VNLSACL 189
            ||...|.||  :||.:|.:||.:.:...|..:.|..|..:..:.::.::..::..:  ..||...
  Rat   331 PKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEEPYKEIDGIATTRYSVAGLSPYS 395

  Fly   190 THTITLDTRNN-----ASVVVDTDATDVDTQYAEPGDLVMNVTNLASGITMITWGDPSEKN-CIS 248
            .:...:...||     ||..|.|. |......:.|.|:...:  |:|...::.|.:|.|.| .|.
  Rat   396 DYEFRVVAVNNIGRGPASEPVLTQ-TSEQAPSSAPRDVQARM--LSSTTILVQWKEPEEPNGQIQ 457

  Fly   249 NY-----------VFKWQRNDCGTDQNQDTT-----------------TDVPSTETTNEIDYVTT 285
            .|           |..|.:::..  .:|.||                 |.:.....:::|..:|.
  Rat   458 GYRVYYTMDPTQHVNNWMKHNVA--DSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQ 520

  Fly   286 T-----PMETTPDTPSD-EVKCEWTD-----------VSSDGKLRE-----------YLLTDLQG 322
            |     |:....:..|: .:...||.           |..||...|           |.|..|:.
  Rat   521 TGVPGQPLNFKAEPESETSILLSWTPPRSDTIASYELVYRDGDQGEEQRITIEPGTSYRLQGLKP 585

  Fly   323 CDLYTFQVFINENSTAKASQTFTSAEKLVSA-VYEPSPTAYPTQLHWT----------WFSP--Q 374
            ..||.|::      :|::.|...::...:|| ..:..|:|.|..:..|          |..|  :
  Rat   586 NSLYYFRL------SARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVE 644

  Fly   375 NHPKCVANYSV---TLTGPIQRSENKTMNVITEETFAIFDDLDPCGIYLVEIVPNQLNGSAGTKY 436
            .....:..||:   .:.|...| .::.:.:.::.|..:.:.|:....|.:.:..:...|......
  Rat   645 KQNGIITEYSLKYAAVDGEDYR-PHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESL 708

  Fly   437 QEQSTVGEDQPSVIQDPV-VEA-EAYSMEVSWKTP----EYADLCIDGYRL-------------- 481
            .......||.||.....| ||| .|.:::|||::|    ::..  |.||::
  Rat   709 SVLIRTDEDVPSGPPRKVEVEAVNATAVKVSWRSPVPNKQHGQ--IRGYQVHYVKMENGEPKGQP 771

  Fly   482 ---------SGWMEDDKLVEVEALSITTQNTTVVFDKNLLACQVYIIQIIPYTKENLDGQLRQVG 537
                     :.|..||          .|::..::  ..|.....|.:.:..||.:....:.:...
  Rat   772 MLKDVMLADAQWEFDD----------ATEHDMII--SGLQPETSYSLTVTAYTTKGDGARSKPKL 824

  Fly   538 VETKAA-------IVDYTKVKLEMKNAGSEFIDLIAFNADYNNSCPTIFALFTCNATTQVRNPYA 595
            |.|..|       ::::|    :|..|      ||.::...:...|
  Rat   825 VSTTGAVPGRPRLVINHT----QMNTA------LIQWHPPVDTFGP------------------- 860

  Fly   596 ERYVEGHSKQGFNASLSPLSPY-----------------ATYVCKVILYNVAGPSEPVV---DAD 640
               ::|:..:.....:.||:..                 |:|:.::...|..|..|.:|   ...
  Rat   861 ---LQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYIFRLSARNKVGFGEEMVKEISVP 922

  Fly   641 MHTTTYFPEQPESVMLEKSTVSSLLFNWQPPTYT--NGPIKYYQAFLMRHEASYFVPADCAIVEQ 703
            ....|.||:...|   |.:|.:|:..:||||...  ||.|..| ..|.|......:|.:..||..
  Rat   923 EEVPTGFPQNLHS---EGTTSTSVQISWQPPVLAERNGVITKY-TLLYRDINVPLLPMEHLIVPA 983

  Fly   704 DTKSETKGDPSVNFTGLAPAVRYMMQVAAQNDFGMGVYTEPVIGITLPAVSDSVTQLTVLTQGPV 768
            ||        |:..|||.....|.::|.|....|.|.|:..|...|||     |.|........|
  Rat   984 DT--------SMTLTGLKSDTTYDVKVRAHTSKGPGPYSPSVQFRTLP-----VDQAVFAKNFHV 1035

  Fly   769 NNNAVYEANVTITWKVPCKSNGDIEYFQLAFNG----------TRN---NFAPVSFERRVELDTG 820
              .||.:.:|.::|::|...|..:.:..|..:|          |:.   |..|......|..:.|
  Rat  1036 --KAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRG 1098

  Fly   821 NKQGRMSYTET--------EMQPQF----DYTVEVSVKNRDVEQLSSSVPG-------------- 859
            |..|.:.:..|        ..:|.|    :....::|:..|| ..:.::.|
  Rat  1099 NSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPDV-PANENIKGYYIIIVPLKKSRGK 1162

  Fly   860 ---SWQSPAGLPTIPSDELIKQM---RANVEETSNPTKTAIVRLPADIMTS--ASGDIKWMALMI 916
               .|:||   ..:..|||:|::   |.::...........:....|::.:  ..||.|......
  Rat  1163 FIKPWESP---DEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFT 1224

  Fly   917 SQKNCAGVPHLKYDVSSDWPKVLSYQEAGADGTGDCSLEYQTTEERWHPEPVQRQRRDGEVTSDE 981
            :::..:|..::.:.::     |:.:.|         |..|.|:.   :.:||.....|.:..:||
  Rat  1225 NKQLQSGQEYVFFVLA-----VMDHAE---------SKMYATSP---YSDPVVSMDLDPQPITDE 1272

  Fly   982 E------------------IVFTIGLDKCSEVQK----------TYCNGPLLPD---TDYNVVVR 1015
            |                  ||..|.|.|.|:..:          :..|...:|.   ||...:.|
  Rat  1273 EEGLIWVVGPVLAVVFIICIVIAILLYKSSKPDRKRAESESRKSSLPNSKEVPSHHPTDPVELRR 1337

  Fly  1016 L-FTASGYSDAAV---LNFKTKAAIKVTLILVSVCSCLLLAFVLGLTVLWVRKRLAWKRDSGQGI 1076
            | |...|..|:..   |:|.:.|:.....||                            :....|
  Rat  1338 LNFQTPGSDDSGYPGNLHFSSMASHPPIPIL----------------------------ELADHI 1374

  Fly  1077 EDPFGNVIAKNFAIFYTEVAKPEKLAREFKEITVVALELSYSASELGCHKNRYADIFPYDKNRVI 1141
            |....|...| |:..|..:...::...|            :|..|:...|||||::..||.:||:
  Rat  1375 ERLKANDNLK-FSQEYESIDPGQQFTWE------------HSNLEVNKPKNRYANVIAYDHSRVL 1426

  Fly  1142 LDI--DAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTI 1204
            |..  ...||||:||::|||:.::..||||||..||:..||||||.:.....:|.:|:..|.:.:
  Rat  1427 LSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRV 1491

  Fly  1205 KCHEYYP---YNVRGLTVTIKSKEVLELYDRTELTVVHDKYGLKEK--VIHYYFKKWPDHGVPED 1264
            ||.:|:|   ....|| |.:...:.:||......|....|.|..||  |..:.|..||||||||.
  Rat  1492 KCDQYWPSRGTETHGL-VQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEH 1555

  Fly  1265 PMHLIMFVKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQR 1329
            |...:.|:::||....|...|:||||||||||||.||.:|.:::|:|.|..::|:..|..:|.||
  Rat  1556 PTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQR 1620

  Fly  1330 MKMVQTQQQYTFLYACTYELV 1350
            ..||||:.||.|::....|.|
  Rat  1621 NYMVQTEDQYIFIHDALLEAV 1641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020	31/102 (30%)
		PTPc	1100..1345	CDD:214550	99/251 (39%)
		PTPc	1125..1348	CDD:238006	96/229 (42%)
Ptprd	XP_038967340.1	I-set	31..123	CDD:400151
		Ig strand A'	39..43	CDD:409353
		Ig strand B	46..55	CDD:409353
		Ig strand C	61..66	CDD:409353
		Ig strand C'	69..72	CDD:409353
		Ig strand D	75..83	CDD:409353
		Ig strand E	84..94	CDD:409353
		Ig strand F	102..110	CDD:409353
		Ig strand G	113..123	CDD:409353
		IgI_2_RPTP_IIa_LAR_like	135..234	CDD:409400
		Ig strand B	151..155	CDD:409400
		Ig strand C	164..168	CDD:409400
		Ig strand E	198..202	CDD:409400
		Ig strand F	212..217	CDD:409400
		Ig strand G	224..227	CDD:409400
		IgI_3_RPTP_IIa_LAR_like	247..328	CDD:409401
		Ig strand B	261..265	CDD:409401
		Ig strand C	274..278	CDD:409401
		Ig strand E	295..299	CDD:409401
		Ig strand F	307..312	CDD:409401
		Ig strand G	320..323	CDD:409401
		FN3	331..420	CDD:238020	21/89 (24%)
		FN3	427..519	CDD:238020	17/95 (18%)
		FN3	524..612	CDD:238020	18/93 (19%)
		FN3	620..714	CDD:238020	12/94 (13%)
		fn3	721..820	CDD:394996	20/112 (18%)
		FN3	832..927	CDD:238020	15/126 (12%)
		FN3	930..1021	CDD:238020	31/102 (30%)
		FN3	1031..>1092	CDD:238020	12/62 (19%)
		R-PTPc-D-1	1362..1645	CDD:350472	109/322 (34%)
		R-PTP-D-2	1646..1937	CDD:350476
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19134
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010