Protein Alignment Ptp52F and Ptprz1

DIOPT Version :10

• Sequence 1: NP_611093.2
• Gene: Ptp52F / 36790
• FlyBaseID: FBgn0034085
• Length: 1433
• Species: Drosophila melanogaster
• Sequence 2: NP_037212.2
• Gene: Ptprz1 / 25613
• RGDID: 3455
• Length: 2316
• Species: Rattus norvegicus
• Alignment Length: 1761
• Identity: 383/1761 - (21%)
• Similarity: 611/1761 - (34%)
• Gaps: 583/1761 - (33%)

  Fly    39 SQELAE---KVEVTVVSTVYTLGFSISNEADYSIDKVICRNGSGSET-----EANAAHVCENLN- 94
            ||::||   :.|:::.|.:.|      |...:|::.......|||:|     :.|.:...|:||
  Rat   504 SQQVAEFNPEREMSLPSQIGT------NLPPHSVEGTSASLNSGSKTLLVFPQMNLSGTAESLNM 562

  Fly    95 -PCTFYTSV---VSFRSNV-------------SGKPPPS-------DQTIYAYTEYKQPKTTVTS 135
             ..|.|..|   :|...|:             ||..|.|       |...:.||........||.
  Rat   563 VSITEYKEVSADLSEEENLLTDFKLDSGADDSSGSSPASSTVPFSTDNLSHGYTSSSDTPEAVTY 627

  Fly   136 VV----ATANTIK---------------------------VTWQTNDRACVESFGITAKATDYTK 169
            .|    :|.|.::                           :|.|:...:..|.| :...:||
  Rat   628 DVLRPESTRNALEDSAPSGSEESLKDPSLEGSVWFPGSTDLTTQSETGSGREGF-LQVNSTD--- 688

  Fly   170 SFQLLNDKSSQTFVNLSACLTHTITLD-TRNNASVVVDTD----------ATDVD----TQYAEP 219
             ||:  |:|.:|        |.|.:.| |.:....|.|.:          .|:|.    |..:.|
  Rat   689 -FQV--DESRET--------TETFSPDATASRGPSVTDMEMPHYSTFAYPPTEVTPHAFTPSSRP 742

  Fly   220 GDLVMNVTNLASGITMITW-GDPSEKNCISNYVFKWQRNDCGTDQNQDTT--------------- 268
            .||......|.|..|...: |:...:...|:.||.........:|..:||
  Rat   743 LDLAPTSNILHSQTTQPVYNGETPLQPSYSSEVFPLVTPLLLDNQTLNTTPAASSSDSALHATPV 807

  Fly   269 ---------------TDVP---------STETTNEIDYVTTTPMETTPDTPSDEVKCEWTDVSSD 309
                           .|.|         |::..:.:..|:.|..:.|.....||:....:.:.:.
  Rat   808 FPSVGVSFDSILSSYDDAPLLPFSSASFSSDLFHHLHTVSQTLPQVTSAAERDELSLHASLLVAG 872

  Fly   310 GKLREYLLTD--LQGCDLYTFQVFINENS--------------TAKASQTFTSAEKLVSAVYEPS 358
            |.|   ||..  :|..|:.:.||.|:..|              |:..||..:.:..:|...|...
  Rat   873 GDL---LLEPSLVQYSDVMSHQVTIHAASDTLEFGSESAVLYKTSMVSQIESPSSDVVMHAYSSG 934

  Fly   359 P-TAYPTQLHWTWFSPQNHPKCVANYSVTLTGPIQRSENKTMNVITEETFAIFDDLDPCGIYLVE 422
            | |:|..:       ..:|...|::.|..   |:..|    :.|..:.:..|    :|..|.|.|
  Rat   935 PETSYAIE-------GSHHVLTVSSSSAI---PVHDS----IGVADQGSLLI----NPSHISLPE 981

  Fly   423 I-----------VPNQLNGSAGTKYQEQSTVGEDQPSVIQD-----------PVVEAE------- 458
            .           :|..|:|..     |.|....|...::.|           ||..|:
  Rat   982 SSFITPTASLLQLPPALSGDG-----EWSGASSDSELLLPDTDGLRTLNMSSPVSVADFTYTTSV 1041

  Fly   459 -------------AYSMEVSWKTPEYADLCIDGYR---------LSGWMEDDKLVEVEALSITTQ 501
                         .|..|...|...::|:......         ::.|.|..|...|...||.:.
  Rat  1042 SGDDIKPLSKGEMMYGNETELKMSSFSDMAYPSKSTVVPKMSDIVNKWSESLKETSVSVSSINSV 1106

  Fly   502 NT-------TVVFDKNLLACQVYIIQIIP-YTKENLDGQL-RQVGVETKAAIVDYTKVKLEMKNA 557
            .|       |.|||:.:......|..:.| :|.....|.. .:.|:.|
  Rat  1107 FTESLVYPITKVFDQEISRVPEIIFPVKPTHTASQASGDTWLKPGLST----------------- 1154

  Fly   558 GSEFIDLIAFNADYNNSCPTIFALFTCNATTQVRNPYAERYVEGHSKQGFNASLSPL-----SPY 617
                           ||.|.:    :..|:::|.:|                |..||     ||:
  Rat  1155 ---------------NSEPAL----SDTASSEVLHP----------------STQPLLYEAASPF 1184

  Fly   618 ATYVCKVILYNVAGPSEPVVDADMHTTTYFPEQP------ESVMLEKSTVS-------------S 663
            .|   :.:|.    ||.|..|.|....|..|..|      |:.|:|:|:.|             |
  Rat  1185 NT---EALLQ----PSFPASDVDTLLKTALPSGPRDPVLTETPMVEQSSSSMSLPLASESASSKS 1242

  Fly   664 LLFNWQPPTYTNGPIKYYQAFLMR-----HEASYFVPADCAIVEQ---DTKSETKGDPSVN---- 716
            .|.....|.....|...:...|.|     ....||        ||   .:||..:..||::
  Rat  1243 TLHFTSVPVLNMSPSDVHPTSLQRLTVPHSREEYF--------EQGLLKSKSPQQVLPSLHSHDE 1299

  Fly   717 FTGLA---------PAVRYMMQV------AAQND------FGMGVYTEPVIGIT---LPAVSDSV 757
            |...|         |..|:....      ..||.      :...::..|.|.||   |..:..:|
  Rat  1300 FFQTAHLDISQAYPPKGRHAFATPILSIDEPQNTLISRLVYSEDIFMHPEISITDKALTGLPTTV 1364

  Fly   758 TQLTVLT-------QGPVNNNAV---YEANVTIT-WKVPCKS-------------------NGDI 792
            :.:.:.|       .||::...|   .:.:||.| ..:|.|:                   :||
  Rat  1365 SDVLIATDHSVPLGSGPISMTTVSPNRDDSVTTTKLLLPSKATSKPTHSARSDADLVGGGEDGD- 1428

  Fly   793 EYFQLAFNGTRNNFAPVSFERRVELDTGNKQGRMS-YTETEMQPQFDYTVEVSVKNRDVEQLSSS 856
            :|....::...::..||           ||....| |.|::.:          |.|....|.||.
  Rat  1429 DYDDDDYDDIDSDRFPV-----------NKCMSCSPYRESQEK----------VMNDSDTQESSL 1472

  Fly   857 VPGSWQSPAGLPTIPSDELIKQMRANVEETSNPTKTAIVRLPADIMTSASGDIKWMALMISQKNC 921
            |.            .||.:...:..|.||.:..|....|....|.....|        |:.||:.
  Rat  1473 VD------------QSDPISHLLSENTEEENGGTGVTRVDKSPDKSPPPS--------MLPQKHN 1517

  Fly   922 AG------------VPHLKYDVSSDWPKVLSYQEAGA-DGTGDCSLEYQTTEERWHPEPVQRQRR 973
            .|            :||.  ..|..|..:.|.:|:|: .||.|...:.:|:.:...|: |..:..
  Rat  1518 DGREDRDIQMGSAVLPHT--PGSKAWAVLTSDEESGSGQGTSDSLNDNETSTDFSFPD-VNEKDA 1579

  Fly   974 DGEVTSDEEIVFT--------------IGLDKCSEVQKTYCNGPLLPDTDYNVVVRLFTASGYSD 1024
            ||.:.:|:..:..              .|:...||.:.          ::.:...|:..|.|
  Rat  1580 DGVLEADDTGIAPGSPRSSTPSVTSGHSGVSNSSEAEA----------SNSSHESRIGLAEG--- 1631

  Fly  1025 AAVLNFKTKAAIKVTLILVSVCSCLLLAFVLGLTVLWVRKRLA----WKRDSGQ----------- 1074
               |..:.||.|  .|::||..:.:.|..::|:.:.| ||...    :..|:..
  Rat  1632 ---LESEKKAVI--PLVIVSALTFICLVVLVGILIYW-RKCFQTAHFYLEDNTSPRVISTPPTPI 1690

  Fly  1075 -GIEDPFGNVIAKNFAIFYTEVAKPEKLAREFKEITVVALELSYSASELGC-----------HKN 1127
             .|.|..|.:..|:|.....::........||:.:.....|:.....:||.           |||
  Rat  1691 FPISDDIGAIPIKHFPKHVADLHASNGFTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKN 1755

  Fly  1128 RYADIFPYDKNRV----ILDIDAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYN 1188
            ||.:|..||.:||    :.:.|.:.:|||||:::||:.|.|.|||.|||...:..||||||.::|
  Rat  1756 RYVNIVAYDHSRVKLTQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHN 1820

  Fly  1189 VRVIVQVTQFREGNTIKCHEYYPYN----VRGLTVTIKSKEVLELYDRTELTVVHDKYGLKE--- 1246
            |.|||.:|...|....||.:|:|.:    .....|..|:.:||..|.....|:.:.|  :|:
  Rat  1821 VEVIVMITNLVEKGRRKCDQYWPTDGSEEYGSFLVNQKNVQVLAYYTVRNFTLRNTK--IKKGSQ 1883

  Fly  1247 -------KVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLD 1304
                   .|..|::.:|||.||||..:.::.||:|....||.:..|:|||||||||||||:|.||
  Rat  1884 KGRSSGRLVTQYHYTQWPDMGVPEYSLPVLAFVRKTAQAKRHAVGPVVVHCSAGVGRTGTYIVLD 1948

  Fly  1305 LIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVKHK---------------- 1353
            .::|:::.|..:|||..:|.:|.||..:|||::||.|::....|.:..|
  Rat  1949 SMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVPDSHIHSYVNTL 2013

  Fly  1354 -IP-------------------------RAALKMDGRPKSVTVPAIPSPK-KVSFPDVD-VGSEY 1390
             ||                         ..|||...|.|:.|...||..: :|....:. .|::|
  Rat  2014 LIPGPSGKTKLEKQFQLLSQSNILQSDYSTALKQCNREKNRTSSIIPVERSRVGISSLSGEGTDY 2078

  Fly  1391 VSSAPI 1396
            ::::.|
  Rat  2079 INASYI 2084

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020	29/152 (19%)
		PTPc	1100..1345	CDD:214550	102/273 (37%)
Ptprz1	NP_037212.2	alpha_CARP_receptor_like	45..298	CDD:239396
		fn3	313..401	CDD:394996
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	433..499
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	518..537		4/24 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	586..624		7/37 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	636..720		18/98 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1141..1172		9/82 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1204..1228		7/23 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1401..1521		31/161 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1545..1622		15/87 (17%)
		PTP_DSP_cys	1718..1995	CDD:475123	103/278 (37%)
		R-PTP-Z-2	2078..2281	CDD:350507	2/7 (29%)