DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp52F and pyp2

DIOPT Version :9

Sequence 1:	NP_611093.2	Gene:	Ptp52F / 36790	FlyBaseID:	FBgn0034085	Length:	1433	Species:	Drosophila melanogaster
Sequence 2:	NP_594899.1	Gene:	pyp2 / 2542200	PomBaseID:	SPAC19D5.01	Length:	711	Species:	Schizosaccharomyces pombe

Alignment Length:	870	Identity:	212/870 - (24%)
Similarity:	308/870 - (35%)	Gaps:	234/870 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   525 TKENLDGQLRQVGVETKAA--IVDYTKVKLEMKNAGSEFIDLIAFNADYNNSCPT---------- 577
            :|:..:..|:....:|::.  |:|   ::|..|.|.|...:.|      |.|.||
pombe     6 SKDEFNSTLKSFEEQTESVSWIID---LRLHSKYAVSHIKNAI------NVSLPTALLRRPSFDI 61

  Fly   578 --IFALFTCNATTQVRNPYAERYVEGHSKQGFNASLSPLSPY--ATYVCKVIL----YNVAGPSE 634
              :||...||....:....| .::...|..|.|.....:..:  ..|..|:.|    :.....|.
pombe    62 GKVFACIKCNVKVSLDEINA-IFLYDSSMAGMNRIYDLVQKFRRGGYSKKIYLLSNGFEAFASSH 125

  Fly   635 PVVDADMHTTTYFPEQPESVMLEKSTVSSLLFNWQPPTYTNGPIKYYQAFLMRHEASYFVPADCA 699
            |  ||.:.|.......|..:.:.::....:| :...|:..:.||....:|.:|...:...|....
pombe   126 P--DAIVSTEMVKESVPYKIDINENCKLDIL-HLSDPSAVSTPISPDYSFPLRVPINIPPPLCTP 187

  Fly   700 IVEQDTKSETKGDPSV-NFTGLAPAVRYMMQVAAQNDFGMGVYTEPVIGITLPAVSDSVTQLTVL 763
            .|..||.||....... .|:||.|                       ..|..|..| ||.....:
pombe   188 SVVSDTFSEFASHAEYPGFSGLTP-----------------------FSIHSPTAS-SVRSCQSI 228

  Fly   764 TQGPVN-NNAVYEANV-------TITWKVPCKSNGDIE-YFQLAFNGTRNNFAPVSFERRVELDT 819
            ...|:: .|:.::|.:       .|:....|.|..|.: .|.:..|..:...|..|........:
pombe   229 YGSPLSPPNSAFQAEMPYFPISPAISCASSCPSTPDEQKNFFIVGNAPQQTPARPSLRSVPSYPS 293

  Fly   820 GNKQGRMSYTETEMQPQFDYTVEVSVKNRDVEQLSSSVPGSWQSPAGLPTIPSDELIKQMRANVE 884
            .|.|.|.|.:.......:       ||       ||:|.....|.|.|..||...:.:...|..:
pombe   294 SNNQRRPSASRVRSFSNY-------VK-------SSNVVNPSLSQASLEIIPRKSMKRDSNAQND 344

  Fly   885 ETSNPTKTAIVRLPADIMTSASGDIKWMALMISQKNCAGVPHLKYDVSSDWPKVLSYQEAGADGT 949
            .||.             |||            ..|...|:.:.:     |.||....:.|.
pombe   345 GTST-------------MTS------------KLKPSVGLSNTR-----DAPKPGGLRRAN---- 375

  Fly   950 GDCSLEYQTTEERWHPEPVQRQRRDGEVTSDEEIVFTIGLDKCSEVQKTYCNGPLLPDTDYNVVV 1014
                            :|...:...|.:.|.|.                  .||
pombe   376 ----------------KPCFNKETKGSIFSKEN------------------KGP----------- 395

  Fly  1015 RLFTASGYSDAAVLNFKTKAAIKVTLILVSVCSCLLLAFVLGLTVLWVRKRLAWKRDSGQGIEDP 1079
              ||.:.:           .|.|     ||...|.:||.:...::.:..|||
pombe   396 --FTCNPW-----------GAKK-----VSPPPCEVLADLNTASIFYKFKRL------------- 429

  Fly  1080 FGNVIAKNFAIFYTEVAKPEKLAREFKEITVVALELSYSASELGCHKNRYADIFPYDKNRVILDI 1144
                         .|:.....||....:.....|..|.|.|.  ..||||.||.||||.||.|.:
pombe   430 -------------EEMEMTRSLAFNDSKSDWCCLASSRSTSI--SRKNRYTDIVPYDKTRVRLAV 479

  Fly  1145 DAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVR--VIVQVTQFREGNTIKCH 1207
            ....|||||||.||  ...|:|||.|.|||.:::|||.|:...:..  |||.:|...|..:.||.
pombe   480 PKGCSDYINASHID--VGNKKYIACQAPKPGTLLDFWEMVWHNSGTNGVIVMLTNLYEAGSEKCS 542

  Fly  1208 EYYPYN-------VRGLTVTIKSKEVLE-LYDRTELTVVHDKYGLKEKVIHYYFKKWPDHGVP-- 1262
            :|:|.|       ..||.::::..|..| |...|.|..:....|..:.:.|::...|.|...|
pombe   543 QYWPDNKDHALCLEGGLRISVQKYETFEDLKVNTHLFRLDKPNGPPKYIHHFWVHTWFDKTHPDI 607

  Fly  1263 EDPMHLIMFVKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKS---------ESKINI 1318
            |....:|..:.||     |:..|:.||||||||||||||.:|.|:|..|:         :||..|
pombe   608 ESITGIIRCIDKV-----PNDGPMFVHCSAGVGRTGTFIAVDQILQVPKNILPKTTNLEDSKDFI 667

  Fly  1319 FETVKKLRFQRMKMVQTQQQYTFLY 1343
            |..|..||.|||||||..:|:.|||
pombe   668 FNCVNSLRSQRMKMVQNFEQFKFLY 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020	17/101 (17%)
		PTPc	1100..1345	CDD:214550	104/265 (39%)
		PTPc	1125..1348	CDD:238006	98/240 (41%)
pyp2	NP_594899.1	DSP_MapKP	4..129	CDD:238723	28/134 (21%)
		COG5599	405..709	CDD:227886	114/328 (35%)
		PTPc	461..697	CDD:238006	98/239 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	145	1.000	Domainoid score	I1146
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910