Protein Alignment Ptp52F and Ptprt

DIOPT Version :10

• Sequence 1: NP_611093.2
• Gene: Ptp52F / 36790
• FlyBaseID: FBgn0034085
• Length: 1433
• Species: Drosophila melanogaster
• Sequence 2: XP_017172075.1
• Gene: Ptprt / 19281
• MGIID: 1321152
• Length: 1487
• Species: Mus musculus
• Alignment Length: 1482
• Identity: 318/1482 - (21%)
• Similarity: 501/1482 - (33%)
• Gaps: 438/1482 - (29%)

  Fly   185 LSACLTHTITLDTRN----NASVVVDTDATDVDTQYAEPGDLVMNVTNLASGITMITWGDPSEKN 245
            |:.||...:.|..:.    .|...........|..|:..|..|...||..:...:.||..|....
Mouse     7 LALCLLRLLLLGLQRPPLPGAGAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTWEKPMLDP 71

  Fly   246 CISNYVFKWQRNDCGTDQNQDTTTDVPSTE--TTNEID---YVTTTPMETTPDTPSDEVKCEWTD 305
            .:....| ...|..|....|.....:|:.:  .|:.||   |.::                  .|
Mouse    72 AVPTGSF-MMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSS------------------RD 117

  Fly   306 VSSDGKLREYLLTD--LQGCDLYTFQVFINENSTAKASQTFTSAEKLVSAVYEPSPTAYPTQLHW 368
            .||.|.|..|:..:  .||..::        |.:...::.:..||..:|..:   |..|  |:.:
Mouse   118 RSSPGALNVYVKVNGGPQGNPVW--------NVSGVVTEGWVKAELAISTFW---PHFY--QVIF 169

  Fly   369 TWFSPQNHPKCVANYSV-TLTGPIQ------RSENKTMNVITEETFAIFDDLDPCGIYLVEIVPN 426
            ...|.:.||..:|...| .|..|.:      |.:|..:||....||...
Mouse   170 ESVSLKGHPGYIAVDEVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCI---------------- 218

  Fly   427 QLNGSAGTKYQE------QSTVGEDQPSVIQDPVVEAEAYSMEVSWKTPEYADLCIDGYRLSGWM 485
                 ||.|:.:      |...|.| .:::...||....:|..||  ..:.:...|..||.....
Mouse   219 -----AGGKWSQHDKLWLQQWNGRD-TALMVTRVVNHRRFSATVS--VADTSQRSISKYRCVIRS 275

  Fly   486 EDDKLVEVEALSITTQNTTVVFDKNLLACQVYIIQIIPYTKENLDGQLRQVGVETKAAIVDYTKV 550
            :....|...|..|..:..|.:....|||.....:.|.|
Mouse   276 DGGSGVSNYAELIVKEPPTPIAPPELLAVGATYLWIKP--------------------------- 313

  Fly   551 KLEMKNAGSEFID--LIAFNADYNNSCPTIFALFTCNATTQVRNPYAERYVEGHSKQGFNASLSP 613
                 ||.|...|  :|....:|..:..|                    :.|.|.....|..|..
Mouse   314 -----NANSIIGDGPIILKEVEYRTTTGT--------------------WAETHIVDSPNYKLWH 353

  Fly   614 LSPYATYVCKVILYNV----AGPSEPVVDADMHTTTYFPEQ---PESVMLEKSTVSSLLFNWQPP 671
            |.|...|..:|:|...    .||..|    .:.|.|...:.   |::|.:.......|...|:|.
Mouse   354 LDPDVEYEIRVLLTRPGEGGTGPPGP----PLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPF 414

  Fly   672 TYTNGPIKYYQAFLMRHEASYFVPADCAIVEQDTKSETKGDPSVNFT--GLAPAVRYMMQVAAQN 734
            .|         |....|..:..|.......:|..::|.....|.::|  ||.|.:...:::...|
Mouse   415 GY---------AVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSN 470

  Fly   735 DFG------MGVYTEPVIGITLPAVSDSVTQLTVLTQGPVNNNAVYEANVTITWKVPCKSNGDIE 793
            ..|      :.|.||..:...:|        |..:..||      :|..:.|.||.|.::||.|.
Mouse   471 PEGRMESEELVVQTEEDVPGAVP--------LESIQGGP------FEEKIYIQWKPPNETNGVIT 521

  Fly   794 YFQLAFN--GTRNNFAPVSFERRVELDTGNKQGRM---SYTETEMQPQFDYTVEVS--------V 845
            .:::.:.  |:.:..|.:|.:|.......|:...:   .|..|    .:.:|::.|        |
Mouse   522 LYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGT----TYSFTIKASTAKGFGPPV 582

  Fly   846 KNRDVEQLSSSVPGSWQSPAGLPTIPSDELIKQMRANVEETSNPTKT--AIV--------RLPAD 900
            ..|...::|:  |...:..|..|...:|..|..|....:....|...  .:|        |..||
Mouse   583 TTRIATKISA--PSMPEYDADTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAAD 645

  Fly   901 IMTSASGDIKWMALMISQKNCAGVPHLKYDVSSDWPKVLSYQEA-GADGTGDCSLEYQTTEERWH 964
            |:                 .|..||             :||:.| ..|     ||.|...|.:..
Mouse   646 II-----------------ECFSVP-------------VSYRNASNLD-----SLHYFAAELKPS 675

  Fly   965 PEPVQRQRRDGEVTSDEEIVFTIGLDKCSEVQKTYCNGPLLPDTDYNVVVR-LFTASGYSDAAVL 1028
            ..||.:.             ||:|.:|   ....|.|.||.|...|::..: |..|:|.:....:
Mouse   676 NLPVTQP-------------FTVGDNK---TYNGYWNPPLSPLKSYSIYFQALSKANGETKINCV 724

  Fly  1029 NFKTKAAIKVTLILVSVCSCL-------------------------------LLAFV---LGLTV 1059
            ...|||.:....:......||                               ||.|:   ||:.:
Mouse   725 RLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVML 789

  Fly  1060 LWVRKRLAW--------------KRDSGQGIEDPFGNVIA-----------KNFAIFYT------ 1093
            ...|:|.|:              ::::..|.:...|.|.:           :|...|.:
Mouse   790 TIKRRRNAYSYSYYLSQRKLAKKQKETQSGAQREMGPVASTDKPTAKLGTNRNDEGFSSSSQDVN 854

  Fly  1094 --------EVAKPEKLAREFKEITVVALELSYSASEL---------------------------- 1122
                    |:::|....:.....|...:|:||...:.
Mouse   855 GFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEY 919

  Fly  1123 ------------------GCHKNRYADIFPYDKNRV---ILDIDAEGSDYINASFIDGHTRKKEY 1166
                              ..:||||.:|..||.:||   :||.|.. ||||||::|||:.|.:.|
Mouse   920 EALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPH-SDYINANYIDGYHRPRHY 983

  Fly  1167 IATQGPKPESVMDFWRMILQYNVRVIVQVTQFRE--------------------GNTIKCHEYYP 1211
            ||||||..|:|.||||||.|.|...||.||...|                    ...:||..|:|
Mouse   984 IATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRHPAEHTVGTATLGRAASPGMVKCVRYWP 1048

  Fly  1212 YNVR---GLTVTIKSKEVLELYDRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVK 1273
            .:..   .:.||:...|.|..|.....||....|....::..::|..|||||||.....|:.||:
Mouse  1049 DDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVR 1113

  Fly  1274 KVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQ 1338
            :||....|...|||||||||.||||.||.:|.::...::|..::||..|::||.||:.:|||::|
Mouse  1114 QVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQ 1178

  Fly  1339 YTFLY---------------ACTYELVKHKIPR-------AALKMDGRPKSVTVPAIPSPKKVSF 1381
            |.|::               .|.:..:.:.|.|       :.:|.:.:..::..|.: .|:..|.
Mouse  1179 YVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRV-RPEDCSI 1242

  Fly  1382 PDVDVGSEYVSSAPITDLDDGRPIVQLPSRFSGLRRNSPPGENDNPTSSSNM 1433
            ..:....:...|..:..||...|.:           .|..||:.|..:::.|
Mouse  1243 GLLPRNHDKNRSMDVLPLDRCLPFL-----------ISVDGESSNYINAALM 1283

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020	21/111 (19%)
		PTPc	1100..1345	CDD:214550	104/331 (31%)
Ptprt	XP_017172075.1	MAM	36..193	CDD:214533	39/188 (21%)
		Ig	200..285	CDD:472250	21/108 (19%)
		fn3	298..364	CDD:394996	19/117 (16%)
		FN3	394..484	CDD:238020	19/98 (19%)
		fn3	506..581	CDD:394996	16/78 (21%)
		R-PTPc-T-1	936..1192	CDD:350478	100/256 (39%)
		R-PTPc-T-2	1277..1482	CDD:350482	1/7 (14%)