DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp52F and Ptprs

DIOPT Version :10

Sequence 1:NP_611093.2 Gene:Ptp52F / 36790 FlyBaseID:FBgn0034085 Length:1433 Species:Drosophila melanogaster
Sequence 2:NP_035348.2 Gene:Ptprs / 19280 MGIID:97815 Length:1907 Species:Mus musculus


Alignment Length:1504 Identity:345/1504 - (22%)
Similarity:561/1504 - (37%) Gaps:420/1504 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 SESQELAEKVEVTVVSTVYTLGFSISNEADYSIDKVICRNGSGSETEANAAHVCENLNPCTFYTS 101
            |:||:...:::..:.:|.|::| .:|..::|.|                             :.|
Mouse   356 SKSQDGPYQIKEDITTTRYSIG-GLSPNSEYEI-----------------------------WVS 390

  Fly   102 VVSFRSNVSGKPPPSDQTIYAYTEYKQPKTTVTSVVA---TANTIKVTWQTNDRACVESFGI--- 160
            .|    |..|:.||| :::...|..:.|.:...:|.|   :|.|:.|.|:..    ||..|:   
Mouse   391 AV----NSIGQGPPS-ESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEP----VEPNGLIRG 446

  Fly   161 -----TAKATDYTKSFQLLN-DKSSQTFV-NLSACLTHTITLDTRNNASVVVDTDATDVDTQYAE 218
                 |.:......::|..| |.|..|.| :|....|:|:.:....:......:|...|.||...
Mouse   447 YRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGV 511

  Fly   219 PGDLVMNVTNLASGITMI--TWGDPSEKNCISNYVFKWQRNDCGTDQNQ--DTTT-----DV-PS 273
            ||. .||:...|...|.|  :|..|.:::.| .|...::..|.|.:..:  |.||     |: |:
Mouse   512 PGQ-PMNLRAEAKSETSIGLSWSAPRQESVI-KYELLFREGDRGREVGRTFDPTTAFVVEDLKPN 574

  Fly   274 TETTNEI------------DYVTTTPMETTPDTPSDEVKCEWTDVSSDGKLREYLLTDLQGCDLY 326
            ||....:            ..|....::..|..|..:|||                |.|:     
Mouse   575 TEYAFRLAARSPQGLGAFTAVVRQRTLQAKPSAPPQDVKC----------------TSLR----- 618

  Fly   327 TFQVFINENSTAKASQTFTSAEKLVSAVYEPSPTAYPTQLHWTWFSPQNHPKCVANYSVTL--TG 389
                     |||          .|||  :.|.|             |:.|...:..|||..  .|
Mouse   619 ---------STA----------ILVS--WRPPP-------------PETHNGALVGYSVRYRPLG 649

  Fly   390 PIQRSENKTMNVITEETFAIFDDLDPCGIYLVEIVPNQLNGSAGTKYQEQSTVGEDQPSVIQDP- 453
            .......:..|:....|..:.:.|:....|.|..|          .|.|.....|..|.|::.. 
Mouse   650 SEDPDPKEVNNIPPTTTQILLEALEKWTEYRVTAV----------AYTEVGPGPESSPVVVRTDE 704

  Fly   454 --------VVEAEAY---SMEVSWKTP----EYADLCIDGY-----RLSG-------WMEDDKLV 491
                    .|||||.   ::.|.|::|    ::..  |.||     |:.|       .::|..|.
Mouse   705 DVPSAPPRKVEAEALNATAIRVLWRSPTPGRQHGQ--IRGYQVHYVRMEGAEARGPPRIKDIMLA 767

  Fly   492 EVEALSITTQNTTVVFDKNLLACQVYIIQIIPYTKENLDGQLRQVGVETKAAIVDYTKVKLEMKN 556
            :.:.:.||          ||.....|.|.:..||.:....:.:...|.||.|::....:.::...
Mouse   768 DAQEMVIT----------NLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTP 822

  Fly   557 AGSEFI-----------DLIAFNADY--NNSCPTIFALFTCNATTQVRNPYAERYVEGHSKQGFN 608
            .||...           .::.:...:  .::.|....|..          :..|:.         
Mouse   823 EGSLLARWEPPADAAEDPVLGYRLQFGREDAAPATLELAA----------WERRFA--------- 868

  Fly   609 ASLSPLSPYATYVCKVILYNVAGPSEPVVDADMHTTTYFPEQ-----PESVMLEKSTVS--SLLF 666
               :|....||||.::.....||..|....|     ...||.     |: ::.....||  |:|.
Mouse   869 ---APAHKGATYVFRLAARGRAGLGEEAAAA-----LSIPEDAPRGFPQ-ILGAAGNVSAGSVLL 924

  Fly   667 NWQP--PTYTNGPIKYYQAFLMRHEASYFVPADCAIVEQDTKSETKGDPSVNFTGLAPAVRYMMQ 729
            .|.|  |...||.|..|...:  .||.  .|......|....::...:.::...||.|...|.::
Mouse   925 RWLPPVPAERNGAIIKYTVSV--REAG--APGPATETELAAAAQPGAETALTLRGLRPETAYELR 985

  Fly   730 VAAQNDFGMGVYTEPVIGITLPAVSDSVTQLTVLTQGPVNNNA--VYEANVTITWKVPCKSNGDI 792
            |.|....|.|.::.|   :......|.|:        |.|...  :.:.:|.::|:.|...|...
Mouse   986 VRAHTRRGPGPFSPP---LRYRLARDPVS--------PKNFKVKMIMKTSVLLSWEFPDNYNSPT 1039

  Fly   793 EYFQLAFNGTRNNFAPVSFERRVELDTGNKQGRMSYTETEMQPQFDYTVEVSVKNRDVEQLSSSV 857
            .| ::.:||             :.||...:..:...  |.::|...|...::.:...:..|..:|
Mouse  1040 PY-KIQYNG-------------LTLDVDGRTTKKLI--THLKPHTFYNFVLTNRGSSLGGLQQTV 1088

  Fly   858 PG--SWQSPAGLPTI----PSDELIKQMRANVEETSNPTKTAIVRLPADIMTSASGDIKWMALMI 916
            ..  ::...:|.|::    .:|..|                 :|.|| |..:..:....::.::.
Mouse  1089 TARTAFNMLSGKPSVAPKPDNDGFI-----------------VVYLP-DGQSPVTVQNYFIVMVP 1135

  Fly   917 SQKNCAGVPHLKYDVSSDWPKVLSYQEAGADGTGDCSLEYQTTEERWHPEPVQ----RQRRDGEV 977
            .:|:..|          .:|.:|...|       |..||          |.:|    .|||....
Mouse  1136 LRKSRGG----------QFPVLLGSPE-------DMDLE----------ELIQDISRLQRRSLRH 1173

  Fly   978 TSDEEI--------------VFTIGLDKCSEVQKTY---CNGPLLPDTDYNVVV--------RLF 1017
            :...|:              ||..|      .||.|   .|..|.|...|.:.|        ..|
Mouse  1174 SRQLEVPRPYIAARFSILPAVFHPG------NQKQYGGFDNRGLEPGHRYVLFVLAVLQKNEPTF 1232

  Fly  1018 TASGYSDAAVLNFKTKAAI---KVTLILVSVCSCLLLAFVLGLTV---LWVRKRLAWKRDSGQGI 1076
            .||.:||...|:......|   :..||.| :...|.:.|::.:.:   |:..|..:.::||    
Mouse  1233 AASPFSDPFQLDNPDPQPIVDGEEGLIWV-IGPVLAVVFIICIVIAILLYKNKPDSKRKDS---- 1292

  Fly  1077 EDPFGNVIAKNF---------------------------AIFYTEVAK---------PEKLAREF 1105
             :|....:..|.                           .|..|::|:         ..||::|:
Mouse  1293 -EPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPITDMAEHMERLKANDSLKLSQEY 1356

  Fly  1106 KEITVVALELSYSASELGCH--KNRYADIFPYDKNRVILD--IDAEGSDYINASFIDGHTRKKEY 1166
            :.|. ...:.::..|.|..:  |||||::..||.:||||.  ....|||||||:::||:.|:..|
Mouse  1357 ESID-PGQQFTWEHSNLEANKPKNRYANVIAYDHSRVILQPLEGIMGSDYINANYVDGYRRQNAY 1420

  Fly  1167 IATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYNVRG------LTVTIKSKE 1225
            ||||||.||:..|||||:.:.....:|.:|:..|.:.|||.:|:|.  ||      :.||:  .:
Mouse  1421 IATQGPLPETFGDFWRMVWEQRSATVVMMTRLEEKSRIKCDQYWPN--RGTETYGFIQVTL--LD 1481

  Fly  1226 VLELYDRTELTVVHDKYGLKEK--VIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSYSPIVV 1288
            .:||......|....|.|..||  |.|:.|..||||||||.|...:.|:::||....|...||||
Mouse  1482 TMELATFCVRTFSLHKNGSSEKREVRHFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVV 1546

  Fly  1289 HCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELV--- 1350
            ||||||||||.||.:|.:::|:|:|..::::..|..:|.||..||||:.||.|::....|.|   
Mouse  1547 HCSAGVGRTGCFIVIDAMLERIKTEKTVDVYGHVTLMRSQRNYMVQTEDQYGFIHEALLEAVGCG 1611

  Fly  1351 KHKIPRAAL 1359
            ..::|..:|
Mouse  1612 NTEVPARSL 1620

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp52FNP_611093.2 FN3 648..749 CDD:238020 27/109 (25%)
PTPc 1100..1345 CDD:214550 107/256 (42%)
PtprsNP_035348.2 I-set 33..124 CDD:400151
Ig strand B 50..54 CDD:409570
Ig strand C 63..67 CDD:409570
Important for binding to glycosaminoglycan chains. /evidence=ECO:0000269|PubMed:19833921, ECO:0000269|PubMed:21454754 68..72
Ig strand E 86..93 CDD:409570
Ig strand F 104..109 CDD:409570
Ig strand G 117..120 CDD:409570
IgI_2_RPTP_IIa_LAR_like 137..226 CDD:409400
Ig strand A' 143..147 CDD:409400
Ig strand B 150..159 CDD:409400
Ig strand C 164..170 CDD:409400
Ig strand C' 172..174 CDD:409400
Ig strand D 183..187 CDD:409400
Ig strand E 190..195 CDD:409400
Ig strand F 204..211 CDD:409400
Ig strand G 214..225 CDD:409400
IgI_3_RPTP_IIa_LAR_like 235..316 CDD:409401
Ig strand A 235..237 CDD:409401
Ig strand A' 241..245 CDD:409401
Ig strand B 248..256 CDD:409401
Ig strand C 261..267 CDD:409401
Ig strand C' 269..271 CDD:409401
Ig strand D 274..278 CDD:409401
Ig strand E 283..288 CDD:409401
Ig strand F 295..302 CDD:409401
Ig strand G 306..315 CDD:409401
FN3 309..815 CDD:442628 121/576 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 691..711 3/19 (16%)
FN3 916..1004 CDD:238020 24/94 (26%)
FN3 1009..1092 CDD:238020 17/106 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1286..1313 4/31 (13%)
R-PTPc-S-1 1329..1610 CDD:350473 112/285 (39%)
R-PTP-S-2 1612..1901 CDD:350475 2/9 (22%)
Blue background indicates that the domain is not in the aligned region.

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