Protein Alignment Ptp52F and Ptpro

DIOPT Version :10

• Sequence 1: NP_611093.2
• Gene: Ptp52F / 36790
• FlyBaseID: FBgn0034085
• Length: 1433
• Species: Drosophila melanogaster
• Sequence 2: XP_036021846.1
• Gene: Ptpro / 19277
• MGIID: 1097152
• Length: 1261
• Species: Mus musculus
• Alignment Length: 1493
• Identity: 332/1493 - (22%)
• Similarity: 548/1493 - (36%)
• Gaps: 479/1493 - (32%)

  Fly    24 GVQGQTVGSL-----VAVSESQELAEKVEVT-VVSTVYTLGFSISNEADYSIDKVICRNGSGSET 82
            |.....|||:     |||.:...:...:|.: :||........::.|:         :|......
Mouse    52 GASRPNVGSIVTTFHVAVQDDNNIVVSLEASDIVSPASVYVVRVAGES---------KNYFFEFE 107

  Fly    83 EANAAHVCENLNPCTFY-----TSVVSFRSNVSGKP-----------PPSDQTIYAYTEYK-QPK 130
            |.|:......:...|::     .::|....||..||           |.:..:||   :|| .|:
Mouse   108 EFNSTLPPPVVFKATYHGLYYIITLVVVNGNVVTKPSRSITVLTKPLPVTSVSIY---DYKPSPE 169

  Fly   131 TTVTSVVATANTIKV-------TWQTNDRACVESFGITAKATDYTKSFQLLND------KSSQTF 182
            |.|...:.......|       .|:..|..       |....|:.|...:.|.      .|:.||
Mouse   170 TGVLFEIHYPEKYNVFSRVNISYWEGRDFR-------TMLYKDFFKGKTVFNHWLPGLCYSNITF 227

  Fly   183 VNLSACLTHTITLDTRNNASVVVDTDATDVDTQYA----EPGDLVMNVTNLASGITMITWGDPSE 243
            ..:|..        |.|.:::|..:..:....|:.    .|.::.:...||...    .|.:||.
Mouse   228 QLVSEA--------TFNKSTLVEYSGVSHEPKQHRTAPYPPRNISVRFVNLNKN----NWEEPSG 280

  Fly   244 KNCISNYVFKWQRNDCGTDQNQDTTTDVPSTETTNEIDYVTTTPMETTPDTPSDEVKCEWTDVSS 308
            .....::: |..::..|.|:......:.|.           |.|...:..:|...|...|.|.:|
Mouse   281 SFPEDSFI-KPPQDSIGRDRRFHFPEETPE-----------TPPSNVSSGSPPSNVSSAWPDPNS 333

  Fly   309 DGKLREYLLTDLQGCDLYTFQVFINENSTA--KASQTFTSA-------EKLVSAVYEPSP---TA 361
                     ||.:.    |.|.|..::::|  :..:.|.||       |..:....:|:.   :|
Mouse   334 ---------TDYES----TSQPFWWDSASAAPENEEDFVSALPADYDTETTLDRTEKPTADPFSA 385

  Fly   362 YPTQLHWTWFSPQNHPKCVANYSVTLTGPIQRSENKT-MNVITEETFAIFDDLDPCGIYLVEIVP 425
            :|.|:..:|..|: .|.....:::.    |:|.||.| ...:.||......:|...|.|.:.:..
Mouse   386 FPVQMTLSWLPPK-PPTAFDGFNIL----IEREENFTDYLTVDEEAHEFVAELKEPGKYKLSVTT 445

  Fly   426 NQLNGSAGTKYQEQSTVGEDQPSVIQDPVVEAEAYSMEVSWKTPEYADLCIDGYRLSGWMED--- 487
            ...:|:..|: :.||                |::.|..:| .|.|             |:|:
Mouse   446 FSSSGACETR-KSQS----------------AKSLSFYIS-PTGE-------------WIEELTE 479

  Fly   488 -DKLVEVEALSITTQNTTVVFDKNLLACQVYIIQIIPYTKENLDGQLRQVGVETKAAIVDYTKVK 551
             .:.|.|..||.||                                          |::.:|
Mouse   480 KPQHVSVHVLSSTT------------------------------------------ALMSWT--- 499

  Fly   552 LEMKNAGSEFIDLIAFNADYNNSCPTIFALFTCNATTQVRNPYAERYVEGHSKQGFNAS---LSP 613
                          :...:||::..::.:| ||.     :...::|..:.:..| .|:|   :..
Mouse   500 --------------SSQENYNSTIVSVVSL-TCQ-----KQKESQRLEKQYCTQ-VNSSKPVIEN 543

  Fly   614 LSPYATYVCKVILYNVAG-----PSEPVVDADMHT----TTYFPEQPESVML----------EKS 659
            |.|.|.|  :|::|...|     ||:||..|.:.|    ...:|..|.:|:|          .|.
Mouse   544 LVPGAQY--QVVMYLRKGPLIGPPSDPVTFAIVPTGIKDLMLYPLGPTAVVLSWTRPILGVFRKY 606

  Fly   660 TVSSLLFNWQPPTYTNGPIKYYQAFLMRHEASYFVPADCAIVEQDTKSETKGDPSVNFTGLAPAV 724
            .|....||  |.|.|:....||:           :.|..::.           .||....|.||.
Mouse   607 VVEMFYFN--PTTMTSEWTTYYE-----------IAATVSLT-----------ASVRIASLLPAW 647

  Fly   725 RYMMQVAAQNDFGMGVYTEPVIG---------ITLPAVSDSVTQLTVLTQGPVNNNAVYEANVTI 780
            .|..:|.      |..:.:|.:.         ||.| |:..:|.:...      |:.:|     |
Mouse   648 YYNFRVT------MVTWGDPELSCCDSSTISFITAP-VAPEITSVEYF------NSLLY-----I 694

  Fly   781 TWKVPCKSNGDIEYFQLAFNGTRNNFAPVSFERRVE---LDTGNKQGRMSYTETEMQPQFDYTVE 842
            :|     :.||..             ..:|..|.:.   :..|.|:.:.|.|...|      |..
Mouse   695 SW-----TYGDAT-------------TDLSHSRMLHWMVVAEGRKKIKKSVTRNVM------TAI 735

  Fly   843 VSVKNRDVEQLSSSVPGSWQSPAGLPTIPSDELIKQMRANVEETSNPTKTAIVRL----PADIM- 902
            :|:...|:..||                        :.|..|..||.:...:|:|    |..:.
Mouse   736 LSLPPGDIYNLS------------------------VTACTERGSNTSLPRLVKLEPAPPKSLFA 776

  Fly   903 ---TSASGDIKWMALMISQKNCAGVPHLKYDVSSDWPKVLSYQEAGADGTGDCSLEYQTTEERWH 964
               |..|..:.|:.        .||        :|:.:|.. |:.|:...|...
Mouse   777 VNKTQTSVTLLWVE--------EGV--------ADFFEVFC-QQLGSGHNGKLQ----------- 813

  Fly   965 PEPVQRQRRDGEVTSDEEIVFTIGLDKCSEVQKTYCNGPLLPDTDYNVVVRLF---TASGYSDAA 1026
             |||       .|:|.   |.||              ..|||.|.||..|..|   |.|..:..|
Mouse   814 -EPV-------AVSSH---VVTI--------------SSLLPATAYNCSVTSFSHDTPSVPTFIA 853

  Fly  1027 VLNFKTKAAIKVTLI-LVSVCSCLLLAFVLGLTVLWVRKRLAWKRDSGQGIEDPFG--------- 1081
            |....|:....|.:| ::::.|.||:..:|...|:..:|.|...|:.|.|....|.
Mouse   854 VSTMVTEVNPNVVVISVLAILSTLLIGLLLVTLVILRKKHLQMARECGAGTFVNFASLEREGKLP 918

  Fly  1082 ----------------------------NVIAKN---------------FAIFYTEVAKPE--KL 1101
                                        |..:||               |..:..::||..  |.
Mouse   919 YSWRRSVFALLTLLPSCLWTDYLLAFYINPWSKNGLKKRKLTNPVQLDDFDSYIKDMAKDSDYKF 983

  Fly  1102 AREFKEITVVALELSYSASELGCH--KNRYADIFPYDKNRVILDI--DAEGSDYINASFIDGHTR 1162
            :.:|:|:.::.|::.:.|::|..:  ||||.:|.|||.:||.|..  :.||:|||||::|.|:..
Mouse   984 SLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNS 1048

  Fly  1163 KKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYNVR-----GLTVTIK 1222
            .:||||||||.||:..|||:|:||....:||.:||..|...:||..|:|:...     .:||.:.
Mouse  1049 PQEYIATQGPLPETRNDFWKMVLQQKSHIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMV 1113

  Fly  1223 SKEVLELYDRTELTVVH-DKYGLKEKVIHYYFKKWPDHGVPEDPMH----LIMFVKKVKAEKRPS 1282
            |:|..|.:......:.: |:   .:.|:|:.:..|||||||  |.:    ::.||..|:.:...|
Mouse  1114 SEEEEEDWASRHFRINYADE---AQDVMHFNYTAWPDHGVP--PANAAESILQFVFTVRQQAAKS 1173

  Fly  1283 YSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYAC 1345
            ..|:::|||||||||||||.||.::|.::....::|...|.::|..||.||||::||.|::.|
Mouse  1174 KGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQC 1236

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020	23/119 (19%)
		PTPc	1100..1345	CDD:214550	100/258 (39%)
Ptpro	XP_036021846.1	FN3	479..571	CDD:238020	28/159 (18%)
		FN3	575..675	CDD:238020	24/129 (19%)
		fn3	770..850	CDD:394996	29/132 (22%)
		R-PTPc-O	996..1240	CDD:350462	97/246 (39%)