Protein Alignment Ptp52F and Ptprk

DIOPT Version :10

• Sequence 1: NP_611093.2
• Gene: Ptp52F / 36790
• FlyBaseID: FBgn0034085
• Length: 1433
• Species: Drosophila melanogaster
• Sequence 2: XP_006512669.1
• Gene: Ptprk / 19272
• MGIID: 103310
• Length: 1485
• Species: Mus musculus
• Alignment Length: 937
• Identity: 215/937 - (22%)
• Similarity: 339/937 - (36%)
• Gaps: 272/937 - (29%)

  Fly   598 YVEGHSKQGFNASLSPLSPYATYVCKVILY-----NVAGPSEPVVDADMHTTTYFPE---QPESV 654
            :.|.|:.......|..|.|...|..:|:|.     ....|..|::     |.|...|   .|:::
Mouse   336 WTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLI-----TRTKCAEPMRTPKTL 395

  Fly   655 MLEKSTVSSLLFNWQPPTYT-------NGPIKYYQAFLMRHEASYFVPADCAIVEQDTKSETKGD 712
            .:.:.....:..:|:...|.       |..|.|:  :...|..|   .|||  ::.|.|:
Mouse   396 KIAEIQARRIAVDWESLGYNITRCHTFNVTICYH--YFRGHNES---RADC--LDMDPKA----- 448

  Fly   713 PSVNFTGLAPAVRYMMQVAAQNDFGMGVYTEPVIGITLPAVSDSVTQLTVLTQGPVNNNAV---- 773
            |......|.|.....:::...|..|.....|.:|            |......|||...::
Mouse   449 PQHVVNHLPPYTNVSLKMILTNPEGRKESEETII------------QTDEDVPGPVPVKSLQGTS 501

  Fly   774 YEANVTITWKVPCKSNGDIEYFQLAFNGTRNNFAPVSFERRVEL-----DTGNKQGRMSYTETEM 833
            :|..:.:.||.|.:.||.|..::::::..|      ||:..|.:     ...|......:....:
Mouse   502 FENKIFLNWKEPLEPNGIITQYEVSYSSIR------SFDPAVPVAGPPQTVSNLWNSTHHVFMHL 560

  Fly   834 QPQFDYTVEVSVKNRDVEQLSSSVPGSWQSPA-------GLPTIPSDELIKQMRANVEETSNPTK 891
            .|...|...:.         :|:|.|...:.|       ..|::|..|       .|:.:.|.|.
Mouse   561 HPGTTYQFFIR---------ASTVKGFGPATAINVTTNISAPSLPDYE-------GVDASLNETA 609

  Fly   892 TAIVRL--PADIMTSASGDIKWMALMISQKNCAGVPHLKYDVSSDWPKVLSYQEAGADGTGDCSL 954
            |.|..|  ||.   :....|....:::.|.:    ||            .:.:||||.......:
Mouse   610 TTITVLLRPAQ---AKGAPISAYQIVVEQLH----PH------------RTKREAGAMECYQVPV 655

  Fly   955 EYQTTEERWHPEPVQRQRRDGEVTSDEEIVFTIGLDKCSEVQKTYCNGPLLPDTDYNV------- 1012
            .||.......|.....:...|.:  .|...||:|.::   ..|.:.|.||.|...||:
Mouse   656 TYQNALSGGAPYYFAAELPPGNL--PEPAPFTVGDNR---TYKGFWNPPLAPRKGYNIYFQAMSS 715

  Fly  1013 --------VVRLFT-ASGYSDAAVLNFKTKAAIKVTLILVSVCSCLLLAFVLGLTVLWVRKR-LA 1067
                    .||:.| |:...:..|:....|...:|..|.......|:...:|.:.::.|:|| :.
Mouse   716 VEKETKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVIVIVKKRYIC 780

  Fly  1068 WKRDSGQGIEDPFGNVIAKNFA------IFYTEVAKPEK--LAREFKEIT--VVALELSYS---- 1118
            |:|           ::..:|..      .:|.::||..|  :....:|:|  |.|::.||:
Mouse   781 WRR-----------HICIRNIRRSYYSYSYYLKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQST 834

  Fly  1119 ----------------------------------------------------------------- 1118
                                                                             
Mouse   835 LHAEDPLSLTFMDQHNFSPRLPNDPLVPTAVLVPITDENHSATAESSRLLDVPRYLCEGTESPYQ 899

  Fly  1119 ---------ASELGCH-------------------------------------KNRYADIFPYDK 1137
                     .::|..|                                     ||||.:|..||.
Mouse   900 TGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDH 964

  Fly  1138 NRVILD--IDAEGSDYINASFI------DGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQ 1194
            :||||.  .|...||||||::|      ||:.|...|||||||..|:|.|||||:.|.....||.
Mouse   965 SRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMVWQEQSACIVM 1029

  Fly  1195 VTQFREGNTIKCHEYYPYNVR---GLTVTIKSKEVLELYDRTELTVVHDKYGLKEKVIHYYFKKW 1256
            ||...|...:||::|:|.:..   ...||....|.|..|.....|:....|....:|..::|..|
Mouse  1030 VTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGW 1094

  Fly  1257 PDHGVPEDPMHLIMFVKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFET 1321
            ||||||.....|:.|:::||....||..|||||||||.||||.:|.:|:::...:.|..::|:..
Mouse  1095 PDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNC 1159

  Fly  1322 VKKLRFQRMKMVQTQQQYTFLYACTYE 1348
            ||.||.:|:.||||::||.|::....|
Mouse  1160 VKALRSRRINMVQTEEQYIFIHDAILE 1186

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020	21/110 (19%)
		PTPc	1100..1345	CDD:214550	106/374 (28%)
Ptprk	XP_006512669.1	MAM	31..191	CDD:214533
		IG_like	201..287	CDD:214653
		Ig strand B	211..215	CDD:409353
		Ig strand C	225..231	CDD:409353
		Ig strand E	252..256	CDD:409353
		Ig strand F	266..271	CDD:409353
		fn3	293..370	CDD:394996	8/33 (24%)
		FN3	<458..>670	CDD:442628	49/264 (19%)
		fn3	487..582	CDD:394996	20/109 (18%)
		PTP_DSP_cys	911..1189	CDD:475123	100/276 (36%)
		R-PTPc-K-2	1275..1480	CDD:350484