DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp52F and Ptprf

DIOPT Version :9

Sequence 1:	NP_611093.2	Gene:	Ptp52F / 36790	FlyBaseID:	FBgn0034085	Length:	1433	Species:	Drosophila melanogaster
Sequence 2:	XP_006502927.1	Gene:	Ptprf / 19268	MGIID:	102695	Length:	1924	Species:	Mus musculus

Alignment Length:	1568	Identity:	354/1568 - (22%)
Similarity:	582/1568 - (37%)	Gaps:	472/1568 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ILWIAGVQGQTVGSLVAVSESQELAEKVEVTV---------------VSTVYTLGFSISNEADYS 68
            :|.::.|......:.||:|....:....:|||               .:|..||.:...|....|
Mouse   290 VLELSNVMRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNTEPVS 354

  Fly    69 IDKVICR----NGSGSETE--ANAAHVCENLNPCTFYTSVVSFR---SNVSGKPPPSDQTIYAYT 124
            ...:..|    :|...|.:  |:..:....|:|.:.|    :||   .|..|:.||| :.:.|.|
Mouse   355 FYGIQYRAAGTDGPFQEVDGVASTRYSIGGLSPFSEY----AFRVLAVNSIGRGPPS-EAVRART 414

  Fly   125 EYKQPKTTVTSVVA---TANTIKVTWQTNDRACVESFGITAKATDYTKSFQLLNDKSSQTFVNLS 186
            ..:.|.:....|.|   :|:|:.|.|:..:    |..|:       .:.:::.....|:.  .||
Mouse   415 GEQAPSSPPRRVQARMLSASTMLVQWEPPE----EPNGL-------VRGYRVYYTPDSRR--PLS 466

  Fly   187 ACLTHT---------------ITLDTRNNASVVV----DTDATDVDTQY---AEPGDLVMNVTNL 229
            |...|.               ||...|..|...|    .:....|.||.   |:|.|...|
Mouse   467 AWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAN---- 527

  Fly   230 ASGITMI--TWGDPSEKNCISNYVFKWQRNDCGTDQNQDTTTDVPSTETTNEIDYVTT------- 285
            |...|.|  :|..|.::..:...:..|...|.|  |....|.|..|:.|..::...|.
Mouse   528 AESDTRIQLSWLLPPQERIVKYELVYWAAEDEG--QQHKVTFDPTSSYTLEDLKPDTLYHFQLAA 590

  Fly   286 ---------TP------METTPDTPSDEVKCEWTDVSS--------------------------- 308
                     ||      .::||..|..:|.|..|..::
Mouse   591 RSDLGVGVFTPTVEARTAQSTPSAPPQKVTCVSTGSTTVRVSWVPPPADSRNGIITQYSVAYEAV 655

  Fly   309 ----------DGKLREYLLTDLQGCDLYT-FQVFINENSTAKASQTFTSAEKLVSAVYEPSPTAY 362
                      ||..||:...||.|.:.:| ::|::..::                   :..|
Mouse   656 DGEDRKRHVVDGISREHSSWDLLGLEKWTEYRVWVRAHT-------------------DVGP--- 698

  Fly   363 PTQLHWTWFSPQNHPKCVANYSVTLTGPIQRSENKTMNVITEETFAIFDDLDPCGIYLVEI---- 423
                     .|::.|..|.......:||.::.|                 ::|.....|.:
Mouse   699 ---------GPESSPVLVRTDEDVPSGPPRKVE-----------------VEPLNSTAVHVSWKL 737

  Fly   424 -VPN----QLNGSAGTKYQEQSTVGEDQPSVIQDPVV--------EAEAYSMEVSWKTPEYA-DL 474
             |||    |:.|...|..:.::.....|| :|||.::        |:|.|...:|..|||.. .:
Mouse   738 PVPNKQHGQIRGYQVTYVRLENGEPRGQP-IIQDVMLAEAQWRPEESEDYETTISGLTPETTYSI 801

  Fly   475 CIDGYRLSGWMEDDKLVEVEALSITTQNTTVVFDKNLLACQVYIIQIIPYTKENLDGQLRQVGVE 539
            .:..|...|.....|...|..........|::.  :..|....::|..|  .:.|.|:|
Mouse   802 TVAAYTTKGDGARSKPKVVTTTGAVPGRPTMMV--STTAMHTALLQWHP--PKELPGEL------ 856

  Fly   540 TKAAIVDYTKVKLEMKNAGSEFIDLIAFNADYNNSCPTIFALFTCNATTQVRNPYAERYVEGHSK 604
                 :.|   :|:.:.|.....:.|.|                                 |...
Mouse   857 -----LGY---RLQYRRADEARPNTIDF---------------------------------GKDD 880

  Fly   605 QGFNASLSPLSPYATYVCKVILYNVAGPSEPVVDADMHTTTYFPEQ-----PESVMLEKSTVSSL 664
            |.|  :::.|...||||.::...|.|||.|   :.:...||  ||.     |:::.:...|.|:.
Mouse   881 QHF--TVTGLHKGATYVFRLAAKNRAGPGE---EFEKEITT--PEDVPSGFPQNLRVTGLTTSTT 938

  Fly   665 LFNWQPPTYT--NGPIKYYQAFLMRHEASYFVPADCAIVEQDTKSETK-----GDPSVNFTGLAP 722
            ...|.||...  ||.|..|                 .:|.:|..|:.:     .|..:...||.|
Mouse   939 ELTWDPPVLAERNGHITNY-----------------TVVYRDINSQLELQNVTNDTHLTLLGLKP 986

  Fly   723 AVRYMMQVAAQNDFGMGVYTEPVIGITLPAVSDSVTQLTVLTQGPVNNNAVYEANVTITWKVPCK 787
            ...|.::|.|....|.|..:..:...|:|..........|.        |..:.:|.::|:||..
Mouse   987 DTTYDIKVRAHTSKGAGPLSPSIQSRTMPVEQVFAKNFRVA--------AAMKTSVLLSWEVPDS 1043

  Fly   788 SNGDIEYFQLAFNGTRNNFAPVSFERRVELDTGNKQGRMSYTETEMQPQFDYTVEVSVKNRDVEQ 852
            ....:. |::.:||           :.||:| |:...::.   .::||..:|:  ..:.||
Mouse  1044 YKSAVP-FKILYNG-----------QSVEVD-GHSMRKLI---ADLQPNTEYS--FVLMNR---- 1086

  Fly   853 LSSSVPGSWQ-------SPAGLP--TIPSDELIKQMR--ANVEETSNPTKTAIVRLPADIMTSAS 906
              .|..|..|       :|..||  .:|:...|:..|  .::.:..:|:.
Mouse  1087 --GSSAGGLQHLVSIRTAPDLLPQKPLPASAFIEDGRFSLSMPQVQDPSL--------------- 1134

  Fly   907 GDIKWMALMISQKNCAG----VPHLKYDVSSDWPKVLSYQEAGADGTGDCSLEYQTTEERWHPEP 967
              ::|..:::...:..|    .|........:..::|...|.|                   .|.
Mouse  1135 --VRWFYIVVVPIDRVGGNLLAPRWNTPEELELDELLEAIEQG-------------------EEK 1178

  Fly   968 VQRQRRDGE-----VTSDEEIV---FTIGLDKCSEVQKTYCNGPLLPDTDYNVVV---------- 1014
            .:|:||..|     |.:..:::   ||:| ||.|  .:.:.|.||.||..|...|
Mouse  1179 QRRRRRQAERLKPYVAAQVDVLPDTFTLG-DKKS--YRGFYNRPLSPDLSYQCFVLASLKEPMDQ 1240

  Fly  1015 RLFTASGYSDAAVLN-------------FKTKAAIKVTLILVSVCSCLLLAFVLGLTVLWVRKRL 1066
            :.:.:|.|||..|:.             :.|...:.|.||::.|.:.|          |:.|||.
Mouse  1241 KRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIVIAIL----------LFKRKRT 1295

  Fly  1067 ---AWKRDSGQGIED---------------------------PFGNVIAKNFAIFYTEVA----- 1096
               :.|.:...|::|                           |..:.:..:..|..|::|
Mouse  1296 HSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGSSAPSCPNISSMRDHPPIPITDLADNIER 1360

  Fly  1097 -KPE---KLAREFKEITVVALELSY--SASELGCHKNRYADIFPYDKNRVIL-DID-AEGSDYIN 1153
             |..   |.::|::.|. ...:.::  |.||:...|||||::..||.:||:| .|| ..||||||
Mouse  1361 LKANDGLKFSQEYESID-PGQQFTWENSNSEVNKPKNRYANVIAYDHSRVLLTSIDGVPGSDYIN 1424

  Fly  1154 ASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYNVRG-- 1216
            |::|||:.::..|||||||.||::.|||||:.:.....:|.:|:..|.:.:||.:|:|  |||
Mouse  1425 ANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWP--VRGTE 1487

  Fly  1217 ----LTVTIKSKEVLELYDRTELTVVHDKYGLKEK--VIHYYFKKWPDHGVPEDPMHLIMFVKKV 1275
                :.||:  .:.:||...|..|....|.|..||  :..:.|..||||||||.|..::.|:::|
Mouse  1488 TYGLIQVTL--VDTVELATYTMRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRV 1550

  Fly  1276 KAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYT 1340
            ||.......|:||||||||||||.||.:|.:::|:|.|..::|:..|..:|.||..||||:.||.
Mouse  1551 KACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYV 1615

  Fly  1341 FLYACTYE 1348
            |::....|
Mouse  1616 FIHEALLE 1623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020	24/112 (21%)
		PTPc	1100..1345	CDD:214550	107/256 (42%)
		PTPc	1125..1348	CDD:238006	101/232 (44%)
Ptprf	XP_006502927.1	I-set	33..124	CDD:369462
		Ig2_RPTP_IIa_LAR_like	152..232	CDD:319301
		Ig3_RPTP_IIa_LAR_like	252..320	CDD:143216	5/29 (17%)
		FN3	325..414	CDD:238020	20/93 (22%)
		FN3	421..513	CDD:238020	19/104 (18%)
		FN3	518..607	CDD:238020	20/94 (21%)
		FN3	615..709	CDD:238020	17/124 (14%)
		FN3	716..822	CDD:238020	27/123 (22%)
		FN3	827..916	CDD:238020	25/144 (17%)
		FN3	925..1013	CDD:238020	22/104 (21%)
		FN3	1022..>1081	CDD:238020	16/84 (19%)
		PTP_DSP_cys	1352..1627	CDD:391942	111/277 (40%)
		R-PTP-F-2	1629..1919	CDD:350477
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010