Protein Alignment Ptp52F and Ptprb

DIOPT Version :10

• Sequence 1: NP_611093.2
• Gene: Ptp52F / 36790
• FlyBaseID: FBgn0034085
• Length: 1433
• Species: Drosophila melanogaster
• Sequence 2: XP_036011586.1
• Gene: Ptprb / 19263
• MGIID: 97809
• Length: 2361
• Species: Mus musculus
• Alignment Length: 1436
• Identity: 329/1436 - (22%)
• Similarity: 556/1436 - (38%)
• Gaps: 312/1436 - (21%)

  Fly    37 SESQELAEKVEVTVVSTVYTLGFSISNEA--------------DYSIDKVICRNGSG---SETEA 84
            :|.:.:.:||:          |.|:||.|              |:...:|..:|...   ::|..
Mouse  1013 TEERTVPDKVQ----------GISVSNSARSDYLKVSWVHATGDFDHYEVTIKNRESFIQTKTIP 1067

  Fly    85 NAAHVCE--NLNPCTFYTSVVSFRSNVSGKPPPSDQ----TIYAYTEYKQPKTTVTSVVATANTI 143
            .:.:.||  .|.|...|:..||.:   ||:...|:|    ||      .:|...:|.:..:...:
Mouse  1068 KSENECEFIELVPGRLYSVTVSTK---SGQYEASEQGTGRTI------PEPVKDLTLLNRSTEDL 1123

  Fly   144 KVTWQTNDRACVESFGITAKATDYTKSF---QLLNDKSSQTFVNLS-----ACLTHTITLDTRNN 200
            .||| :.....|:.:.:.....| .|.|   .|:|..:...|..|:     ..|..||:.|.:.:
Mouse  1124 HVTW-SRANGDVDQYEVQLLFND-MKVFPHIHLVNTATEYKFTALTPGRHYKILVLTISGDVQQS 1186

  Fly   201 ASVVVDTDATDVDTQYAEPGDLVMNVTNLASGIT---MITW----GDPSEKNCISNYVFKWQRND 258
            |.:    :...|.:       .|.|:...|:|.|   |:||    ||      :.:||....|.|
Mouse  1187 AFI----EGLTVPS-------TVKNIHISANGATDRLMVTWSPGGGD------VDSYVVSAFRQD 1234

  Fly   259 CGTDQNQDTTTDVPSTETTNEIDYVTTTPMETTPDTPSDE--------VKCEWTDVSSDGKLREY 315
            ...|.                         :|.|...|:.        .|.....||..|.||
Mouse  1235 EKVDS-------------------------QTIPKHASEHTFHRLEAGAKYRIAIVSVSGSLR-- 1272

  Fly   316 LLTDLQGCDLYTFQVFINENSTAKASQTF-TSAEKLVSAVYEPSPTAYPT-QLHWTWFSPQNHPK 378
                               |......||. .|.:.:|:|      .||.: .|..:|   |....
Mouse  1273 -------------------NQIDALGQTVPASVQGVVAA------NAYSSNSLTVSW---QKALG 1309

  Fly   379 CVANYSVTLTGPIQRSEN-KTMNVITEETFA---IFDDLDPCGIYLVEIVPNQLNGSAGTKYQEQ 439
            ....|.:.|.     :|| ..::.::|...|   .|:||.|...|.::|    |..|.|...:|.
Mouse  1310 VAERYDILLL-----NENGLLLSNVSEPATARQHKFEDLTPGKKYKMQI----LTVSGGLFSKES 1365

  Fly   440 STVGEDQPSVIQD-PVVEAEAYSMEVSWKTPEYADLCIDGYRLSGWMEDDKLVEVEALSITTQNT 503
            ...|...|:.:.: .:.|..:..:...|...|..   :..|.:..:..|..|.|...:....|:.
Mouse  1366 QAEGRTVPAAVTNLRITENSSRYLSFGWTASEGE---LSWYNIFLYNPDRTLQERAQVDPLVQSF 1427

  Fly   504 TVVFDKNLLACQVYIIQIIPYTKENLDGQLRQVGVETKAAIVDYTKVKLEMKNAGSEFIDLIAF- 567
            :.   :|||..::|.:.|:.::.| |..:....|....||:       ..:|.:.....|.:.|
Mouse  1428 SF---QNLLQGRMYKMVIVTHSGE-LSNESFIFGRTVPAAV-------NHLKGSHRNTTDSLWFS 1481

  Fly   568 ----NADYNNSCPTIFALFTCNATTQVRNPYAERYVEGHSKQGFNASLSPLSPYATYVCKVILYN 628
                :.|::     .:.|...|.....:..:.|:.|.....||    |.|...|..||     ..
Mouse  1482 WSPASGDFD-----FYELILYNPNGTKKENWKEKDVTEWRFQG----LVPGRKYTLYV-----VT 1532

  Fly   629 VAGPSEPVVDADMHTTTYFPEQPESVMLEKSTVSSLLFNWQ-PPTYTNGPIKYYQAFLMRHEASY 692
            .:|.....|..:..|.   |..|..:.......:||...|: ||.:|:     |..|    |..:
Mouse  1533 HSGDLSNKVTGEGRTA---PSPPSLLSFADVANTSLAITWKGPPDWTD-----YNDF----ELQW 1585

  Fly   693 FVPADCAIVEQDTKSETKGDPSVNFTGLAPAVRYMMQVAAQNDFGMGVYTEPVIGITLPAVSDSV 757
            | |.| |:...:..|..|.:..:.: ||.|...|...|...:......|::|:.|    :|....
Mouse  1586 F-PGD-ALTIFNPYSSRKSEGRIVY-GLHPGRSYQFSVKTVSGDSWKTYSKPISG----SVRTKP 1643

  Fly   758 TQLTVLTQGPVNNNAVYEANVTITWKVPCKSNGDIEYFQLAFNGTRNNFAPVSFERRVELDTGNK 822
            .::..|...|.|:.|     :..:|..|     |.::...:....:.:...:.|.|::|.:....
Mouse  1644 DKIQNLHCRPQNSTA-----IACSWIPP-----DSDFDGYSIECRKMDTQEIEFSRKLEKEKSLL 1698

  Fly   823 QGRMSYTETEMQPQFDYTVEVSVKNRDV------EQLSSSVPGSWQSPAGLPTIPSDELIKQMRA 881
            ...|      :.|...|.|.:.|::..:      :...:.:....|.|..:.....|.||.  ::
Mouse  1699 NIMM------LVPHKRYLVSIKVQSAGMTSEVVEDSTITMIDRPPQPPPHIRVNEKDVLIS--KS 1755

  Fly   882 NVEETSNPTKTAIVRLPADIMTSASGDIKWMALMISQKNCAGVPHLKYDVSSDWPKVLSYQEAGA 946
            ::..|.|          ....:..:|.:|:.|:::.:.:  .:..||.:.....|..|.|:.
Mouse  1756 SINFTVN----------CSWFSDTNGAVKYFAVVVREAD--SMDELKPEQQHPLPSYLEYRH--- 1805

  Fly   947 DGTGDCSLE-YQTTEERWHPEPVQRQRRDGEVTSDEEIVFTIGLD------KCSEVQKTYCNGPL 1004
                :.|:. |||..       ...:..:...:|.:.....:|.:      ||...|:.:|:|||
Mouse  1806 ----NASIRVYQTNY-------FASKCAESPDSSSKSFNIKLGAEMDSLGGKCDPSQQKFCDGPL 1859

  Fly  1005 LPDTDYNVVVRL-----------FTASGYSDAAV-LNFKTKA--------AIKVTLILVSVCSCL 1049
            .|.|.|.:.:|.           ||...|||... :...|::        .:...|.|:.:...|
Mouse  1860 KPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSMPITTESEPLFGVIEGVSAGLFLIGMLVAL 1924

  Fly  1050 LLAFVLGLTVLWVRK----RLAWKRDSGQGIEDPFGN---------VIAKNFAIFYTEVAKPEK- 1100
            :..|:........|:    ||:.:||....:....|.         :....|...:.::.....
Mouse  1925 VAFFICRQKASHSRERPSARLSIRRDRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNY 1989

  Fly  1101 -LAREFKEITVVALELSYSASEL--GCHKNRYADIFPYDKNRV-ILDIDAEG-SDYINASFIDGH 1160
             |::|::::..|....|...:.|  ...||||.:|.|||.:|| :.::|.:. |||||||:|.|:
Mouse  1990 LLSKEYEDLKDVGRSQSCDIALLPENRGKNRYNNILPYDASRVKLCNVDDDPCSDYINASYIPGN 2054

  Fly  1161 TRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYN-----VRGLTVT 1220
            ..::||||||||.|.:..|||:|..:.||..||.|||..|...:||..|:|.:     ...|.:.
Mouse  2055 NFRREYIATQGPLPGTKDDFWKMAWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDPLYYGDLILQ 2119

  Fly  1221 IKSKEVLELYDRTELTVVHDKYGLKEKVI-HYYFKKWPDHGVPEDPMHLIMFVKKVK--AEKRPS 1282
            :.|:.||..:...|..:..::.....::| |:::..||||||||....||.||:.|:  ..:.|.
Mouse  2120 MVSESVLPEWTIREFKICSEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPG 2184

  Fly  1283 YSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTY 1347
            ..|.||||||||||||||:.||.|:|:|.|:..::|:..|..||..|:.||||:.||.:|:.|..
Mouse  2185 AGPTVVHCSAGVGRTGTFVALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVR 2249

  Fly  1348 ELVKHK 1353
            ::::.|
Mouse  2250 DVLRAK 2255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020	25/101 (25%)
		PTPc	1100..1345	CDD:214550	104/258 (40%)
Ptprb	XP_036011586.1	beta-trefoil_Ricin_MRC-like	18..133	CDD:483961
		Herpes_BLLF1	<158..>352	CDD:282904
		FN3	<370..>545	CDD:442628
		FN3	398..483	CDD:238020
		fn3	579..658	CDD:394996
		fn3	681..742	CDD:394996
		fn3	757..835	CDD:394996
		FN3	856..1309	CDD:442628	79/388 (20%)
		FN3	<1341..1674	CDD:442628	80/393 (20%)
		fn3	1550..1632	CDD:394996	21/93 (23%)
		fn3	1644..1723	CDD:394996	15/94 (16%)
		PTP_tm	1761..1898	CDD:465889	31/162 (19%)
		R-PTPc-B	2019..2246	CDD:350465	98/226 (43%)