Protein Alignment Ptp52F and Ptpn11

DIOPT Version :10

• Sequence 1: NP_611093.2
• Gene: Ptp52F / 36790
• FlyBaseID: FBgn0034085
• Length: 1433
• Species: Drosophila melanogaster
• Sequence 2: NP_035332.1
• Gene: Ptpn11 / 19247
• MGIID: 99511
• Length: 597
• Species: Mus musculus
• Alignment Length: 520
• Identity: 148/520 - (28%)
• Similarity: 222/520 - (42%)
• Gaps: 136/520 - (26%)

  Fly   916 ISQKNCAGVPHLKYDV------SSDW----------PKVLSYQEAGADGTGDCSLEYQTTEERWH 964
            :.:|| ..|..|||.:      |..|          .|:|:  |.|..|:      :...|.:.|
Mouse    88 LKEKN-GDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLT--EKGKHGS------FLVRESQSH 143

  Fly   965 PEPVQRQRRDGE---VTSDEEIVFTIGLDKCSEVQKTYCNGPLLPD-TDYNVVVRLFTASGYSDA 1025
            |.......|.|:   .::|.:...|..:.:|.|::.....|..... ||
Mouse   144 PGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTD---------------- 192

  Fly  1026 AVLNFKTKAAIKVTLILVSVCSCLLLAFVLGLTVLWVRKRLAWKRDSGQGIEDPFGNVIAKNFAI 1090
            .|.::|....::                .|| |||.:::.|               |....|.|.
Mouse   193 LVEHYKKNPMVE----------------TLG-TVLQLKQPL---------------NTTRINAAE 225

  Fly  1091 FYTEVAKPEKLA-----------REFKEITVVALELSYSASE----LGCHKNRYADIFPYDKNRV 1140
            ..:.|.:..|||           .||:.:.....:|.||..|    ...:||||.:|.|:|..||
Mouse   226 IESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRV 290

  Fly  1141 IL---DIDAEGSDYINASFI--------DGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQ 1194
            :|   |.:...||||||:.|        :....||.||||||....:|.|||||:.|.|.||||.
Mouse   291 VLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVM 355

  Fly  1195 VTQFREGNTIKCHEYYPYNVRGLTVTIKSKEVLELYDRTELTVVHDKYGLKE------------- 1246
            .|:..|....||.:|:|..     ..:|...|:.:.:..| :..|| |.|:|
Mouse   356 TTKEVERGKSKCVKYWPDE-----YALKEYGVMRVRNVKE-SAAHD-YTLRELKLSKVGQALLQG 413

  Fly  1247 ----KVIHYYFKKWPDHGVPEDPMHLIMFVKKV--KAEKRPSYSPIVVHCSAGVGRTGTFIGLDL 1305
                .|..|:|:.|||||||.||..::.|:::|  |.|......|:|||||||:|||||||.:|:
Mouse   414 NTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIVDAGPVVVHCSAGIGRTGTFIVIDI 478

  Fly  1306 IMQRLKS---ESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVKHKIPRAALKMDGRPKS 1367
            ::..::.   :..|::.:|::.:|.||..||||:.||.|:|..    |:|.|.....:::...||
Mouse   479 LIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMA----VQHYIETLQRRIEEEQKS 539

  Fly  1368  1367
            Mouse   540  539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020
		PTPc	1100..1345	CDD:214550	106/292 (36%)
Ptpn11	NP_035332.1	SH2_N-SH2_SHP_like	5..103	CDD:198203	6/15 (40%)
		SH2_C-SH2_SHP_like	111..218	CDD:198185	26/162 (16%)
		PTPc-N11	272..528	CDD:350453	100/266 (38%)