DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp52F and ptp-4

DIOPT Version :9

Sequence 1:	NP_611093.2	Gene:	Ptp52F / 36790	FlyBaseID:	FBgn0034085	Length:	1433	Species:	Drosophila melanogaster
Sequence 2:	NP_001255470.1	Gene:	ptp-4 / 177898	WormBaseID:	WBGene00010558	Length:	1159	Species:	Caenorhabditis elegans

Alignment Length:	1009	Identity:	233/1009 - (23%)
Similarity:	381/1009 - (37%)	Gaps:	259/1009 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   462 MEVSWKTPEYADLCIDGYRLSGWMEDDKLV---EVEALSITTQNTTVVFDKNLLACQVYIIQIIP 523
            |...::||...       |...|.:||.||   :.:.|:.:::...|...:..|....|.:::.|
Worm    47 MAPDFETPRLV-------RRLDWFQDDSLVASYQQDILADSSRQWWVSDGRYQLIRPFYTLRVSP 104

  Fly   524 YTKENLDGQLR------------------QVGVETKAAIVDYTKVK---------LEMKNAGSEF 561
            .|.|: .|..|                  ::.|..|.......::|         :...||....
Worm   105 VTPED-SGTYRCRLETDPLFSSPQSTATQELAVMVKPVAPSSPEIKTFTNRSITLVWTHNAARAH 168

  Fly   562 IDLIAFNADYNN-SCPTIFALFT-CNATTQVRNPYAERYVEGHSKQGFNASLSPLSPYATYVCKV 624
            ..::.|:..... |..|.|.:.. .||||.:                    :..||||..|...|
Worm   169 RPILRFSVSVRTVSDNTRFVMAAPSNATTVI--------------------VDNLSPYTLYAFSV 213

  Fly   625 ILYNVAGPSEPVVDADMHTTTYFPEQPESVMLEKSTVSSLL-FNWQPPTYTNGPIKYYQAFLMRH 688
            ...|.||.|:...:....|....|.:|..:...::..|..: ....||...||.:..|...:.
Worm   214 RAENSAGSSDFGPETTFRTLGESPNRPPQIQKIRNITSECVEVTITPPDEMNGELDKYLVLIQ-- 276

  Fly   689 EASYFVPADCAIVEQDTKSETKGDPS---VNFTGLAPAVRYMMQVAAQNDFG------MGVYTE- 743
                      |:.|...:..|...|:   :....|:|:..|.:.:.|.|.||      :..:||
Worm   277 ----------AVNETIPRKMTFDKPTSTPLTICALSPSTDYALAIEADNGFGTSPQATLVFHTED 331

  Fly   744 ------PVIGITLPAVSDSVTQLTVLTQGP--------VNNNAVYEANVTITWKVPCKSNGDIEY 794
                  |....|||.|..  .::|||...|        :..:..|:|.....||        ||:
Worm   332 SVPNWSPSTITTLPVVGK--PEITVLWPAPPLNATEKVIKYHLYYKAKNEDQWK--------IEH 386

  Fly   795 FQLAFNGTRNNFAPVSFERRVELDTGNKQGRMSYTETEMQPQFDYTVEVSVKNRDVE--QLSSSV 857
            ..::.||.::..                   ..|...::.|...|.:.||......|  |.:.||
Worm   387 LNVSPNGVKSKL-------------------FKYRLVDLNPNTQYRIRVSASTIKGEGAQSADSV 432

  Fly   858 PGSWQSPAGLP-TIPSDEL-------IKQMRANVEETSN----PTKTAIVRLPADIMTSASGDIK 910
            .   |:..|.| |:...:|       :| :|.|.|.:.|    ||.|..|       |:.:..::
Worm   433 A---QTDVGEPGTVTFKDLNFDCKNGVK-LRWNYEPSVNSKKSPTFTVKV-------TNQTTSLQ 486

  Fly   911 WMALMISQKNCAGVPHLKYDVSSDWPKVLSYQEAGADGTGDCSL--EYQTTEERWHPEPVQRQRR 973
            :...|:|           .|:.                  |.||  ||..     ....::|...
Worm   487 FNTTMLS-----------LDII------------------DLSLYDEYTL-----RIIVLERSTI 517

  Fly   974 D------GEVTSDEEIVFTIGLDKCSEVQKTYCNGPLLPDTDYNVVVRLFTASGYSDAAVLNFKT 1032
            |      |:.:...:.:..   |||| .|.::|:    |.   ....:|.:::|..
Worm   518 DNSTILIGKYSDSHQFILK---DKCS-YQSSFCS----PG---EKCAKLTSSAGNP--------- 562

  Fly  1033 KAAIKVTLILVSVCSCLLLAFVLGLTVLWVR-----KRLAWKRD-------------SGQGIED- 1078
                :...:|:.:.:.::.||:..:.|.:.|     |.|..|::             ...|.||
Worm   563 ----RYISVLIVIFAIIIFAFICFVIVHFARGSMNFKHLLKKKEKCVYLEEISPLVYDSAGQEDI 623

  Fly  1079 P----FGNV--IAKNFAI-FYTEVAKPEKLAREFKEITVVALELSYSASELGCHKNRYADIFPYD 1136
            |    :|.|  :.:|.:: |.|:.   :.|..:...|..|....|.|:|:....||||.:|...:
Worm   624 PVELFYGYVEDLNRNDSLKFKTQF---QILESQTSGIDSVDSGESNSSSDENSQKNRYNNIGAIE 685

  Fly  1137 KNRVILDIDAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREG 1201
            ..|:.|: ...|:|||||:::|....:..|||||.|.|.:..|||.||.|....:||.:|...|.
Worm   686 ATRIRLN-SPTGNDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVED 749

  Fly  1202 NTIKCHEYYPYNVRGLTVTIKSKEVLELYDRTELTVVHDKYGLK--------EKVIH-YYFKKWP 1257
            ...||.:|:| :.:....|..:.:|..:.:.|.....|....||        |:.:| .:|..||
Worm   750 GKRKCDQYWP-SQQDSPQTFGNYQVTLVSESTNAHFSHRILDLKIAKAVPAVERKVHQLHFMGWP 813

  Fly  1258 DHGVPEDPMHLIMFVKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETV 1322
            |||||.....|:.||.  ......|..|:||||||||||:|::|.:|.:.:.|.|..::|:...:
Worm   814 DHGVPSSVFPLLSFVH--YTSDIHSTGPVVVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHL 876

  Fly  1323 KKLRFQRMKMVQTQQQYTFLYACTYELVKHKIPR 1356
            ..:|.||.|:|||.:||.|.:....:|::|.|.|
Worm   877 THMRRQRAKLVQTLEQYIFCHEAIRQLIRHGITR 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020	22/117 (19%)
		PTPc	1100..1345	CDD:214550	88/253 (35%)
		PTPc	1125..1348	CDD:238006	82/231 (35%)
ptp-4	NP_001255470.1	IG_like	<83..120	CDD:214653	8/37 (22%)
		FN3	140..232	CDD:238020	21/111 (19%)
		FN3	237..326	CDD:238020	19/100 (19%)
		FN3	338..435	CDD:238020	26/128 (20%)
		PTPc	642..900	CDD:214550	90/264 (34%)
		PTPc	675..900	CDD:238006	82/228 (36%)
		Y_phosphatase	<977..1128	CDD:278528
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010