DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp52F and ptpn-22

DIOPT Version :9

Sequence 1:	NP_611093.2	Gene:	Ptp52F / 36790	FlyBaseID:	FBgn0034085	Length:	1433	Species:	Drosophila melanogaster
Sequence 2:	NP_500128.2	Gene:	ptpn-22 / 176981	WormBaseID:	WBGene00021507	Length:	469	Species:	Caenorhabditis elegans

Alignment Length:	427	Identity:	126/427 - (29%)
Similarity:	195/427 - (45%)	Gaps:	96/427 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1079 PFGN--VIAKNFA--------IFYTEVAKPEKLAREFKEITV----VALELSYSASELGC----- 1124
            |.||  :..||.|        :...|...|:...|.|.:|.|    :.:|..|.:.   |
Worm    64 PNGNPVIFEKNPAMDGLLREFLKEEEAYTPQDYLRRFYQIRVEQEKLRMEAEYRSE---CAVAPQ 125

  Fly  1125 H--KNRYADIFPYDKNRVILDIDAEGSD-YINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQ 1186
            |  :|||.||.|||||||.:..|:|..: |:|||.|.....|.|:||.|.|.|.::.::|:||.:
Worm   126 HYARNRYRDILPYDKNRVEIQKDSENPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDE 190

  Fly  1187 YNVRVIVQVTQFREGNTIKCHEYYPYNV------RGLTVTIKSKEVLELYDRTE-----LTVVHD 1240
            :.|.::|.:.:..|.|.|||..|:|..|      ....:|::.:   :|:|..|     |.:.:.
Worm   191 HRVSLVVILCKLVELNKIKCERYWPEQVGESELFGDYEITLEEE---KLFDDDEYLMRCLKMENQ 252

  Fly  1241 KYGLKEKVIHYYFKKWPDHGVP---EDPMHLIMFVKKVKAEKRP-SYSPIVVHCSAGVGRTGTFI 1301
            ..|...||...::::|||||.|   :..:::|..::.:..|..| ..|||:||||||||||||.|
Worm   253 TTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEEVSPQDSSPILVHCSAGVGRTGTII 317

  Fly  1302 GLDLIMQRLKSES--KINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVKHKI---------- 1354
            .::.|.:::|:|:  .|:||..|..||.||..|||||.|:.|::.|.....:..:
Worm   318 AINFIREQMKAETLHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYCRRHLGIIEEPKLDL 382

  Fly  1355 --PRAALKMD-GRPKSVTVPAIPSP----------------------KKVSFPDVDVGSEYVSSA 1394
              |.|...:. |...||.:.|.|:|                      ...:..|.|..:|..:|.
Worm   383 APPVATADLPVGSSGSVRLIAPPTPTTGPSTDQTATIANYNQLHHHQSSSNHMDEDTSTEEAASV 447

  Fly  1395 PITDLDDGRPIVQLPSRFSGLRRNSPPGENDNPTSSS 1431
            |  |..:..|              :|.|..|..:|::
Worm   448 P--DFPEEPP--------------APMGPEDLGSSAA 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020
		PTPc	1100..1345	CDD:214550	98/273 (36%)
		PTPc	1125..1348	CDD:238006	92/242 (38%)
ptpn-22	NP_500128.2	PTPc	102..365	CDD:214550	97/268 (36%)
ptpn-22	NP_500128.2	PTPc	129..365	CDD:238006	91/238 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010