DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp52F and F54F12.1

DIOPT Version :9

Sequence 1:	NP_611093.2	Gene:	Ptp52F / 36790	FlyBaseID:	FBgn0034085	Length:	1433	Species:	Drosophila melanogaster
Sequence 2:	NP_499709.1	Gene:	F54F12.1 / 176727	WormBaseID:	WBGene00010072	Length:	1217	Species:	Caenorhabditis elegans

Alignment Length:	1367	Identity:	262/1367 - (19%)
Similarity:	459/1367 - (33%)	Gaps:	448/1367 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 LNDKSS---QTFVNLSACLTHTITLD-TRNNASVV--------VDTDATDVD----TQYAEPGDL 222
            |.|:|:   .|...::|.....:.|: .|...|::        .|...|::|    .:.:..|:|
Worm    13 LEDRSTAFQYTSPLVTAIQNRLVVLEKVRQGCSIMRNYSTLPGKDEYKTELDILSKLRLSIDGEL 77

  Fly   223 VMNVTNLASGITMIT-WGDPSEKNCISNYVFKWQRNDCGTDQNQDTTTDVPSTETTNEIDYVTTT 286
            :::...:...:..|: |.|......:||| |:...:|....:::|.:       .:|.:|.:
Worm    78 ILSTGRVIPLLNKISNWQDGKPVEDVSNY-FQAIVSDLKILEDKDLS-------FSNIVDTI--- 131

  Fly   287 PMETTPDTPSDEVKCEWTDVSSDGKLREYLLTDLQGCDLYTFQV-------------FINENSTA 338
                      :::|..:.:.:|   ..|.||.:....|:...:|             |.|.:.:.
Worm   132 ----------NKLKNSFENANS---FVELLLAEKTFRDMLVAKVSYEDELMNALKEQFQNVHQSI 183

  Fly   339 KASQTF--------------------------------TSAEKLVSAVYEPSPTAYPTQLHWTWF 371
            ::||:.                                ...|:|:.|||.            .|.
Worm   184 QSSQSLLPVLKALRKVIGSHVNGLELSYKYIAGLPSGKLDLEELIQAVYH------------NWI 236

  Fly   372 SPQNHPKCVANYSVTLTGPIQRSENKTMNVITEETFAIFDDLDPCGIYLVEIVP---------NQ 427
            ..:     :.|:|                ||..:....|..|:|..:.|..:..         ||
Worm   237 KNR-----IINHS----------------VIASDLVKGFGLLNPLKVLLAPVESKWQSMKDENNQ 280

  Fly   428 LNGSAGTKYQEQSTVGEDQPSVI-------------QDPVVEAEAYSM-EVSWKTPEYADLCIDG 478
            .:....:|.||:.|...|..|:|             .||     .|:: |:|........|.:..
Worm   281 HSMEEISKIQEEITTLPDVSSIINTTDSFANCGSDFHDP-----KYNISEISEVVELMNQLNLKV 340

  Fly   479 YRLSGWMEDDKLVEVEALSI---------TTQNTTVVFDKNLLACQVY--IIQIIPYTKENLDGQ 532
            .:||.:   :.|.|::.|::         ||....:|..||:.:...:  :::|:...|::||..
Worm   341 RQLSRF---EYLNELKNLTVLKDILVNPPTTDEGKIVVIKNMKSEPKFEKVLEILVNFKKDLDAL 402

  Fly   533 LRQVGVETKAAIVDYTKVKLEMKNAGS-----------EFIDLIAFNADYNNSCPTIFALFTCNA 586
            ...||...|.|    .:|..:.||.||           :|.|.:...||  :..|.|..:....:
Worm   403 QSAVGEMPKLA----DEVNGKFKNIGSYHNEVNAPHFLKFYDCLNDLAD--DGMPMIQMISVIQS 461

  Fly   587 TTQVRNPYAERYVEGHSKQGFNASLSPL-----------SPYATYV------CKVILYN----VA 630
            ...:.||.....|  :|......||..|           ||.|..:      .::..:|    |.
Worm   462 IRSLSNPSENAIV--NSVISSQPSLKSLQVSGTGFKNVTSPEALALNGSLPDSQISAFNLGMAVQ 524

  Fly   631 GPSE--PVVDADMHTTTYFPEQPESVMLEKSTVSSLL-------FNWQPPTYTNGP---IKYYQA 683
            |.|:  .|.|..:...|...:..|.:...||..:..|       .:....|..:|.   :|....
Worm   525 GLSQIKKVQDNRVKLETIKEQHAEIIETSKSNTTLTLSLSRLKDLSESLSTTLSGITTFVKTING 589

  Fly   684 F--LMRHEASYFVPADCAIVEQDTKSETKGDPSVNFTGLAPAVRYMMQVAAQNDFGMGVYTEPVI 746
            |  |.|..::....::..|.  |..|..||....:|..:..||:                  .|.
Worm   590 FQGLKRKRSTLDFESNGKIF--DKASSIKGFTGFDFLAIMDAVK------------------AVD 634

  Fly   747 GITLPAVSDSVTQLTVLTQGPVNNNAVYEANVTITWKVPCKSNGDIEYFQLAFNGTRNNFAPVSF 811
            |....:|.|::.:|:.:                           |:::.:..|..     ||.:.
Worm   635 GTKYSSVIDALEKLSTM---------------------------DLDFQKYKFKE-----APATL 667

  Fly   812 ERRVELDTGNKQGRMSYTETEMQPQ---FDYTVEVSVKNRDVEQLSSSVPGSWQSPAGLPTIPSD 873
             :.::|...:....::    .::||   .|.|....|   .:.....|:.|: .||:..|.:|
Worm   668 -KAMDLFFASYASNLA----ALRPQPTTSDPTAAAPV---PIPNNKGSLNGN-PSPSSPPLLP-- 721

  Fly   874 ELIKQMRANVEETSNPTKTAIVRLPADIMTSASGDIKWMALMISQKN--------CAGVPHLKYD 930
            .:.....|...|.||.....|..:...::.:..|.|.:......:|.        .|.:|.|...
Worm   722 PVASSTPAATPEESNMLLYIIGAVGGLLVVAIIGVILFFVFFQKKKKKEDKPDDPPAPLPVLPPV 786

  Fly   931 VSSDWP---------KVLSYQEAGADGTGDCSLEYQTTEERWHPEPVQRQRRDGEVTSDEEIVFT 986
            |.:..|         |.||..|..||                ||.....|.:|.::..:|.:..:
Worm   787 VPAPAPVVPAPAPVVKELSVDETQAD----------------HPSLQSFQLQDTQMMPEESLALS 835

  Fly   987 --------IGLDK-CSEVQKTYCNGPLLPDTDYNVVVRLFTASGYSDAAVLNFKTKAAIKVTLIL 1042
                    :...| |::..:.:..|  :.||.:.:.|.:.|            .|:|.|......
Worm   836 DVVVQGIRVAAAKLCTKSPQEWAEG--IYDTIWKLDVMVST------------NTQANISQRRHT 886

  Fly  1043 VSVCSCLLLAFVLGLTVLWVRKRLAWKRDSGQGIEDPFGNVIAKNFAIFYTEVAKPEKLAREFKE 1107
            :.:|....:|.::                   |..|||.|.....|.
Worm   887 LFLCEPKTMAKLV-------------------GFPDPFINANVMKFG------------------ 914

  Fly  1108 ITVVALELSYSASELGCHKNRYADIFPYDKNRVILDIDAEGSDYINASFIDGHTRKKEYIATQGP 1172
                  |:|:                          |.|:|.       :|| |...|.|:...|
Worm   915 ------EISW--------------------------IMAQGP-------MDG-TEHLEKISKVPP 939

  Fly  1173 KPE--SVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYNV------RGLTVTIKS------ 1223
            ||:  ::...|.:|.||:|.::.|:....|.:..|...||...|      ...|||.||
Worm   940 KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSINTKLE 1004

  Fly  1224 ----KEVLELYDRTELTVVHDKY---GLKEKVIHYYFKKWPDHGVPEDP---MHLIMFVKKVKAE 1278
                |:...:|:   |...:|::   .||:.|...:|..|||||.|::|   :.:|.|.:..|
Worm  1005 NFTDKKSFVMYN---LEYKNDQWQDKKLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCESYK-- 1064

  Fly  1279 KRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLY 1343
                 :.::||||||||||||.:.:...:|...:|...|:...|..:|..|...||:.||..:|.
Worm  1065 -----TSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLI 1124

  Fly  1344 AC 1345
            .|
Worm  1125 VC 1126

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020	20/112 (18%)
		PTPc	1100..1345	CDD:214550	70/268 (26%)
		PTPc	1125..1348	CDD:238006	69/245 (28%)
F54F12.1	NP_499709.1	Y_phosphatase	879..1127	CDD:278528	80/335 (24%)
F54F12.1	NP_499709.1	PTPc	884..1127	CDD:238006	79/330 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19134
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100