Protein Alignment Ptp52F and ptp-3

DIOPT Version :10

• Sequence 1: NP_611093.2
• Gene: Ptp52F / 36790
• FlyBaseID: FBgn0034085
• Length: 1433
• Species: Drosophila melanogaster
• Sequence 2: NP_001263671.1
• Gene: ptp-3 / 174685
• WormBaseID: WBGene00004215
• Length: 2248
• Species: Caenorhabditis elegans
• Alignment Length: 1771
• Identity: 355/1771 - (20%)
• Similarity: 622/1771 - (35%)
• Gaps: 590/1771 - (33%)

  Fly   113 PPPSDQTIYAYTEYKQPKTTVTSVVATANTIKVTWQ------------TNDRACVES------FG 159
            |||             |...|.|.| |:.::.:||:            .|.|...|:      |.
 Worm   383 PPP-------------PVNIVVSSV-TSESVVITWKPPKYNEAINKYVVNYRLKSENKDDAALFA 433

  Fly   160 ITAKATDYTKSFQLLNDKSS-----QTFVN------LSACLTHTITLDTRNNASVVVDTDATDVD 213
            ..::|.|.:.|.:....:||     :|..|      |.|..|:..|:.:.....|.:::...:..
 Worm   434 KDSRAEDESDSERYSEGRSSRGKTMETLENSLVIDGLVAFQTYEFTVRSAGPVGVGLESLPVEAQ 498

  Fly   214 TQYAEPGDLVMN--VTNLASGITMITWGDPSEKN-CISNY------------VFKWQRNDCGTDQ 263
            |:.::|....::  ..:|.....::.||...:.| .|:.|            :.:|:::|..:|:
 Worm   499 TKPSKPATAPVSPQARSLNRDSILVKWGPCEQPNGLITGYKVYYTNDLVTTPIREWKQHDAKSDE 563

  Fly   264 NQDTTTDV------------PSTETTNEIDYVTTT----------PMETTPDTPSDEVKCEWTDV 306
            ...|...:            .::|..:.:..:.|.          ||.|.....|..::..|...
 Worm   564 FMTTINGLEPDSRYFVRVIAQNSEGDSPLSTLVTVATRQGIPGQPPMLTVKALDSRRMQLTWDKP 628

  Fly   307 --------------SSDGKL--------REYLLTDLQGCDLYTFQVFINENSTAKASQTFTSAEK 349
                          :|||:.        .::::|.|.....|.|:|....:   :....||  |.
 Worm   629 LYSSPVVGYTVRYNTSDGEKELTLTSPHEKHVVTGLHPDKYYYFRVAAYSD---RGQGEFT--EP 688

  Fly   350 LVSAVYEPSPTAYPT------------QLHWTWFSPQNHPKCVANYSVTLTGPIQRSENKTMN-- 400
            ::|......|.:.||            ::.|.....:.....:..|.:..   .:..::||.|
 Worm   689 MISKTIASIPLSSPTIVSAAATSSKSVEIRWKGPEQKKLNGVLTAYRINY---FRLEDSKTANLE 750

  Fly   401 ---------------------VITEETFAIFDDLDPCGIYLVEIVPNQLNGSAGTKYQEQSTVG- 443
                                 |.::.|..:..||.|...|.:.:..:.::|     |..:|::.
 Worm   751 SVEYDEDMDDSSSFLDRMSVVVPSDATSYVLSDLLPYSSYEITVAASTMDG-----YGPESSIRV 810

  Fly   444 ----EDQPSVIQDPVVE-AEAYSMEVSWKTPEYADLCIDGYRLSGWMEDDKLVEVEALSITTQNT 503
                ||.||..::...| ..|.|::::|..|..|:..:.||    ::..|::|..|.:.......
 Worm   811 VKTLEDVPSAPRNFNAELTSATSVKLTWDAPAAANGALLGY----YVYLDRMVNGEPVVEKGSKK 871

  Fly   504 TVVFDKNLLACQVYIIQIIPYTK---------ENLDGQLRQVGVETKAAIVDYTKVKLEMKNAGS 559
            .:|..::.......:..:.|.|:         .|.||:..    |.|:.|.         :....
 Worm   872 RIVMIRDSSKRYFELDSLDPNTEYSFRLNAFNRNGDGEFS----ERKSIIT---------QGIPP 923

  Fly   560 EFIDLIAFNADYNNSCPTIFALFTCNATTQVRNP--------------YAERYVEGHSKQGFNAS 610
            |..::::.:.|.:.  |.:.|...........|.              |.:.||:..:..|.:.|
 Worm   924 EAPEIVSVSLDRDE--PPVVARIEWKMPKMKPNETPIEKYNLWLRAQGYPDSYVKAKTVDGTDLS 986

  Fly   611 LSPLSPYATYVCKVIL--YNVAGPSEPVVDADMHTTTYFPE-QPESVMLEKSTVSSLLFNWQPPT 672
            .:....:...|..|:|  .|..|.|:...:. :.|....|: :|..|..|... ..::.:|:||:
 Worm   987 TTISGLWMGVVYDVLLAAENREGRSQNATET-IATPVGSPDGEPIDVQYEVMK-GKIVVSWRPPS 1049

  Fly   673 --YTNGPIKYYQAFLMRHEASYFVPADCAIVEQDTKSETKGDPSVNFTGLAPAVR-YMMQVAAQN 734
              ..||.|..|:|.|...:|:           .|...:....||.:.|......| |:.:|||..
 Worm  1050 EEKRNGNITSYKAILSAMDAT-----------ADRYEQPVPAPSTSSTFEVNVRRAYLFKVAAAT 1103

  Fly   735 DFGMGVYTE-------------PVIGITLPAVSDSVT---------------------------- 758
            ..|:|.|:.             |...:.:.|.|:|..
 Worm  1104 MKGIGPYSPVLTINPDPAALVGPPTNVRVEATSNSTAVVQWDFESQKADSFVVKYMHEPGNRMDT 1168

  Fly   759 ----QLTVLT--------------------------------QGPVNNNAVYEANVTITW----- 782
                ||.|::                                |||.::......:||.|:
 Worm  1169 EKWKQLPVVSIDKENPKRFAVVSDLNAHKPYAFCVLAVKNNRQGPCSDPPTVLESVTPTYMVQNL 1233

  Fly   783 KVPCKSNGDIEYFQLAFNGTRNNFAPVSFERRVELDTGNKQGRMSYTETEMQ------------- 834
            :|..|::..:: ....:||.||    |.|       ..|..||..|...|:|
 Worm  1234 RVLWKTSNSVQ-LTWEYNGPRN----VGF-------YVNHTGRKDYVNHELQEKTMSTPGFGQDV 1286

  Fly   835 -------------PQFDYTVEVSVKNRDVEQLSSSVPGS---W-------QSPAGLP-------- 868
                         |...||:.|.|:        :..||:   |       ..|.|.|
 Worm  1287 DEKHREYLWTNLRPHMMYTIHVGVR--------TLPPGARKYWPQEVVTITDPTGPPFVDVPKLV 1343

  Fly   869 ----TIPSDELIKQMRANVEETSNPTKTAIVRLPADIMTSASGDIKWMAL--MISQKNCAGVPHL 927
                |.|..::|:...| .||....:...|:.:||:..|....::..:.|  ..::|.......|
 Worm  1344 DSSGTQPGQQMIRLTPA-TEEYGPISHYWIILVPANYSTEDVVNLDPIELEKATAEKRAQLARSL 1407

  Fly   928 KYDVSSDWPKVLSYQEAGADGTGDCSLEYQTTEE--------------RWHPEPVQRQRRDGEVT 978
            ....|....:..|  |.|.|..   |..|...|:              |...:.|::|.|:.:
 Worm  1408 SVSPSKKLKRKAS--EVGDDSQ---SASYHPKEKRARRATVPGAYVTARLSADRVKQQYRNNQ-- 1465

  Fly   979 SDEEIVFTIGLDKCSEVQKTYCNGPLLPDTDYNVVVRLFTASG--------------------YS 1023
                 .|.:|   .|::...:.|.||..:..|.:::|.|..:.                    ||
 Worm  1466 -----PFIVG---DSQLYDGFTNYPLEHNLHYRLMMRAFAKNDVRTKDSFEQRAPMSEKLSRMYS 1522

  Fly  1024 DAAVLN-FKTKAAIK----VTLILVSVCSCLLLAF-VLGLTVLW--------------------- 1061
            |:.:.. |..|:|::    .:...|..|...|:.| ::|:.:.|
 Worm  1523 DSVLTEPFTIKSALRGASQKSSPWVGACIAFLVLFSIVGMLICWWLRCNKKSAGRHPRHGSITKV 1587

  Fly  1062 ----------------VRKRLAWKRDSGQGIEDPF----GNVIAKNFAIFY-------------- 1092
                            ..|.|:...:.|:.|.:|:    ||...::....|
 Worm  1588 ALTGNIMNGGGGIPGETSKLLSTSNEYGRQIMNPYEQMNGNHHMESSMDLYPLPTSHSRSNGYAP 1652

  Fly  1093 ---------------TEVAKP-----------EKL--------AREFKEI-TVVALELSYSASEL 1122
                           |.|:.|           |:|        ..||:.| |.......:|::::
 Worm  1653 VPVAIPSLPNNGNNMTTVSHPAVPIAELANHIERLRMNNNAGFQSEFESIETGQHFTWEHSSADM 1717

  Fly  1123 GCHKNRYADIFPYDKNRVIL-DIDA-EGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMIL 1185
            ..||||||::..||.:||:| :::. .|.|||||:::||:.:.:.|||||||.||:..|||||:.
 Worm  1718 NKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPRSYIATQGPLPETFSDFWRMVW 1782

  Fly  1186 QYNVRVIVQVTQFREGNTIKCHEYYPYNVRGLTVTIKSKEVLELYDRTELTVVH-DKYGLK---- 1245
            :.....||.:|...|.:.:||.:|:|  .|| |.|....||      |.|..|| ..|.::
 Worm  1783 EEQSVTIVMLTNLEERSRVKCDQYWP--SRG-TATYGDIEV------TLLESVHLAHYTMRTMRL 1838

  Fly  1246 --------EKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSYSPIVVHCSAGVGRTGTFIG 1302
                    .::.|..:..|||||||:.|...::|:|:||........||:.|||||:||||.||.
 Worm  1839 KMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTLNPNDAGPIISHCSAGIGRTGAFIV 1903

  Fly  1303 LDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVKH---KIPRAAL----- 1359
            :|.:::||:.::.::|:..|..||.||..||||::||.|::....:.|..   ::|.:.|
 Worm  1904 IDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSGSTEVPASRLHQHLH 1968

  Fly  1360 --------KMDG--------------------------RPKSVTVPAIP--SPKKVS--FPDVDV 1386
                    ::.|                          |||:..:.|:|  |.:.:.  .|..|
 Worm  1969 ILSQPSADQLSGIDMEFRHLTTLKWTSNRCTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGAD- 2032

  Fly  1387 GSEYVSSAPITDLDDG 1402
            ||:|::::.|    ||
 Worm  2033 GSDYINASWI----DG 2044

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020	27/117 (23%)
		PTPc	1100..1345	CDD:214550	100/268 (37%)
ptp-3	NP_001263671.1	Ig	93..185	CDD:472250
		Ig strand B	109..113	CDD:409353
		Ig strand C	122..126	CDD:409353
		Ig strand E	146..152	CDD:409353
		Ig strand F	163..168	CDD:409353
		Ig strand G	177..180	CDD:409353
		Ig	197..288	CDD:472250
		Ig strand B	212..216	CDD:409353
		Ig strand C	225..229	CDD:409353
		Ig strand E	252..256	CDD:409353
		Ig strand F	266..271	CDD:409353
		Ig strand G	278..281	CDD:409353
		Ig	309..380	CDD:472250
		Ig strand B	312..316	CDD:409353
		Ig strand C	325..329	CDD:409353
		Ig strand E	347..351	CDD:409353
		Ig strand F	359..364	CDD:409353
		Ig strand G	372..375	CDD:409353
		FN3	383..499	CDD:238020	26/129 (20%)
		FN3	449..932	CDD:442628	82/512 (16%)
		FN3	<769..1140	CDD:442628	80/407 (20%)
		fn3	1125..1213	CDD:394996	8/87 (9%)
		R-PTPc-LAR-1	1716..1953	CDD:350401	95/245 (39%)
		R-PTP-LAR-2	2001..2238	CDD:350402	14/49 (29%)