Protein Alignment Ptp52F and PTPRT

DIOPT Version :10

• Sequence 1: NP_611093.2
• Gene: Ptp52F / 36790
• FlyBaseID: FBgn0034085
• Length: 1433
• Species: Drosophila melanogaster
• Sequence 2: NP_573400.3
• Gene: PTPRT / 11122
• HGNCID: 9682
• Length: 1460
• Species: Homo sapiens
• Alignment Length: 1423
• Identity: 309/1423 - (21%)
• Similarity: 497/1423 - (34%)
• Gaps: 403/1423 - (28%)

  Fly   213 DTQYAEPGDLVMNVTNLASGITMITWGDPSEKNCISNYVFKWQRNDCGTDQNQDTTTDVPSTE-- 275
            |..|:..|..|...||..:...:.||..|.....:....| ...|..|....|.....:|:.:
Human    35 DEHYSNCGYSVALGTNGFTWEQINTWEKPMLDQAVPTGSF-MMVNSSGRASGQKAHLLLPTLKEN 98

  Fly   276 TTNEID---YVTTTPMETTPDTPSDEVKCEWTDVSSDGKLREYLLTD--LQGCDLYTFQVFINEN 335
            .|:.||   |.::                  .|.||.|.|..|:..:  .||..::        |
Human    99 DTHCIDFHYYFSS------------------RDRSSPGALNVYVKVNGGPQGNPVW--------N 137

  Fly   336 STAKASQTFTSAEKLVSAVYEPSPTAYPTQLHWTWFSPQNHPKCVANYSV-TLTGPIQ------R 393
            .:...::.:..||..:|..:   |..|  |:.:...|.:.||..:|...| .|..|.:      |
Human   138 VSGVVTEGWVKAELAISTFW---PHFY--QVIFESVSLKGHPGYIAVDEVRVLAHPCRKAPHFLR 197

  Fly   394 SENKTMNVITEETFAIFDDLDPCGIYLVEIVPNQLNGSAGTKYQE------QSTVGEDQPSVIQD 452
            .:|..:||....||...                     ||.|:.:      |...|.| .:::..
Human   198 LQNVEVNVGQNATFQCI---------------------AGGKWSQHDKLWLQQWNGRD-TALMVT 240

  Fly   453 PVVEAEAYSMEVSWKTPEYADLCIDGYRLSGWMEDDKLVEVEALSITTQNTTVVFDKNLLACQVY 517
            .||....:|..||  ..:.|...:..||.....:....|...|..|..:..|.:....|||....
Human   241 RVVNHRRFSATVS--VADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAVGAT 303

  Fly   518 IIQIIPYTKENLDGQLRQVGVETKAAIVDYTKVKLEMKNAGSEFID--LIAFNADYNNSCPTIFA 580
            .:.|.|                                ||.|...|  :|....:|..:..|
Human   304 YLWIKP--------------------------------NANSIIGDGPIILKEVEYRTTTGT--- 333

  Fly   581 LFTCNATTQVRNPYAERYVEGHSKQGFNASLSPLSPYATYVCKVILYNV----AGPSEPVVDADM 641
                             :.|.|.....|..|..|.|...|..:|:|...    .||..|    .:
Human   334 -----------------WAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGP----PL 377

  Fly   642 HTTTYFPEQ---PESVMLEKSTVSSLLFNWQPPTYTNGPIKYYQAFLMRHEASYFVPADCAIVEQ 703
            .|.|...:.   |::|.:.......|...|:|..|         |....|..:..|.......:|
Human   378 TTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGY---------AVTRCHSYNLTVQYQYVFNQQ 433

  Fly   704 DTKSETKGDPSVNFT--GLAPAVRYMMQVAAQNDFG------MGVYTEPVIGITLPAVSDSVTQL 760
            ..::|.....|.::|  ||.|.:...:::...|..|      :.|.||..:...:|        |
Human   434 QYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVP--------L 490

  Fly   761 TVLTQGPVNNNAVYEANVTITWKVPCKSNGDIEYFQLAFN--GTRNNFAPVSFERRVELDTGNKQ 823
            ..:..||      :|..:.|.||.|.::||.|..:::.:.  |:.:..|.:|.:|.......|:.
Human   491 ESIQGGP------FEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNET 549

  Fly   824 GRM---SYTETEMQPQFDYTVEVSVKNRDVEQLSSSVPGSWQSPAGLPTIPSDELIKQMRANVEE 885
            ..:   .|..|    .:.:|::.|........:::.:.....:|: :|...:|..:
Human   550 HHLFVGLYPGT----TYSFTIKASTAKGFGPPVTTRIATKISAPS-MPEYDTDTPL--------- 600

  Fly   886 TSNPTKTAIVRL--PADIMTSASGDIKWMALMISQK------------NCAGVPHLKYDVSSDWP 936
              |.|.|.|..:  ||.   |....:....|::.::            .|..||
Human   601 --NETDTTITVMLKPAQ---SRGAPVSVYQLVVKEERLQKSRRAADIIECFSVP----------- 649

  Fly   937 KVLSYQEAGA-DGTGDCSLEYQTTEERWHPEPVQRQRRDGEVTSDEEIVFTIGLDKCSEVQKTYC 1000
              :||:.|.: |     ||.|...|.:....||.:.             ||:|.:|   ....|.
Human   650 --VSYRNASSLD-----SLHYFAAELKPANLPVTQP-------------FTVGDNK---TYNGYW 691

  Fly  1001 NGPLLPDTDYNVVVR-LFTASGYSDAAVLNFKTKAAIKVTLILVSVCSCL--------------- 1049
            |.||.|...|::..: |..|:|.:....:...|||.:....:......||
Human   692 NPPLSPLKSYSIYFQALSKANGETKINCVRLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEP 756

  Fly  1050 ----------------LLAFV---LGLTVLWVRKRLAW-----------KRDSGQGIEDPFGNV- 1083
                            ||.|:   ||:.:...|:|.|:           ::::..|.:...|.|
Human   757 EKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVA 821

  Fly  1084 ----------IAKNFAIFYT--------------EVAKPEKLAREFKEITVVALELSYSASEL-- 1122
                      .::|...|.:              |:::|....:.....|...:|:||...:.
Human   822 SADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQP 886

  Fly  1123 --------------------------------------------GCHKNRYADIFPYDKNRV--- 1140
                                                        ..:||||.:|..||.:||
Human   887 AIRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLL 951

  Fly  1141 ILDIDAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIK 1205
            :||.|.. ||||||::|||:.|.:.|||||||..|:|.||||||.|.|...||.||...|...:|
Human   952 VLDGDPH-SDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVK 1015

  Fly  1206 CHEYYPYNVR---GLTVTIKSKEVLELYDRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPEDPMH 1267
            |..|:|.:..   .:.||:...|.|..|.....||....|....::..::|..|||||||.....
Human  1016 CVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATG 1080

  Fly  1268 LIMFVKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKM 1332
            |:.||::||....|...|||||||||.||||.||.:|.::...::|..::||..|::||.||:.:
Human  1081 LLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNL 1145

  Fly  1333 VQTQQQYTFLY---------------ACTYELVKHKIPR-------AALKMDGRPKSVTVPAIPS 1375
            |||::||.|::               .|.:..:.:.|.|       :.:|.:.:..::..|.: .
Human  1146 VQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRV-R 1209

  Fly  1376 PKKVSFPDVDVGSEYVSSAPITDLDDGRPIVQLPSRFSGLRRNSPPGENDNPTSSSNM 1433
            |:..|...:....:...|..:..||...|.:           .|..||:.|..:::.|
Human  1210 PEDCSIGLLPRNHDKNRSMDVLPLDRCLPFL-----------ISVDGESSNYINAALM 1256

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020	21/111 (19%)
		PTPc	1100..1345	CDD:214550	104/311 (33%)
PTPRT	NP_573400.3	MAM	29..189	CDD:214533	39/185 (21%)
		fn3	294..360	CDD:394996	19/117 (16%)
		FN3	390..480	CDD:238020	19/98 (19%)
		fn3	502..577	CDD:394996	16/78 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	809..858		6/48 (13%)
		R-PTPc-T-1	929..1165	CDD:350478	100/236 (42%)
		R-PTPc-T-2	1250..1455	CDD:350482	1/7 (14%)