Protein Alignment Ptp52F and ptprh

DIOPT Version :10

• Sequence 1: NP_611093.2
• Gene: Ptp52F / 36790
• FlyBaseID: FBgn0034085
• Length: 1433
• Species: Drosophila melanogaster
• Sequence 2: XP_012822947.2
• Gene: ptprh / 101733801
• XenbaseID: XB-GENE-992810
• Length: 1327
• Species: Xenopus tropicalis
• Alignment Length: 1530
• Identity: 370/1530 - (24%)
• Similarity: 574/1530 - (37%)
• Gaps: 439/1530 - (28%)

  Fly    13 IHALILILWIAG--VQGQTVGSLV-AVSESQELAEKVEVTVVSTVYTLGFSISNEAD-----YSI 69
            :.:||.::|..|  |..|:|.|.| :||.|         .:.:|..||.:...|:.|     |||
 Frog    16 LFSLIFLIWHGGTPVAAQSVPSPVQSVSIS---------NITTTNVTLSWVPPNDTDKDTYTYSI 71

  Fly    70 DKV-------ICRNGSGSETEANAAHVCENLNPCTFYT-SVVSFRSN---------VSGKPPPSD 117
            ...       :.:|.||:.|:..      .|.|..||| ||.:..||         :||
 Frog    72 TVYNGSSPWNLPKNISGTSTQVT------GLMPGVFYTFSVFTVTSNGTMSSQNGSISG------ 124

  Fly   118 QTIYAYTEYKQPKTTVTSVVATANTIKVTWQTNDRACVESFGITAKATDYTKSFQLLNDKSSQTF 182
                         |||.|.|.:.:...:|                 .|:.|.|:...||.:..|:
 Frog   125 -------------TTVPSPVQSVSVSNIT-----------------TTNVTLSWVPPNDINKDTY 159

  Fly   183 VNLSACLTHTITLDTRNNASVVVDTDATDVDTQYAEPGDLVMNVTNLASGITMITWGDPSEKNCI 247
                   |::||:  .|.:|                |.|...|::..::.:|.:.   |......
 Frog   160 -------TYSITV--YNGSS----------------PWDWPKNISGTSTQVTGLI---PGVFYTF 196

  Fly   248 SNYVFKWQRNDCGTDQNQDTT-TDVPSTETTNEIDYVTTTPMETTPDTPSDEVKCEWT------- 304
            |  ||....|...:.|...|: |.|||...:..|..:.||.:..:...|:|..|..:|
 Frog   197 S--VFTVTSNGTMSSQAGSTSGTTVPSPVQSVSISNIMTTNVTLSWVPPNDINKDTYTYSITVYN 259

  Fly   305 -DVSSDGKLREYLLTDLQGCD----------LYTFQVFINENSTAKASQTFTSAEKLVSAVYEPS 358
             ..|.:|.      |::.|..          .|||.||...::..|:||..:::...|     ||
 Frog   260 GSTSWNGP------TNISGTSTQVTGLIPGVYYTFSVFTVTSNGTKSSQAGSTSGTTV-----PS 313

  Fly   359 P-------TAYPTQLHWTWFSPQNHPKCVANYSVTLT-------GPIQRSENKTMNVITEETFAI 409
            |       ....|.:..:|..|.:..|....||:|::       ||  ::.:.|..::|
 Frog   314 PVQSVSISNIMTTNVTLSWVPPNDINKDTYTYSITVSNGSSPWNGP--KNISGTSTLVT------ 370

  Fly   410 FDDLDPCGIYLVEIVPNQLNGSAGTKYQEQSTVGEDQPSVIQDPVVEAEAY-SMEVSWKTPEYAD 473
              .|.|...|...:.....||:..:  |..||.|..:|...:|..:.:... ::.:||..|.  |
 Frog   371 --GLIPGVYYTFSVFTVTSNGTMSS--QNGSTSGTTEPLPAKDLTITSRTMTTLNLSWTPPN--D 429

  Fly   474 LCIDGYRLSGWMEDDKLVEVEALSITTQNTT--VVFDKNLLACQV--------YIIQIIPYTK-- 526
            :..:.|..|             ::::..:||  :...||..:.||        |.|.:...|.
 Frog   430 INSNTYSYS-------------INLSNGSTTWNITTPKNANSAQVTDLLPGVTYTISVYTLTSSG 481

  Fly   527 ------ENLDGQLRQVGVETKAAIVDYTKVKLEMKNAGSEFIDLIAFNADYN--NSCPTIFALFT 583
                  :::.|..|. .:.|..:|:..|...:.:.....:.|:...:....|  ||..:    :.
 Frog   482 TISSGVDSIKGTTRP-SLVTTVSIIKQTNNSVTISWTPPQDINQATYMYSINVTNSAGS----WN 541

  Fly   584 CNATTQVRNPYAERYVEGHSKQGFNASLSPLSPYATYV-CKVILYNVAGPSEPVVDADMHTTTYF 647
            .|::|.|           .||:     :..|.|..||. |   :|.|........|....::|..
 Frog   542 VNSSTNV-----------SSKE-----VLDLLPGVTYTFC---VYTVTSDGTKSSDCSPDSSTTR 587

  Fly   648 PEQPESVMLEKSTVSSLLFNWQPPTYTNGPIKYYQAFLMRHEASYFVPADCAIVEQDTKSETKGD 712
            |...:.|.::..|..|:..:|..|...|.. .||          |.:...|.....:..|
 Frog   588 PTLVKDVTVKSQTTDSVTLSWTTPNDINKG-SYY----------YLITTACGTTTCNVNS----- 636

  Fly   713 PSVNFTG-----LAPAVRYMMQVAAQNDFGMGVYTEPVIGITLPAVSDSVTQLTVLTQGP----- 767
             :||..|     |.|.:.|.          ..|||     :|....:.|....|..|..|
 Frog   637 -TVNANGATVASLLPGLTYQ----------FSVYT-----VTSDGTNSSAFASTSGTTAPNAPTS 685

  Fly   768 VNNNAVYEANVTITWKVPCKSNGDIEYFQLAFNGTRNNFAPVSFERRVELDTGNKQGRMSYTETE 832
            |:.|.|....:::.|..|...|             :||:....|.:|     .|:....|.|...
 Frog   686 VSGNPVNTTALSVNWTPPNDLN-------------KNNYTYTVFWQR-----NNESLNQSITSNT 732

  Fly   833 -----MQPQFDYTVEV--------SVKNRDVEQLSSSVPG--------------SWQSPAGLPTI 870
                 :.....|.|.|        |||.....|.:..|||              ||       ||
 Frog   733 TIIGGLTAGNQYNVSVISVINNVPSVKAVAYLQTNPEVPGGFKIVTITNSSVNVSW-------TI 790

  Fly   871 PSDELIKQMRAN-VEETSNPTK-----------------TA---IVRLPADIMTSASGDIKWMA- 913
            ||......:..| |..|||.||                 ||   |:|..:...:.:||.|...|
 Frog   791 PSGGSFSGIEINAVSGTSNLTKQFTGPSSEGILDGLIPGTAYNLILRSFSSYPSGSSGRISRRAT 855

  Fly   914 --------------LMISQKNCAGVPHLK----YDVSSDWPKVLSYQEAGADGTGDCSLEYQTTE 960
                          :.:......|:...|    |.:     ||.....:|:         |.:.
 Frog   856 TNNIITYSNPIIEKVQLDPNTVTGITCTKVGGGYQL-----KVAFVCPSGS---------YSSI- 905

  Fly   961 ERWHPEPVQRQRRDGEVTSDEEIVFTIGLDKCSE---VQKTYCNGPLLPDTDYNVVVRLFTASGY 1022
                           ::.:|.....||....||:   ||.      |.|.|.|.:.|.....|
 Frog   906 ---------------KILADGNEKETIPAQNCSQGATVQS------LQPATKYIITVETVADS-- 947

  Fly  1023 SDAAVLNFKTKAAIKVTLILVSVCSCLLLAFVLGLTVLWV-RKRLAWKRDSGQGIEDPF----GN 1082
              ..|.:|.......|.:|:.|:...||...|:||...:| |||        :|.::||    ||
 Frog   948 --RQVSDFIICYTDNVGVIVGSIFGVLLFLLVVGLIAYFVLRKR--------RGSKNPFKKERGN 1002

  Fly  1083 -----------VIAKNFAIFYTEVAKPEK--LAREFKEITVVALELSYSASELGCH--KNRYADI 1132
                       |:...|..:|........  .|.|:::::.|.:..|..|:||..:  |||:.::
 Frog  1003 MQKINIVRMPSVMKSAFPDYYQRQHADSDFGFAEEYQQLSNVGINQSKLAAELSENRSKNRFTNV 1067

  Fly  1133 FPYDKNRVILD-IDA-EGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQV 1195
            .|||.:||.|: ||| |.||||||:::.|:...||:||:|||.|.:..||||||.:..|..||.:
 Frog  1068 LPYDHSRVRLNRIDADETSDYINANYMPGYNSSKEFIASQGPLPNTSADFWRMIWENQVSTIVML 1132

  Fly  1196 TQFREGNTIKCHEYYPYNVR-----GLTVTIKSKEVLELYDRTELTVVHDKYGLKEKVIHYYFKK 1255
            |...|...:||..|:|.:..     .:|||:.|:.:|..:...:.|:.|.|....:...|::|..
 Frog  1133 TNCMENGRVKCEHYWPLDYTPCTYGDITVTVTSEMILPDWTVRDFTLKHAKQQGNKHARHFHFTV 1197

  Fly  1256 WPDHGVPEDPMHLIMF---VKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKIN 1317
            ||||||||:...::.|   |::....||.| .|.|||||||||||||.|.||.::|:::.|.:|.
 Frog  1198 WPDHGVPENTTTIVEFRNLVREYMDLKRSS-GPTVVHCSAGVGRTGTLIALDYLIQKMEKEQRIG 1261

  Fly  1318 IFETVKKLRFQRMKMVQTQQQYTFLYACTYELVKH 1352
            |:..|:|:|..|..||||:.||.||..|..:|:::
 Frog  1262 IYSFVQKMRQNRPLMVQTESQYVFLNKCMLDLIQN 1296

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020	21/105 (20%)
		PTPc	1100..1345	CDD:214550	106/258 (41%)
ptprh	XP_012822947.2	FN3	<25..489	CDD:442628	124/582 (21%)
		FN3	268..791	CDD:442628	126/635 (20%)
		FN3	771..837	CDD:473895	18/72 (25%)
		R-PTPc-H	1062..1294	CDD:350467	99/232 (43%)