Protein Alignment Ptp52F and PTPRU

DIOPT Version :10

• Sequence 1: NP_611093.2
• Gene: Ptp52F / 36790
• FlyBaseID: FBgn0034085
• Length: 1433
• Species: Drosophila melanogaster
• Sequence 2: NP_005695.3
• Gene: PTPRU / 10076
• HGNCID: 9683
• Length: 1446
• Species: Homo sapiens
• Alignment Length: 1204
• Identity: 249/1204 - (20%)
• Similarity: 414/1204 - (34%)
• Gaps: 394/1204 - (32%)

  Fly   347 AEKLVSAVYEPSPTAYPTQLHW--TWFSPQNHPKCVANYSVTLTGPIQRSENK---------TMN 400
            ||.:|..  .|:|.|.|..|..  |:...|     :...|:...|||.|.|.:         .::
Human   278 AELIVKE--PPTPIAPPQLLRAGPTYLIIQ-----LNTNSIIGDGPIVRKEIEYRMARGPWAEVH 335

  Fly   401 VITEETFAIFDDLDPCGIYLVEIVPNQLNGSAGTKYQEQSTVGEDQPSVIQDPVVEAEAYSMEVS 465
            .::.:|:.:: .|||...|.:.::..: .|..||        |...|.:|.
Human   336 AVSLQTYKLW-HLDPDTEYEISVLLTR-PGDGGT--------GRPGPPLIS-------------- 376

  Fly   466 WKTPEYADLCIDGYRLSGWMEDDKLVEVEALSITTQNTTVVFDKNLLACQVYIIQI-IPYTKENL 529
             :|.     |.:..|....:   ...|::|..:|.|...:.:  |:..|..|.:.: ..||..:.
Human   377 -RTK-----CAEPMRAPKGL---AFAEIQARQLTLQWEPLGY--NVTRCHTYTVSLCYHYTLGSS 430

  Fly   530 DGQLRQVGVETKAAIVDYTKVKLEMKNAGSEFIDLIAFNADYNNSCPTIFALFTCNATTQVRNPY 594
            ..|..:..|:|:..:..||     :||
Human   431 HNQTIRECVKTEQGVSRYT-----IKN-------------------------------------- 452

  Fly   595 AERYVEGHSKQGFNASLSPLSPYATYVCKVILYNVAGPSEP-----VVDADMHTTTYFPEQPESV 654
                               |.||.....:::|.|..|..|.     ..|.|:         |..:
Human   453 -------------------LLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDV---------PSGI 489

  Fly   655 MLEKSTVSSL----LFNWQPPTYTNGPIKYYQAFLMRHEASYFVPADCAIVEQDTKSETKGDPSV 715
            ..|..|.:.|    ...|:.|...||.|..|       |.||             :|....||:|
Human   490 AAESLTFTPLEDMIFLKWEEPQEPNGLITQY-------EISY-------------QSIESSDPAV 534

  Fly   716 N------------------FTGLAPAVRYMMQVAAQ--NDFGMGVYTEPVIGITLPA-------- 752
            |                  |:.|.|...|:..|.|:  ..||....||....|:.|:
Human   535 NVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPS 599

  Fly   753 -VSDSVTQLTVL---TQGPVNNNAVYEA--------------------NVTITWKVPCKSNGDIE 793
             :.:|...:|||   .||.....:||:.                    .|.:|::. ..:.|.:.
Human   600 PLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEA-ALARGLVH 663

  Fly   794 YFQLAFNGTRNNFAPVSFERRVELDTGNKQGRMSYTETEMQPQFDYTVEVSVKNRDVEQLSSSVP 858
            ||..       ..|..|....:....|:.|....:....::|:..|.:..        |.:|.:.
Human   664 YFGA-------ELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYF--------QAASHLK 713

  Fly   859 GSWQSPAGLPTIPSDELIKQMRANVEETSNPTKTAIVRLPADIMTSASGDIKWMALM------IS 917
            |  ::......|......|:.:..:|.:....:..:      |:...:|.:..:.|:      |.
Human   714 G--ETRLNCIRIARKAACKESKRPLEVSQRSEEMGL------ILGICAGGLAVLILLLGAIIVII 770

  Fly   918 QKNCAGVPHLKYDVSSDWPKVLSYQEAGAD---------GTGDCSLEYQTT---EER-------W 963
            :|   |..|..|   |.:||.::..:|..:         ...|.|...|:|   :||       .
Human   771 RK---GRDHYAY---SYYPKPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDT 829

  Fly   964 HPEPVQRQRRDGEVTSDEEIVFTIGLDKCSEVQKTYCNGPLLPDTDYNVVVRLFTASGYSDAAVL 1028
            |....:..:|.|.||....::.......|......|..|.|.|
Human   830 HGYSTRGDQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQLHP---------------------- 872

  Fly  1029 NFKTKAAIKVTLILVSVCSCLLLAFVLGLTVLWVRKRLAWKRDSGQGIEDPFGNVIAKNFAIFYT 1093
                  |::|..:|..:..                    .|...|.|.:..:     ::|...:.
Human   873 ------AVRVADLLQHINQ--------------------MKTAEGYGFKQEY-----ESFFEGWD 906

  Fly  1094 EVAKPEKLAREFKEITVVALELSYSASELGCHKNRYADIFP-YDKNRVILD--IDAEGSDYINAS 1155
            ...|.:|:                        |....:..| ||::||.|.  :....:|||||:
Human   907 ATKKKDKV------------------------KGSRQEPMPAYDRHRVKLHPMLGDPNADYINAN 947

  Fly  1156 FIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYN---VRGL 1217
            :|||:.|...:|||||||||.|.|||||:.|.:...||.:|:..|...:||..|:|.:   ...:
Human   948 YIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDI 1012

  Fly  1218 TVTIKSKEVLELYDRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPS 1282
            .:.:...|.|..|......:....|..:.:|..::|..||:||||.....|:.|:::|||...|.
Human  1013 KIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPD 1077

  Fly  1283 YSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLY---- 1343
            ..|||:|||||.||||.:|.||:::...:.|..::|:..||.|..:|:.|:||::||.|::
Human  1078 AGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAIL 1142

  Fly  1344 -AC--------------TYELVKHKIPRA--------------------------ALKMDGRPKS 1367
             ||              ||:.:....|::                          ||....|.|:
Human  1143 EACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKN 1207

  Fly  1368 VTVPAIPSPKKVSF---PDVDVGSEYVSSAPITD 1398
            .::..:|..:.:.|   .|.| .:.|:::| :||
Human  1208 RSMDVLPPDRCLPFLISTDGD-SNNYINAA-LTD 1239

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020	28/124 (23%)
		PTPc	1100..1345	CDD:214550	86/255 (34%)
PTPRU	NP_005695.3	MAM	22..186	CDD:214533
		fn3	291..365	CDD:394996	16/80 (20%)
		FN3	<347..>624	CDD:442628	74/401 (18%)
		fn3	494..577	CDD:394996	23/102 (23%)
		Mediates interaction with CTNNB1. /evidence=ECO:0000250	771..887		27/169 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	833..861		5/27 (19%)
		R-PTPc-U-1	943..1147	CDD:350480	79/203 (39%)
		R-PTPc-U-2	1232..1438	CDD:350485	4/9 (44%)