DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp52F and ptprdb

DIOPT Version :9

Sequence 1:	NP_611093.2	Gene:	Ptp52F / 36790	FlyBaseID:	FBgn0034085	Length:	1433	Species:	Drosophila melanogaster
Sequence 2:	XP_021330723.1	Gene:	ptprdb / 100073332	ZFINID:	ZDB-GENE-070615-38	Length:	1955	Species:	Danio rerio

Alignment Length:	1568	Identity:	357/1568 - (22%)
Similarity:	573/1568 - (36%)	Gaps:	425/1568 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEATNWKQSHRRIHALILILWIAGVQGQTVGSLVAVSESQELAEKVEVTVVSTVYTLGFSISNEA 65
            :|.||.:||.......:..|.:.    :||..:...:........|.:...:|..||.:...|
Zfish   296 LELTNVRQSANYTCVAMSTLGVI----ETVAQITVKALPNPPGSPVVMERSATSITLMWDSGN-- 354

  Fly    66 DYSIDKVICRNGSGSETE--------ANAAHVCENLNPCTFY-TSVVSFRSNVSGKPPPSDQTIY 121
            .:.:...|.:....|.|:        |...:....|:|.:.| ..||:..|...|.|.|:.....
Zfish   355 PHPVSYYIIQYRPSSSTDPFKEIDAIATTRYSVGGLSPYSHYHFRVVAVNSIGRGAPSPTVDART 419

  Fly   122 AYTEYKQPKTTVTSVVATANTIKVTWQTNDRACVESFGITAKATDYTKSFQLLNDKSSQ------ 180
            |......|...|...:.:.:|..|.|:..:.|..:..|....   ||....|   ..||
Zfish   420 AEQAPSSPPRRVRGRMLSGSTAMVQWEEPEEANGQVVGYRVY---YTSDSSL---SVSQWEKEMV 478

  Fly   181 ---TFVNLSACLTHTITLDTRNNASVVVDTDATDVDTQY-------AEPGDLVMNVTNLASGITM 235
               .|:|:.. ||...|...|..|...|.......|...       ::|.:|...|.:..|  .:
Zfish   479 RGANFLNIRD-LTPNKTYYIRVLAFTAVGDGPLSSDLHIIAKTGVPSQPTELKAEVKSETS--IL 540

  Fly   236 ITWGDPSEKNCISNYVFKWQRNDCGTDQNQDTTTDVPSTETTNEIDYVTTTPMETTPDTPSDEVK 300
            ::|..|:..               |||           ..|..|:.|       ...|.|..::.
Zfish   541 LSWIPPAHS---------------GTD-----------AITGYELIY-------RLGDQPEQKIT 572

  Fly   301 CEWTDVSSDGKLREYLLTDLQGCDLYTFQV----------FINENSTAKASQTFTSAEKLVSAVY 355
               .|.||     .|||.:|:....|.||:          |.:| .|.:..||        .::.
Zfish   573 ---FDPSS-----SYLLKNLKPFSTYVFQLAARSKHGLGAFTSE-ITVQTPQT--------QSIP 620

  Fly   356 EP------SPTAYPTQLHWTWFSPQNHPK-CVANYSVTLTGPIQRSENKTMNV--ITEETFAI-F 410
            .|      ||::  |.|..:|.||..... .|..||:.... ::|.::....:  |....|.. .
Zfish   621 PPQDVTCTSPSS--TSLLLSWASPPTDENGIVTGYSIRYVA-VERDKDPVQKISDIPSNCFRYRI 682

  Fly   411 DDLDPCGIYLVEIVPNQLNGSAGTKYQEQSTVGEDQPSVIQDP----VVEAEAYSMEVSWKTPEY 471
            :.|....:|.|.|..:..||.............||.||.  .|    ||...|.|..||||.|
Zfish   683 EGLKKGTLYSVTIAAHTDNGQGPESLPILVRTEEDVPSA--PPRGVDVVVLNATSARVSWKPP-- 743

  Fly   472 ADLCIDGYRLSGWMEDDKLVEVEALSITTQNTTVVFDKNLLACQVYIIQIIPYTKENLDGQLRQV 536
                                                                 ..|...|::|
Zfish   744 -----------------------------------------------------VAERQHGKIR-- 753

  Fly   537 GVETKAAIVDYTKVKLEMKNAGSEFIDLIAFNADYNNSCPTIFALFTCNATTQVRNPYAERYVEG 601
            |.:     |.|.:     :.||...:                             :|....::..
Zfish   754 GFQ-----VTYAR-----RTAGERTV-----------------------------SPRIREHLLR 779

  Fly   602 HSKQGFNAS------LSPLSPYATYVCKVILYNVAGP---SEPVVDADMHTTTYFPEQPESVMLE 657
            ..:|..|.|      |:.|.|...|...|..:...|.   |:|:|   :.|....|..| .:.:.
Zfish   780 DPQQPQNDSIEHEVILTDLWPNTEYSVTVAAFTSKGDGARSKPIV---IRTKPSLPGMP-LLTVV 840

  Fly   658 KSTVSSLLFNWQPPTYTNGPIKYYQAFLMRHEASYFVPADCAIVEQDTKSETKGDPSVNFTGLAP 722
            .|..|:.|..||||.....|:..|:  |...:|.   |:....:.|:..:|.:   |...:.|:.
Zfish   841 SSEDSTALLKWQPPPTGLSPVLGYR--LSYGQAD---PSSDTFMVQELDAEER---SYTVSSLSA 897

  Fly   723 AVRYMMQVAAQNDFGM-------------------GVYTEPVI--GITLPAVSDSVTQLTVLTQG 766
            .|.|:.::||:..:|.                   |:.|:|:.  |.|: :|.::|..|..||..
Zfish   898 GVLYVFRLAARTVWGYGSSAQVTLLIPNVVQTTTDGMITDPMTTEGQTM-SVQENVPILANLTAE 961

  Fly   767 PVNNNAVYEANVTITWKVPCKSNGDIEYFQLAFNGTRNNFAPVSFERRVELDTGNKQGRMSYTET 831
            .:|:     ::..:.|:.| |:...|:.:::.|..|.:|...::.|..|...|....|..:.||
Zfish   962 SINS-----SSAILRWERP-KNYDGIQGYRVWFAVTYSNGTDIAMESDVSETTVVLHGLRANTE- 1019

  Fly   832 EMQPQFDYTVEVSVKNRDVEQLSSSVPGSWQSPAGLPTIPSDELI-------KQMRANV------ 883
                   |...|.:       ||...||.:..|..:.|.|::|:.       ..|:::|
Zfish  1020 -------YVARVCM-------LSKQGPGPYSLPISIKTQPAEEVFAVNFKVKAAMKSSVLLTWES 1070

  Fly   884 EETSNPTKTAIV------------RLPADIMTSASGDIKWMALMISQKNCAGVPHLKYDVSSDWP 936
            ..|||..::.|:            ||...::|.......:..|:.|:.:..|....:.|..:. |
Zfish  1071 RTTSNKAQSLIISYGDGESVEVDGRLGQKLVTKLKPQSLYNFLLTSKSDSTGGLQHRTDAMTA-P 1134

  Fly   937 KVLSYQEAGADGTGDCS---LEYQTTEERWHPE-------PVQRQRRDG---------EVTSDE- 981
            .:::.:....|.|...|   |:..|.:.:.:..       |::|||...         |:..||
Zfish  1135 NLMTRKPQLLDKTSSQSIAILQLPTVQGQANVRGFYILVVPLKRQRAGNFQNMWSDPDEMNLDEL 1199

  Fly   982 --EIVFT---IGLDKCSE----------------------VQKTYCNGPLLPDTDYNVVV----- 1014
              ||..|   :.|.:.:|                      |...:.|.||:...:|...|
Zfish  1200 LREINGTGRSVRLRRQAEAKPYITAHFQNLPAEFKLGDGHVYGAFMNRPLVNGQEYVCFVLAILE 1264

  Fly  1015 ----RLFTASGYSDAAVLNFKTKAAI--KVTLILVSVCSCLLLAFVLGLTVLWV-------RKRL 1066
                .:::.|.:|||.:.:......|  :...:|..|...|.:.|::.:.:|.:       |||.
Zfish  1265 LGQNTVYSTSPFSDAVLFSDVEPQPIVDEEEGLLWVVGPVLAVIFIISIVILILLFKSKPDRKRA 1329

  Fly  1067 -----------AWKRDSGQGIEDPFGNVIAKNF---------AIFYTEV-AKPEKL--------A 1102
                       :.|..|.|...||. .:...||         .:..:|: |..|::        :
Zfish  1330 ELEGRKCSFPSSGKAMSSQHPSDPV-ELRRINFPTAGMTSHPPVSVSELPAHIERMKANDSLRFS 1393

  Fly  1103 REFKEITVVALELSYSAS--ELGCHKNRYADIFPYDKNRVIL-DID-AEGSDYINASFIDGHTRK 1163
            :|::.|. ...:.|:..|  |:...|||||::..||..||.| :.| ..|.|||||:||||:.|:
Zfish  1394 QEYESID-PGQQFSWEHSNLEINKPKNRYANVIAYDHTRVALTNTDGVAGGDYINANFIDGYRRQ 1457

  Fly  1164 KEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTI--------KCHEYYPYNVRGLTVT 1220
            ..|||||||.|::..|||||:.:.:...::.:|:..|.:.:        ||.:|:|  .|| |.|
Zfish  1458 GAYIATQGPMPDTFSDFWRMVWEQHTANVIMITKLEEKSRMPSYFFSKNKCDQYWP--SRG-TET 1519

  Fly  1221 IKSKEVLELYDRTEL--------TVVHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKA 1277
            ....:| .|.|..||        .:.....|.|.:|..:.|..|||.||||.|...:.|:::|||
Zfish  1520 YGLMQV-SLLDTVELATYCVRTFALFKSGSGEKREVRQFQFTAWPDQGVPEHPTPFLAFLRRVKA 1583

  Fly  1278 EKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFL 1342
            ...|...||||||||||||||.||.:|.:::|:|.|..::|:..|..:|.||..||||::||.|:
Zfish  1584 CNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERVKQEKTLDIYGHVTLMRSQRNYMVQTEEQYVFI 1648

  Fly  1343 YACTYELV 1350
            |....|.|
Zfish  1649 YEALLEAV 1656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020	27/121 (22%)
		PTPc	1100..1345	CDD:214550	105/272 (39%)
		PTPc	1125..1348	CDD:238006	100/240 (42%)
ptprdb	XP_021330723.1	I-set	32..123	CDD:254352
		Ig2_RPTP_IIa_LAR_like	151..233	CDD:319301
		Ig3_RPTP_IIa_LAR_like	257..325	CDD:143216	8/32 (25%)
		FN3	330..419	CDD:238020	18/90 (20%)
		FN3	426..517	CDD:238020	21/97 (22%)
		FN3	523..613	CDD:238020	27/133 (20%)
		fn3	620..707	CDD:306538	20/89 (22%)
		FN3	722..827	CDD:238020	31/203 (15%)
		FN3	829..920	CDD:238020	23/99 (23%)
		FN3	957..1043	CDD:238020	23/106 (22%)
		PTPc	1417..1654	CDD:238006	100/240 (42%)
		PTPc	1686..1945	CDD:214550
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010