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Protein Alignment lbk and LINGO1

DIOPT Version :10

Sequence 1:	NP_611091.2	Gene:	lbk / 36788	FlyBaseID:	FBgn0034083	Length:	1252	Species:	Drosophila melanogaster
Sequence 2:	NP_116197.4	Gene:	LINGO1 / 84894	HGNCID:	21205	Length:	620	Species:	Homo sapiens

Alignment Length:	766	Identity:	151/766 - (19%)
Similarity:	250/766 - (32%)	Gaps:	262/766 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   364 RTLDLSRNKLHTIELNSFPKSNNLVHLILSFNEITNVNEHSFATLNNLTDLELSNNRLSTLPIRV 428
            |.|||.:|::.|:                        |:..||:..:|.:|||:.|.:|.:....
Human    74 RLLDLGKNRIKTL------------------------NQDEFASFPHLEELELNENIVSAVEPGA 114

  Fly   429 FKNLNQLKKLALNFNQLE-INWSTFRGLESMKNLQLKSNKIRALQDGVFYVMHKIETIDLAMNQI 492
            |.||..|:.|.|..|:|: |....|.||.::..|.:..|||..|.|.:|..::.::::::..|.:
Human   115 FNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDL 179

  Fly   493 SSLSRQGLFNLTKLRHLNLSFNAISRIEVDTWEFTQSLEVLDLSNNAINEFKPQHLDCLHRLKTL 557
            ..:|.:....|..|..|.|....::.|..:.......|.||.|.:..||..:......|:|||.|
Human   180 VYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVL 244

  Fly   558 NLAHNRLQYLQENTFDCV--KNLEELNLRRNRLSWIIEDQSAAAPFKGLR--------------- 605
            .::|  ..||...|.:|:  .||..|::....|:        |.|:..:|
Human   245 EISH--WPYLDTMTPNCLYGLNLTSLSITHCNLT--------AVPYLAVRHLVYLRFLNLSYNPI 299

  Fly   606 ------------KLRRLDLHGNNLKQISTKAMSGLNNLEILNLGSNALASIQVNAFEHMLRLNKL 658
                        :|:.:.|.|..|..:...|..|||.|.:||:..|.|.:::.:.|..:..|..|
Human   300 STIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETL 364

  Fly   659 VFKSLNFICDCDLVWF--QQWLKNRFPQQAEHAVCGYPEHLLDRHLKSLSSSELVCVDSPKPRVE 721
            :..|....|||.|:|.  ::|..|...||   ..|..||.:..:..|..
Human   365 ILDSNPLACDCRLLWVFRRRWRLNFNRQQ---PTCATPEFVQGKEFKDF---------------- 410

  Fly   722 QEPDDMLAVNAANITLECIASSPTAASLAAADELKIKWRHDNQHVQERPAVHDGASTETQIRHDL 786
              ||.:|                                 .|.....|..:.|..:.:
Human   411 --PDVLL---------------------------------PNYFTCRRARIRDRKAQQ------- 433

  Fly   787 STNQTSIYGYLRLTNVTYESAGRYQCVVSNAFGTTYAQKFKISIGIHPTFLQVPSNLTLDAGEMA 851
                                                                    :.:|.|...
Human   434 --------------------------------------------------------VFVDEGHTV 442

  Fly   852 RLVCSASGDPTPEIALQKFGGSEFPAATERRLQVIREENAFLITNAKPSDSGIYTCTALSAAGEI 916
            :.||.|.|||.|.|...........|.:..||.|. .:....:..|:..|:|.|.|.|.:|.|
Human   443 QFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVF-PDGTLEVRYAQVQDNGTYLCIAANAGG-- 504

  Fly   917 KVNATLVVNDKPQPSIPLVHQEVVVGRTCVLQCLSETANADFELEHPHREWFKENKPIHISPTAP 981
                    ||    |:| .|                                     :|:...:|
Human   505 --------ND----SMP-AH-------------------------------------LHVRSYSP 519

  Fly   982 DGDRYYFSNNKELLVILNAQSNDAGHFRCEITDNSRTFTLQSELVVVKENLNWVVLLVGIITVTV 1046
            |   :....||....|    ||..|......|..:..|....:.:::...:.::..| |::   :
Human   520 D---WPHQPNKTFAFI----SNQPGEGEANSTRATVPFPFDIKTLIIATTMGFISFL-GVV---L 573

  Fly  1047 ICVVVDCCIIWCTLRYQKKKLRMSLAAERHSTQLR--PRSLADLGCSYDEA 1095
            .|:|:  ..:|...:...|          |:.::.  ||. :|.|.|..:|
Human   574 FCLVL--LFLWSRGKGNTK----------HNIEIEYVPRK-SDAGISSADA 611

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.