DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lbk and lrig1

DIOPT Version :9

Sequence 1:	NP_611091.2	Gene:	lbk / 36788	FlyBaseID:	FBgn0034083	Length:	1252	Species:	Drosophila melanogaster
Sequence 2:	XP_688817.4	Gene:	lrig1 / 560325	ZFINID:	ZDB-GENE-031113-23	Length:	1022	Species:	Danio rerio

Alignment Length:	966	Identity:	302/966 - (31%)
Similarity:	464/966 - (48%)	Gaps:	95/966 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   261 YNIDCPKDCKCLNVLFDCDKLHLERVPV-LPSYVQTLHLANNKLNDTTVLEIRNLLNLTKVSLKR 324
            |...||::|.|.....||.:|.:..||. ||.....|:|::|||....:..:.||.:|.:|.|..
Zfish    28 YGAPCPQNCTCTLDTTDCSRLDMTDVPQDLPKSTVHLNLSHNKLTAVDMDILSNLPHLREVRLDH 92

  Fly   325 NLLEVIPKF-IGLSGLKHLVLANNHITSISSESLAALPLLRTLDLSRNKLHTIELNSFPKSNNLV 388
            |.|..||.| ...:.:..|:|.:|.|..:....|.....|.|||||.|.:..:..:.||....:.
Zfish    93 NELTSIPSFGDAAASVVTLLLHHNRIRRLEGSLLQNFSALETLDLSNNDITELREHCFPLGLQIK 157

  Fly   389 HLILSFNEITNVNEHSFATL-NNLTDLELSNNRLSTLPIRVFKNLNQLKKLALNFNQLE-INWST 451
            .|.||.|:|.::...:|..| .:|..|.||.|||:.||::..: |.:|.:|.|:.|:|. |...|
Zfish   158 DLHLSSNKIVHLEFGAFKNLAGSLQILRLSRNRLTHLPVKGLE-LPKLTQLELSRNRLRLIEGLT 221

  Fly   452 FRGLESMKNLQLKSNKIRALQDGVFYVMHKIETIDLAMNQISSLSRQGLFNLTKLRHLNLSFNAI 516
            |:||.|::.|:|:.|.|..|.||.|:.:.::..:.|..|.:..::...|:.|..|..|.|:.|:|
Zfish   222 FQGLSSLEVLKLQRNNISKLTDGAFWGLARMRVLHLDYNSLREVNSGSLYGLESLLQLYLANNSI 286

  Fly   517 SRIEVDTWEFTQSLEVLDLSNNAINEFKPQHLDCLHRLKTLNLAHNRLQYLQENTFDCVKNLEEL 581
            |....:.|.|.:.|..|:||.|.:.:........|..|.:|.|.||.:.::.|..|..:.:|..|
Zfish   287 SNFNPEGWGFCERLRELNLSYNNLTKLSEGSFAKLVNLISLRLGHNSISHITEGAFRGLSSLRTL 351

  Fly   582 NLRRNRLSWIIEDQSAAAPFKGLRKLRRLDLHGNNLKQISTKAMSGLNNLEILNLGSNALASIQV 646
            .|..|.:|..|||.|.|  |.||..|.:|.|.||.:|.::.||.|||..||.||||.||:.|||.
Zfish   352 ELDHNDISGTIEDTSGA--FTGLENLNKLTLFGNKIKSVAKKAFSGLEALEHLNLGENAIRSIQP 414

  Fly   647 NAFEHMLRLNKLVFKSLNFICDCDLVWFQQWLKNRFPQQAEHAVCGYPEHLLDRHLKSLSSSELV 711
            .||..|..|..|..:|.:|:|||.|.||..||..|.......|.|.:||.|....:........|
Zfish   415 EAFSKMKNLRYLHIQSDSFLCDCQLHWFPDWLLTRGLNPGVQATCAHPESLKGTSIYQAPPQSFV 479

  Fly   712 CVDSPKPRVEQEPDDMLAVNAANITLECIASSPTAASLAAADELKIKWRHDNQHVQERPA----- 771
            |.|.|||::...|....||...::.|.|.|:|      :::..:...|..|.:.:::...
Zfish   480 CDDLPKPQITVHPVTTAAVLGKDVRLTCTAAS------SSSSPMTFTWLKDQETLRQAEVENFAH 538

  Fly   772 --VHDGASTETQIRHDLSTNQTSIYGYLRLTNVTYESAGRYQCVVSNAFGTTYAQKFKISIGIHP 834
              ..||...|          .|:|   |.|.:||:...|||||::||.||::|:.|.::::.:.|
Zfish   539 VRASDGGVME----------YTTI---LHLRHVTFNHEGRYQCIISNHFGSSYSNKARVTVNVLP 590

  Fly   835 TFLQVPSNLTLDAGEMARLVCSASGDPTPEIALQKFGGSEFPAATERRLQVIREENAFLITNAKP 899
            :|::.|.::|:..|..|||.|:|.|.|||::|.||.||::||||.|||::|:.:::.|.|.:.||
Zfish   591 SFVKTPRDITIRTGTKARLECAAEGHPTPQVAWQKDGGTDFPAARERRMRVMPDDDVFFIMDVKP 655

  Fly   900 SDSGIYTCTALSAAGEIKVNATLVVNDKPQPSIPLVHQEVVVGRTCVLQCLSETANADFELEHPH 964
            .|.|:|:|||.:.||.|..|.||.|.:.|..:..:..:.||||.|..|||.:      .....|.
Zfish   656 EDMGVYSCTAKNTAGMISANVTLTVLETPHLAQEMEDRNVVVGETVALQCKA------LGSPPPR 714

  Fly   965 REWFKENKPIHISPTAPDGDRYYFSNNKELLVILNAQSNDAGHFRCEITDNSRTFTLQSELVVVK 1029
            ..|.|..:|:..|      ||::|:...:||||.::...|||.:.|.:::...|....|:|.|.:
Zfish   715 ITWLKGEEPLRAS------DRHHFTPGNQLLVIGSSTLEDAGRYTCVMSNTLGTERAHSQLTVYQ 773

  Fly  1030 ENLNWV------VLLVGIITVTVICVVVDCCIIWCTLRYQKKKLRMSLAAERHSTQLR---PRSL 1085
            ......      .:.||||.:.|:..:|...::|..:.||.:|.....:.....|.:.   |..|
Zfish   774 RFEECAPFTSPSTVTVGIIIIAVVTSIVVTSLVWVCIIYQTRKKSEECSVNTDETIVPPDVPSYL 838

  Fly  1086 ADLGCSYDEANHRRLTVMSTPPSEQR----------------CLEQGLTLS----YLRQ-----T 1125
            :..| :..|.....:.|.|...|:..                |||...:.|    ||..     :
Zfish   839 SSQG-TLSERQDVCIRVESNGGSQPNGRIESNGYDVPVVCADCLENSTSYSKHCNYLPHDLAPPS 902

  Fly  1126 DLEAQQDH-------LSSKDSGTGSDAAVKR--------TLDDFEVAMPSHKHHTD 1166
            .:|.||.|       ||::....|:...:::        |..|.....||...::|
Zfish   903 GMEYQQTHQTSTFTSLSNEPHCNGTPNGLRKDNQTPIFPTNHDRVTISPSSNQYSD 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lbk	NP_611091.2	LRR_RI	<275..446	CDD:238064	57/173 (33%)
		leucine-rich repeat	293..316	CDD:275380	7/22 (32%)
		LRR_8	316..373	CDD:290566	20/57 (35%)
		leucine-rich repeat	317..338	CDD:275380	8/21 (38%)
		leucine-rich repeat	339..362	CDD:275380	5/22 (23%)
		leucine-rich repeat	363..386	CDD:275380	9/22 (41%)
		LRR_8	386..445	CDD:290566	21/59 (36%)
		leucine-rich repeat	387..410	CDD:275380	7/23 (30%)
		leucine-rich repeat	411..434	CDD:275380	10/22 (45%)
		leucine-rich repeat	435..457	CDD:275380	10/22 (45%)
		LRR_8	457..516	CDD:290566	17/58 (29%)
		leucine-rich repeat	458..481	CDD:275380	8/22 (36%)
		leucine-rich repeat	482..505	CDD:275380	4/22 (18%)
		LRR_RI	<498..669	CDD:238064	66/170 (39%)
		LRR_8	504..564	CDD:290566	19/59 (32%)
		leucine-rich repeat	506..529	CDD:275380	8/22 (36%)
		leucine-rich repeat	530..553	CDD:275380	6/22 (27%)
		leucine-rich repeat	554..577	CDD:275380	7/22 (32%)
		LRR_8	576..641	CDD:290566	31/64 (48%)
		leucine-rich repeat	578..604	CDD:275380	11/25 (44%)
		leucine-rich repeat	607..630	CDD:275380	11/22 (50%)
		leucine-rich repeat	631..652	CDD:275380	13/20 (65%)
		LRRCT	665..712	CDD:214507	15/46 (33%)
		IG	734..823	CDD:214652	24/95 (25%)
		Ig	735..823	CDD:143165	24/94 (26%)
		I-set	834..924	CDD:254352	43/89 (48%)
		Ig	851..924	CDD:299845	38/72 (53%)
		IG	936..1027	CDD:214652	27/90 (30%)
		Ig	961..1020	CDD:143165	17/58 (29%)
lrig1	XP_688817.4	LRRNT	31..63	CDD:214470	11/31 (35%)
		leucine-rich repeat	63..84	CDD:275380	7/20 (35%)
		LRR_RI	77..334	CDD:238064	83/257 (32%)
		LRR_8	83..142	CDD:290566	20/58 (34%)
		leucine-rich repeat	85..107	CDD:275380	8/21 (38%)
		leucine-rich repeat	108..131	CDD:275380	5/22 (23%)
		LRR_8	132..191	CDD:290566	21/58 (36%)
		leucine-rich repeat	132..155	CDD:275380	9/22 (41%)
		leucine-rich repeat	156..180	CDD:275380	7/23 (30%)
		leucine-rich repeat	181..203	CDD:275380	10/22 (45%)
		LRR_8	202..262	CDD:290566	21/59 (36%)
		leucine-rich repeat	204..227	CDD:275380	10/22 (45%)
		leucine-rich repeat	228..251	CDD:275380	8/22 (36%)
		LRR_8	251..310	CDD:290566	17/58 (29%)
		leucine-rich repeat	252..275	CDD:275380	4/22 (18%)
		leucine-rich repeat	276..299	CDD:275380	8/22 (36%)
		LRR_8	299..358	CDD:290566	17/58 (29%)
		leucine-rich repeat	300..323	CDD:275380	6/22 (27%)
		leucine-rich repeat	324..347	CDD:275380	7/22 (32%)
		leucine-rich repeat	348..372	CDD:275380	11/25 (44%)
		LRR_4	373..414	CDD:289563	21/40 (53%)
		LRR_8	374..433	CDD:290566	28/58 (48%)
		leucine-rich repeat	375..398	CDD:275380	11/22 (50%)
		leucine-rich repeat	399..420	CDD:275380	13/20 (65%)
		LRRCT	433..481	CDD:214507	16/47 (34%)
		Ig_3	485..572	CDD:290638	25/105 (24%)
		IG_like	492..586	CDD:214653	29/112 (26%)
		I-set	590..680	CDD:254352	43/89 (48%)
		Ig_1	607..681	CDD:143240	38/73 (52%)
		I-set	684..771	CDD:254352	28/98 (29%)
		IGc2	698..761	CDD:197706	21/74 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582158
Domainoid	1	1.000	104	1.000	Domainoid score	I6649
eggNOG	1	0.900	-	-		E2759_KOG4194
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	434	1.000	Inparanoid score	I1666
OMA	1	1.010	-	-		QHG49439
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001817
OrthoInspector	1	1.000	-	-		otm25863
orthoMCL	1	0.900	-	-		OOG6_104558
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3392
SonicParanoid	1	1.000	-	-		X1179
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.690