DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lbk and rtn4rl2b

DIOPT Version :9

Sequence 1:	NP_611091.2	Gene:	lbk / 36788	FlyBaseID:	FBgn0034083	Length:	1252	Species:	Drosophila melanogaster
Sequence 2:	NP_982350.1	Gene:	rtn4rl2b / 403309	ZFINID:	ZDB-GENE-040310-2	Length:	457	Species:	Danio rerio

Alignment Length:	563	Identity:	106/563 - (18%)
Similarity:	169/563 - (30%)	Gaps:	236/563 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   250 AAAAAAKASNKYNID---------------------CPKDCKC--LNVLFDCDKLHLERVPV-LP 290
            |||.:|:|||.....                     ||:.|.|  :.:...|...:...||. :|
Zfish     5 AAARSARASNTLTFKSGLTLWLVIWLLACRCAPGQACPRLCVCYHMPMTVSCQSQNFTSVPAGVP 69

  Fly   291 SYVQTLHLANNKLNDTTVLEIRNLLNLTKVSLKRNLLEVIPKFIGLSGLKHLVLANNHITSISSE 355
            ...|.:.|.||::.:
Zfish    70 YDSQRVFLQNNRITE-------------------------------------------------- 84

  Fly   356 SLAALPLLRTLDLSRNKLHTIELNSFPKSNNLVHLILSFNEITNVNEHSFATLNNLTDLELSNNR 420
                                :..:||.....:  |.|..|.||.:...:|:.|..|.:|:||:|
Zfish    85 --------------------LRADSFGFETQV--LWLYSNNITWIEAGAFSNLRVLEELDLSDN- 126

  Fly   421 LSTLPIRVFKNLNQLKKLALNFNQLEINWSTFRGLESMKNLQLKSNKIRALQDGVFYVMHKIETI 485
                        ..|::|         :...|||||.:::|.:....:..|...:|:.::.::.:
Zfish   127 ------------PSLRRL---------DGGAFRGLERLQSLHMHRCHLTELPADLFHKLYSLQFL 170

  Fly   486 DLAMNQISSLSRQGLF-NLTKLRHLNLSFNAISRIEVDTWEFTQSLEVLDLSNNAINEFKPQHLD 549
            .|..||:::|. .||| :|..|.||
Zfish   171 YLQENQLTNLP-DGLFSDLVNLTHL---------------------------------------- 194

  Fly   550 CLHRLKTLNLAHNRLQYLQENTFDCVKNLEELNLRRNRLSWIIEDQSAAAPFKGLRKLRRLDLHG 614
            .||        .||::.:.||.                             |:||..|.||.||.
Zfish   195 FLH--------GNRIRTVSENA-----------------------------FRGLVNLDRLLLHD 222

  Fly   615 NNLKQISTKAMSGLNNLEILNLGSNALASIQVNAFE-----HMLRLNKLVFKSLNFICDCDLVWF 674
            |.::|:..::...|..|.||.|.:|:|..:...|..     ..||||     ...:.|.|:....
Zfish   223 NRIRQVHRRSFRDLGRLTILYLFNNSLQELPGQALRDTSSVQFLRLN-----GNPWTCGCEARSL 282

  Fly   675 QQWLKNRFPQQAEHAVCGYPEHLLDRHLKSLSSSELVCVDSPKPRVEQEPDDMLAVNAANITLEC 739
            .:|.:.                      ..:|||:|.| .||.||..|   |:..:...:..| |
Zfish   283 WEWFRK----------------------ARISSSDLTC-SSPAPRKGQ---DLRFLRELDFAL-C 320

  Fly   740 IASSP--TAASLAAADELKIKWRHDNQHVQERPAVHDGASTET 780
            ....|  .|.:.......|.:|.............|...|:||
Zfish   321 PLPDPGSMAGTTTTTFSTKTRWWFSKNKPASSSKSHFHKSSET 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lbk	NP_611091.2	LRR_RI	<275..446	CDD:238064	24/171 (14%)
		leucine-rich repeat	293..316	CDD:275380	4/22 (18%)
		LRR_8	316..373	CDD:290566	0/56 (0%)
		leucine-rich repeat	317..338	CDD:275380	0/20 (0%)
		leucine-rich repeat	339..362	CDD:275380	0/22 (0%)
		leucine-rich repeat	363..386	CDD:275380	2/22 (9%)
		LRR_8	386..445	CDD:290566	14/58 (24%)
		leucine-rich repeat	387..410	CDD:275380	7/22 (32%)
		leucine-rich repeat	411..434	CDD:275380	5/22 (23%)
		leucine-rich repeat	435..457	CDD:275380	6/21 (29%)
		LRR_8	457..516	CDD:290566	14/59 (24%)
		leucine-rich repeat	458..481	CDD:275380	3/22 (14%)
		leucine-rich repeat	482..505	CDD:275380	8/23 (35%)
		LRR_RI	<498..669	CDD:238064	36/176 (20%)
		LRR_8	504..564	CDD:290566	6/59 (10%)
		leucine-rich repeat	506..529	CDD:275380	3/22 (14%)
		leucine-rich repeat	530..553	CDD:275380	1/22 (5%)
		leucine-rich repeat	554..577	CDD:275380	4/22 (18%)
		LRR_8	576..641	CDD:290566	16/64 (25%)
		leucine-rich repeat	578..604	CDD:275380	1/25 (4%)
		leucine-rich repeat	607..630	CDD:275380	8/22 (36%)
		leucine-rich repeat	631..652	CDD:275380	7/25 (28%)
		LRRCT	665..712	CDD:214507	7/46 (15%)
		IG	734..823	CDD:214652	10/49 (20%)
		Ig	735..823	CDD:143165	10/48 (21%)
		I-set	834..924	CDD:254352
		Ig	851..924	CDD:299845
		IG	936..1027	CDD:214652
		Ig	961..1020	CDD:143165
rtn4rl2b	NP_982350.1	LRRNT	40..71	CDD:214470	8/30 (27%)
		leucine-rich repeat	53..70	CDD:275380	3/16 (19%)
		leucine-rich repeat	73..93	CDD:275380	6/89 (7%)
		LRR_RI	93..>326	CDD:238064	77/366 (21%)
		LRR_8	95..153	CDD:290566	20/81 (25%)
		leucine-rich repeat	95..117	CDD:275380	7/23 (30%)
		leucine-rich repeat	118..142	CDD:275380	11/45 (24%)
		leucine-rich repeat	143..166	CDD:275380	3/22 (14%)
		LRR_8	166..225	CDD:290566	26/136 (19%)
		LRR_4	166..206	CDD:289563	15/88 (17%)
		leucine-rich repeat	167..190	CDD:275380	8/23 (35%)
		leucine-rich repeat	191..214	CDD:275380	12/99 (12%)
		LRR_8	214..272	CDD:290566	19/62 (31%)
		leucine-rich repeat	215..238	CDD:275380	8/22 (36%)
		leucine-rich repeat	239..262	CDD:275380	7/22 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000