DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lbk and rtn4rl2a

DIOPT Version :9

Sequence 1:	NP_611091.2	Gene:	lbk / 36788	FlyBaseID:	FBgn0034083	Length:	1252	Species:	Drosophila melanogaster
Sequence 2:	NP_982346.1	Gene:	rtn4rl2a / 403307	ZFINID:	ZDB-GENE-040310-4	Length:	458	Species:	Danio rerio

Alignment Length:	448	Identity:	99/448 - (22%)
Similarity:	166/448 - (37%)	Gaps:	151/448 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   368 LSRNKLHTIELNSFPKSNNLVHLILSFNEITNVNEHSFATLNNLTDLELSNNRLSTLPIRVFKNL 432
            |..|::..:.:.||.....:  |.|..|.||.:...:|:.|.:|.:|:|.:|          .||
Zfish    77 LQNNRITELRVGSFAFGTQV--LWLFSNNITWIEAGAFSELRDLEELDLGDN----------PNL 129

  Fly   433 NQLKKLALNFNQLEINWSTFRGLESMKNLQLKSNKIRALQDGVFYVMHKIETIDLAMNQISSLSR 497
            ::|:            ...|||||.:::|.:...|:.||...:|   ||
Zfish   130 HRLE------------GGAFRGLEKLQSLHMHRCKLAALPHDIF---HK---------------- 163

  Fly   498 QGLFNLTKLRHLNLSFNAISRIEVDTWEFTQSLEVLDLSNNAINEFKPQHLDCLHRLKTLNLAHN 562
                                                                 |:.|:.|.|..|
Zfish   164 -----------------------------------------------------LYSLQFLYLQEN 175

  Fly   563 RLQYLQENTFDCVKNLEELNLRRNRLSWIIEDQSAAAPFKGLRKLRRLDLHGNNLKQISTKAMSG 627
            :|.::|::.|..:.||.:|.|..||:..:.|:     .|:||..|.||.||.|.::|::.:|...
Zfish   176 QLHFIQDDLFADLINLSQLFLHGNRIRTLSEN-----VFRGLVNLDRLLLHDNRVRQVNRRAFRD 235

  Fly   628 LNNLEILNLGSNALASIQVNAFEHMLRLNKLVFKSLN---FICDCDL--VWFQQWLKNRFPQQAE 687
            |..|.:|.|.:|:||.:...|   |..::.:.|..||   :.|.|:.  :|       .|.:.|.
Zfish   236 LGQLTMLFLFNNSLAELPGQA---MRDVSSIEFLRLNNNPWACGCEARPLW-------EFFRGAR 290

  Fly   688 HAVCGYPEHLLDRHLKSLSSSELVCVDSPKPRVEQEPDDMLAVNAANITLECIASSPTAASLAAA 752
                             |||||::|. ||..|..|:...:..::.|      :...|...|||..
Zfish   291 -----------------LSSSEVLCA-SPASRRGQDLRFLREMDFA------LCPLPDPGSLAGT 331

  Fly   753 DELKIK-----WRHDNQHVQERPAVHDGASTETQIRHDLSTNQTSIYGYLRLTNVTYE 805
            ......     |...|:.|.....:.: .|:||: .|..:..::|:..    |:..||
Zfish   332 TTTTFSTKTRWWFSKNKPVSTSKGIFE-KSSETK-AHPYTGGKSSVTS----TSTKYE 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lbk	NP_611091.2	LRR_RI	<275..446	CDD:238064	18/77 (23%)
		leucine-rich repeat	293..316	CDD:275380
		LRR_8	316..373	CDD:290566	2/4 (50%)
		leucine-rich repeat	317..338	CDD:275380
		leucine-rich repeat	339..362	CDD:275380
		leucine-rich repeat	363..386	CDD:275380	4/17 (24%)
		LRR_8	386..445	CDD:290566	14/58 (24%)
		leucine-rich repeat	387..410	CDD:275380	7/22 (32%)
		leucine-rich repeat	411..434	CDD:275380	6/22 (27%)
		leucine-rich repeat	435..457	CDD:275380	5/21 (24%)
		LRR_8	457..516	CDD:290566	7/58 (12%)
		leucine-rich repeat	458..481	CDD:275380	5/22 (23%)
		leucine-rich repeat	482..505	CDD:275380	0/22 (0%)
		LRR_RI	<498..669	CDD:238064	39/173 (23%)
		LRR_8	504..564	CDD:290566	5/59 (8%)
		leucine-rich repeat	506..529	CDD:275380	0/22 (0%)
		leucine-rich repeat	530..553	CDD:275380	1/22 (5%)
		leucine-rich repeat	554..577	CDD:275380	7/22 (32%)
		LRR_8	576..641	CDD:290566	23/64 (36%)
		leucine-rich repeat	578..604	CDD:275380	7/25 (28%)
		leucine-rich repeat	607..630	CDD:275380	9/22 (41%)
		leucine-rich repeat	631..652	CDD:275380	7/20 (35%)
		LRRCT	665..712	CDD:214507	10/48 (21%)
		IG	734..823	CDD:214652	15/77 (19%)
		Ig	735..823	CDD:143165	15/76 (20%)
		I-set	834..924	CDD:254352
		Ig	851..924	CDD:299845
		IG	936..1027	CDD:214652
		Ig	961..1020	CDD:143165
rtn4rl2a	NP_982346.1	leucine-rich repeat	53..70	CDD:275380
		LRR_8	73..127	CDD:290566	15/61 (25%)
		leucine-rich repeat	73..93	CDD:275380	4/15 (27%)
		LRR_RI	94..>329	CDD:238064	82/369 (22%)
		leucine-rich repeat	95..117	CDD:275380	7/23 (30%)
		leucine-rich repeat	118..142	CDD:275380	11/45 (24%)
		leucine-rich repeat	143..166	CDD:275380	8/94 (9%)
		LRR_8	166..225	CDD:290566	23/63 (37%)
		leucine-rich repeat	167..190	CDD:275380	7/22 (32%)
		leucine-rich repeat	191..214	CDD:275380	9/27 (33%)
		LRR_8	214..272	CDD:290566	20/60 (33%)
		leucine-rich repeat	215..238	CDD:275380	9/22 (41%)
		leucine-rich repeat	239..262	CDD:275380	8/25 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000