DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lbk and CG32055

DIOPT Version :9

Sequence 1:	NP_611091.2	Gene:	lbk / 36788	FlyBaseID:	FBgn0034083	Length:	1252	Species:	Drosophila melanogaster
Sequence 2:	NP_729599.1	Gene:	CG32055 / 39188	FlyBaseID:	FBgn0052055	Length:	534	Species:	Drosophila melanogaster

Alignment Length:	435	Identity:	118/435 - (27%)
Similarity:	202/435 - (46%)	Gaps:	34/435 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   293 VQTLHLANNKLNDTTVLEIRNLLNLTKVSLKRN-LLEVIPKFIGLSGLKHLVLAN---NHITSIS 353
            :|.|:|.:.:|::....:..|...:....:..| :|.:..|.  :||..:||.||   |.|..|.
  Fly   100 LQKLNLTHAQLDELKSEQFPNPSEMINFDVSYNDILAITTKL--MSGFGNLVYANFSENLIAVIE 162

  Fly   354 SESLAALPLLRTLDLSRNKLHTIELNSFPKSNNLVHLILSFNEITNVNEHSFATLNNLTDLELSN 418
            ..:...:..||.|||:.|....|.|.   ::.||..|.:|.|.:.:........|..|.:|.|.:
  Fly   163 PNAFRHMKNLRFLDLTTNYQENITLG---ENANLRFLSISNNNLRDFQWCHLRVLPKLEELHLHS 224

  Fly   419 NRLSTLPIRVFKNLNQLKKLALNFNQL-EINWSTFRG---LESMKNLQLKSNKIRALQDGVFYVM 479
            |.|..|.:.:|..|..|:.|.::.|.| ||..:.|..   :..::.|...||.::.|.|.||..:
  Fly   225 NWLEHLDMGIFYALPNLRVLNVSNNNLFEIKRTLFMAPGEIAPLELLDYSSNIVKVLDDSVFCRL 289

  Fly   480 HKIETIDLAMNQISSLSRQGLFNLTKLRHLNLSFNAISRIEVDTWEFTQSLEVLDLSNNAINEFK 544
            .|:.|::|.:|||:.:..:....|:.|:.|:|..|.||.:..|.:....:||.||||.|.|.:..
  Fly   290 KKLRTLNLWLNQINRIHPRAFLGLSSLQTLHLQGNKISILPDDVFANLTALEKLDLSKNNIQKLG 354

  Fly   545 PQHLD--CLHRLKTLNLAHNRLQYLQENTFDCVKNLEELNLRRNRLSWIIEDQSAAAPFKGLRKL 607
            .:...  .|.:|..|:|::|.:..|.......:..::||.||||||  :..|....||   ||:|
  Fly   355 LRVFGERILRKLIYLDLSNNYIADLHPLALSSMPFIKELRLRRNRL--VSLDLRMFAP---LRQL 414

  Fly   608 RRLDLHGNNLKQISTKAMSGLNNLEILNLGSNALASI-QVNAFEHMLRLNKLVFKSLNFICDCDL 671
            :.|.::.|.|::|..:.:..|:.|..|.|.:|.|..: .:.:.:::|:|..:..:...:.|.| |
  Fly   415 QLLTINENRLEEIDGEILDTLDRLNHLELNNNRLTFLPDLKSSQNLLQLRNITLEGNPWQCLC-L 478

  Fly   672 VWFQQWLKNRFPQQAEHAVCGYPEHLLDRHLKSLSSSELVCVDSP 716
            .....||..|....|..:...:            |..:.:||.:|
  Fly   479 DEITSWLNGRHVSYARPSSAYF------------SGRKPLCVVTP 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lbk	NP_611091.2	LRR_RI	<275..446	CDD:238064	43/157 (27%)
		leucine-rich repeat	293..316	CDD:275380	5/22 (23%)
		LRR_8	316..373	CDD:290566	18/60 (30%)
		leucine-rich repeat	317..338	CDD:275380	3/21 (14%)
		leucine-rich repeat	339..362	CDD:275380	7/25 (28%)
		leucine-rich repeat	363..386	CDD:275380	8/22 (36%)
		LRR_8	386..445	CDD:290566	17/58 (29%)
		leucine-rich repeat	387..410	CDD:275380	5/22 (23%)
		leucine-rich repeat	411..434	CDD:275380	8/22 (36%)
		leucine-rich repeat	435..457	CDD:275380	7/25 (28%)
		LRR_8	457..516	CDD:290566	18/58 (31%)
		leucine-rich repeat	458..481	CDD:275380	7/22 (32%)
		leucine-rich repeat	482..505	CDD:275380	6/22 (27%)
		LRR_RI	<498..669	CDD:238064	49/173 (28%)
		LRR_8	504..564	CDD:290566	20/61 (33%)
		leucine-rich repeat	506..529	CDD:275380	7/22 (32%)
		leucine-rich repeat	530..553	CDD:275380	9/24 (38%)
		leucine-rich repeat	554..577	CDD:275380	5/22 (23%)
		LRR_8	576..641	CDD:290566	23/64 (36%)
		leucine-rich repeat	578..604	CDD:275380	11/25 (44%)
		leucine-rich repeat	607..630	CDD:275380	6/22 (27%)
		leucine-rich repeat	631..652	CDD:275380	5/21 (24%)
		LRRCT	665..712	CDD:214507	8/46 (17%)
		IG	734..823	CDD:214652
		Ig	735..823	CDD:143165
		I-set	834..924	CDD:254352
		Ig	851..924	CDD:299845
		IG	936..1027	CDD:214652
		Ig	961..1020	CDD:143165
CG32055	NP_729599.1	leucine-rich repeat	76..99	CDD:275380
		leucine-rich repeat	100..123	CDD:275380	5/22 (23%)
		LRR_8	128..180	CDD:290566	17/53 (32%)
		leucine-rich repeat	128..147	CDD:275380	5/20 (25%)
		leucine-rich repeat	148..171	CDD:275380	7/22 (32%)
		leucine-rich repeat	172..192	CDD:275380	8/22 (36%)
		LRR_RI	<187..400	CDD:238064	63/215 (29%)
		LRR_8	192..251	CDD:290566	17/58 (29%)
		leucine-rich repeat	193..216	CDD:275380	5/22 (23%)
		leucine-rich repeat	217..240	CDD:275380	8/22 (36%)
		leucine-rich repeat	241..267	CDD:275380	7/25 (28%)
		leucine-rich repeat	268..291	CDD:275380	7/22 (32%)
		LRR_8	290..350	CDD:290566	21/59 (36%)
		leucine-rich repeat	292..315	CDD:275380	6/22 (27%)
		leucine-rich repeat	316..339	CDD:275380	7/22 (32%)
		LRR_8	340..400	CDD:290566	20/59 (34%)
		leucine-rich repeat	340..365	CDD:275380	9/24 (38%)
		leucine-rich repeat	366..389	CDD:275380	5/22 (23%)
		leucine-rich repeat	390..413	CDD:275380	12/27 (44%)
		LRR_8	391..448	CDD:290566	23/61 (38%)
		leucine-rich repeat	414..437	CDD:275380	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010