Protein Alignment lbk and Toll-7

DIOPT Version :10

• Sequence 1: NP_611091.2
• Gene: lbk / 36788
• FlyBaseID: FBgn0034083
• Length: 1252
• Species: Drosophila melanogaster
• Sequence 2: NP_523797.1
• Gene: Toll-7 / 37272
• FlyBaseID: FBgn0034476
• Length: 1446
• Species: Drosophila melanogaster
• Alignment Length: 1471
• Identity: 294/1471 - (19%)
• Similarity: 492/1471 - (33%)
• Gaps: 478/1471 - (32%)

  Fly    88 LLLITYMLLITAATICQSAAQSPSSSNGNGVGGSGSTGGSPLSALLKSGGASYNQQLPQQQLFAM 152
            ||..::.|.:.:|...:.:..|.|:..|.|.|.:.:.          |....|:..|......:.
  Fly     8 LLGFSWSLAVESALAPKESESSASAMLGAGTGAAATV----------SLSGDYSSLLSNVPAASP 62

  Fly   153 LTRNGGGSSGP--RSSGGNRGYTSARQHFMALSEDYSDADVDEEDMAALHYPLSASHPPAGVQGS 215
            :..|....|||  :.|....|.:|..                    .||.  |....|...:||:
  Fly    63 VPANPSQPSGPANQCSWSYNGTSSVH--------------------CALR--LIERQPGLDLQGA 105

  Fly   216 SSSSGISIQSGSL---ETNGFVA-------------DDGGQYEHAQKALEAAAAAAKAS-NKYNI 263
            ..||.::||...|   |:...||             |.....:....|.|..|...... :.:|.
  Fly   106 DGSSQLTIQCSELYLFESTLPVAVFARLQTLEALRLDSCKLLQLPNNAFEGLATLKSLRLSTHNS 170

  Fly   264 D---------CPKDCKCLNVLFDCDKLHLERVPVLPS-------YVQTLHLANNKLNDTTVLEIR 312
            :         .|.....|..|.|.| |....:..|||       .:|.|:|..|::.....:...
  Fly   171 EWGPTRTLELFPDSLGGLKQLTDLD-LGDNNLRQLPSGFLCPVGNLQVLNLTRNRIRTAEQMGFA 234

  Fly   313 NL----------LNLTKVSLKRNLLEVIPKFIGLSGLK---HLVLANNHITSISSESLAALPLLR 364
            ::          ..|..:....|.|..|.:..|:|.|:   ||.||.|:::.:|.|:||.|..||
  Fly   235 DMNCGAGSGSAGSELQVLDASHNELRSISESWGISRLRRLQHLNLAYNNLSELSGEALAGLASLR 299

  Fly   365 TLDLSRNKLHTIELNSFPKSNNLVHLILSFNEITNVNEHSFATLNNLTDLELSNNRLSTLPI--R 427
            .::||.|.|.|:....|..|..|..:.|..||:..:.:..|..|..|..::||.|:|::..:  .
  Fly   300 IVNLSNNHLETLPEGLFAGSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNT 364

  Fly   428 VFKNLNQLKKLALNFNQL-EINWSTFRGLESMKNLQLKSNKIRALQDGVFYVMHKIETIDLAMNQ 491
            .|..|.:|..|.|..|.| .|::.||:.|..::.|.|::|.|..::|..|..::.:.|::||.|:
  Fly   365 TFAGLIRLIVLNLAHNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAENR 429

  Fly   492 ISSLSRQGLFN-LTKLRHLNLSFNAISRIEVDTWEFTQSLEVLDLSNNAINE------------- 542
            :.:|..: ||| |..|..|.|:.|.||.:|...::....|:.||||:|.:||
  Fly   430 LHTLDDK-LFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPRALQDLAMLRT 493

  Fly   543 ----------FKPQHLDCLH------------------------RLKTLNLAHNRLQYLQENTFD 573
                      |..|....||                        ||..||||.||:|.::..:||
  Fly   494 LDLGENQIRTFDNQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFD 558

  Fly   574 CVKNLE-------------------------ELNLRRNRLSWIIEDQSAAAPFKGLRKLRRLDLH 613
              ||.|                         .|||..|.|.|.   ..|..|    ..|:.||:|
  Fly   559 --KNFELEAIRLDRNFLADINGVFATLVSLLWLNLSENHLVWF---DYAFIP----SNLKWLDIH 614

  Fly   614 GNNL----------KQISTKA-------------MSGLNNLEILNLGSNALASIQVNAFE----- 650
            ||.:          ::|..|.             ||..|.:|:|.:.:|.:.::|.|||.
  Fly   615 GNYIEALGNYYKLQEEIRVKTLDASHNRITEIGPMSIPNTIELLFINNNLIGNVQPNAFVDKANL 679

  Fly   651 -----HMLRLNKLVFKSLN-------------------FICDCDLVWFQQWLKNRFPQQAEHAVC 691
                 :..:|:||..:.|.                   |.|||.:.|.|: :.|...:|
  Fly   680 ARVDLYANQLSKLQLQQLRVAPVVAPKPLPEFYLGGNPFECDCTMDWLQR-INNLTTRQ------ 737

  Fly   692 GYPEHLLDRHLKSLSSSELVCV------DSPKPRVEQEPDDMLAVNAANITLECIASSPTAASLA 750
                     |.:.:..:.:.||      .:.:|.....|.|.|....::....|......|....
  Fly   738 ---------HPRVMDMANIECVMPHARGAAVRPLSGLRPQDFLCRYESHCFALCHCCDFDACDCE 793

  Fly   751 AADELKIKWRHDNQHVQERPAVHDGASTETQIRHDLSTNQTSIY-----------------GYLR 798
            ..........||  .:.....|..|....|::...:..:.:.:|                 ..||
  Fly   794 MTCPSNCTCYHD--QIWSTNVVDCGGQQTTELPRRVPMDSSVVYLDGNNFPVLKNHAFIGRKNLR 856

  Fly   799 -----------LTNVTYESAGRYQC--VVSNAFGTTYAQKFKISIGIHPTFLQVPSNLTLDAGEM 850
                       :.|.|:.|....|.  :..|...|.:..:|:....:...:||.....|::...:
  Fly   857 ALYVNGSQVAAIQNRTFASLASLQLLHLADNKLRTLHGYEFEQLSALRELYLQNNQLTTIENATL 921

  Fly   851 ARL----VCSASGDPTPEIALQKFGGSEFPAATER----------RLQVIR------EENAFLIT 895
            |.|    :....|:....:.:.:...:.|....:.          |.|.::      .:||.::.
  Fly   922 APLAALELIRIDGNRLVTLPIWQMHATHFGTRLKSISLGRNQWSCRCQFLQALTSYVADNALIVQ 986

  Fly   896 NAKPSDSGIYTCTALSAAG-----------------EIKVNAT------------LVVNDKPQPS 931
            :|:    .||...|.|..|                 |:..|||            ::.:..|:..
  Fly   987 DAQ----DIYCMAASSGTGSAALEDSSSNSGSLEKRELDFNATGAACTDYYSGGSMLQHGIPESY 1047

  Fly   932 IPLVHQEVVVGRTCVLQCLSETANADFELEHPHREWFKENKPIHI-SPTAPDGDRYYFSNNKELL 995
            |||      :.....|..|.......|......|.|...:..:.: .|...:.::.|     :.:
  Fly  1048 IPL------LAAALALLFLLVVIAMVFAFRESLRIWLFAHYGVRVFGPRCEESEKLY-----DAV 1101

  Fly   996 VILNAQSNDAGHFRCEITDNSRTFTLQSELVVVKENLNWVVLLVGIITVTVICVVVDCCIIWCTL 1060
            ::.:|:.::   |.|:        .|.::|...:..|.             :|
  Fly  1102 LLHSAKDSE---FVCQ--------HLAAQLETGRPPLR-------------VC------------ 1130

  Fly  1061 RYQKKKLRMSLAAERHSTQLRPRSLADLGCSYD--EANH--RRLTVMSTPPSEQRCLEQGLTLSY 1121
                               |:.|.||.....|.  ||..  ||:.::             ||.::
  Fly  1131 -------------------LQHRDLAHDATHYQLLEATRVSRRVVIL-------------LTRNF 1163

  Fly  1122 LRQTDLEAQQDHLSSKDSGTGSDAAVKRTLDDFEVAMPSHKHHTDDEEEEEVEEVYEENEPPYIK 1186
            | ||:....:...|..|:..|....:. .:::.|||.         |.|.::|.:      ||:|
  Fly  1164 L-QTEWARCELRRSVHDALRGRPQKLV-IIEEPEVAF---------EAESDIELL------PYLK 1211

  Fly  1187 ------------HTYE-VNYAEPEQHLFLQNNN-------HNYD--------------------- 1210
                        |.:| :.||.|..:...:.||       ||::
  Fly  1212 TSAVHRIRRSDRHFWEKLRYALPVDYPTFRGNNYTLELDHHNHERVKQPASPGLLYRQAPPPAYC 1276

  Fly  1211 --GGGIGVAGGVNKMVP-NALLRKCSAGASGSNYSSIQQCT 1248
              ...:|: |.|.::|| ||.:      .:..|||:....|
  Fly  1277 GPADAVGI-GAVPQVVPVNASV------PAEQNYSTATTAT 1310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbk	NP_611091.2	LRR	<293..642	CDD:443914	122/460 (27%)
		leucine-rich repeat	293..316	CDD:275380	4/32 (13%)
		leucine-rich repeat	317..338	CDD:275380	5/20 (25%)
		leucine-rich repeat	339..362	CDD:275380	11/25 (44%)
		leucine-rich repeat	363..386	CDD:275380	9/22 (41%)
		leucine-rich repeat	387..410	CDD:275380	6/22 (27%)
		leucine-rich repeat	411..434	CDD:275380	7/24 (29%)
		leucine-rich repeat	435..457	CDD:275380	9/22 (41%)
		leucine-rich repeat	458..481	CDD:275380	6/22 (27%)
		leucine-rich repeat	482..505	CDD:275380	9/23 (39%)
		leucine-rich repeat	506..529	CDD:275380	7/22 (32%)
		leucine-rich repeat	530..553	CDD:275380	12/69 (17%)
		leucine-rich repeat	554..577	CDD:275380	10/22 (45%)
		leucine-rich repeat	578..604	CDD:275380	9/50 (18%)
		leucine-rich repeat	607..630	CDD:275380	10/45 (22%)
		leucine-rich repeat	631..652	CDD:275380	7/30 (23%)
		LRRCT	665..712	CDD:214507	9/46 (20%)
		Ig_3	717..816	CDD:464046	18/128 (14%)
		Ig	835..924	CDD:472250	21/137 (15%)
		Ig strand B	851..855	CDD:409353	2/7 (29%)
		Ig strand C	864..868	CDD:409353	0/3 (0%)
		Ig strand E	890..894	CDD:409353	2/3 (67%)
		Ig strand F	904..909	CDD:409353	2/4 (50%)
		Ig strand G	917..920	CDD:409353	0/2 (0%)
		Ig_3	927..1013	CDD:464046	14/86 (16%)
Toll-7	NP_523797.1	LRR	45..473	CDD:443914	114/451 (25%)
		leucine-rich repeat	136..159	CDD:275380	3/22 (14%)
		leucine-rich repeat	160..190	CDD:275380	3/29 (10%)
		leucine-rich repeat	191..214	CDD:275380	7/23 (30%)
		leucine-rich repeat	215..248	CDD:275380	4/32 (13%)
		leucine-rich repeat	249..273	CDD:275380	7/23 (30%)
		leucine-rich repeat	274..297	CDD:275380	10/22 (45%)
		leucine-rich repeat	298..321	CDD:275380	9/22 (41%)
		leucine-rich repeat	322..345	CDD:275380	6/22 (27%)
		leucine-rich repeat	346..371	CDD:275380	7/24 (29%)
		LRR	369..>675	CDD:443914	84/315 (27%)
		leucine-rich repeat	372..395	CDD:275380	9/22 (41%)
		leucine-rich repeat	396..419	CDD:275380	6/22 (27%)
		leucine-rich repeat	420..443	CDD:275380	9/23 (39%)
		leucine-rich repeat	444..467	CDD:275380	7/22 (32%)
		leucine-rich repeat	468..488	CDD:275380	8/19 (42%)
		leucine-rich repeat	491..514	CDD:275380	3/22 (14%)
		leucine-rich repeat	515..536	CDD:275380	0/20 (0%)
		leucine-rich repeat	539..562	CDD:275380	12/24 (50%)
		leucine-rich repeat	563..585	CDD:275380	0/21 (0%)
		leucine-rich repeat	586..626	CDD:275380	14/46 (30%)
		leucine-rich repeat	627..653	CDD:275380	4/25 (16%)
		LRRCT	716..772	CDD:214507	14/71 (20%)
		LRR	<812..>963	CDD:443914	20/150 (13%)
		leucine-rich repeat	812..829	CDD:275380	3/16 (19%)
		leucine-rich repeat	833..854	CDD:275380	1/20 (5%)
		leucine-rich repeat	855..878	CDD:275380	5/22 (23%)
		leucine-rich repeat	879..902	CDD:275380	4/22 (18%)
		leucine-rich repeat	903..926	CDD:275380	5/22 (23%)
		leucine-rich repeat	927..953	CDD:275380	2/25 (8%)
		TIR	1098..1235	CDD:214587	38/226 (17%)