DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lbk and CG14762

DIOPT Version :9

Sequence 1:	NP_611091.2	Gene:	lbk / 36788	FlyBaseID:	FBgn0034083	Length:	1252	Species:	Drosophila melanogaster
Sequence 2:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster

Alignment Length:	453	Identity:	121/453 - (26%)
Similarity:	217/453 - (47%)	Gaps:	71/453 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   302 KLNDTTVL-EIRNLLNLTK--------------VSLKRNLLEVIPKFIGLS-GLKHLVLANNHIT 350
            |.|...:| |..:|.::||              :.|:.|.|..:..|:.|: .::||.:.|:.:.
  Fly    53 KKNGLDILCETTDLAHITKSMGTLKGKSPIIFYLKLRHNNLPKLQGFVFLALDIRHLTIHNSSLA 117

  Fly   351 SISSESLAALPL-LRTLDLSRNKLHTIELNSFPKSNNLVHLILSFNEITNVNEHSFATLNNLTDL 414
            :|...:|::|.. |..||:|.|::.|:...:.....:|:.|.|:.|:||.::.::|..|..|..|
  Fly   118 AIEENALSSLGAGLTQLDVSLNQMKTVPSQALQHLFHLLILNLNHNKITVIHNNAFEGLETLEIL 182

  Fly   415 ELSNNRLSTLPIRVFKNL-NQLKKLALNFNQL-EINWSTFRGLESMKNLQLKSNKIRALQDGVFY 477
            .|..|:::.:....|:.| :.:|:|.|..|.| .|.......|.::|.|:::.||||.:.:|.|.
  Fly   183 TLYENKITQIDPEAFRGLEDHIKRLNLGGNDLTNIPQKALSILSTLKKLEIQENKIRTISEGDFE 247

  Fly   478 VMHKIETIDLAMNQISSLSRQGLFNLTKLRHLNLSFNAISRIEVDTWE-FTQSLEVLDLSNNAIN 541
            .:..::::.||.|.|:::......:||.|..|.|..|.||.|:.|.:: ..::|:.|.|.:|.|:
  Fly   248 GLQSLDSLILAHNMITTVPANVFSHLTLLNSLELEGNKISVIDKDAFKGLEENLQYLRLGDNQIH 312

  Fly   542 EFKPQHLDCLHRLKTLNLAHNRLQYLQENTFDCV-KNLEELNLRRNRLSWIIEDQSAAAPFKGLR 605
            ....:.|..||||:.|:|.:|.:..|.|:.|... .:|..|||::
  Fly   313 TIPSEALRPLHRLRHLDLRNNNINVLAEDAFTGFGDSLTFLNLQK-------------------- 357

  Fly   606 KLRRLDLHGNNLKQISTKAMSGLNNLEILNLGSNALASIQVNAFEHM---LRLNKLVFKSLNFIC 667
                     |::|.:.:.....||:||.|||.:|.|..|..:..|.:   ||:..:....||  |
  Fly   358 ---------NDIKVLPSLLFENLNSLETLNLQNNKLQRIPQDIMEPVIDTLRIIDITDNPLN--C 411

  Fly   668 DCDLVWFQQW---LKNRFPQ--QAEHAVCGYPEHL-LDRH---LKSLSSSELVCVD---SPKP 718
            .|:|.||.:.   |||:..:  |.:..:|    |: ||..   ::::.:.::.|..   ||.|
  Fly   412 SCELTWFPKLLEDLKNKDDEMSQKKKPLC----HMSLDNREYFVQAMPTEKMHCAGLNVSPSP 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lbk	NP_611091.2	LRR_RI	<275..446	CDD:238064	43/162 (27%)
		leucine-rich repeat	293..316	CDD:275380	5/14 (36%)
		LRR_8	316..373	CDD:290566	18/72 (25%)
		leucine-rich repeat	317..338	CDD:275380	7/35 (20%)
		leucine-rich repeat	339..362	CDD:275380	6/22 (27%)
		leucine-rich repeat	363..386	CDD:275380	6/22 (27%)
		LRR_8	386..445	CDD:290566	18/59 (31%)
		leucine-rich repeat	387..410	CDD:275380	8/22 (36%)
		leucine-rich repeat	411..434	CDD:275380	6/23 (26%)
		leucine-rich repeat	435..457	CDD:275380	7/22 (32%)
		LRR_8	457..516	CDD:290566	18/58 (31%)
		leucine-rich repeat	458..481	CDD:275380	8/22 (36%)
		leucine-rich repeat	482..505	CDD:275380	5/22 (23%)
		LRR_RI	<498..669	CDD:238064	48/175 (27%)
		LRR_8	504..564	CDD:290566	22/60 (37%)
		leucine-rich repeat	506..529	CDD:275380	8/23 (35%)
		leucine-rich repeat	530..553	CDD:275380	7/22 (32%)
		leucine-rich repeat	554..577	CDD:275380	7/23 (30%)
		LRR_8	576..641	CDD:290566	14/64 (22%)
		leucine-rich repeat	578..604	CDD:275380	4/25 (16%)
		leucine-rich repeat	607..630	CDD:275380	3/22 (14%)
		leucine-rich repeat	631..652	CDD:275380	9/20 (45%)
		LRRCT	665..712	CDD:214507	13/55 (24%)
		IG	734..823	CDD:214652
		Ig	735..823	CDD:143165
		I-set	834..924	CDD:254352
		Ig	851..924	CDD:299845
		IG	936..1027	CDD:214652
		Ig	961..1020	CDD:143165
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	5/19 (26%)
		LRR_RI	93..384	CDD:238064	88/319 (28%)
		leucine-rich repeat	107..129	CDD:275380	6/21 (29%)
		leucine-rich repeat	131..154	CDD:275380	6/22 (27%)
		LRR_8	154..214	CDD:290566	18/59 (31%)
		leucine-rich repeat	155..178	CDD:275380	8/22 (36%)
		leucine-rich repeat	179..203	CDD:275380	6/23 (26%)
		leucine-rich repeat	204..227	CDD:275380	7/22 (32%)
		LRR_8	226..286	CDD:290566	18/59 (31%)
		leucine-rich repeat	228..251	CDD:275380	8/22 (36%)
		leucine-rich repeat	252..275	CDD:275380	5/22 (23%)
		LRR_8	276..335	CDD:290566	21/58 (36%)
		leucine-rich repeat	276..300	CDD:275380	8/23 (35%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..349	CDD:275380	7/23 (30%)
		LRR_8	349..409	CDD:290566	19/88 (22%)
		leucine-rich repeat	350..373	CDD:275380	7/51 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910