Protein Alignment lbk and IGFALS

DIOPT Version :10

• Sequence 1: NP_611091.2
• Gene: lbk / 36788
• FlyBaseID: FBgn0034083
• Length: 1252
• Species: Drosophila melanogaster
• Sequence 2: NP_001139478.1
• Gene: IGFALS / 3483
• HGNCID: 5468
• Length: 643
• Species: Homo sapiens
• Alignment Length: 580
• Identity: 160/580 - (27%)
• Similarity: 249/580 - (42%)
• Gaps: 106/580 - (18%)

  Fly   198 ALHYPLSASHPPAGVQGSSSS----SGISIQSGSLETNGFVADDGGQYEHAQKALEAAAAAAKAS 258
            ||..|...:.||||  |.:.:    |.:::...|||.    ||.|...|....|
Human    31 ALLGPPPQASPPAG--GLALALLLLSWVALGPRSLEG----ADPGTPGEAEGPA----------- 78

  Fly   259 NKYNIDCPKDCKC--------LNVLFDCDKLHLERVP-VLPSYVQTLHLANNKLNDTTVLEIRNL 314
                  ||..|.|        |:|.  |...:|.|:| .:|...|.|.|..|
Human    79 ------CPAACVCSYDDDADELSVF--CSSRNLTRLPDGVPGGTQALWLDGN------------- 122

  Fly   315 LNLTKVSLKRNLLEVIP-KFIGLSGLKHLVLANNHITSISSESLAALPLLRTLDLSRNKLHTIEL 378
                      ||..|.| .|..||.|..|.|....:.|:..::|..|..|..|.|.||:|.::.|
Human   123 ----------NLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLAL 177

  Fly   379 NSFPKSNNLVHLILSFNEITNVNEHSFATLNNLTDLELSNNRLSTLPIRVFKNLNQLKKLALNFN 443
            .:|..:..|..|.||.|.::.:.:..|..|.:|.||.|..|.|:.||...|:.|..|::|.|..|
Human   178 GTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGN 242

  Fly   444 QLE-INWSTFRGLESMKNLQLKSNKIRALQDGVFYVMHKIETIDLAMNQISSLSRQGLFNLTKLR 507
            :|. :..:.|.||..::.|.|..|.:||::..||..:.:::.:.|..|.|::::......|..||
Human   243 RLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALR 307

  Fly   508 HLNLSFNAISRIEVDTWEFTQSLEVLDLSNNAINEFKPQHLDCLHRLKTLNLAHNRLQYLQENTF 572
            .|:||.|.::.:..||:.....|.||.||:|||...:|:....||.|:.|.|.|||::.|.|.:|
Human   308 WLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSF 372

  Fly   573 DCVKNLEELNLRRNRLSWIIEDQSAAAPFKGLRKLRRLDLHGNNLKQISTKAMSGLNNLEILNLG 637
            :.:..||.|.|..|:|     .:..|..|.||..:..::|.||.|:.:..:...||..|..|:|.
Human   373 EGLGQLEVLTLDHNQL-----QEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLE 432

  Fly   638 SNALASIQVNAFEHMLRLNKLVFKSLNFICDCDLVWFQQWLKNRFPQQAEHAVCGYPE------- 695
            .:.|..|:.:.|..:..|.:|      |:.|..||..:           |.::.|..|
Human   433 GSCLGRIRPHTFTGLSGLRRL------FLKDNGLVGIE-----------EQSLWGLAELLELDLT 480

  Fly   696 -----HLLDRHLKSLSSSELVCVDSPKPRVEQEPDDMLA-------VNAANITLECIASS 743
                 ||..|..:.|...|.:.:.  :.|:.:.|.|.|.       ::.::..||.:.:|
Human   481 SNQLTHLPHRLFQGLGKLEYLLLS--RNRLAELPADALGPLQRAFWLDVSHNRLEALPNS 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbk	NP_611091.2	LRR	<293..642	CDD:443914	108/350 (31%)
		leucine-rich repeat	293..316	CDD:275380	4/22 (18%)
		leucine-rich repeat	317..338	CDD:275380	6/21 (29%)
		leucine-rich repeat	339..362	CDD:275380	6/22 (27%)
		leucine-rich repeat	363..386	CDD:275380	8/22 (36%)
		leucine-rich repeat	387..410	CDD:275380	7/22 (32%)
		leucine-rich repeat	411..434	CDD:275380	10/22 (45%)
		leucine-rich repeat	435..457	CDD:275380	8/22 (36%)
		leucine-rich repeat	458..481	CDD:275380	7/22 (32%)
		leucine-rich repeat	482..505	CDD:275380	4/22 (18%)
		leucine-rich repeat	506..529	CDD:275380	8/22 (36%)
		leucine-rich repeat	530..553	CDD:275380	10/22 (45%)
		leucine-rich repeat	554..577	CDD:275380	9/22 (41%)
		leucine-rich repeat	578..604	CDD:275380	8/25 (32%)
		leucine-rich repeat	607..630	CDD:275380	6/22 (27%)
		leucine-rich repeat	631..652	CDD:275380	6/20 (30%)
		LRRCT	665..712	CDD:214507	12/58 (21%)
		Ig_3	717..816	CDD:464046	7/34 (21%)
		Ig	835..924	CDD:472250
		Ig strand B	851..855	CDD:409353
		Ig strand C	864..868	CDD:409353
		Ig strand E	890..894	CDD:409353
		Ig strand F	904..909	CDD:409353
		Ig strand G	917..920	CDD:409353
		Ig_3	927..1013	CDD:464046
IGFALS	NP_001139478.1	LRRNT	78..116	CDD:214470	12/56 (21%)
		leucine-rich repeat	95..113	CDD:275380	6/19 (32%)
		leucine-rich repeat	114..137	CDD:275380	10/45 (22%)
		LRR	132..574	CDD:443914	124/431 (29%)
		leucine-rich repeat	138..161	CDD:275380	6/22 (27%)
		leucine-rich repeat	162..185	CDD:275380	8/22 (36%)
		leucine-rich repeat	186..209	CDD:275380	7/22 (32%)
		leucine-rich repeat	210..233	CDD:275380	10/22 (45%)
		leucine-rich repeat	234..257	CDD:275380	8/22 (36%)
		leucine-rich repeat	258..281	CDD:275380	7/22 (32%)
		leucine-rich repeat	282..305	CDD:275380	4/22 (18%)
		leucine-rich repeat	306..324	CDD:275380	7/17 (41%)
		leucine-rich repeat	354..377	CDD:275380	9/22 (41%)
		leucine-rich repeat	378..401	CDD:275380	10/27 (37%)
		leucine-rich repeat	402..423	CDD:275380	4/20 (20%)
		leucine-rich repeat	426..447	CDD:275380	6/20 (30%)
		leucine-rich repeat	450..473	CDD:275380	8/39 (21%)
		leucine-rich repeat	474..497	CDD:275380	4/22 (18%)
		leucine-rich repeat	498..519	CDD:275380	5/22 (23%)
		leucine-rich repeat	522..543	CDD:275380	3/17 (18%)
		leucine-rich repeat	546..565	CDD:275380
		LRRCT	574..618	CDD:214507