DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lbk and CG8852

DIOPT Version :9

Sequence 1:	NP_611091.2	Gene:	lbk / 36788	FlyBaseID:	FBgn0034083	Length:	1252	Species:	Drosophila melanogaster
Sequence 2:	NP_608790.2	Gene:	CG8852 / 33577	FlyBaseID:	FBgn0031548	Length:	663	Species:	Drosophila melanogaster

Alignment Length:	845	Identity:	172/845 - (20%)
Similarity:	291/845 - (34%)	Gaps:	290/845 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   210 AGVQGSSSSSGISIQSGSLETNGFVADDGGQYEHAQKALEAAAAAAKASNKYN----IDCPKDCK 270
            ||...||::..||:....:               .:..|...:::.::.|.:.    |||.::..
  Fly    29 AGDAMSSANESISLPPACV---------------IRATLYKTSSSERSQNDFGLPLAIDCSENSS 78

  Fly   271 CLNVLFDCDKLHLERVP----VLPSYVQTLHLANNKLNDTTVLE-IRNLLNLTKVSLKRNLLEVI 330
            .....||   |..:||.    |.....||..|..:...    || :.|.::|..|.::|
  Fly    79 MGMNYFD---LGAQRVAGKRHVSLDGFQTPPLGISSYG----LEYLDNCVDLESVEIQR------ 130

  Fly   331 PKFIGLSGLK---------HLVLAN---NHITSISSESLAALPLLRTLDLSRNKLHTIELNSFPK 383
              |:|.:.||         :|...:   |.:.::|.|::..||.|:.|.|.:|.|..:|.  |.:
  Fly   131 --FVGDATLKLSCGGALIPNLTAVSFRYNELGTLSGETIQDLPHLKILHLQQNSLRYLEY--FKE 191

  Fly   384 SNNLVH--------LILSFNEITNVNEHSFATLNNLTDLELSNNRLSTLPIRVFKNLNQLKKLAL 440
            .::|..        |:|.||||          ||.|.:|    .|||         |..::|:..
  Fly   192 HSDLEELLIQDERDLVLRFNEI----------LNQLPEL----RRLS---------LRNVEKIED 233

  Fly   441 NFNQLEINWSTFRGL-ESMKNLQLKSNKIRALQDGVFYV---MHKIETIDLAMNQISSLSRQGLF 501
            .|         .|.| |::.:|.:::..|   |.||.|:   :.|:..:.:...|:...:.|...
  Fly   234 QF---------LRILPENLTDLIIENTPI---QPGVLYLTEGVAKLVNVTITNCQLKGFALQPAH 286

  Fly   502 NLTKLRHLNLSFNAISRIEVDTWEFTQSLEVLDLSNNAINEFKPQHLDCLHRLKTLNLAHNRLQY 566
            || .:.:||||.||||.:.:.......:|..||||.|.:     :||:.....:|.:|   |..:
  Fly   287 NL-DIMYLNLSGNAISSLNISFESGPSTLLTLDLSRNRL-----EHLNFTWFYRTTSL---RSLH 342

  Fly   567 LQENTFDCVKNLEELNLRRNRLSWIIEDQSAAAPFKGLRKLRRLDLHGNNLKQISTKAMSGLNNL 631
            ||||.|                                        |..:|.|:...:.:.::::
  Fly   343 LQENHF----------------------------------------HSLSLFQLGFISSASIHHI 367

  Fly   632 EILNLGSNALASIQVNAFEHMLRLNKLVFKSLNFICDCDLVWFQQWLKNRFPQQAE-HAVCGYPE 695
            :   |.||.|.|.:......:...|..:..|::     |..|..||:.|....|.: ..:..|.:
  Fly   368 D---LRSNELMSFRDTENADLPSWNPQLRISID-----DNPWSCQWMLNFSHMQPQLFRLFQYSK 424

  Fly   696 HLLDRHLKSLSSSELVCVDSPKPRVEQEPDDMLAVNAANITLECIASSPTAASLAAADELKIKWR 760
            ::...::..||     |  :|:....:||..:..:....|       :.|.:|:..
  Fly   425 YISHININGLS-----C--TPQEPPSEEPPKVRRIMHVRI-------NGTDSSIPV--------- 466

  Fly   761 HDNQHVQERPAVHDGASTETQIRH---DLSTNQTS-------------------IYGYL---RLT 800
                     |..|...|:.|.:..   :|..:|.|                   :|.||   ||.
  Fly   467 ---------PHPHGNVSSFTVLYGNPVELHRSQRSLALIIVFMLPLGIAFLFLLLYLYLHCERLF 522

  Fly   801 NVTYESAGRYQCVVSNAFGTTYAQKFKISIGIHPTFLQVPSNLTLDAGEMARLVCSASGDPTP-E 864
            :::|.::| ..|     ||..     |.|.|  |.|        :|..::.|...:..|...| :
  Fly   523 HLSYYASG-LPC-----FGGE-----KSSSG--PRF--------VDHVDIVRYPIANGGSSCPVD 566

  Fly   865 IALQKFGGSEFPAATERRLQVIREENAFLITNAKPSDSGIYTCTALSAAGEIKVNATLVVNDKPQ 929
            :..:...|.|.|.:                     ..:.|..||.
  Fly   567 VETELPDGYETPVS---------------------GGTSICNCTG-------------------- 590

  Fly   930 PSIPLVHQEVVVGRTCVLQCLSETANADFELEHPHREWFKEN------KPIHISPTAPDGDRYYF 988
                  |:|....||..:...|..|...::|....:|...||      ..:...||||..|...|
  Fly   591 ------HRESTCSRTHHVTYESLPAELPYQLYAEIKEQADENGDADEVLAVTTGPTAPIYDHLSF 649

Fly 989 988
Fly 650 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lbk	NP_611091.2	LRR_RI	<275..446	CDD:238064	49/195 (25%)
		leucine-rich repeat	293..316	CDD:275380	6/23 (26%)
		LRR_8	316..373	CDD:290566	17/68 (25%)
		leucine-rich repeat	317..338	CDD:275380	5/20 (25%)
		leucine-rich repeat	339..362	CDD:275380	7/34 (21%)
		leucine-rich repeat	363..386	CDD:275380	7/22 (32%)
		LRR_8	386..445	CDD:290566	17/66 (26%)
		leucine-rich repeat	387..410	CDD:275380	8/30 (27%)
		leucine-rich repeat	411..434	CDD:275380	6/22 (27%)
		leucine-rich repeat	435..457	CDD:275380	4/22 (18%)
		LRR_8	457..516	CDD:290566	16/61 (26%)
		leucine-rich repeat	458..481	CDD:275380	6/25 (24%)
		leucine-rich repeat	482..505	CDD:275380	4/22 (18%)
		LRR_RI	<498..669	CDD:238064	37/170 (22%)
		LRR_8	504..564	CDD:290566	18/59 (31%)
		leucine-rich repeat	506..529	CDD:275380	8/22 (36%)
		leucine-rich repeat	530..553	CDD:275380	8/22 (36%)
		leucine-rich repeat	554..577	CDD:275380	8/22 (36%)
		LRR_8	576..641	CDD:290566	6/64 (9%)
		leucine-rich repeat	578..604	CDD:275380	0/25 (0%)
		leucine-rich repeat	607..630	CDD:275380	3/22 (14%)
		leucine-rich repeat	631..652	CDD:275380	5/20 (25%)
		LRRCT	665..712	CDD:214507	9/47 (19%)
		IG	734..823	CDD:214652	20/113 (18%)
		Ig	735..823	CDD:143165	20/112 (18%)
		I-set	834..924	CDD:254352	12/90 (13%)
		Ig	851..924	CDD:299845	9/73 (12%)
		IG	936..1027	CDD:214652	16/59 (27%)
		Ig	961..1020	CDD:143165	9/34 (26%)
CG8852	NP_608790.2	LRR_RI	114..348	CDD:238064	77/287 (27%)
		LRR_8	147..213	CDD:290566	18/67 (27%)
		leucine-rich repeat	149..172	CDD:275380	5/22 (23%)
		leucine-rich repeat	173..194	CDD:275380	7/22 (32%)
		leucine-rich repeat	220..242	CDD:275380	9/43 (21%)
		leucine-rich repeat	243..266	CDD:275380	6/25 (24%)
		leucine-rich repeat	267..287	CDD:275380	2/19 (11%)
		leucine-rich repeat	288..313	CDD:275380	9/25 (36%)
		LRR_8	291..348	CDD:290566	23/64 (36%)
		leucine-rich repeat	314..337	CDD:275380	9/27 (33%)
		leucine-rich repeat	364..387	CDD:275378	5/25 (20%)
		leucine-rich repeat	392..403	CDD:275378	3/15 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438699
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930