DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lbk and haf

DIOPT Version :9

Sequence 1:	NP_611091.2	Gene:	lbk / 36788	FlyBaseID:	FBgn0034083	Length:	1252	Species:	Drosophila melanogaster
Sequence 2:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster

Alignment Length:	1031	Identity:	220/1031 - (21%)
Similarity:	336/1031 - (32%)	Gaps:	334/1031 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   342 LVLANNHITSISSESLAALPLLRTLDLSRNKLHTIELNSFPKSNNLV-HLILSFNEITNVNEHSF 405
            |:..||...|...:::.:...|..|.||...:..|...:|....::: :|.|..|.:.:|...:.
  Fly    85 LLYVNNSTISELPDAVFSNLSLHNLQLSSCGIQRIATGAFKGQESVLRNLNLQDNLLADVPVEAL 149

  Fly   406 ATLNNLTDLELSNNRLSTLPIRVFKNLNQLKKLALNFNQLEINWSTFRGLE-SMKNLQLKSNKIR 469
            ..|..|..|:||.|:||.:|...|..|.:|..|.||.|.:.:..:.||||| |:|||.||..|.|
  Fly   150 KVLGKLNLLDLSKNQLSHIPDDAFVGLTKLSTLKLNDNNVTLASNAFRGLEQSLKNLNLKGTKQR 214

  Fly   470 ALQDGVFYVMHKIETIDLAMNQISSLSRQGLFNLTKLRHLNLSFNAISRIEVDTWEFTQSLEVLD 534
            .:.:.:                      :||                           :||..||
  Fly   215 KVPESI----------------------RGL---------------------------KSLAFLD 230

  Fly   535 LSNNAINEFKP----QHLDCLHRLKTLNLAHNRLQYLQENTFDCV-KNLEELNLRRNRLSWIIED 594
            ||.|.|.|...    :..|.|..|..|||..|.:|.:.|..|..| |.|..|:|..|.|:
  Fly   231 LSQNGIKELPGAGGIRVFDGLDALTALNLERNLIQSIGETAFAGVRKTLSSLSLLNNLLA----- 290

  Fly   595 QSAAAPFKGLRKLRRLDLHGNNLKQISTKAMSGLNNLEILNLGSNALASIQVNAFEHM---LRLN 656
            :........|::||.||:..|.|..:...|..|...:.:|.|..|.|:|:...||.|:   ||..
  Fly   291 EFPIGAVHSLKELRVLDIGFNLLTSLPEAAFRGNPGITLLALDGNPLSSVPEGAFAHLNATLRGL 355

  Fly   657 KLVFKSLNFICDCDLVWFQQWLKN---------RFPQQAEHAVCGYPEHLLDRHLKSLSSSELVC 712
            .|..:.|:  |||.|.|..:|::|         |.||     .||.|....||...|:...||.|
  Fly   356 SLGGRFLH--CDCKLRWVAEWIRNGDLQVTSRERNPQ-----FCGTPPRFRDRGFYSIQPEELSC 413

  Fly   713 --------------VDSPKPRVEQEPDDM---LAVNAANITLECIASSPTAASLAAADELKIKWR 760
                          .|:.||.:...||.:   .......:.....||:|..:|::
  Fly   414 PDIADAALRGPVGLADNLKPTLPSSPDSVEYETGTGTGTVGTGTAASAPVTSSVS---------- 468

  Fly   761 HDNQHVQERPAVHDGASTETQIRHDLSTNQTSIYGYLRLTNVTYESAGRYQCVVSNAFGTTYAQK 825
                           :||.|       |..|:     ..|..|.|...|..........||....
  Fly   469 ---------------SSTST-------TTPTT-----TTTTTTAEPTTRRSTTRPPTKSTTTISA 506

  Fly   826 FKISIGIHPTFLQVPSNLTLDAGEMARLVCSASGDPTPEIALQKFGGSEFPAATERRLQVIREEN 890
            ...|...:|     |.|.| ...:...:..|:|...:...:.....|.:.|...:.
  Fly   507 TTASPASNP-----PVNGT-GTVQATSITTSSSSSSSSSTSTGHGNGKQAPGWRQG--------- 556

  Fly   891 AFLITNAKPSDSGIYTCTALSAAGEIKVNATLVVNDKPQPSIPLV-------------HQEVVV- 941
               :||.. .:||:      ..||.:         .|||.. |||             ..||.|
  Fly   557 ---VTNGN-GNSGV------GGAGGL---------HKPQRP-PLVLGYPPQRGTRIDDANEVQVK 601

  Fly   942 -----GRTCVLQCLSETAN-------------ADFE----LEHPHREWFKENKP----------- 973
                 ..:.::|..|:|||             ..|:    ||...||:..:|.|
  Fly   602 HAFRQDSSVIIQWDSDTANILGFRVVYRLFGEKAFKQGPPLESSEREFKIKNVPAQECIIVCVIS 666

  Fly   974 ---IHISP-TAPDGDRYYFSNNKELLVILNAQSNDAGHFRCEITDNSRTFTLQSELVVVKENLNW 1034
               :|::| |.|      :...:|:..:.:..||                  ..::.:...
  Fly   667 LEELHVTPETVP------YQQCREVRTVASQASN------------------MDKITIAAS---- 703

  Fly  1035 VVLLVGIITVTVICVVVDCCIIWCTLRYQKKKLRMSLAAERHSTQLR------------------ 1081
             ..:.|.|.|.||                     :.:||.|.|.:|:
  Fly   704 -AAICGTIIVAVI---------------------VFIAASRRSRKLQSSQQKSPLPIGGLPVNCC 746

  Fly  1082 -----PRSLADLGCSYDEANHRRLTVMSTPPSEQRCLEQGLTLSYLRQTDLEAQQDHLSSKDSGT 1141
                 |..|..:.......||:..        :|.....|.::...|...:| |.|.:.|..||.
  Fly   747 GPTGSPGPLGSIATLSAFNNHKEW--------DQVSAYSGRSIPRPRIYPVE-QPDDMRSHFSGM 802

  Fly  1142 GSDAAVKRTLDDFE---------------VAMPSHKHHTDDEEEEEVEEVYEENEPPYIKHTYEV 1191
            .......|:|.|.:               .|.||:..::..|..:..:.:...:|     .....
  Fly   803 PGKVGKSRSLADGQSQHSFSNNSHRGYLGSAFPSNLVNSRPELRQSRQSLAAASE-----RMSRA 862

  Fly  1192 NYAEPEQHLFLQNNNHNYDGGGIGV---AGGVNKMVPNALLRKCSAGASGSNYSSI 1244
            :||         .:.|..:|||.|:   .||....:|.:.|...|....|...:||
  Fly   863 SYA---------GSIHGGNGGGGGLGGNGGGGGNGLPVSSLMAMSGMVGGGGPASI 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lbk	NP_611091.2	LRR_RI	<275..446	CDD:238064	30/104 (29%)
		leucine-rich repeat	293..316	CDD:275380
		LRR_8	316..373	CDD:290566	8/30 (27%)
		leucine-rich repeat	317..338	CDD:275380
		leucine-rich repeat	339..362	CDD:275380	4/19 (21%)
		leucine-rich repeat	363..386	CDD:275380	6/22 (27%)
		LRR_8	386..445	CDD:290566	20/59 (34%)
		leucine-rich repeat	387..410	CDD:275380	5/23 (22%)
		leucine-rich repeat	411..434	CDD:275380	10/22 (45%)
		leucine-rich repeat	435..457	CDD:275380	10/22 (45%)
		LRR_8	457..516	CDD:290566	10/58 (17%)
		leucine-rich repeat	458..481	CDD:275380	7/22 (32%)
		leucine-rich repeat	482..505	CDD:275380	2/22 (9%)
		LRR_RI	<498..669	CDD:238064	50/178 (28%)
		LRR_8	504..564	CDD:290566	16/63 (25%)
		leucine-rich repeat	506..529	CDD:275380	0/22 (0%)
		leucine-rich repeat	530..553	CDD:275380	10/26 (38%)
		leucine-rich repeat	554..577	CDD:275380	9/23 (39%)
		LRR_8	576..641	CDD:290566	18/64 (28%)
		leucine-rich repeat	578..604	CDD:275380	5/25 (20%)
		leucine-rich repeat	607..630	CDD:275380	8/22 (36%)
		leucine-rich repeat	631..652	CDD:275380	7/20 (35%)
		LRRCT	665..712	CDD:214507	18/55 (33%)
		IG	734..823	CDD:214652	15/88 (17%)
		Ig	735..823	CDD:143165	15/87 (17%)
		I-set	834..924	CDD:254352	14/89 (16%)
		Ig	851..924	CDD:299845	10/72 (14%)
		IG	936..1027	CDD:214652	22/128 (17%)
		Ig	961..1020	CDD:143165	12/73 (16%)
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	55/215 (26%)
		leucine-rich repeat	86..105	CDD:275380	3/18 (17%)
		leucine-rich repeat	106..129	CDD:275380	6/22 (27%)
		LRR_8	131..189	CDD:338972	20/57 (35%)
		leucine-rich repeat	131..154	CDD:275380	5/22 (23%)
		leucine-rich repeat	155..178	CDD:275380	10/22 (45%)
		leucine-rich repeat	179..202	CDD:275380	10/22 (45%)
		leucine-rich repeat	203..225	CDD:275380	9/70 (13%)
		leucine-rich repeat	226..253	CDD:275380	10/26 (38%)
		LRR_8	254..337	CDD:338972	27/87 (31%)
		leucine-rich repeat	254..302	CDD:275380	16/52 (31%)
		leucine-rich repeat	303..326	CDD:275380	8/22 (36%)
		leucine-rich repeat	327..350	CDD:275380	8/22 (36%)
		PCC	332..>413	CDD:188093	29/87 (33%)
		PRK10927	<1061..>1097	CDD:236797
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910