DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment lbk and Lrig3

DIOPT Version :9

Sequence 1:NP_611091.2 Gene:lbk / 36788 FlyBaseID:FBgn0034083 Length:1252 Species:Drosophila melanogaster
Sequence 2:NP_796126.4 Gene:Lrig3 / 320398 MGIID:2443955 Length:1117 Species:Mus musculus


Alignment Length:1041 Identity:330/1041 - (31%)
Similarity:524/1041 - (50%) Gaps:139/1041 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   197 AALHYPLSASHPPAGVQGSSSSSGISIQSGSLETNGFVADDGGQYEHAQKALEAAAAAAKASNKY 261
            |||...|.|....||..|          ||.....|.:.||..|.                    
Mouse    11 AALGLLLCAGLGRAGPAG----------SGGHGAPGQLLDDDAQR-------------------- 45

  Fly   262 NIDCPKDCKCLNVLFDCDKLHLERVP-VLPSYVQTLHLANNKLNDTTVLEIRNLLNLTKVSLKRN 325
              .||..|.||..|.||.:..|.|:| .||::|..|.|::|:|:......:.:|.:|.:|.|..|
Mouse    46 --PCPAACHCLGDLLDCSRRRLVRLPDPLPAWVTRLDLSHNRLSFIQTSSLSHLQSLQEVKLNNN 108

  Fly   326 LLEVIPKFIGLS-GLKHLVLANNHITSISSESLAALPLLRTLDLSRNKLHTIELNSFPKSNNLVH 389
            .||.||....:| .::.|.||.|.|..|..|.|.|...|.|||||.|.:..:. .:||.. .|.:
Mouse   109 ELETIPNLGSISANIRQLSLAGNAIDKILPEQLEAFQSLETLDLSNNNISELR-TAFPPL-QLKY 171

  Fly   390 LILSFNEITNVNEHSFATL-NNLTDLELSNNRLSTLPIRVFKNLNQLKKLALNFNQLE-INWSTF 452
            |.::.|.::::....|..| :.|..|:|:.||:|.:|.::|| |.||:.|.||.|::: ::..||
Mouse   172 LYINNNRVSSMEPGYFDNLASTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTF 235

  Fly   453 RGLESMKNLQLKSNKIRALQDGVFYVMHKIETIDLAMNQISSLSRQGLFNLTKLRHLNLSFNAIS 517
            :||.::|:|:::.|.:..|.||.|:.:..:|.:.|..|.::.:::..|:.|..||.|:||.|||:
Mouse   236 QGLGALKSLKMQRNGVTKLMDGAFWGLSNMEVLQLDHNNLTEITKGWLYGLLMLRELHLSQNAIN 300

  Fly   518 RIEVDTWEFTQSLEVLDLSNNAINEFKPQHLDCLHRLKTLNLAHNRLQYLQENTFDCVKNLEELN 582
            ||..|.|||.|.|..|||:.|.::.........|..|..|::.:|::.|:.:..|..:.:|:.|:
Mouse   301 RISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNALHIGNNKVSYIADCAFRGLTSLKTLD 365

  Fly   583 LRRNRLSWIIEDQSAAAPFKGLRKLRRLDLHGNNLKQISTKAMSGLNNLEILNLGSNALASIQVN 647
            ||.|.:||.|||.|.|  |.||.:||:|.|.||.::.|:.||.:||:.||.|:|..||:.|:|.|
Mouse   366 LRNNEISWTIEDMSGA--FSGLDRLRQLILQGNRIRSITKKAFAGLDTLEHLDLSGNAIMSLQSN 428

  Fly   648 AFEHMLRLNKLVFKSLNFICDCDLVWFQQWL-KNRFPQQAEHAVCGYPEHLLDRHLKSLSSSELV 711
            ||..|.:|.:|...:.:.:|||.|.|..||: :|.| |...:|.|.:|:.|..|.:.::|....|
Mouse   429 AFSQMKKLQQLHLNTSSLLCDCQLRWLPQWVAENNF-QSFVNASCAHPQLLKGRSIFTVSPDGFV 492

  Fly   712 CVDSPKPRVEQEPDDMLAVNAANITLECIASSPTAASLAAADELKIKWRHDNQHVQERPAVHDGA 776
            |.|.|||::..:|:...|:..::::..|.|:|.:.:.:..|      |:.||:.:|:        
Mouse   493 CDDFPKPQITVQPETQSAIKGSDVSFTCSAASSSDSPMTFA------WKKDNEALQD-------- 543

  Fly   777 STETQIRHDLSTNQTSIYGY---LRLTNVTYESAGRYQCVVSNAFGTTYAQKFKISIGIHPTFLQ 838
             .|.:....|......:..|   |||.||.:.|.|:||||:||.||::|:.|.|::|.:.|:|.:
Mouse   544 -AEMENYAHLRAQGGELMEYTTILRLRNVEFTSEGKYQCVISNHFGSSYSVKAKLTINMLPSFTK 607

  Fly   839 VPSNLTLDAGEMARLVCSASGDPTPEIALQKFGGSEFPAATERRLQVIREENAFLITNAKPSDSG 903
            .|.:||:.||.||||.|:|.|.|.|:||.||.||::||||.|||:.|:.|::.|.|.:.|..|.|
Mouse   608 TPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIG 672

  Fly   904 IYTCTALSAAGEIKVNATLVVNDKPQPSIPLVHQEVVVGRTCVLQCLSETANADFELEHPHREWF 968
            :|:|||.::||.:..||||.|.:.|....||:.:.|..|.|.||||::..:      ..|...|.
Mouse   673 VYSCTAQNSAGSVSANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGS------PPPRLNWT 731

  Fly   969 KENKPIHISPTAPDGDRYYFSNNKELLVILNAQSNDAGHFRCEITDNSRTFTLQSELVVVK---- 1029
            |::.|:.::      :|::|:...:||:|:::..:|||.:.||:::...|......|.|:.    
Mouse   732 KDDSPLVVT------ERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTC 790

  Fly  1030 ----------ENLNWVVLLVGIITVTVICVVVDCCIIWCTLRYQKKKLRMSLAAERHSTQLRPRS 1084
                      :...|..  ||::.:.|:|.||...::|..:.|..::                  
Mouse   791 DSPHMTAPSLDGDGWAT--VGVVIIAVVCCVVGTSLVWVVIIYHTRR------------------ 835

  Fly  1085 LADLGCSYDEANHRRLTVMSTPPSEQRCLEQGLTLSYL-RQTDLEAQQDHLSSKDSGTGSDAAVK 1148
             .:..||....:...|      |::        ..||| .|..|..:||...|.:||:.......
Mouse   836 -RNEDCSITNTDETNL------PAD--------IPSYLSSQGTLADRQDGYISSESGSHHQFVTS 885

  Fly  1149 RTLDDFEVAMPSHKH----HTDDEEEEEVEEVYEENEPPYIKHTYEVNYAEPEQHLFLQNNNHNY 1209
            .....|   :|.|..    |.||..|.:||...:....|::..|..|         :||.|.::.
Mouse   886 SGGGFF---LPQHDGAGTCHFDDSSEADVEAASDPFLCPFVGSTGPV---------YLQGNLYSP 938

  Fly  1210 D 1210
            |
Mouse   939 D 939

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
lbkNP_611091.2 LRR_RI <275..446 CDD:238064 62/173 (36%)
leucine-rich repeat 293..316 CDD:275380 6/22 (27%)
LRR_8 316..373 CDD:290566 25/57 (44%)
leucine-rich repeat 317..338 CDD:275380 9/21 (43%)
leucine-rich repeat 339..362 CDD:275380 9/22 (41%)
leucine-rich repeat 363..386 CDD:275380 9/22 (41%)
LRR_8 386..445 CDD:290566 21/59 (36%)
leucine-rich repeat 387..410 CDD:275380 5/23 (22%)
leucine-rich repeat 411..434 CDD:275380 10/22 (45%)
leucine-rich repeat 435..457 CDD:275380 9/22 (41%)
LRR_8 457..516 CDD:290566 18/58 (31%)
leucine-rich repeat 458..481 CDD:275380 7/22 (32%)
leucine-rich repeat 482..505 CDD:275380 5/22 (23%)
LRR_RI <498..669 CDD:238064 69/170 (41%)
LRR_8 504..564 CDD:290566 24/59 (41%)
leucine-rich repeat 506..529 CDD:275380 14/22 (64%)
leucine-rich repeat 530..553 CDD:275380 6/22 (27%)
leucine-rich repeat 554..577 CDD:275380 5/22 (23%)
LRR_8 576..641 CDD:290566 31/64 (48%)
leucine-rich repeat 578..604 CDD:275380 13/25 (52%)
leucine-rich repeat 607..630 CDD:275380 11/22 (50%)
leucine-rich repeat 631..652 CDD:275380 11/20 (55%)
LRRCT 665..712 CDD:214507 16/47 (34%)
IG 734..823 CDD:214652 26/91 (29%)
Ig 735..823 CDD:143165 26/90 (29%)
I-set 834..924 CDD:254352 46/89 (52%)
Ig 851..924 CDD:299845 38/72 (53%)
IG 936..1027 CDD:214652 23/90 (26%)
Ig 961..1020 CDD:143165 15/58 (26%)
Lrig3NP_796126.4 LRR 1 75..98 5/22 (23%)
LRR_8 76..133 CDD:290566 19/56 (34%)
leucine-rich repeat 76..99 CDD:275378 6/22 (27%)
LRR_RI 81..324 CDD:238064 88/245 (36%)
LRR 2 99..120 8/20 (40%)
leucine-rich repeat 100..146 CDD:275378 18/45 (40%)
LRR_8 122..179 CDD:290566 21/58 (36%)
LRR 3 122..143 8/20 (40%)
LRR 4 146..168 9/23 (39%)
leucine-rich repeat 147..168 CDD:275380 9/22 (41%)
LRR_8 168..227 CDD:290566 21/59 (36%)
leucine-rich repeat 169..192 CDD:275380 5/22 (23%)
LRR 5 169..189 4/19 (21%)
LRR 6 193..214 9/21 (43%)
leucine-rich repeat 194..216 CDD:275380 10/22 (45%)
LRR_8 215..275 CDD:290566 20/59 (34%)
LRR 7 216..237 8/20 (40%)
leucine-rich repeat 217..240 CDD:275380 9/22 (41%)
LRR 8 240..261 7/20 (35%)
leucine-rich repeat 241..264 CDD:275380 7/22 (32%)
LRR_RI 262..>446 CDD:238064 71/185 (38%)
LRR_8 263..323 CDD:290566 25/59 (42%)
LRR 9 264..285 4/20 (20%)
leucine-rich repeat 265..288 CDD:275380 5/22 (23%)
LRR 10 288..309 12/20 (60%)
leucine-rich repeat 289..312 CDD:275380 14/22 (64%)
LRR_8 312..371 CDD:290566 16/58 (28%)
LRR 11 312..333 5/20 (25%)
leucine-rich repeat 313..336 CDD:275380 6/22 (27%)
LRR 12 336..357 5/20 (25%)
leucine-rich repeat 337..360 CDD:275380 5/22 (23%)
LRR_8 359..422 CDD:290566 31/64 (48%)
LRR 13 360..382 12/23 (52%)
leucine-rich repeat 361..385 CDD:275380 13/25 (52%)
LRR 14 387..408 9/20 (45%)
leucine-rich repeat 388..411 CDD:275380 11/22 (50%)
LRR 15 411..432 11/20 (55%)
leucine-rich repeat 412..433 CDD:275380 11/20 (55%)
LRRCT 446..494 CDD:214507 17/48 (35%)
I-set 499..599 CDD:254352 32/114 (28%)
Ig 500..587 CDD:299845 26/101 (26%)
I-set 603..693 CDD:254352 46/89 (52%)
Ig_1 620..694 CDD:143240 38/73 (52%)
I-set 697..784 CDD:254352 26/98 (27%)
IGc2 711..774 CDD:197706 20/74 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1019..1093
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 102 1.000 Domainoid score I6816
eggNOG 1 0.900 - - E2759_KOG4194
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H62452
Inparanoid 1 1.050 483 1.000 Inparanoid score I1433
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG49439
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001817
OrthoInspector 1 1.000 - - otm44361
orthoMCL 1 0.900 - - OOG6_104558
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3392
SonicParanoid 1 1.000 - - X1179
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1413.760

Return to query results.
Submit another query.