Protein Alignment lbk and Rtn4rl2

DIOPT Version :10

• Sequence 1: NP_611091.2
• Gene: lbk / 36788
• FlyBaseID: FBgn0034083
• Length: 1252
• Species: Drosophila melanogaster
• Sequence 2: NP_852045.1
• Gene: Rtn4rl2 / 311169
• RGDID: 727797
• Length: 420
• Species: Rattus norvegicus
• Alignment Length: 360
• Identity: 91/360 - (25%)
• Similarity: 136/360 - (37%)
• Gaps: 93/360 - (25%)

  Fly   365 TLDLSRNKLHTIELNSFPKSNNLVHLILSFNEITNVNEHSFATLNNLTDLELSNNRLSTL-PIRV 428
            |:....|...::.| |.|.|..  .|.|..|.|.::...:|..  ||..|.|.:|.|||: |
  Rat    43 TVSCQANNFSSVPL-SLPPSTQ--RLFLQNNLIRSLRPGTFGP--NLLTLWLFSNNLSTIYP--- 99

  Fly   429 FKNLNQLKKLALNFNQLEINWSTFRGLESMKNLQLKSNK-IRALQDGVFYVMHKIETIDLAMNQI 492
                                 .|||.|::::.|.|..|: :|:|:...|..:.:::::.|...|:
  Rat   100 ---------------------GTFRHLQALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQL 143

  Fly   493 SSLSRQGLFNLTKLRHLNLSFNAISRIEVDTWEFTQSLEVLDLSNNAINEFKPQHLDCLHRLKTL 557
            |||.......|..|::|.|.
  Rat   144 SSLPGNIFRGLVSLQYLYLQ--------------------------------------------- 163

  Fly   558 NLAHNRLQYLQENTFDCVKNLEELNLRRNRLSWIIEDQSAAAPFKGLRKLRRLDLHGNNLKQIST 622
               .|.|.:||::.|..:.||..|.|..|||..:.|.     .|:||..|.||.||||.|:.:..
  Rat   164 ---ENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEH-----VFRGLGSLDRLLLHGNRLQGVHR 220

  Fly   623 KAMSGLNNLEILNLGSNALASIQVNAFEHMLRLNKLVFKSLNFICDCDL----VWFQQWLKNRFP 683
            .|..||:.|.||.|.:|:|||:...|...:..|..|...:..:.|||..    .|||     |..
  Rat   221 AAFHGLSRLTILYLFNNSLASLPGEALADLPALEFLRLNANPWACDCRARPLWAWFQ-----RAR 280

  Fly   684 QQAEHAVCGYPEHLLDRHLKSLSSSELVCVDSPKP 718
            ..:....|..|.....|.|::|..::......|.|
  Rat   281 VSSSDVTCATPPERQGRDLRTLRDTDFQACPPPTP 315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbk	NP_611091.2	LRR	<293..642	CDD:443914	71/278 (26%)
		leucine-rich repeat	293..316	CDD:275380
		leucine-rich repeat	317..338	CDD:275380
		leucine-rich repeat	339..362	CDD:275380
		leucine-rich repeat	363..386	CDD:275380	6/20 (30%)
		leucine-rich repeat	387..410	CDD:275380	5/22 (23%)
		leucine-rich repeat	411..434	CDD:275380	8/23 (35%)
		leucine-rich repeat	435..457	CDD:275380	4/21 (19%)
		leucine-rich repeat	458..481	CDD:275380	6/23 (26%)
		leucine-rich repeat	482..505	CDD:275380	6/22 (27%)
		leucine-rich repeat	506..529	CDD:275380	3/22 (14%)
		leucine-rich repeat	530..553	CDD:275380	0/22 (0%)
		leucine-rich repeat	554..577	CDD:275380	5/22 (23%)
		leucine-rich repeat	578..604	CDD:275380	8/25 (32%)
		leucine-rich repeat	607..630	CDD:275380	11/22 (50%)
		leucine-rich repeat	631..652	CDD:275380	9/20 (45%)
		LRRCT	665..712	CDD:214507	12/50 (24%)
		Ig_3	717..816	CDD:464046	1/2 (50%)
		Ig	835..924	CDD:472250
		Ig strand B	851..855	CDD:409353
		Ig strand C	864..868	CDD:409353
		Ig strand E	890..894	CDD:409353
		Ig strand F	904..909	CDD:409353
		Ig strand G	917..920	CDD:409353
		Ig_3	927..1013	CDD:464046
Rtn4rl2	NP_852045.1	LRR	<55..>261	CDD:443914	75/287 (26%)
		LRR 1	61..82		6/22 (27%)
		leucine-rich repeat	62..83	CDD:275380	5/24 (21%)
		LRR 2	83..104		11/44 (25%)
		leucine-rich repeat	84..107	CDD:275380	12/46 (26%)
		LRR 3	107..129		6/21 (29%)
		leucine-rich repeat	108..132	CDD:275380	6/23 (26%)
		LRR 4	132..153		5/20 (25%)
		leucine-rich repeat	133..156	CDD:275380	6/22 (27%)
		LRR 5	156..177		8/68 (12%)
		leucine-rich repeat	157..180	CDD:275380	8/70 (11%)
		LRR 6	180..201		9/25 (36%)
		leucine-rich repeat	181..204	CDD:275380	10/27 (37%)
		LRR 7	204..225		9/20 (45%)
		leucine-rich repeat	205..228	CDD:275380	11/22 (50%)
		LRR 8	228..249		9/20 (45%)
		leucine-rich repeat	229..252	CDD:275380	9/22 (41%)
		LRRCT	261..311	CDD:214507	12/54 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	286..390		7/30 (23%)
		PHA03247	289..>369	CDD:223021	6/27 (22%)
		Important for interaction with MAG. /evidence=ECO:0000269|PubMed:19420245	315..327		1/1 (100%)