DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lbk and Lrig2

DIOPT Version :9

Sequence 1:	NP_611091.2	Gene:	lbk / 36788	FlyBaseID:	FBgn0034083	Length:	1252	Species:	Drosophila melanogaster
Sequence 2:	NP_001101180.1	Gene:	Lrig2 / 310753	RGDID:	1309554	Length:	1054	Species:	Rattus norvegicus

Alignment Length:	1030	Identity:	324/1030 - (31%)
Similarity:	512/1030 - (49%)	Gaps:	149/1030 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 AQKALEAAAAAAKASNKYNIDCPKDCKCLNVLFDCDKLHLERV-------PVLPSYVQTLHLANN 301
            ||..|...||.|..       ||..|.|...|.||.:..|..:       |:.|. :.:|.|::|
  Rat    28 AQALLLLPAAGAGL-------CPAPCSCRLPLLDCSRRKLPALSWRALSGPLSPD-ISSLDLSHN 84

  Fly   302 KLNDTTV-LEIRNLLNLTKVSLKRNLLEVIPKFIG--LSGLKHLVLANNHITSISSESLAALPLL 363
            :|::..: ||..   .|.:|.:..|.|..||.| |  ...:..|.|.:|.|..|::|:......|
  Rat    85 RLSNWNISLESE---TLQEVKMNYNELTEIPYF-GEPTPNITQLSLVHNLIPEINAEAFQLYSAL 145

  Fly   364 RTLDLSRNKLHTIELNSFPKSNNLVHLILSFNEITNVNEHSFATLN-NLTDLELSNNRLSTLPIR 427
            .:||||.|.:..|:.:|||:. :|.:|.||.|.||.:....|..|: :|..::|:.||:|.:|.:
  Rat   146 ESLDLSSNIISEIKTSSFPRM-SLKYLNLSNNRITTLEAGCFDNLSGSLLVVKLNRNRISMIPPK 209

  Fly   428 VFKNLNQLKKLALNFNQLEI-NWSTFRGLESMKNLQLKSNKIRALQDGVFYVMHKIETIDLAMNQ 491
            ||| |..|:.|.|..|:::| ...||:||:|:::|:::.|.|..|:||.|:.::.:|.::|..|.
  Rat   210 VFK-LPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNN 273

  Fly   492 ISSLSRQGLFNLTKLRHLNLSFNAISRIEVDTWEFTQSLEVLDLSNNAINEFKPQHLDCLHRLKT 556
            ::.:.:..|:.|..|:.|.:|.|||.:|..|.|||.|.|..||||.|.:..........|..|:.
  Rat   274 LTGVHKGWLYGLRMLQQLYVSQNAIEKISPDAWEFCQRLSALDLSYNQLTRLDESAFVGLSLLER 338

  Fly   557 LNLAHNRLQYLQENTFDCVKNLEELNLRRNRLSWIIEDQSAAAPFKGLRKLRRLDLHGNNLKQIS 621
            |||..||:.::.:..|..:.||:.|:||.|.:||.|||  |:..|.||:.|.:|.|.||.:|.::
  Rat   339 LNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIED--ASEVFSGLKSLTKLILQGNRIKSVT 401

  Fly   622 TKAMSGLNNLEILNLGSNALASIQVNAFEHMLRLNKLVFKSLNFICDCDLVWFQQWL-KNRFPQQ 685
            .||..||.:||.|:|.:||:.|||.|||. ...|.:||..:.:.:|||.|.|..||| .|.|
  Rat   402 QKAFVGLESLEYLDLNNNAIMSIQENAFS-QTHLKELVLNTSSLLCDCHLKWLLQWLVDNNF--- 462

  Fly   686 AEHAV---CGYPEHLLDRHLKSLSSSELVCVDSPKPRVEQEPDDMLAVNAANITLECIASSPTAA 747
             .|:|   |.:||.|..:.:.::...:.||.|..||::...|::.:|:...|:||.|.|.|.:.:
  Rat   463 -HHSVNVSCAHPEWLAGQSILNVDLKDFVCDDFLKPQIRTHPENTVALRGVNVTLMCTAVSSSDS 526

  Fly   748 SLAAADELKIKWRHDNQHVQE-------RPAVHDGASTETQIRHDLSTNQTSIYGYLRLTNVTYE 805
            .::..      ||.|::.:.:       |....||.:.|          .||:   |||.:|.:.
  Rat   527 PMSTL------WRKDSEILYDVDIENFVRYRQQDGEALE----------YTSV---LRLFSVNFT 572

  Fly   806 SAGRYQCVVSNAFGTTYAQKFKISIGIHPTFLQVPSNLTLDAGEMARLVCSASGDPTPEIALQKF 870
            ..|:|||:|:|.||:.|:||.|:::...|:||:.|.:||:..|.||||.|:|.|.|||:|:.||.
  Rat   573 DEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMARLECAAEGHPTPQISWQKD 637

  Fly   871 GGSEFPAATERRLQVIREENAFLITNAKPSDSGIYTCTALSAAGEIKVNATLVVNDKPQPSIPLV 935
            ||::||||.|||:.|:.|::.|.|.|.|..|.|||:|.|.:.||.:..||:|.|.:.|....||.
  Rat   638 GGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNIAGGLSANASLTVLETPSFIRPLE 702

  Fly   936 HQEVVVGRTCVLQCLSETANADFELEHPHREWFKENKPIHISPTAPDGDRYYFSNNKELLVILNA 1000
            .:.|..|.|.||||::..:.|      |...|.|::.|:.::      :|::|:...:||:|::|
  Rat   703 DKTVTRGETAVLQCIAGGSPA------PRLNWTKDDGPLLVT------ERHFFAAANQLLIIVDA 755

  Fly  1001 QSNDAGHFRCEITDNSRTFTLQSELVVVK-------------ENLNWVVLLVGIITVTVICVVVD 1052
            ...|||.:.|.:::...|......|.|:.             |:..|..  |||:.:.|:|.||.
  Rat   756 GLEDAGKYTCLMSNTLGTERGHIYLNVISSPNCDSSQNSIGHEDDGWTT--VGIVIIVVVCCVVG 818

  Fly  1053 CCIIWCTLRYQKKKL----------RMSLAAE------RHSTQLRPRSLADLGCSYDEA-NHRRL 1100
            ..:||..:.|..::.          .::|.|:      ...|...|:.    |.|..|| :|::|
  Rat   819 TSLIWVIVIYHMRRKDEDYSITNTEELNLPADIPSYLSSQGTLSEPQE----GYSNSEAGSHQQL 879

  Fly  1101 TVMSTPPSEQRCLEQGLTLSYLRQTDLEAQQDHLSSKDSGTGSDAAVKRTLDDFEVAMPSHKH-- 1163
                .||:      .|.|              | ...|.|||:........|:..:...:.::
  Rat   880 ----MPPA------SGYT--------------H-KGTDGGTGTRVICSDCYDNANIYSRTREYCP 919

  Fly  1164 HTDDEEEEEVEEVYEE-----------NEPPYIKHTYEVNYAEPEQHLFLQNNNH 1207
            :|...||:.:::....           :.||......|......|:.|.....||
  Rat   920 YTYIAEEDALDQALSSLMVQMPKETFLSHPPQDAANLESLMPPTERELSAFPTNH 974

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lbk	NP_611091.2	LRR_RI	<275..446	CDD:238064	59/181 (33%)
		leucine-rich repeat	293..316	CDD:275380	6/23 (26%)
		LRR_8	316..373	CDD:290566	20/58 (34%)
		leucine-rich repeat	317..338	CDD:275380	8/22 (36%)
		leucine-rich repeat	339..362	CDD:275380	6/22 (27%)
		leucine-rich repeat	363..386	CDD:275380	10/22 (45%)
		LRR_8	386..445	CDD:290566	23/59 (39%)
		leucine-rich repeat	387..410	CDD:275380	9/23 (39%)
		leucine-rich repeat	411..434	CDD:275380	10/22 (45%)
		leucine-rich repeat	435..457	CDD:275380	9/22 (41%)
		LRR_8	457..516	CDD:290566	17/58 (29%)
		leucine-rich repeat	458..481	CDD:275380	7/22 (32%)
		leucine-rich repeat	482..505	CDD:275380	5/22 (23%)
		LRR_RI	<498..669	CDD:238064	69/170 (41%)
		LRR_8	504..564	CDD:290566	24/59 (41%)
		leucine-rich repeat	506..529	CDD:275380	11/22 (50%)
		leucine-rich repeat	530..553	CDD:275380	7/22 (32%)
		leucine-rich repeat	554..577	CDD:275380	7/22 (32%)
		LRR_8	576..641	CDD:290566	30/64 (47%)
		leucine-rich repeat	578..604	CDD:275380	12/25 (48%)
		leucine-rich repeat	607..630	CDD:275380	10/22 (45%)
		leucine-rich repeat	631..652	CDD:275380	12/20 (60%)
		LRRCT	665..712	CDD:214507	16/50 (32%)
		IG	734..823	CDD:214652	27/95 (28%)
		Ig	735..823	CDD:143165	26/94 (28%)
		I-set	834..924	CDD:254352	46/89 (52%)
		Ig	851..924	CDD:299845	38/72 (53%)
		IG	936..1027	CDD:214652	24/90 (27%)
		Ig	961..1020	CDD:143165	15/58 (26%)
Lrig2	NP_001101180.1	LRR_RI	<50..204	CDD:238064	49/159 (31%)
		leucine-rich repeat	98..120	CDD:275380	8/22 (36%)
		LRR_8	119..178	CDD:290566	21/59 (36%)
		leucine-rich repeat	121..144	CDD:275380	6/22 (27%)
		LRR_RI	136..398	CDD:238064	98/265 (37%)
		leucine-rich repeat	145..167	CDD:275380	10/22 (45%)
		LRR_8	167..226	CDD:290566	23/59 (39%)
		leucine-rich repeat	168..192	CDD:275380	9/23 (39%)
		leucine-rich repeat	193..215	CDD:275380	10/22 (45%)
		leucine-rich repeat	216..239	CDD:275380	9/22 (41%)
		LRR_8	239..298	CDD:290566	17/58 (29%)
		leucine-rich repeat	240..263	CDD:275380	7/22 (32%)
		leucine-rich repeat	264..287	CDD:275380	5/22 (23%)
		leucine-rich repeat	288..311	CDD:275380	11/22 (50%)
		LRR_8	311..370	CDD:290566	20/58 (34%)
		leucine-rich repeat	312..335	CDD:275380	7/22 (32%)
		leucine-rich repeat	336..359	CDD:275380	7/22 (32%)
		LRR_8	358..421	CDD:290566	30/64 (47%)
		leucine-rich repeat	360..384	CDD:275380	12/25 (48%)
		LRR_4	385..426	CDD:289563	18/40 (45%)
		leucine-rich repeat	387..410	CDD:275380	10/22 (45%)
		leucine-rich repeat	411..433	CDD:275380	12/22 (55%)
		LRRCT	444..492	CDD:214507	17/51 (33%)
		Ig	501..597	CDD:299845	33/114 (29%)
		IG	503..597	CDD:214652	33/112 (29%)
		I-set	601..691	CDD:254352	46/89 (52%)
		Ig_1	618..692	CDD:143240	38/73 (52%)
		I-set	695..782	CDD:254352	27/98 (28%)
		Ig	713..782	CDD:299845	21/80 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I6761
eggNOG	1	0.900	-	-		E2759_KOG4194
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	483	1.000	Inparanoid score	I1396
OMA	1	1.010	-	-		QHG49439
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001817
OrthoInspector	1	1.000	-	-		otm46457
orthoMCL	1	0.900	-	-		OOG6_104558
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1179
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830