DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lbk and Lrig2

DIOPT Version :9

Sequence 1:	NP_611091.2	Gene:	lbk / 36788	FlyBaseID:	FBgn0034083	Length:	1252	Species:	Drosophila melanogaster
Sequence 2:	NP_001020238.1	Gene:	Lrig2 / 269473	MGIID:	2443718	Length:	1054	Species:	Mus musculus

Alignment Length:	1048	Identity:	326/1048 - (31%)
Similarity:	515/1048 - (49%)	Gaps:	178/1048 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 AQKALEAAAAAAKASNKYNIDCPKDCKCLNVLFDCDKLHLERVPV---------LPSYVQTLHLA 299
            |.:.|.||.|..         ||..|.|...|.||.:   .::|.         |||.:.:|.|:
Mouse    30 ALRLLPAARAGL---------CPAPCACRLPLLDCSR---RKLPAPSWRALSGPLPSDISSLDLS 82

  Fly   300 NNKL-NDTTVLEIRNLLNLTKVSLKRNLLEVIPKF------IGLSGLKHLVLANNHITSISSESL 357
            :|:| |....||.:   .|.:|.:..|.|..||.|      |.|..|.|     |.|..|::|:.
Mouse    83 HNRLSNWNNTLESQ---TLQEVKMNYNELTEIPYFGEPTPNITLLSLVH-----NLIPEINAEAF 139

  Fly   358 AALPLLRTLDLSRNKLHTIELNSFPKSNNLVHLILSFNEITNVNEHSFATLNNLTD----LELSN 418
            .....|.:||||.|.:..|:.:|||:. :|.:|.||.|.|:.:....|   :||:|    ::|:.
Mouse   140 ELYSALESLDLSSNIISEIKTSSFPRM-SLKYLNLSNNRISTLEAGCF---DNLSDSLLVVKLNR 200

  Fly   419 NRLSTLPIRVFKNLNQLKKLALNFNQLEI-NWSTFRGLESMKNLQLKSNKIRALQDGVFYVMHKI 482
            ||:|.:|.:||| |..|:.|.|..|:::| ...||:||:|:::|:::.|.|..|:||.|:.::.:
Mouse   201 NRISMIPPKVFK-LPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNM 264

  Fly   483 ETIDLAMNQISSLSRQGLFNLTKLRHLNLSFNAISRIEVDTWEFTQSLEVLDLSNNAINEFKPQH 547
            |.::|..|.::.:::..|:.|..|:.|.:|.|||.:|..|.|||.|.|..||||.|.:.......
Mouse   265 EELELEHNNLTGVNKGWLYGLRMLQQLYMSQNAIEKISPDAWEFCQRLSELDLSYNQLTRLDESA 329

  Fly   548 LDCLHRLKTLNLAHNRLQYLQENTFDCVKNLEELNLRRNRLSWIIEDQSAAAPFKGLRKLRRLDL 612
            ...|..|:.|||..||:.::.:..|..:.||:.|:||.|.:||.|||.|.|  |.||:.|.:|.|
Mouse   330 FVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNDISWAIEDASEA--FSGLKSLTKLIL 392

  Fly   613 HGNNLKQISTKAMSGLNNLEILNLGSNALASIQVNAFEHMLRLNKLVFKSLNFICDCDLVWFQQW 677
            .||.:|.::.||..||.:||.|:|.:||:.|||.|||. ...|..||..:.:.:|||.|.|..||
Mouse   393 QGNRIKSVTQKAFIGLESLEYLDLNNNAIMSIQENAFS-QTHLKGLVLNTSSLLCDCHLKWLLQW 456

  Fly   678 L-KNRFPQQAEHAV---CGYPEHLLDRHLKSLSSSELVCVDSPKPRVEQEPDDMLAVNAANITLE 738
            | .|.|    .|:|   |.:||.|..:.:.::...:.||.|..||::...|:..:|:...|:||.
Mouse   457 LVDNNF----HHSVNVSCAHPEWLAGQSILNVDLKDFVCDDFLKPQIRTHPESTIALRGVNVTLT 517

  Fly   739 CIASSPTAASLAAADELKIKWRHDNQHVQE-------RPAVHDGASTETQIRHDLSTNQTSIYGY 796
            |.|.|.:.:.::..      ||.|::.:.:       |....||.:.|          .||:
Mouse   518 CTAVSSSDSPMSTI------WRKDSEILYDVDIENFVRYRQQDGEALE----------YTSV--- 563

  Fly   797 LRLTNVTYESAGRYQCVVSNAFGTTYAQKFKISIGIHPTFLQVPSNLTLDAGEMARLVCSASGDP 861
            |||.:|.:...|:|||:|:|.||:.|:||.|:::...|:||:.|.:||:..|.||||.|:|.|.|
Mouse   564 LRLFSVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMARLECAAEGHP 628

  Fly   862 TPEIALQKFGGSEFPAATERRLQVIREENAFLITNAKPSDSGIYTCTALSAAGEIKVNATLVVND 926
            ||:|:.||.||::||||.|||:.|:.|::.|.|.|.|..|.|||:|.|.:.||.:..||:|.|.:
Mouse   629 TPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNIAGGLSANASLTVLE 693

  Fly   927 KPQPSIPLVHQEVVVGRTCVLQCLSETANADFELEHPHREWFKENKPIHISPTAPDGDRYYFSNN 991
            .|....||..:.|..|.|.||||::..:.|      |...|.|::.|:.::      :|::|:..
Mouse   694 TPSFIRPLEDKTVTRGETAVLQCIAGGSPA------PRLNWTKDDGPLLVT------ERHFFAAA 746

  Fly   992 KELLVILNAQSNDAGHFRCEITDNSRTFTLQSELVVVK-------------ENLNWVVLLVGIIT 1043
            .:||:|::|...|||.:.|.:::...|......|.|:.             |:..|..  |||:.
Mouse   747 NQLLIIVDAGLEDAGKYTCLMSNTLGTERGHIYLNVISSPNCDSSQSSIGHEDDGWTT--VGIVI 809

  Fly  1044 VTVICVVVDCCIIWCTLRYQKKKL----------RMSLAAE------RHSTQLRPRSLADLGCSY 1092
            :.|:|.||...:||..:.|..::.          .::|.|:      ...|...|:.    |.|.
Mouse   810 IVVVCCVVGTSLIWVIVIYHMRRKNEDYSITNTEELNLPADIPSYLSSQGTLSEPQE----GYSN 870

  Fly  1093 DEA-NHRRLTVMSTPPSEQRCLEQGLTLSYLRQTDLEAQQDHLSSKDSGTGSDAAVKRTLDDFEV 1156
            .|| :|::|    .||:      .|.|              |..: |.|.|:........|:..:
Mouse   871 SEAGSHQQL----MPPA------NGYT--------------HRGT-DGGAGTRVICSDCYDNANI 910

  Fly  1157 AMPSHKH--HTDDEEEEEVEEVYEENEPPYIKHTYEVNYAEPEQHLFLQNNNHNYDGGGIGVAGG 1219
            ...:.::  :|...||:.:::..........|.|:   .:.|.|.                 |..
Mouse   911 YSRTREYCPYTYIAEEDVLDQALSSLMVQMPKETF---LSHPPQD-----------------AAN 955

  Fly  1220 VNKMVPNA 1227
            :..::|:|
Mouse   956 LESLIPSA 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lbk	NP_611091.2	LRR_RI	<275..446	CDD:238064	62/190 (33%)
		leucine-rich repeat	293..316	CDD:275380	7/23 (30%)
		LRR_8	316..373	CDD:290566	21/62 (34%)
		leucine-rich repeat	317..338	CDD:275380	9/26 (35%)
		leucine-rich repeat	339..362	CDD:275380	6/22 (27%)
		leucine-rich repeat	363..386	CDD:275380	10/22 (45%)
		LRR_8	386..445	CDD:290566	23/62 (37%)
		leucine-rich repeat	387..410	CDD:275380	7/22 (32%)
		leucine-rich repeat	411..434	CDD:275380	11/26 (42%)
		leucine-rich repeat	435..457	CDD:275380	9/22 (41%)
		LRR_8	457..516	CDD:290566	17/58 (29%)
		leucine-rich repeat	458..481	CDD:275380	7/22 (32%)
		leucine-rich repeat	482..505	CDD:275380	5/22 (23%)
		LRR_RI	<498..669	CDD:238064	70/170 (41%)
		LRR_8	504..564	CDD:290566	24/59 (41%)
		leucine-rich repeat	506..529	CDD:275380	11/22 (50%)
		leucine-rich repeat	530..553	CDD:275380	7/22 (32%)
		leucine-rich repeat	554..577	CDD:275380	7/22 (32%)
		LRR_8	576..641	CDD:290566	31/64 (48%)
		leucine-rich repeat	578..604	CDD:275380	13/25 (52%)
		leucine-rich repeat	607..630	CDD:275380	10/22 (45%)
		leucine-rich repeat	631..652	CDD:275380	12/20 (60%)
		LRRCT	665..712	CDD:214507	16/50 (32%)
		IG	734..823	CDD:214652	27/95 (28%)
		Ig	735..823	CDD:143165	26/94 (28%)
		I-set	834..924	CDD:254352	46/89 (52%)
		Ig	851..924	CDD:299845	38/72 (53%)
		IG	936..1027	CDD:214652	24/90 (27%)
		Ig	961..1020	CDD:143165	15/58 (26%)
Lrig2	NP_001020238.1	LRR_RI	<16..204	CDD:238064	61/197 (31%)
		leucine-rich repeat	53..75	CDD:275378	5/24 (21%)
		LRR 1	75..96		7/20 (35%)
		LRR 2	97..118		7/20 (35%)
		leucine-rich repeat	98..120	CDD:275380	7/21 (33%)
		LRR_8	119..178	CDD:290566	23/64 (36%)
		LRR 3	120..141		8/25 (32%)
		leucine-rich repeat	121..144	CDD:275380	8/27 (30%)
		LRR_RI	<136..344	CDD:238064	75/212 (35%)
		LRR 4	144..165		9/20 (45%)
		leucine-rich repeat	145..167	CDD:275380	10/22 (45%)
		LRR_8	167..226	CDD:290566	23/62 (37%)
		LRR 5	167..188		7/23 (30%)
		leucine-rich repeat	168..192	CDD:275380	9/26 (35%)
		LRR 6	192..213		8/21 (38%)
		leucine-rich repeat	193..215	CDD:275380	9/22 (41%)
		LRR 7	215..236		7/20 (35%)
		leucine-rich repeat	216..239	CDD:275380	9/22 (41%)
		LRR_8	239..298	CDD:290566	17/58 (29%)
		LRR 8	239..260		8/20 (40%)
		leucine-rich repeat	240..263	CDD:275380	7/22 (32%)
		LRR 9	263..284		4/20 (20%)
		leucine-rich repeat	264..287	CDD:275380	5/22 (23%)
		LRR 10	287..308		9/20 (45%)
		leucine-rich repeat	288..311	CDD:275380	11/22 (50%)
		LRR_8	311..370	CDD:290566	20/58 (34%)
		LRR 11	311..332		6/20 (30%)
		leucine-rich repeat	312..335	CDD:275380	7/22 (32%)
		LRR 12	335..356		7/20 (35%)
		leucine-rich repeat	336..359	CDD:275380	7/22 (32%)
		LRR_8	358..421	CDD:290566	31/64 (48%)
		LRR_4	359..401	CDD:289563	22/43 (51%)
		LRR 13	359..381		13/23 (57%)
		leucine-rich repeat	360..384	CDD:275380	13/25 (52%)
		LRR_4	385..426	CDD:289563	18/40 (45%)
		LRR 14	386..407		8/20 (40%)
		leucine-rich repeat	387..410	CDD:275380	10/22 (45%)
		LRR 15	410..431		12/21 (57%)
		leucine-rich repeat	411..430	CDD:275380	11/18 (61%)
		LRRCT	444..492	CDD:214507	17/51 (33%)
		Ig	501..597	CDD:299845	33/114 (29%)
		IG_like	503..597	CDD:214653	33/112 (29%)
		I-set	601..691	CDD:254352	46/89 (52%)
		Ig_1	618..692	CDD:143240	38/73 (52%)
		I-set	695..782	CDD:254352	27/98 (28%)
		Ig	713..782	CDD:299845	21/80 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I6816
eggNOG	1	0.900	-	-		E2759_KOG4194
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	483	1.000	Inparanoid score	I1433
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49439
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001817
OrthoInspector	1	1.000	-	-		otm44361
orthoMCL	1	0.900	-	-		OOG6_104558
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3392
SonicParanoid	1	1.000	-	-		X1179
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860