DRSC/TRiP Functional Genomics Resources

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Protein Alignment lbk and Lingo2

DIOPT Version :10

Sequence 1:NP_611091.2 Gene:lbk / 36788 FlyBaseID:FBgn0034083 Length:1252 Species:Drosophila melanogaster
Sequence 2:NP_780725.2 Gene:Lingo2 / 242384 MGIID:2442298 Length:606 Species:Mus musculus


Alignment Length:848 Identity:173/848 - (20%)
Similarity:278/848 - (32%) Gaps:329/848 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   263 IDCPKDCKCLNVLFDCDKLHLERVPVLPSYVQTLHLANNKLNDTTVLEIRNLLNLTKVSLKRNLL 327
            |.||..|:|                          .|.||                .||..|..|
Mouse    26 IGCPARCEC--------------------------SAQNK----------------SVSCHRRRL 48

  Fly   328 EVIPKFIGLSGLKHLVLANNHITSISSESLAALPLLRTLDLSRNKLHTIELNSFPKSNNLVHLIL 392
            ..||:.|.:. .|.|.|:.|.:.||:.|...:.|||..:|||.|.:..:|..:|   |||.    
Mouse    49 LAIPEGIPIE-TKILDLSKNRLKSINPEEFISYPLLEEIDLSDNIIANVEPGAF---NNLF---- 105

  Fly   393 SFNEITNVNEHSFATLNNLTDLELSNNRLSTLPIRVFKNLNQLKKLALNFNQLEINWS-TFRGLE 456
                             ||..|.|..|||..:|:.||..|:.|.||.::.|::.|... .|:.|.
Mouse   106 -----------------NLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLH 153

  Fly   457 SMKNLQLKSNKIRALQDGVFYVMHKIETIDLAMNQISSLSRQGLFNLTK-----LRHLNLS---- 512
            ::|:|::..|.:..:....|..:..:|.:.|....::::..:.|.:|..     |:|||::    
Mouse   154 NLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLIALHLKHLNINNMPV 218

  Fly   513 ------FNAISRIEVDTWEFTQSLEVLDL----SNNAINEFKPQHLDCLHRLKTLNLAHNRLQYL 567
                  |: :..:|:|.|      .:|||    |...:|            |.:|::.:..|..:
Mouse   219 YAFKRLFH-LKNLEIDYW------PLLDLMPANSLYGLN------------LTSLSITNTNLSTV 264

  Fly   568 QENTFDCVKNLEELNLRRNRLSWIIEDQSAAAPFKGLRKLRRLDLHGNNLKQISTKAMSGLNNLE 632
            ....|..:..|..|||..|.:|.|     .|..|..|.:|:.|.:.|..|:.|...:..||..|.
Mouse   265 PFLAFKHLVYLTHLNLSYNPISTI-----EAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLR 324

  Fly   633 ILNLGSNALASIQVNAFEHMLRLNKLVFKSLNFICDCDLVWFQQWLKN-RFPQQAEHAVCGYPEH 696
            :||:..|.|.:::.|.|.....|..|...:....|||.|:|..|...| :|..|  ..:|..|:.
Mouse   325 VLNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLLWLLQRQPNLQFGGQ--QPMCAGPDT 387

  Fly   697 LLDRHLKSLSSSEL----VCVDSPKPRVEQEPDDMLAVNAANITLECIASSPTAASLAAADELKI 757
            :.:|..|...|:.|    .|   .||::.                                    
Mouse   388 IRERSFKDFHSTALSFYFTC---KKPKIR------------------------------------ 413

  Fly   758 KWRHDNQHVQERPAVHDGASTETQIRHDLSTNQTSIYGYLRLTNVTYESAGRYQCVVSNAFGTTY 822
                                 |.:::|                                      
Mouse   414 ---------------------EKKLQH-------------------------------------- 419

  Fly   823 AQKFKISIGIHPTFLQVPSNLTLDAGEMARLVCSASGDPTPEIALQKFGGSEFPAATERRLQVIR 887
                                |.:|.|:..:|.|:|.|||.|.|:.          .|.||..:..
Mouse   420 --------------------LLVDEGQTVQLECNADGDPQPVISW----------VTPRRRFITT 454

  Fly   888 EEN---------AFLITNAKPSDSGIYTCTALSAAGEIKVNATLVVNDKPQPSIPLVHQEVVVGR 943
            :.|         ...|..|:..|||:|.|.|.:|||.....|:|.|.                |.
Mouse   455 KSNGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTVK----------------GF 503

  Fly   944 TCVLQCLSETANADFELEHPHREWFKENKPIHISPTAPDGDRYYFSNNKELLVILNAQSNDAGHF 1008
            |                                      .||:.::|...:.:   ..|||.   
Mouse   504 T--------------------------------------SDRFLYANRTPMYM---TDSNDT--- 524

  Fly  1009 RCEITD--NSRTFTLQSELVVVKENLNWVVLLVGIITVTVICVVVDCCIIWCTLRYQKKKLRMSL 1071
               :::  |:.||:|..:.::|...:.         ..|.:.||:.|.::.......|.|.:.|:
Mouse   525 ---VSNGTNANTFSLDLKTILVSTAMG---------CFTFLGVVLFCFLLLFVWSRGKGKHKNSI 577

  Fly  1072 AAE 1074
            ..|
Mouse   578 DLE 580

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
lbkNP_611091.2 LRR <293..642 CDD:443914 93/368 (25%)
leucine-rich repeat 293..316 CDD:275380 3/22 (14%)
leucine-rich repeat 317..338 CDD:275380 7/20 (35%)
leucine-rich repeat 339..362 CDD:275380 7/22 (32%)
leucine-rich repeat 363..386 CDD:275380 7/22 (32%)
leucine-rich repeat 387..410 CDD:275380 1/22 (5%)
leucine-rich repeat 411..434 CDD:275380 10/22 (45%)
leucine-rich repeat 435..457 CDD:275380 7/22 (32%)
leucine-rich repeat 458..481 CDD:275380 4/22 (18%)
leucine-rich repeat 482..505 CDD:275380 4/22 (18%)
leucine-rich repeat 506..529 CDD:275380 8/32 (25%)
leucine-rich repeat 530..553 CDD:275380 5/26 (19%)
leucine-rich repeat 554..577 CDD:275380 4/22 (18%)
leucine-rich repeat 578..604 CDD:275380 9/25 (36%)
leucine-rich repeat 607..630 CDD:275380 7/22 (32%)
leucine-rich repeat 631..652 CDD:275380 7/20 (35%)
LRRCT 665..712 CDD:214507 15/51 (29%)
Ig_3 717..816 CDD:464046 4/98 (4%)
Ig 835..924 CDD:472250 28/97 (29%)
Ig strand B 851..855 CDD:409353 1/3 (33%)
Ig strand C 864..868 CDD:409353 1/3 (33%)
Ig strand E 890..894 CDD:409353 1/12 (8%)
Ig strand F 904..909 CDD:409353 2/4 (50%)
Ig strand G 917..920 CDD:409353 0/2 (0%)
Ig_3 927..1013 CDD:464046 8/85 (9%)
Lingo2NP_780725.2 LRRNT 27..60 CDD:214470 14/75 (19%)
leucine-rich repeat 39..57 CDD:275380 8/33 (24%)
LRR 48..>340 CDD:443914 88/340 (26%)
LRR 1 58..79 7/21 (33%)
leucine-rich repeat 59..82 CDD:275380 7/22 (32%)
LRR 2 82..103 8/23 (35%)
leucine-rich repeat 83..106 CDD:275380 10/46 (22%)
LRR 3 106..127 10/20 (50%)
leucine-rich repeat 107..130 CDD:275380 10/22 (45%)
LRR 4 130..151 6/20 (30%)
leucine-rich repeat 131..154 CDD:275380 7/22 (32%)
LRR 5 154..175 4/20 (20%)
leucine-rich repeat 155..178 CDD:275380 4/22 (18%)
LRR 6 178..199 3/20 (15%)
leucine-rich repeat 179..202 CDD:275380 4/22 (18%)
LRR 7 202..223 4/20 (20%)
leucine-rich repeat 203..250 CDD:275380 12/53 (23%)
LRR 8 226..247 7/27 (26%)
LRR 9 250..271 5/32 (16%)
leucine-rich repeat 251..274 CDD:275380 4/22 (18%)
LRR 10 274..295 9/25 (36%)
leucine-rich repeat 275..298 CDD:275380 10/27 (37%)
LRR 11 298..319 5/20 (25%)
leucine-rich repeat 299..322 CDD:275380 7/22 (32%)
LRR 12 322..343 7/20 (35%)
leucine-rich repeat 323..343 CDD:275380 7/19 (37%)
PCC 327..>391 CDD:188093 18/65 (28%)
Ig 411..500 CDD:472250 30/213 (14%)
Ig strand B 428..432 CDD:409353 1/3 (33%)
Ig strand C 441..445 CDD:409353 1/13 (8%)
Ig strand E 466..470 CDD:409353 0/3 (0%)
Ig strand F 480..485 CDD:409353 2/4 (50%)
Ig strand G 493..496 CDD:409353 0/2 (0%)

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