DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lbk and sma-10

DIOPT Version :9

Sequence 1:	NP_611091.2	Gene:	lbk / 36788	FlyBaseID:	FBgn0034083	Length:	1252	Species:	Drosophila melanogaster
Sequence 2:	NP_499896.1	Gene:	sma-10 / 176849	WormBaseID:	WBGene00020649	Length:	881	Species:	Caenorhabditis elegans

Alignment Length:	878	Identity:	237/878 - (26%)
Similarity:	398/878 - (45%)	Gaps:	130/878 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   269 CKCLNVLFDCDKLHLERVP-VLPS------------------------YVQTLHLANNKLNDTTV 308
            |.|:..:.||..|.|..:| .:|:                        ::|||.::||.:.....
Worm    29 CHCVGNVVDCSSLDLSEIPTTIPNNTRILLLSDNEIESIDKSRLKGFYFLQTLDISNNIIRHIDF 93

  Fly   309 LEIRNLLNLTKVSLKRNLLEVIPKFIG---LSGLKHLVLANNHITSISSESLAALPLLRTLDLSR 370
            ....||.||..:::::|.|..||:  |   |..|:.|.|.:|.|::::||.|:.|..:|::||||
Worm    94 EFFYNLPNLKILNIRKNRLARIPR--GSHELGHLEKLDLRSNLISTVTSEELSYLAAVRSVDLSR 156

  Fly   371 NKLHTIELNSFPKSNNLVHLILSFNEITNVNEHSFATLNNLTDLELSNNRLSTLPIRVFKNLNQL 435
            |.:..:...:.....|:..|.|:.|.||::....|::.|.|..|:|:.|.::||....|..|.:|
Worm   157 NLISYLPKPTTSAKVNIEKLDLASNSITDIGTDHFSSFNTLVTLKLARNHITTLNQFSFSRLRKL 221

  Fly   436 KKLALNFNQL-EINWSTFRGLESMKNLQLKSNKIRALQDGVFYVMHKIETIDLAMNQISSLSRQG 499
            :.|.|..|.: |:.:..|..|.|::|:.|..|.:..|.||:||....::.::|:.|::.:::...
Worm   222 ESLDLTRNMIREVRFLAFNQLPSLQNVSLARNDVYRLDDGMFYACEGLKHLNLSTNRVQAVTEGW 286

  Fly   500 LFNLTKLRHLNLSFNAISRIEVDTWEFTQSLEVLDLSNNAINEFKPQHLDCLHRLKTLNLAHNRL 564
            :|.||.|..|:||:|.|....:.:|..|..|:.|.|.:|.|..........|.:|:.|.|:.|.:
Worm   287 MFGLTSLEVLDLSYNQIQSFHISSWSHTPKLKWLSLHSNRIQSLPSGSFRVLRQLEELILSANSI 351

  Fly   565 QYLQENTFDCVKNLEELNLRRNRLSWIIED----QSAAAPFKGLRKLRRLDLHGNNLKQISTKAM 625
            ..|.:.....:.:|.:|:|..|.|:..:||    .:.:.||     ||.|....|.|:.|..:|.
Worm   352 DSLHKFALVGMSSLHKLDLSSNTLAVCVEDGAVLYNTSMPF-----LRSLRFTNNQLRVIPKRAF 411

  Fly   626 SGLNNLEILNLGSNALASIQVNAFEHMLRLNKLVFKSLNFICDCDLVWFQQWL-KNRFPQQAEHA 689
            .....||.|:|..|.:|:|...||| .|.|.:||..|.:.:|||.:.|...|: :.:..:.:..|
Worm   412 ERFPALEELDLTDNPIATIHPEAFE-PLELKRLVMNSSSILCDCQISWLASWIYRLKLDKSSIIA 475

  Fly   690 VCGYPEHLLDRHLKSLSSSELVC-VDSPKPRVEQEPDDM--LAVNAANITLECIASSPTAASLAA 751
            .|.||..|.|.::.::.::.|.| .|||:.::.::|.::  |....|..|.....:||
Worm   476 KCSYPPPLADLYVVAIDTANLTCHNDSPRAKIVRQPVEVSTLIGEKARFTCNVYGASP------- 533

  Fly   752 ADELKIKWRHDNQHVQERPAVHDGASTETQIRHDLSTNQTSIY-----------GYLRLTNVTYE 805
               |.|:|| ..::.|.|..|.|.|:.       ||.|:|::.           ..|.|.||...
Worm   534 ---LSIEWR-VMENGQPRVLVQDSATF-------LSINRTAVVNGTFDERELAAAELLLDNVAMT 587

  Fly   806 SAGRYQCVVSNAFGTTYAQKFKISIGIHPTFLQVPSNLTLDAGEMARLVCSASGDPTPEIALQKF 870
            ....||||..|.||:.::...|:.:...|.|...|.::.|..|:.|:.:|:|:|.|.|||. ..|
Worm   588 DNSEYQCVARNRFGSDFSTHVKLQVYQAPKFTYTPEDMPLLVGQTAKFLCAATGTPRPEIK-WAF 651

  Fly   871 GGSEFPAATERRLQVIREENAFLITNAKPSDSGIYTCTALSAAGEIKVNATLVV--NDKPQPSIP 933
            ....||||..|||.|...::...|.|....|.|.|||.|.:.||:.:.:|.|:|  |....|..|
Worm   652 EQIPFPAAEARRLYVTPNDDHIYIMNVTKEDQGAYTCHATNVAGQTQASANLIVFENFFHYPESP 716

  Fly   934 LVHQEVVVGRTCV-LQCLSETANADFELEHPHREWFKENKPIHISPTAPDGDRYYFSNNKELLVI 997
            .:...::..|..: :.|     :.|.........|.::.:.|.....|.      ||:|.::|.:
Worm   717 DLSPMLIKKRDALKIDC-----SCDLISSRQRMVWKRQQQVILFLKKAK------FSDNDQILTL 770

  Fly   998 LNAQSNDAGHFRCEI----------------------TDNSRTFT--------LQSELV-VVKEN 1031
            .....:|:|.:.||:                      ..:..|.|        :.|:|| .:|..
Worm   771 TQTTFSDSGEYSCELWVDDTILMRKITMVKVVNEDEFVSSEATLTQRVQRIRAMASKLVDNIKST 835

  Fly  1032 LNWV----------VLLVGIITVTVICVVVDCC 1054
            .|.:          ::::|:||...||:....|
Worm   836 GNGIYLMASCSAFGLMILGVITSICICIAKCSC 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lbk	NP_611091.2	LRR_RI	<275..446	CDD:238064	56/199 (28%)
		leucine-rich repeat	293..316	CDD:275380	7/22 (32%)
		LRR_8	316..373	CDD:290566	23/59 (39%)
		leucine-rich repeat	317..338	CDD:275380	7/23 (30%)
		leucine-rich repeat	339..362	CDD:275380	9/22 (41%)
		leucine-rich repeat	363..386	CDD:275380	6/22 (27%)
		LRR_8	386..445	CDD:290566	20/58 (34%)
		leucine-rich repeat	387..410	CDD:275380	6/22 (27%)
		leucine-rich repeat	411..434	CDD:275380	8/22 (36%)
		leucine-rich repeat	435..457	CDD:275380	7/22 (32%)
		LRR_8	457..516	CDD:290566	19/58 (33%)
		leucine-rich repeat	458..481	CDD:275380	8/22 (36%)
		leucine-rich repeat	482..505	CDD:275380	4/22 (18%)
		LRR_RI	<498..669	CDD:238064	54/174 (31%)
		LRR_8	504..564	CDD:290566	19/59 (32%)
		leucine-rich repeat	506..529	CDD:275380	8/22 (36%)
		leucine-rich repeat	530..553	CDD:275380	6/22 (27%)
		leucine-rich repeat	554..577	CDD:275380	5/22 (23%)
		LRR_8	576..641	CDD:290566	21/68 (31%)
		leucine-rich repeat	578..604	CDD:275380	9/29 (31%)
		leucine-rich repeat	607..630	CDD:275380	7/22 (32%)
		leucine-rich repeat	631..652	CDD:275380	10/20 (50%)
		LRRCT	665..712	CDD:214507	12/47 (26%)
		IG	734..823	CDD:214652	27/99 (27%)
		Ig	735..823	CDD:143165	27/98 (28%)
		I-set	834..924	CDD:254352	34/89 (38%)
		Ig	851..924	CDD:299845	29/72 (40%)
		IG	936..1027	CDD:214652	19/122 (16%)
		Ig	961..1020	CDD:143165	12/80 (15%)
sma-10	NP_499896.1	LRRNT	29..54	CDD:214470	8/24 (33%)
		leucine-rich repeat	55..77	CDD:275380	0/21 (0%)
		LRR_8	78..135	CDD:290566	19/58 (33%)
		LRR_4	78..116	CDD:289563	11/37 (30%)
		leucine-rich repeat	78..101	CDD:275380	7/22 (32%)
		LRR_RI	100..303	CDD:238064	65/204 (32%)
		leucine-rich repeat	102..124	CDD:275380	7/23 (30%)
		leucine-rich repeat	125..148	CDD:275380	9/22 (41%)
		leucine-rich repeat	149..172	CDD:275380	6/22 (27%)
		LRR_8	172..231	CDD:290566	20/58 (34%)
		leucine-rich repeat	173..196	CDD:275380	6/22 (27%)
		leucine-rich repeat	197..220	CDD:275380	8/22 (36%)
		leucine-rich repeat	221..244	CDD:275380	7/22 (32%)
		LRR_8	243..303	CDD:290566	19/59 (32%)
		leucine-rich repeat	245..268	CDD:275380	8/22 (36%)
		LRR_RI	269..453	CDD:238064	55/189 (29%)
		leucine-rich repeat	269..292	CDD:275380	4/22 (18%)
		leucine-rich repeat	293..316	CDD:275380	8/22 (36%)
		LRR_8	315..373	CDD:290566	14/57 (25%)
		leucine-rich repeat	317..340	CDD:275380	6/22 (27%)
		leucine-rich repeat	341..364	CDD:275380	5/22 (23%)
		leucine-rich repeat	365..392	CDD:275380	7/26 (27%)
		LRR_8	393..450	CDD:290566	22/57 (39%)
		leucine-rich repeat	393..416	CDD:275380	7/22 (32%)
		leucine-rich repeat	417..438	CDD:275380	10/21 (48%)
		I-set	506..612	CDD:254352	31/123 (25%)
		Ig	522..606	CDD:143165	28/101 (28%)
		I-set	616..705	CDD:254352	34/89 (38%)
		Ig	633..705	CDD:299845	29/72 (40%)
		Ig	716..786	CDD:299845	15/80 (19%)
		IG	719..788	CDD:214652	14/79 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H62452
Inparanoid	1	1.050	296	1.000	Inparanoid score	I1660
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49439
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001817
OrthoInspector	1	1.000	-	-		oto18824
orthoMCL	1	0.900	-	-		OOG6_104558
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1179
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.870