DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lbk and iglr-2

DIOPT Version :9

Sequence 1:	NP_611091.2	Gene:	lbk / 36788	FlyBaseID:	FBgn0034083	Length:	1252	Species:	Drosophila melanogaster
Sequence 2:	NP_498834.1	Gene:	iglr-2 / 176175	WormBaseID:	WBGene00022580	Length:	773	Species:	Caenorhabditis elegans

Alignment Length:	830	Identity:	162/830 - (19%)
Similarity:	269/830 - (32%)	Gaps:	305/830 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   387 LVHLILSFNEITNVNEHSFATLNNLTDLELSN---------NRLSTLPIRVF----KNLNQLKKL 438
            :|.:::..:..|:....| ::.:...||:|..         .|.||..|:.|    ..|.:::|:
Worm     8 VVAILIQIHTTTSQRNRS-SSPSGFLDLQLEKCPQVLGCRCVRDSTRNIQCFSIDESKLLEIQKI 71

  Fly   439 -ALNFNQLEI-NW-------STFRGLESMKNLQLKSNKIRALQDGVFYVMHKIETIDLAMNQISS 494
             ..|..:||: ||       ..|.....::::.|:...:.:|...|.:...|:.:|:.:....||
Worm    72 YGSNIQRLELHNWQHDQLNFDIFAPFPQLEHIILRDGDLESLNGTVIHPTLKVLSIENSELTSSS 136

  Fly   495 LSRQGLFNLTKLRHLNLSFNAISRIEVDTWEFTQSLEVLDLSNNAINEFKPQHLDCLHRLKTLNL 559
            ...:.|....|::.|:||.|...:.|.||  ....|::||||.|.|:     ||:..:.|:.||:
Worm   137 EVCRLLSIFPKIQSLSLSKNYFEKFECDT--SNTKLKILDLSQNRIS-----HLEVPNTLRVLNV 194

  Fly   560 AHNRLQYLQENTFDCVK-NLEELNLRRNRLS-WIIEDQSAAAPFKGLRKLRRLDLHGNNLKQIST 622
            :.|||     .:|:.:. .|.:|::..|:|| |...|.   ..|..||.|..:.|......|:..
Worm   195 SRNRL-----TSFENISTKLTDLDISFNKLSLWPSFDD---WKFPNLRSLSAIKLDLQTGFQLDA 251

  Fly   623 KAMSGLN----NLEILNLGSNALASIQVNAFEHMLRLNKLVFKSLNFICDCDLVWFQQWLKN--- 680
            ..::.||    :|..||.              |.:...||...|..::.:         |:|
Worm   252 PLLNSLNIDGASLRYLNF--------------HQILTPKLKKFSARYLTE---------LRNIAG 293

  Fly   681 RFPQQAEHAVCGYPEHLLDRHLKSLSSSELVCVDSPKPRVEQEPDDMLAVNAANITLECIASSPT 745
            |.|.......      ..|..|::|                  |.|.:.:::.|
Worm   294 RLPSTVTDVA------FTDTMLRTL------------------PADFIPMSSTN----------- 323

  Fly   746 AASLAAADELKIKWRHDNQHVQERPAVHDGASTETQIRHDLSTN-----------------QTSI 793
                               |:|             ::..|.|||                 ||||
Worm   324 -------------------HMQ-------------KVSFDFSTNQLLCDKCLLQWSLPVYAQTSI 356

  Fly   794 YGYLRLTNVTYESAGRYQCVVSNAFGTTYAQKFKISIGIHPTFLQVPSNLTLDAGEMARLVCSAS 858
            .....||....|||.....||:|..|..|.:..|      ||.:.                |.:.
Worm   357 RKDCNLTREEIESASCKIGVVANDTGIQYGKYEK------PTAIS----------------CFSY 399

  Fly   859 GDPTPEIALQKFGGSEFPAATERRLQVIREENAFLITNAKPSDSGIYTCTALSAAGEIKVNATLV 923
            |.|:|:|:..:|.    ||........|.:|.::  ||...:....|         ||:...:|:
Worm   400 GVPSPKISWWRFR----PAEKLGSYDPITDEISY--TNVSETMKESY---------EIQSGGSLL 449

  Fly   924 VNDKPQPSIPLVHQEVVVGRTCVLQCLSETANADFELEHPHREWFKENKPIHISPTAPDGDRYYF 988
            :.                                                   ||.....:||
Worm   450 IR---------------------------------------------------SPNRSHVERY-- 461

  Fly   989 SNNKELLVILNAQSNDAG--HFRCEITDNSRTFTLQSELVVVKENLNWV-------VLLVGIITV 1044
                 :.|:.|....|.|  |||.:.                   |:|.       |...|:.|.
Worm   462 -----VCVVENEYGKDYGIYHFRLDY-------------------LDWYSYDVFNSVFWGGLATS 502

  Fly  1045 TVICVVVDCC-IIWCTLRYQKKKLRMSLAAERHS---------TQLRPRSLADLGCSYDEANHRR 1099
            .::|::.... |.|...|  |..|.....|||.|         .:.|.|.:..|...|.    :|
Worm   503 LIVCLISFLLNITWILTR--KSALWWIQRAERLSRVRKMVEAMEKYRVRQMESLHEKYT----KR 561

  Fly  1100 LTVMSTPPSEQRCLEQGLTLSYLRQTD---------LEAQQDHLSSKDSG 1140
            :.::.....:|   .:.|.:||..|.:         ::|...||.:...|
Worm   562 VQIVRDNYHQQ---VEALRVSYASQQEKFQNYKAAQVDAVHSHLDAMRDG 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lbk	NP_611091.2	LRR_RI	<275..446	CDD:238064	14/72 (19%)
		leucine-rich repeat	293..316	CDD:275380
		LRR_8	316..373	CDD:290566
		leucine-rich repeat	317..338	CDD:275380
		leucine-rich repeat	339..362	CDD:275380
		leucine-rich repeat	363..386	CDD:275380
		LRR_8	386..445	CDD:290566	14/71 (20%)
		leucine-rich repeat	387..410	CDD:275380	3/22 (14%)
		leucine-rich repeat	411..434	CDD:275380	9/35 (26%)
		leucine-rich repeat	435..457	CDD:275380	7/30 (23%)
		LRR_8	457..516	CDD:290566	13/58 (22%)
		leucine-rich repeat	458..481	CDD:275380	3/22 (14%)
		leucine-rich repeat	482..505	CDD:275380	4/22 (18%)
		LRR_RI	<498..669	CDD:238064	47/176 (27%)
		LRR_8	504..564	CDD:290566	21/59 (36%)
		leucine-rich repeat	506..529	CDD:275380	7/22 (32%)
		leucine-rich repeat	530..553	CDD:275380	9/22 (41%)
		leucine-rich repeat	554..577	CDD:275380	7/23 (30%)
		LRR_8	576..641	CDD:290566	18/70 (26%)
		leucine-rich repeat	578..604	CDD:275380	8/26 (31%)
		leucine-rich repeat	607..630	CDD:275380	5/26 (19%)
		leucine-rich repeat	631..652	CDD:275380	3/20 (15%)
		LRRCT	665..712	CDD:214507	7/49 (14%)
		IG	734..823	CDD:214652	20/105 (19%)
		Ig	735..823	CDD:143165	19/104 (18%)
		I-set	834..924	CDD:254352	18/89 (20%)
		Ig	851..924	CDD:299845	16/72 (22%)
		IG	936..1027	CDD:214652	11/92 (12%)
		Ig	961..1020	CDD:143165	11/60 (18%)
iglr-2	NP_498834.1	leucine-rich repeat	76..99	CDD:275380	5/22 (23%)
		leucine-rich repeat	100..121	CDD:275380	3/20 (15%)
		LRR_RI	<120..>223	CDD:238064	34/114 (30%)
		leucine-rich repeat	122..147	CDD:275380	5/24 (21%)
		leucine-rich repeat	148..169	CDD:275380	7/22 (32%)
		LRR_8	168..219	CDD:290566	19/60 (32%)
		LRR_4	168..206	CDD:289563	16/47 (34%)
		Ig	394..472	CDD:143165	22/166 (13%)
		Apolipoprotein	550..687	CDD:279749	12/66 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000