DRSC/TRiP Functional Genomics Resources

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Protein Alignment lbk and Lrig1

DIOPT Version :9

Sequence 1:NP_611091.2 Gene:lbk / 36788 FlyBaseID:FBgn0034083 Length:1252 Species:Drosophila melanogaster
Sequence 2:NP_032403.2 Gene:Lrig1 / 16206 MGIID:107935 Length:1091 Species:Mus musculus


Alignment Length:1069 Identity:325/1069 - (30%)
Similarity:514/1069 - (48%) Gaps:140/1069 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   252 AAAAKASNKYNIDCPKDCKCLNVLFDCDKLHLERVP-VLPSYVQTLHLANNKLNDTTVLEIRNLL 315
            :|.|:|..:  ..|...|.|.....||....|..:| .|||:.::|:|:.|:|::.......:|.
Mouse    32 SAGAQAGPR--APCAAACTCAGDSLDCSGRGLATLPRDLPSWTRSLNLSYNRLSEIDSAAFEDLT 94

  Fly   316 NLTKVSLKRNLLEVIPKFIGLS-GLKHLVLANNHITSISSESLAALPLLRTLDLSRNKLHTIELN 379
            ||.:|.|..|.|..||.....| |:..|.|.:|.|.|:....|.:...|..||||.|.:..|..:
Mouse    95 NLQEVYLNSNELTAIPSLGAASIGVVSLFLQHNKILSVDGSQLKSYLSLEVLDLSSNNITEIRSS 159

  Fly   380 SFPKSNNLVHLILSFNEITNVNEHSFATLN-NLTDLELSNNRLSTLPIRVFKNLNQLKKLALNFN 443
            .||....:..|.|:.|.|:.:...:|..|: :|..|.||.||::.||::.|| |.:|.:|.||.|
Mouse   160 CFPNGLRIRELNLASNRISILESGAFDGLSRSLLTLRLSKNRITQLPVKAFK-LPRLTQLDLNRN 223

  Fly   444 QLE-INWSTFRGLESMKNLQLKSNKIRALQDGVFYVMHKIETIDLAMNQISSLSRQGLFNLTKLR 507
            ::. |...||:||:|::.|:|:.|.|..|.||.|:.:.|:..:.|..|.:..::...|:.||.|.
Mouse   224 RIRLIEGLTFQGLDSLEVLRLQRNNISRLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALH 288

  Fly   508 HLNLSFNAISRIEVDTWEFTQSLEVLDLSNNAINEFKPQHLDCLHRLKTLNLAHNRLQYLQENTF 572
            .|:||.|:||||:.|.|.|.|.|..|.||.|.:.....:.|..|..|..|.|:||.:.::.|..|
Mouse   289 QLHLSNNSISRIQRDGWSFCQKLHELILSFNNLTRLDEESLAELSSLSILRLSHNAISHIAEGAF 353

  Fly   573 DCVKNLEELNLRRNRLSWIIEDQSAAAPFKGLRKLRRLDLHGNNLKQISTKAMSGLNNLEILNLG 637
            ..:|:|..|:|..|.:|..|||.|.|  |.||..|.:|.|.||.:|.::.:|.|||.:||.||||
Mouse   354 KGLKSLRVLDLDHNEISGTIEDTSGA--FTGLDNLSKLTLFGNKIKSVAKRAFSGLESLEHLNLG 416

  Fly   638 SNALASIQVNAFEHMLRLNKLVFKSLNFICDCDLVWFQQWLKNRFPQQAEHAVCGYPEHLLDRHL 702
            .||:.|:|.:||..|..|.:|...|.:|:|||.|.|...||..|..|....|.|.:||.|..:.:
Mouse   417 ENAIRSVQFDAFAKMKNLKELYISSESFLCDCQLKWLPPWLMGRMLQAFVTATCAHPESLKGQSI 481

  Fly   703 KSLSSSELVCVDSPKPRVEQEPDDMLAVNAANITLECIASSPTAASLAAADELKIKWRHDNQ--- 764
            .|:.....||.|.|||::..:|:..:||...:|...|.|:|.:::.:..|      |:.||:   
Mouse   482 FSVLPDSFVCDDFPKPQIITQPETTMAVVGKDIRFTCSAASSSSSPMTFA------WKKDNEVLA 540

  Fly   765 --------HVQERPAVHDGASTETQIRHDLSTNQTSIYGYLRLTNVTYESAGRYQCVVSNAFGTT 821
                    ||:    ..||...|          .|:|   |.|.:||:...|||||:::|.||:|
Mouse   541 NADMENFAHVR----AQDGEVME----------YTTI---LHLRHVTFGHEGRYQCIITNHFGST 588

  Fly   822 YAQKFKISIGIHPTFLQVPSNLTLDAGEMARLVCSASGDPTPEIALQKFGGSEFPAATERRLQVI 886
            |:.|.::::.:.|:|.::|.::.:..|..|||.|:|:|.|.|:||.||.||::||||.|||:.|:
Mouse   589 YSHKARLTVNVLPSFTKIPHDIAIRTGTTARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVM 653

  Fly   887 REENAFLITNAKPSDSGIYTCTALSAAGEIKVNATLVVNDKPQPSIPLVHQEVVVGRTCVLQCLS 951
            .:::.|.||:.|..|.|:|:|||.::||.:..||||.|.:.|..::||..:.|.||.|...||.:
Mouse   654 PDDDVFFITDVKIDDMGVYSCTAQNSAGSVSANATLTVLETPSLAVPLEDRVVTVGETVAFQCKA 718

  Fly   952 ETANADFELEHPHREWFKENKPIHISPTAPDGDRYYFSNNKELLVILNAQSNDAGHFRCEITDNS 1016
            ..:..      |...|.|..:|:.::      :|::|:...:|||:.|...:|||.:.||:::..
Mouse   719 TGSPT------PRITWLKGGRPLSLT------ERHHFTPGNQLLVVQNVMIDDAGRYTCEMSNPL 771

  Fly  1017 RTFTLQSELVVV------KENLNWVVLLVGIITVTVICVVVDCCIIWCTLRYQKKKLRMSLAAER 1075
            .|....|:|.::      |:...     |||.|:.|:|.:|...::|..:.||.:|.....:...
Mouse   772 GTERAHSQLSILPTPGCRKDGTT-----VGIFTIAVVCSIVLTSLVWVCIIYQTRKKSEEYSVTN 831

  Fly  1076 HSTQLRPRSLADLGCSYDEANHRRLTVMSTPPSEQ--------------------------RCLE 1114
            ....:.|..:.....|....:.|:.||:.|....|                          .|.:
Mouse   832 TDETIVPPDVPSYLSSQGTLSDRQETVVRTEGGHQANGHIESNGVCLRDPSLFPEVDIHSTTCRQ 896

  Fly  1115 QGLTLSYLRQ-------TDLEAQQDHLSSKDSGTGSDAAVKRTLDDFEVAMPSHKHHTDDEEEEE 1172
            ..|.:.|.|:       .|..|.....:...|...||.:.........|...|.:..|...:|  
Mouse   897 PKLCVGYTREPWKVTEKADRTAAPHTTAHSGSAVCSDCSTDTAYHPQPVPRDSGQPGTASSQE-- 959

  Fly  1173 VEEVYEENEPPYIKHTYEVNYAEPEQHLFLQNNNHNYDG---GGIGVAGGV------NKMVPNAL 1228
                ..:::..|..|                   |.|.|   |...::||.      ::::|:  
Mouse   960 ----LRQHDREYSPH-------------------HPYSGTADGSHTLSGGSLYPSNHDRILPS-- 999

  Fly  1229 LRKCSAGASGSNYSS-----IQQCTTVDI 1252
            |:..:|.|.|:..||     :.:...:|:
Mouse  1000 LKNKAASADGNGDSSWTLAKLHEADCIDL 1028

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
lbkNP_611091.2 LRR_RI <275..446 CDD:238064 59/173 (34%)
leucine-rich repeat 293..316 CDD:275380 5/22 (23%)
LRR_8 316..373 CDD:290566 22/57 (39%)
leucine-rich repeat 317..338 CDD:275380 8/21 (38%)
leucine-rich repeat 339..362 CDD:275380 6/22 (27%)
leucine-rich repeat 363..386 CDD:275380 9/22 (41%)
LRR_8 386..445 CDD:290566 22/59 (37%)
leucine-rich repeat 387..410 CDD:275380 6/23 (26%)
leucine-rich repeat 411..434 CDD:275380 11/22 (50%)
leucine-rich repeat 435..457 CDD:275380 10/22 (45%)
LRR_8 457..516 CDD:290566 20/58 (34%)
leucine-rich repeat 458..481 CDD:275380 8/22 (36%)
leucine-rich repeat 482..505 CDD:275380 4/22 (18%)
LRR_RI <498..669 CDD:238064 72/170 (42%)
LRR_8 504..564 CDD:290566 26/59 (44%)
leucine-rich repeat 506..529 CDD:275380 12/22 (55%)
leucine-rich repeat 530..553 CDD:275380 7/22 (32%)
leucine-rich repeat 554..577 CDD:275380 7/22 (32%)
LRR_8 576..641 CDD:290566 31/64 (48%)
leucine-rich repeat 578..604 CDD:275380 11/25 (44%)
leucine-rich repeat 607..630 CDD:275380 10/22 (45%)
leucine-rich repeat 631..652 CDD:275380 12/20 (60%)
LRRCT 665..712 CDD:214507 16/46 (35%)
IG 734..823 CDD:214652 28/99 (28%)
Ig 735..823 CDD:143165 28/98 (29%)
I-set 834..924 CDD:254352 42/89 (47%)
Ig 851..924 CDD:299845 38/72 (53%)
IG 936..1027 CDD:214652 24/90 (27%)
Ig 961..1020 CDD:143165 16/58 (28%)
Lrig1NP_032403.2 leucine-rich repeat 53..71 CDD:275380 6/17 (35%)
LRR_RI 57..325 CDD:238064 95/268 (35%)
LRR 1 71..92 4/20 (20%)
leucine-rich repeat 72..95 CDD:275380 5/22 (23%)
LRR_8 73..129 CDD:290566 18/55 (33%)
LRR 2 95..116 8/20 (40%)
LRR 3 118..139 7/20 (35%)
LRR_8 142..225 CDD:290566 31/83 (37%)
LRR 4 142..163 8/20 (40%)
leucine-rich repeat 143..166 CDD:275380 9/22 (41%)
LRR 5 166..187 5/20 (25%)
leucine-rich repeat 167..190 CDD:275380 6/22 (27%)
leucine-rich repeat 191..214 CDD:275380 11/23 (48%)
LRR 6 191..212 10/21 (48%)
LRR_8 213..273 CDD:290566 22/59 (37%)
LRR 7 214..235 8/20 (40%)
leucine-rich repeat 215..238 CDD:275380 10/22 (45%)
LRR_RI 238..>423 CDD:238064 74/186 (40%)
LRR 8 238..259 9/20 (45%)
leucine-rich repeat 239..262 CDD:275380 8/22 (36%)
LRR_8 261..321 CDD:290566 24/59 (41%)
LRR 9 262..283 4/20 (20%)
leucine-rich repeat 263..286 CDD:275380 4/22 (18%)
LRR 10 286..307 11/20 (55%)
leucine-rich repeat 287..310 CDD:275380 12/22 (55%)
LRR_8 310..369 CDD:290566 19/58 (33%)
LRR 11 310..331 6/20 (30%)
leucine-rich repeat 311..334 CDD:275380 7/22 (32%)
LRR 12 334..355 7/20 (35%)
leucine-rich repeat 335..358 CDD:275380 7/22 (32%)
LRR 13 358..380 10/23 (43%)
leucine-rich repeat 359..383 CDD:275380 11/25 (44%)
LRR_8 385..441 CDD:290566 25/55 (45%)
LRR 14 385..406 7/20 (35%)
leucine-rich repeat 386..409 CDD:275380 10/22 (45%)
LRR 15 409..430 12/20 (60%)
leucine-rich repeat 410..433 CDD:275380 13/22 (59%)
LRRCT 444..492 CDD:214507 17/47 (36%)
Ig_3 496..583 CDD:290638 29/109 (27%)
I-set 497..597 CDD:254352 34/122 (28%)
I-set 601..691 CDD:254352 42/89 (47%)
Ig_1 618..692 CDD:143240 38/73 (52%)
I-set 695..782 CDD:254352 27/98 (28%)
IGc2 709..772 CDD:197706 19/74 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 912..990 17/102 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1059..1091
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167838319
Domainoid 1 1.000 102 1.000 Domainoid score I6816
eggNOG 1 0.900 - - E2759_KOG4194
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 483 1.000 Inparanoid score I1433
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG49439
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001817
OrthoInspector 1 1.000 - - otm44361
orthoMCL 1 0.900 - - OOG6_104558
Panther 1 1.100 - - O PTHR24373
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3392
SonicParanoid 1 1.000 - - X1179
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1312.830

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