Protein Alignment lbk and LINGO2

DIOPT Version :10

• Sequence 1: NP_611091.2
• Gene: lbk / 36788
• FlyBaseID: FBgn0034083
• Length: 1252
• Species: Drosophila melanogaster
• Sequence 2: NP_689783.1
• Gene: LINGO2 / 158038
• HGNCID: 21207
• Length: 606
• Species: Homo sapiens
• Alignment Length: 835
• Identity: 172/835 - (20%)
• Similarity: 272/835 - (32%)
• Gaps: 303/835 - (36%)

  Fly   263 IDCPKDCKCLNVLFDCDKLHLERVPVLPSYVQTLHLANNKLNDTTVLEIRNLLNLTKVSLKRNLL 327
            |.||..|:|                          .|.||                .||..|..|
Human    26 IGCPARCEC--------------------------SAQNK----------------SVSCHRRRL 48

  Fly   328 EVIPKFIGLSGLKHLVLANNHITSISSESLAALPLLRTLDLSRNKLHTIELNSFPKSNNLVHLIL 392
            ..||:.|.:. .|.|.|:.|.:.|::.|...:.|||..:|||.|.:..:|..:|....||..|.|
Human    49 IAIPEGIPIE-TKILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRL 112

  Fly   393 SFNEITNVNEHSFATLNNLTDLELSNNRLSTLPIRVFKNLNQLKKLALNFNQL-EINWSTFRGLE 456
            ..|.:..|....|..|:|||.|::|.|::..|...:|::|:.||.|.:..|.| .|:...|.||.
Human   113 KGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLL 177

  Fly   457 SMKNLQLKSNKIRALQDGVFYVMHKIETIDLAMNQISSLSRQGLFNLTKLRHLNLSFNAISRIEV 521
            |::.|.|:...:.|:.......:..:.::.|....|:::.......|..|:||          |:
Human   178 SLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHL----------EI 232

  Fly   522 DTWEFTQSLEVLDL----SNNAINEFKPQHLDCLHRLKTLNLAHNRLQYLQENTFDCVKNLEELN 582
            |.|      .:||:    |...:|            |.:|::.:..|..:....|..:..|..||
Human   233 DYW------PLLDMMPANSLYGLN------------LTSLSVTNTNLSTVPFLAFKHLVYLTHLN 279

  Fly   583 LRRNRLSWIIEDQSAAAPFKGLRKLRRLDLHGNNLKQISTKAMSGLNNLEILNLGSNALASIQVN 647
            |..|.:|.|     .|..|..|.:|:.|.:.|..|:.|...:..||..|.:||:..|.|.:::.|
Human   280 LSYNPISTI-----EAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEEN 339

  Fly   648 AFEHMLRLNKLVFKSLNFICDCDLVWFQQWLKNRFPQ---QAEHAVCGYPEHLLDRHLKSLSSSE 709
            .|.....|..|...:....|||.|:|..|    |.|.   ..:..:|..|:.:.:|..|...|:.
Human   340 VFSSPRALEVLSINNNPLACDCRLLWILQ----RQPTLQFGGQQPMCAGPDTIRERSFKDFHSTA 400

  Fly   710 L----VCVDSPKPRVEQEPDDMLAVNAANITLECIASSPTAASLAAADELKIKWRHDNQHVQERP 770
            |    .|   .||::.
Human   401 LSFYFTC---KKPKIR------------------------------------------------- 413

  Fly   771 AVHDGASTETQIRHDLSTNQTSIYGYLRLTNVTYESAGRYQCVVSNAFGTTYAQKFKISIGIHPT 835
                    |.:::|
Human   414 --------EKKLQH--------------------------------------------------- 419

  Fly   836 FLQVPSNLTLDAGEMARLVCSASGDPTPEIALQKFGGSEFPAATERRLQVIREEN---------A 891
                   |.:|.|:..:|.|||.|||.|.|:.          .|.||..:..:.|         .
Human   420 -------LLVDEGQTVQLECSADGDPQPVISW----------VTPRRRFITTKSNGRATVLGDGT 467

  Fly   892 FLITNAKPSDSGIYTCTALSAAGEIKVNATLVVNDKPQPSIPLVHQEVVVGRTCVLQCLSETANA 956
            ..|..|:..|||:|.|.|.:|||.....|:|.|....
Human   468 LEIRFAQDQDSGMYVCIASNAAGNDTFTASLTVKGFA---------------------------- 504

  Fly   957 DFELEHPHREWFKENKPIHISPTAPDGDRYYFSNNKELLVILNAQSNDAGHFRCEITD--NSRTF 1019
                                      .||:.::|...:.:   ..|||.      |::  |:.||
Human   505 --------------------------SDRFLYANRTPMYM---TDSNDT------ISNGTNANTF 534

  Fly  1020 TLQSELVVVKENLNWVVLLVGIITVTVICVVVDCCIIWCTLRYQKKKLRMSLAAE 1074
            :|..:.::|...:.         ..|.:.||:.|.::.......|.|.:.|:..|
Human   535 SLDLKTILVSTAMG---------CFTFLGVVLFCFLLLFVWSRGKGKHKNSIDLE 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbk	NP_611091.2	LRR	<293..642	CDD:443914	93/353 (26%)
		leucine-rich repeat	293..316	CDD:275380	3/22 (14%)
		leucine-rich repeat	317..338	CDD:275380	7/20 (35%)
		leucine-rich repeat	339..362	CDD:275380	6/22 (27%)
		leucine-rich repeat	363..386	CDD:275380	7/22 (32%)
		leucine-rich repeat	387..410	CDD:275380	7/22 (32%)
		leucine-rich repeat	411..434	CDD:275380	8/22 (36%)
		leucine-rich repeat	435..457	CDD:275380	9/22 (41%)
		leucine-rich repeat	458..481	CDD:275380	3/22 (14%)
		leucine-rich repeat	482..505	CDD:275380	3/22 (14%)
		leucine-rich repeat	506..529	CDD:275380	6/22 (27%)
		leucine-rich repeat	530..553	CDD:275380	4/26 (15%)
		leucine-rich repeat	554..577	CDD:275380	4/22 (18%)
		leucine-rich repeat	578..604	CDD:275380	9/25 (36%)
		leucine-rich repeat	607..630	CDD:275380	7/22 (32%)
		leucine-rich repeat	631..652	CDD:275380	7/20 (35%)
		LRRCT	665..712	CDD:214507	14/53 (26%)
		Ig_3	717..816	CDD:464046	4/98 (4%)
		Ig	835..924	CDD:472250	29/97 (30%)
		Ig strand B	851..855	CDD:409353	1/3 (33%)
		Ig strand C	864..868	CDD:409353	1/3 (33%)
		Ig strand E	890..894	CDD:409353	1/12 (8%)
		Ig strand F	904..909	CDD:409353	2/4 (50%)
		Ig strand G	917..920	CDD:409353	0/2 (0%)
		Ig_3	927..1013	CDD:464046	6/85 (7%)
LINGO2	NP_689783.1	LRRNT	27..60	CDD:214470	14/75 (19%)
		leucine-rich repeat	39..57	CDD:275380	8/33 (24%)
		LRR	48..>340	CDD:443914	88/325 (27%)
		LRR 1	58..79		6/21 (29%)
		leucine-rich repeat	59..82	CDD:275380	6/22 (27%)
		LRR 2	82..103		8/20 (40%)
		leucine-rich repeat	83..106	CDD:275380	7/22 (32%)
		LRR 3	106..127		7/20 (35%)
		leucine-rich repeat	107..130	CDD:275380	7/22 (32%)
		LRR 4	130..151		8/20 (40%)
		leucine-rich repeat	131..154	CDD:275380	8/22 (36%)
		LRR 5	154..175		7/20 (35%)
		leucine-rich repeat	155..178	CDD:275380	9/22 (41%)
		LRR 6	178..199		4/20 (20%)
		leucine-rich repeat	179..202	CDD:275380	3/22 (14%)
		LRR 7	202..223		2/20 (10%)
		leucine-rich repeat	203..250	CDD:275380	12/62 (19%)
		LRR 8	226..247		9/36 (25%)
		LRR 9	250..271		5/32 (16%)
		leucine-rich repeat	251..274	CDD:275380	4/22 (18%)
		LRR 10	274..295		9/25 (36%)
		leucine-rich repeat	275..298	CDD:275380	10/27 (37%)
		LRR 11	298..319		5/20 (25%)
		leucine-rich repeat	299..322	CDD:275380	7/22 (32%)
		LRR 12	322..343		7/20 (35%)
		leucine-rich repeat	323..343	CDD:275380	7/19 (37%)
		LRRCT	355..408	CDD:214507	15/59 (25%)
		Ig	411..500	CDD:472250	31/213 (15%)
		Ig strand B	428..432	CDD:409353	1/3 (33%)
		Ig strand C	441..445	CDD:409353	1/13 (8%)
		Ig strand E	466..470	CDD:409353	0/3 (0%)
		Ig strand F	480..485	CDD:409353	2/4 (50%)
		Ig strand G	493..496	CDD:409353	0/2 (0%)