DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lbk and LRIG3

DIOPT Version :9

Sequence 1:	NP_611091.2	Gene:	lbk / 36788	FlyBaseID:	FBgn0034083	Length:	1252	Species:	Drosophila melanogaster
Sequence 2:	NP_700356.2	Gene:	LRIG3 / 121227	HGNCID:	30991	Length:	1119	Species:	Homo sapiens

Alignment Length:	1024	Identity:	328/1024 - (32%)
Similarity:	522/1024 - (50%)	Gaps:	141/1024 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 ADDGGQYEHAQKALEAAAAAAKASNKYNIDCPKDCKCLNVLFDCDKLHLERVP-VLPSYVQTLHL 298
            :|.||:.|..|.:..||..          .||..|:||..|.||.:..|.|:| .|||:|..|.|
Human    27 SDSGGRGELGQPSGVAAER----------PCPTTCRCLGDLLDCSRKRLARLPEPLPSWVARLDL 81

  Fly   299 ANNKLNDTTVLEIRNLLNLTKVSLKRNLLEVIPKFIGLS-GLKHLVLANNHITSISSESLAALPL 362
            ::|:|:......:.:|.:|.:|.|..|.||.||....:| .:..|.||.|.|..|..|.|.....
Human    82 SHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQS 146

  Fly   363 LRTLDLSRNKLHTIELNSFPKSNNLVHLILSFNEITNVNEHSFATL-NNLTDLELSNNRLSTLPI 426
            |.|||||.|.:..:: .:|| :..|.:|.|:.|.:|::....|..| |.|..|:|:.||:|.:|.
Human   147 LETLDLSSNNISELQ-TAFP-ALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPP 209

  Fly   427 RVFKNLNQLKKLALNFNQLE-INWSTFRGLESMKNLQLKSNKIRALQDGVFYVMHKIETIDLAMN 490
            ::|| |.||:.|.||.|::: ::..||:||.::|:|:::.|.:..|.||.|:.:..:|.:.|..|
Human   210 KMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHN 273

  Fly   491 QISSLSRQGLFNLTKLRHLNLSFNAISRIEVDTWEFTQSLEVLDLSNNAINEFKPQHLDCLHRLK 555
            .::.:::..|:.|..|:.|:||.|||:||..|.|||.|.|..|||:.|.::.........|..|.
Human   274 NLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLN 338

  Fly   556 TLNLAHNRLQYLQENTFDCVKNLEELNLRRNRLSWIIEDQSAAAPFKGLRKLRRLDLHGNNLKQI 620
            ||::.:||:.|:.:..|..:.:|:.|:|:.|.:||.|||.:.|  |.||.|||||.|.||.::.|
Human   339 TLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGA--FSGLDKLRRLILQGNRIRSI 401

  Fly   621 STKAMSGLNNLEILNLGSNALASIQVNAFEHMLRLNKLVFKSLNFICDCDLVWFQQWL-KNRFPQ 684
            :.||.:||:.||.|:|..||:.|:|.|||..|.:|.:|...:.:.:|||.|.|..||: :|.| |
Human   402 TKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNF-Q 465

  Fly   685 QAEHAVCGYPEHLLDRHLKSLSSSELVCVDSPKPRVEQEPDDMLAVNAANITLECIASSPTAASL 749
            ...:|.|.:|:.|..|.:.::|....||.|.|||::..:|:...|:..:|::..|.|:|.:.:.:
Human   466 SFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPM 530

  Fly   750 AAADELKIKWRHDNQHVQERPAVHDGASTETQIRHDLSTNQTSIYGY---LRLTNVTYESAGRYQ 811
            ..|      |:.||:      .:||   .|.:....|......:..|   |||..|.:.|.|:||
Human   531 TFA------WKKDNE------LLHD---AEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQ 580

  Fly   812 CVVSNAFGTTYAQKFKISIGIHPTFLQVPSNLTLDAGEMARLVCSASGDPTPEIALQKFGGSEFP 876
            ||:||.||::|:.|.|:::.:.|:|.:.|.:||:.||.||||.|:|.|.|.|:||.||.||::||
Human   581 CVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFP 645

  Fly   877 AATERRLQVIREENAFLITNAKPSDSGIYTCTALSAAGEIKVNATLVVNDKPQPSIPLVHQEVVV 941
            ||.|||:.|:.|::.|.|.:.|..|.|:|:|||.::||.|..||||.|.:.|....||:.:.|..
Human   646 AARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTK 710

  Fly   942 GRTCVLQCLSETANADFELEHPHREWFKENKPIHISPTAPDGDRYYFSNNKELLVILNAQSNDAG 1006
            |.|.||||::..:      ..|...|.|::.|:.::      :|::|:...:||:|:::..:|||
Human   711 GETAVLQCIAGGS------PPPKLNWTKDDSPLVVT------ERHFFAAGNQLLIIVDSDVSDAG 763

  Fly  1007 HFRCEITDNSRTFTLQSELVVVK--------------ENLNWVVLLVGIITVTVICVVVDCCIIW 1057
            .:.||:::...|......|.|:.              ::..|..  ||::.:.|:|.||...::|
Human   764 KYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMTAPSLDDDGWAT--VGVVIIAVVCCVVGTSLVW 826

  Fly  1058 CTLRYQKKKLRMSLAAERHSTQLRPRSLADLGCSYDEANHRRLTVMSTPPSEQRCLEQGLTLSYL 1122
            ..:.|..::                   .:..||....:...|      |::        ..|||
Human   827 VVIIYHTRR-------------------RNEDCSITNTDETNL------PAD--------IPSYL 858

  Fly  1123 -RQTDLEAQQDHLSSKDSGTGSDAAVKRTLDDFEVAMPSHKH----HTDDEEEEEVEEVYE---- 1178
             .|..|..:||...|.:||:............|   :|.|..    |.|:..|.:||...:
Human   859 SSQGTLADRQDGYVSSESGSHHQFVTSSGAGFF---LPQHDSSGTCHIDNSSEADVEAATDLFLC 920

  Fly  1179 ----ENEPPYIK------------HT-------------YEVNYAEPEQ 1198
                ...|.|:|            ||             ||.:|.:.::
Human   921 PFLGSTGPMYLKGNVYGSDPFETYHTGCSPDPRTVLMDHYEPSYIKKKE 969

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lbk	NP_611091.2	LRR_RI	<275..446	CDD:238064	65/173 (38%)
		leucine-rich repeat	293..316	CDD:275380	6/22 (27%)
		LRR_8	316..373	CDD:290566	24/57 (42%)
		leucine-rich repeat	317..338	CDD:275380	9/21 (43%)
		leucine-rich repeat	339..362	CDD:275380	8/22 (36%)
		leucine-rich repeat	363..386	CDD:275380	9/22 (41%)
		LRR_8	386..445	CDD:290566	24/59 (41%)
		leucine-rich repeat	387..410	CDD:275380	7/23 (30%)
		leucine-rich repeat	411..434	CDD:275380	10/22 (45%)
		leucine-rich repeat	435..457	CDD:275380	9/22 (41%)
		LRR_8	457..516	CDD:290566	17/58 (29%)
		leucine-rich repeat	458..481	CDD:275380	7/22 (32%)
		leucine-rich repeat	482..505	CDD:275380	5/22 (23%)
		LRR_RI	<498..669	CDD:238064	70/170 (41%)
		LRR_8	504..564	CDD:290566	24/59 (41%)
		leucine-rich repeat	506..529	CDD:275380	13/22 (59%)
		leucine-rich repeat	530..553	CDD:275380	6/22 (27%)
		leucine-rich repeat	554..577	CDD:275380	7/22 (32%)
		LRR_8	576..641	CDD:290566	31/64 (48%)
		leucine-rich repeat	578..604	CDD:275380	11/25 (44%)
		leucine-rich repeat	607..630	CDD:275380	12/22 (55%)
		leucine-rich repeat	631..652	CDD:275380	11/20 (55%)
		LRRCT	665..712	CDD:214507	16/47 (34%)
		IG	734..823	CDD:214652	27/91 (30%)
		Ig	735..823	CDD:143165	26/90 (29%)
		I-set	834..924	CDD:254352	47/89 (53%)
		Ig	851..924	CDD:299845	39/72 (54%)
		IG	936..1027	CDD:214652	23/90 (26%)
		Ig	961..1020	CDD:143165	15/58 (26%)
LRIG3	NP_700356.2	LRR	20..395	CDD:227223	139/382 (36%)
		leucine-rich repeat	58..74	CDD:275378	6/15 (40%)
		LRR_RI	<65..>245	CDD:238064	67/182 (37%)
		LRR 1	75..96		5/20 (25%)
		leucine-rich repeat	78..99	CDD:275378	5/20 (25%)
		LRR 2	99..120		8/20 (40%)
		leucine-rich repeat	100..115	CDD:275378	7/14 (50%)
		LRR 3	122..142		7/19 (37%)
		leucine-rich repeat	123..146	CDD:275378	8/22 (36%)
		LRR 4	146..167		9/22 (41%)
		leucine-rich repeat	147..168	CDD:275380	9/22 (41%)
		LRR 5	168..189		6/20 (30%)
		leucine-rich repeat	169..192	CDD:275380	7/22 (32%)
		LRR 6	193..214		9/21 (43%)
		leucine-rich repeat	194..216	CDD:275380	10/22 (45%)
		LRR 7	216..237		8/20 (40%)
		leucine-rich repeat	217..240	CDD:275380	9/22 (41%)
		LRR 8	240..261		7/20 (35%)
		leucine-rich repeat	241..264	CDD:275380	7/22 (32%)
		LRR_RI	262..>446	CDD:238064	72/185 (39%)
		LRR 9	264..285		4/20 (20%)
		leucine-rich repeat	265..288	CDD:275380	5/22 (23%)
		LRR 10	288..309		11/20 (55%)
		leucine-rich repeat	289..312	CDD:275380	13/22 (59%)
		LRR 11	312..333		5/20 (25%)
		leucine-rich repeat	313..336	CDD:275380	6/22 (27%)
		LRR 12	336..357		7/20 (35%)
		leucine-rich repeat	337..360	CDD:275380	7/22 (32%)
		LRR 13	360..382		10/23 (43%)
		leucine-rich repeat	361..385	CDD:275380	11/25 (44%)
		LRR_8	387..442	CDD:290566	27/54 (50%)
		LRR 14	387..408		11/20 (55%)
		leucine-rich repeat	388..411	CDD:275380	12/22 (55%)
		LRR 15	411..432		11/20 (55%)
		leucine-rich repeat	412..435	CDD:275380	12/22 (55%)
		LRRCT	446..494	CDD:214507	17/48 (35%)
		Ig_3	498..585	CDD:290638	27/101 (27%)
		I-set	499..599	CDD:254352	33/114 (29%)
		I-set	603..693	CDD:254352	47/89 (53%)
		Ig_1	620..694	CDD:143240	39/73 (53%)
		I-set	697..784	CDD:254352	26/98 (27%)
		IGc2	711..774	CDD:197706	20/74 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1073..1093
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I6838
eggNOG	1	0.900	-	-		E2759_KOG4194
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H62452
Inparanoid	1	1.050	487	1.000	Inparanoid score	I1439
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49439
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001817
OrthoInspector	1	1.000	-	-		otm42308
orthoMCL	1	0.900	-	-		OOG6_104558
Panther	1	1.100	-	-	LDO	PTHR24373
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3392
SonicParanoid	1	1.000	-	-		X1179
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.860