Protein Alignment lbk and LRRN2

DIOPT Version :10

• Sequence 1: NP_611091.2
• Gene: lbk / 36788
• FlyBaseID: FBgn0034083
• Length: 1252
• Species: Drosophila melanogaster
• Sequence 2: NP_006329.2
• Gene: LRRN2 / 10446
• HGNCID: 16914
• Length: 713
• Species: Homo sapiens
• Alignment Length: 618
• Identity: 152/618 - (24%)
• Similarity: 228/618 - (36%)
• Gaps: 140/618 - (22%)

  Fly   250 AAAAAAKASNKYNIDCPKDCKCL-------------NVLFDCDKLHLERV-PVLPSYVQTLHLAN 300
            |.|.||.....:::.||..|.|.             ....||:.|.|..| |.||:..|||.|.:
Human    14 AGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQS 78

  Fly   301 NKLNDTTVLEIRNLLNLTKVSLKRNLLEVIPKFIGLSGLKHLVLANNHITSISSESLAALPLLRT 365
            |.:......|:..|.|||:
Human    79 NSIVRVDQSELGYLANLTE---------------------------------------------- 97

  Fly   366 LDLSRNKLHTIELNSFPKSNNLVHLILSFNEITNVNEHSFATLNNLTDLELSNNRLSTLPIRVFK 430
            ||||:|.........|.....|:.|.|..|::|.:.:||||.|.:|.:|.|::|:|..:..|.|.
Human    98 LDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFS 162

  Fly   431 NLNQLKKLALNFNQL---EINWSTFRGLESMKNLQLKSNKIRALQDGVFYVMHKIETIDLAMNQI 492
            .|:.|.:|.||.|.|   :..|  |..|.:::.|.:..||:.|:.|..|..:..:.::.||...:
Human   163 GLSNLLRLHLNSNLLRAIDSRW--FEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNL 225

  Fly   493 SSLSRQGLFNLTKLRHLNLSFNAISRIEVDTWEFTQSLEVLDLSNNAINEFKPQHLDCLHRLKTL 557
            ..:|...|..|..|..|:...|.::|:.....|....|:.|||:.|.:....|.....:..||.|
Human   226 REISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKEL 290

  Fly   558 NLAHNRLQYLQENTFDCVKNLEELNLRRNRLSWIIEDQSAAAPFKGLRKLRRLDLHGN-NLKQIS 621
            .|                .|:|||         :..|:.|..   .|.:|.:||:..| .|..|.
Human   291 GL----------------NNMEEL---------VSIDKFALV---NLPELTKLDITNNPRLSFIH 327

  Fly   622 TKAMSGLNNLEILNLGSNALASIQVNAFEHMLRLNKLVFKSLNFICDCDLVWFQ-QWLKNRF--P 683
            .:|...|..:|.|.|.:|||:::.....|.:..|.::........|||.:.|.. ...:.||  |
Human   328 PRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTRVRFIEP 392

  Fly   684 QQAEHAVCGYPEHLLDRHLKSLSSSELV--CVDSPKPRVEQEPDDMLAVNAANITLECIASSPTA 746
            |.   .:|..|..|....::.:...|:.  |:....||  ..|..:...:..::.|.|.|
Human   393 QS---TLCAEPPDLQRLPVREVPFREMTDHCLPLISPR--SFPPSLQVASGESMVLHCRA----- 447

  Fly   747 ASLAAADELKIKW------RHDNQHVQERPAVHDGASTETQIRHDLSTNQTSIYGYLRLTNVTYE 805
               .|..|.:|.|      |....|...|..|:.                   .|.|.|..||.|
Human   448 ---LAEPEPEIYWVTPAGLRLTPAHAGRRYRVYP-------------------EGTLELRRVTAE 490

  Fly   806 SAGRYQCVVSNAFGTTYAQKFKISIGIHPTFLQ 838
            .||.|.||..|..|   |....:|:.:....||
Human   491 EAGLYTCVAQNLVG---ADTKTVSVVVGRALLQ 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbk	NP_611091.2	LRR	<293..642	CDD:443914	89/352 (25%)
		leucine-rich repeat	293..316	CDD:275380	7/22 (32%)
		leucine-rich repeat	317..338	CDD:275380	2/20 (10%)
		leucine-rich repeat	339..362	CDD:275380	0/22 (0%)
		leucine-rich repeat	363..386	CDD:275380	6/22 (27%)
		leucine-rich repeat	387..410	CDD:275380	10/22 (45%)
		leucine-rich repeat	411..434	CDD:275380	8/22 (36%)
		leucine-rich repeat	435..457	CDD:275380	9/24 (38%)
		leucine-rich repeat	458..481	CDD:275380	6/22 (27%)
		leucine-rich repeat	482..505	CDD:275380	5/22 (23%)
		leucine-rich repeat	506..529	CDD:275380	5/22 (23%)
		leucine-rich repeat	530..553	CDD:275380	6/22 (27%)
		leucine-rich repeat	554..577	CDD:275380	4/22 (18%)
		leucine-rich repeat	578..604	CDD:275380	5/25 (20%)
		leucine-rich repeat	607..630	CDD:275380	8/23 (35%)
		leucine-rich repeat	631..652	CDD:275380	7/20 (35%)
		LRRCT	665..712	CDD:214507	12/51 (24%)
		Ig_3	717..816	CDD:464046	25/104 (24%)
		Ig	835..924	CDD:472250	2/4 (50%)
		Ig strand B	851..855	CDD:409353
		Ig strand C	864..868	CDD:409353
		Ig strand E	890..894	CDD:409353
		Ig strand F	904..909	CDD:409353
		Ig strand G	917..920	CDD:409353
		Ig_3	927..1013	CDD:464046
LRRN2	NP_006329.2	leucine-rich repeat	337..360	CDD:275378	7/22 (32%)
		PCC	342..>420	CDD:188093	18/80 (23%)
		leucine-rich repeat	361..373	CDD:275378	1/11 (9%)
		Ig	422..514	CDD:472250	29/123 (24%)
		Ig strand B	441..445	CDD:409353	1/3 (33%)
		Ig strand C	454..458	CDD:409353	1/3 (33%)
		Ig strand E	480..484	CDD:409353	2/3 (67%)
		Ig strand F	494..499	CDD:409353	2/4 (50%)
		Ig strand G	507..510	CDD:409353	0/2 (0%)
		LRRNT	28..72	CDD:214470	12/43 (28%)
		leucine-rich repeat	51..69	CDD:275380	7/17 (41%)
		LRR 1	70..91		6/20 (30%)
		leucine-rich repeat	71..94	CDD:275380	7/22 (32%)
		LRR	<85..>324	CDD:443914	75/314 (24%)
		LRR 2	94..115		9/66 (14%)
		leucine-rich repeat	95..118	CDD:275380	8/68 (12%)
		LRR 3	118..139		8/20 (40%)
		leucine-rich repeat	119..142	CDD:275380	10/22 (45%)
		LRR 4	142..163		7/20 (35%)
		leucine-rich repeat	143..166	CDD:275380	8/22 (36%)
		LRR 5	166..187		8/22 (36%)
		leucine-rich repeat	167..190	CDD:275380	9/24 (38%)
		LRR 6	190..211		6/20 (30%)
		leucine-rich repeat	191..214	CDD:275380	6/22 (27%)
		LRR 7	214..235		4/20 (20%)
		leucine-rich repeat	215..238	CDD:275380	5/22 (23%)
		LRR 8	238..259		4/20 (20%)
		leucine-rich repeat	239..262	CDD:275380	5/22 (23%)
		LRR 9	262..283		6/20 (30%)
		leucine-rich repeat	263..286	CDD:275380	6/22 (27%)
		LRR 10	286..305		9/43 (21%)
		leucine-rich repeat	287..311	CDD:275380	11/51 (22%)
		LRR_8	310..371	CDD:404697	16/60 (27%)
		LRR 11	311..333		7/21 (33%)
		leucine-rich repeat	312..334	CDD:275380	7/21 (33%)
		LRR 12	336..357		6/20 (30%)