DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lbk and lrig3

DIOPT Version :9

Sequence 1:	NP_611091.2	Gene:	lbk / 36788	FlyBaseID:	FBgn0034083	Length:	1252	Species:	Drosophila melanogaster
Sequence 2:	XP_002940426.3	Gene:	lrig3 / 100151727	XenbaseID:	XB-GENE-1219309	Length:	1109	Species:	Xenopus tropicalis

Alignment Length:	991	Identity:	319/991 - (32%)
Similarity:	507/991 - (51%)	Gaps:	111/991 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   265 CPKDCKCLNVLFDCDKLHLERVPV-LPSYVQTLHLANNKLNDTTVLEIRNLLNLTKVSLKRNLLE 328
            ||..|:||..|.||.:..|..||. ||.:|..|.|::|||:......:.:|.||.::.|..|.|:
Frog    41 CPSPCRCLGDLLDCSRRKLAVVPANLPEWVVQLDLSHNKLSSINPSSMNHLHNLRELRLNNNELQ 105

  Fly   329 VIPKFIGLS-GLKHLVLANNHITSISSESLAALPLLRTLDLSRNKLHTIELNSFPKSNNLVHLIL 392
            ::|....|| .:....|.||.|..|..|.|.....|.|||||.|.:..:...||| :..|.:|.:
Frog   106 IVPDLGPLSANITLFSLTNNKIEVILPEHLKPYQSLETLDLSNNLITELRAGSFP-TLQLKYLYI 169

  Fly   393 SFNEITNVNEHSFATLN-NLTDLELSNNRLSTLPIRVFKNLNQLKKLALNFNQL-EINWSTFRGL 455
            :.|.|:.:...:|..|: .|..|:|:.||:|.:|.::|| |:.|:.|.||.|:: ||...||:||
Frog   170 NNNRISTMQSGAFDNLSATLQVLKLNKNRISYIPSKMFK-LSNLQHLELNRNRIKEILGLTFQGL 233

  Fly   456 ESMKNLQLKSNKIRALQDGVFYVMHKIETIDLAMNQISSLSRQGLFNLTKLRHLNLSFNAISRIE 520
            :|:|:|:::.|.|..|.||.|:.:..:|.:.|..|:::.:::..|:.|..|:.|:||.||||.|.
Frog   234 DSLKSLRIQRNLITRLMDGAFWGLSTMEILQLDHNRLTEITKGWLYGLLMLQKLHLSQNAISSIT 298

  Fly   521 VDTWEFTQSLEVLDLSNNAINEFKPQHLDCLHRLKTLNLAHNRLQYLQENTFDCVKNLEELNLRR 585
            .|.|||.|.|..|||:.|.:...:......|..|..|.:.:|::.::.:..|..:.:|..|:|:.
Frog   299 PDAWEFCQKLSELDLAFNQLTRLEESSFAGLGLLGGLYIGNNKINFIADGAFRGLSSLNSLDLKS 363

  Fly   586 NRLSWIIEDQSAAAPFKGLRKLRRLDLHGNNLKQISTKAMSGLNNLEILNLGSNALASIQVNAFE 650
            |.:||.|||.:..  |.||.:|:||.|..|.:..|:.||.|.|:.||.|:|..||:.|:|.|||.
Frog   364 NEISWTIEDMNGT--FSGLERLKRLILQDNRITSITKKAFSWLDALEYLDLSDNAITSMQTNAFS 426

  Fly   651 HMLRLNKLVFKSLNFICDCDLVWFQQWLKNRFPQQAEHAVCGYPEHLLDRHLKSLSSSELVCVDS 715
            .|..|.:|...:.:.:|||.|.|..:||.....|...:|.||:|:.|..:.:.::|..:.||.|.
Frog   427 QMKSLQQLYLNTTSLLCDCQLKWLPKWLAESKFQTFVNASCGHPQILKGKSIFAVSPDDFVCDDF 491

  Fly   716 PKPRVEQEPDDMLAVNAANITLECIASSPTAASLAAADELKIKWRHDNQHVQERPAVHDGASTET 780
            |||::..:|:...|:..:|:|..|.|:|.:.:.:..|      |:.||:      .:||   :|.
Frog   492 PKPQITVQPETQSAIKGSNVTFICSAASSSESPMTFA------WKKDNE------LLHD---SEI 541

  Fly   781 QIRHDLSTNQTSIYGY---LRLTNVTYESAGRYQCVVSNAFGTTYAQKFKISIGIHPTFLQVPSN 842
            :....|......:..|   |||.||.:.:.|:||||:||.||.||:.|.|:::.:.|.|.::|.:
Frog   542 ENYAHLRAQGGEVMEYTTILRLRNVEFINEGKYQCVISNHFGPTYSVKAKLTVNMLPLFTKMPMD 606

  Fly   843 LTLDAGEMARLVCSASGDPTPEIALQKFGGSEFPAATERRLQVIREENAFLITNAKPSDSGIYTC 907
            ||:.||..|||.|:|.|.|||:||.||.||::||||.|||:.|:.|::.|.|.|.|..|.|:|:|
Frog   607 LTIRAGSTARLECAAVGHPTPQIAWQKNGGTDFPAARERRMHVMPEDDVFFIVNVKTEDIGVYSC 671

  Fly   908 TALSAAGEIKVNATLVVNDKPQPSIPLVHQEVVVGRTCVLQCLSETANADFELEHPHREWFKENK 972
            ||.::||.|..||||.|.:.|....|||.:....|.|.||||::..:..      |...|.|::.
Frog   672 TAQNSAGSISANATLTVLETPSFLRPLVDRTASKGETTVLQCIAGGSPT------PKVNWTKDDS 730

  Fly   973 PIHISPTAPDGDRYYFSNNKELLVILNAQSNDAGHFRCEI-------------------TDNSRT 1018
            |:.::      :|::|:...:.|:|::....|||.:.||:                   |.:|..
Frog   731 PLVVT------ERHFFAAGNQHLIIVDTDLEDAGKYTCEVSNILGTERGNIHLSVLPNPTCDSPV 789

  Fly  1019 FTLQSELVVVKENLNWVVLLVGIITVTVICVVVDCCIIWCTLRYQKKKLRMSLAAERHSTQLRPR 1083
            .|:|:     .|:..|..  .||:.:.|:|.||...::|..:.|..::
Frog   790 NTIQT-----AEDDGWAT--AGIVIIAVVCCVVGTSLVWVVIIYHTRR----------------- 830

  Fly  1084 SLADLGCSYDEANHRRLTVMSTPPSEQRCLEQGLTLSYL-RQTDLEAQQDHLSSKDSGTGSDAAV 1147
              .:..||....:...|.| .||             ||| .|..|..:||...|.::  ||...:
Frog   831 --KNEDCSVTNTDETNLPV-DTP-------------SYLSSQGTLAERQDGYGSSEN--GSHQFI 877

  Fly  1148 KRTLDDFEVAMPSH-KHHTDDEEEEEVEEVYEENEPPYIKHTYEVNYAEPEQHLFLQNNNHNYDG 1211
            ..::..:.:....: ..|.|:..|.::|...:    |.:     .||......|:|:.|.::.|.
Frog   878 TSSMSGYFLQQRDNGACHLDNGSEADMEVATD----PLL-----FNYTGVPGSLYLRGNTYDPDA 933

  Fly  1212 GGIGVAG-GVNKMVPN 1226
            ..|..|| |:::..||
Frog   934 YEIFHAGYGMDRRTPN 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lbk	NP_611091.2	LRR_RI	<275..446	CDD:238064	61/174 (35%)
		leucine-rich repeat	293..316	CDD:275380	7/22 (32%)
		LRR_8	316..373	CDD:290566	22/57 (39%)
		leucine-rich repeat	317..338	CDD:275380	7/21 (33%)
		leucine-rich repeat	339..362	CDD:275380	7/22 (32%)
		leucine-rich repeat	363..386	CDD:275380	10/22 (45%)
		LRR_8	386..445	CDD:290566	21/59 (36%)
		leucine-rich repeat	387..410	CDD:275380	6/23 (26%)
		leucine-rich repeat	411..434	CDD:275380	10/22 (45%)
		leucine-rich repeat	435..457	CDD:275380	11/22 (50%)
		LRR_8	457..516	CDD:290566	19/58 (33%)
		leucine-rich repeat	458..481	CDD:275380	8/22 (36%)
		leucine-rich repeat	482..505	CDD:275380	5/22 (23%)
		LRR_RI	<498..669	CDD:238064	63/170 (37%)
		LRR_8	504..564	CDD:290566	23/59 (39%)
		leucine-rich repeat	506..529	CDD:275380	13/22 (59%)
		leucine-rich repeat	530..553	CDD:275380	6/22 (27%)
		leucine-rich repeat	554..577	CDD:275380	4/22 (18%)
		LRR_8	576..641	CDD:290566	27/64 (42%)
		leucine-rich repeat	578..604	CDD:275380	10/25 (40%)
		leucine-rich repeat	607..630	CDD:275380	10/22 (45%)
		leucine-rich repeat	631..652	CDD:275380	11/20 (55%)
		LRRCT	665..712	CDD:214507	14/46 (30%)
		IG	734..823	CDD:214652	29/91 (32%)
		Ig	735..823	CDD:143165	28/90 (31%)
		I-set	834..924	CDD:254352	48/89 (54%)
		Ig	851..924	CDD:299845	41/72 (57%)
		IG	936..1027	CDD:214652	23/109 (21%)
		Ig	961..1020	CDD:143165	15/77 (19%)
lrig3	XP_002940426.3	LRRNT	40..67	CDD:214470	11/25 (44%)
		leucine-rich repeat	52..69	CDD:275380	7/16 (44%)
		LRR	<58..>243	CDD:227223	67/186 (36%)
		internalin_A	70..>437	CDD:380193	133/370 (36%)
		leucine-rich repeat	73..93	CDD:275380	6/19 (32%)
		leucine-rich repeat	94..140	CDD:275380	14/45 (31%)
		leucine-rich repeat	141..163	CDD:275380	10/22 (45%)
		leucine-rich repeat	164..187	CDD:275380	6/22 (27%)
		leucine-rich repeat	189..211	CDD:275380	10/22 (45%)
		leucine-rich repeat	212..235	CDD:275380	11/22 (50%)
		leucine-rich repeat	236..259	CDD:275380	8/22 (36%)
		leucine-rich repeat	260..283	CDD:275380	5/22 (23%)
		leucine-rich repeat	284..307	CDD:275380	13/22 (59%)
		leucine-rich repeat	308..331	CDD:275380	6/22 (27%)
		leucine-rich repeat	332..355	CDD:275380	4/22 (18%)
		leucine-rich repeat	356..380	CDD:275380	10/25 (40%)
		leucine-rich repeat	383..406	CDD:275380	10/22 (45%)
		leucine-rich repeat	407..428	CDD:275380	11/20 (55%)
		PCC	411..>489	CDD:188093	26/77 (34%)
		Ig_3	493..580	CDD:404760	28/101 (28%)
		Ig strand A	494..497	CDD:409353	1/2 (50%)
		Ig strand A'	500..505	CDD:409353	1/4 (25%)
		Ig strand B	511..519	CDD:409353	3/7 (43%)
		Ig strand C	526..531	CDD:409353	2/10 (20%)
		Ig strand C'	533..535	CDD:409353	1/7 (14%)
		Ig strand D	552..555	CDD:409353	0/2 (0%)
		Ig strand E	559..565	CDD:409353	3/5 (60%)
		Ig strand F	572..579	CDD:409353	5/6 (83%)
		Ig strand G	586..594	CDD:409353	3/7 (43%)
		IgI_LRIG1-like	600..689	CDD:409420	47/88 (53%)
		Ig strand B	615..619	CDD:409420	3/3 (100%)
		Ig strand C	628..632	CDD:409420	2/3 (67%)
		Ig strand E	654..658	CDD:409420	1/3 (33%)
		Ig strand F	668..673	CDD:409420	2/4 (50%)
		Ig strand G	681..684	CDD:409420	0/2 (0%)
		I-set	692..779	CDD:400151	23/98 (23%)
		Ig strand A	693..695	CDD:409353	0/1 (0%)
		Ig strand A'	700..704	CDD:409353	0/3 (0%)
		Ig strand B	707..714	CDD:409353	4/6 (67%)
		Ig strand C	721..727	CDD:409353	2/5 (40%)
		Ig strand C'	728..730	CDD:409353	0/1 (0%)
		Ig strand D	737..740	CDD:409353	1/2 (50%)
		Ig strand E	743..751	CDD:409353	2/7 (29%)
		Ig strand F	758..766	CDD:409353	3/7 (43%)
		Ig strand G	770..779	CDD:409353	0/8 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	104	1.000	Domainoid score	I6618
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H62452
Inparanoid	1	1.050	474	1.000	Inparanoid score	I1456
OMA	1	1.010	-	-		QHG49439
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001817
OrthoInspector	1	1.000	-	-		otm49536
Panther	1	1.100	-	-	LDO	PTHR24373
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3392
SonicParanoid	1	1.000	-	-		X1179
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.100