Protein Alignment lbk and si:ch211-180f4.1

DIOPT Version :10

• Sequence 1: NP_611091.2
• Gene: lbk / 36788
• FlyBaseID: FBgn0034083
• Length: 1252
• Species: Drosophila melanogaster
• Sequence 2: NP_001373634.1
• Gene: si:ch211-180f4.1 / 100144405
• ZFINID: ZDB-GENE-080327-27
• Length: 744
• Species: Danio rerio
• Alignment Length: 880
• Identity: 184/880 - (20%)
• Similarity: 317/880 - (36%)
• Gaps: 268/880 - (30%)

  Fly   265 CPKDCKCLN-------------VLFDCDKLHLERVPVLPSY-VQTLHLANNKLNDTTVLEIRNLL 315
            ||..|.|..             ...||::|||.|:|...|. .|.|.|.:|.::..| .::::|:
Zfish    29 CPAQCVCETRPWYTPQSVYHQAKTVDCNELHLSRIPWNISVDTQVLLLQSNNISRGT-SQLQSLV 92

  Fly   316 NLTKVSLKRNLLEVIPKFIGLSGLKHLV---LANNHITSISSESLAALPLLRTLDLSRNKLHTIE 377
            |||::.|.:|....|.. :||:.|..||   |..|.|..:....|..|..|..|.::.|::.:|.
Zfish    93 NLTELDLSQNHFTQIHD-VGLNNLTQLVTLYLEENQIKELPDMCLKDLVSLEELYINHNQISSIG 156

  Fly   378 LNSFPKSNNLVHLILSFNEITNVNEHSFATLNNLTDLELSNNRLSTLPIRVFKNLNQLKKLALNF 442
            .|:|....||:.|.|:.|::..::.|.|.:|.||..|.:..|     ||...:::|
Zfish   157 PNAFSGLGNLLRLHLNSNKLVAIDSHWFESLPNLEILMIGEN-----PILGLQDMN--------- 207

  Fly   443 NQLEINWSTFRGLESMKNLQLKSNKIRALQDGVFYVMHKIETIDLAMNQISSLSRQGLFNLTKLR 507
                     |..|..:.:|.|....:|.:.:|.|..:..:|::....|:::::.::.|..|..|:
Zfish   208 ---------FHPLTKLHSLVLAGMGLREIPEGAFQGLEYLESLSFFDNKLTAVPKKALRVLPSLK 263

  Fly   508 HLNLSFNAISRIEVDTWEFTQSLEVLDLSNNAINEFKPQHLDCLHRLKTLNLAHNRLQYLQENTF 572
            .|:|:.|.|.||:...::....||.|.|:|                       ...|..::..:|
Zfish   264 FLDLNKNPIVRIQEGDFQDFPHLEELSLNN-----------------------MEELVAVERGSF 305

  Fly   573 DCVKNLEELNLRRNRLSWIIEDQSAAAPFKGLRKLRRLDLHGNNLKQISTKAMSGLNNLEILNLG 637
            ..:..:.:|.|..|...:.|:    .|.|..:|.||.|.:|.|:|..:..:.:|...||:.::|.
Zfish   306 SNLPQMAKLELYNNPHLFFID----RAAFLKMRGLRTLLIHNNDLTLLPHEIVSAFPNLDEISLH 366

  Fly   638 SNALASIQVNAFEHMLRLNKLVFKSLNFICDCDLVW-----FQQWLKNRFPQQAEHAVCGYPEHL 697
            ||.|.                        |||...|     .|..||...||   ..:|..|:||
Zfish   367 SNPLR------------------------CDCLNNWGPVLGNQSSLKVLEPQ---ITLCASPQHL 404

  Fly   698 LDRHLKSLSSSELVCVDSPKPRVEQEPDDMLAVNAANITLECIASSPTAASLAAADELKIKWRHD 762
            :.:.|:.:.|:..                   ..|:|..|..|
Zfish   405 VGQALQDVVSASW-------------------NGASNTCLPLI---------------------- 428

  Fly   763 NQHVQERPAVHDGASTETQIRHDLSTNQTSIYGYLRLTNVTYESAGRYQCVVSNAFGTTYAQKFK 827
            :||                                                   ||
Zfish   429 SQH---------------------------------------------------AF--------- 433

  Fly   828 ISIGIHPTFLQVPSNLTLDAGEMARLVCSASGDPTPEIALQKFGGSEF------PAATE------ 880
                        |..|.:..|::..|.|.|..||.|:.......|.:.      |::.|
Zfish   434 ------------PPQLNVTLGQLLTLDCWAVADPAPQFYWVTPTGDKVTSEAVSPSSNEGGGTPK 486

  Fly   881 -RRLQVIREENAFLITNAKPSDSGIYTCTALSAAGEIKVNATLVVNDKPQPSIPLVH----QEVV 940
             .|:|   ::.|..|.:.:|.|:|:|||.|.:|.|....:.::.|:.:   |....|    ...|
Zfish   487 KHRMQ---DQGALEIPHIEPEDTGLYTCVAWNAEGADTRSVSVYVDKR---SWNGAHHFGGHHGV 545

  Fly   941 VGRTCVLQCLSETANA-DFELE---HPHR----------EWFK-----ENKPIHISPTAP-DGDR 985
            |..|..|..|::|.:| ...||   ||:.          :|..     :|..|..:...| |...
Zfish   546 VNTTGSLVILAKTVHAQSVVLEWKMHPYAIPSNHEAGQPKWLSATVKIDNPQISYTAMVPVDVQE 610

  Fly   986 YYFSN---NKELLVILNAQSNDAGHFRC-EITDNSRTFTLQSELVVVKENLNWVVLLVGIITVTV 1046
            |..::   :.|..|.|.....:.....| .:|....:|.:  |:|....|:....::..:..:.:
Zfish   611 YNLTHLLPSTEYQVCLTMAGTEQTQHSCINVTTKEASFAV--EMVAQPTNVALAAVMGSMFAICI 673

  Fly  1047 ICVVVDCCIIWCTLRYQKKKLRMSLAA-ERHSTQL 1080
            :.::|    .:...|.::|....||.. .:|:|.:
Zfish   674 MALLV----FYMGRRMKQKSCHHSLKKYMQHTTSI 704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbk	NP_611091.2	LRR	<293..642	CDD:443914	87/351 (25%)
		leucine-rich repeat	293..316	CDD:275380	6/22 (27%)
		leucine-rich repeat	317..338	CDD:275380	7/20 (35%)
		leucine-rich repeat	339..362	CDD:275380	8/25 (32%)
		leucine-rich repeat	363..386	CDD:275380	6/22 (27%)
		leucine-rich repeat	387..410	CDD:275380	7/22 (32%)
		leucine-rich repeat	411..434	CDD:275380	5/22 (23%)
		leucine-rich repeat	435..457	CDD:275380	2/21 (10%)
		leucine-rich repeat	458..481	CDD:275380	5/22 (23%)
		leucine-rich repeat	482..505	CDD:275380	4/22 (18%)
		leucine-rich repeat	506..529	CDD:275380	7/22 (32%)
		leucine-rich repeat	530..553	CDD:275380	5/22 (23%)
		leucine-rich repeat	554..577	CDD:275380	2/22 (9%)
		leucine-rich repeat	578..604	CDD:275380	6/25 (24%)
		leucine-rich repeat	607..630	CDD:275380	7/22 (32%)
		leucine-rich repeat	631..652	CDD:275380	5/20 (25%)
		LRRCT	665..712	CDD:214507	15/51 (29%)
		Ig_3	717..816	CDD:464046	6/98 (6%)
		Ig	835..924	CDD:472250	25/101 (25%)
		Ig strand B	851..855	CDD:409353	1/3 (33%)
		Ig strand C	864..868	CDD:409353	0/3 (0%)
		Ig strand E	890..894	CDD:409353	1/3 (33%)
		Ig strand F	904..909	CDD:409353	3/4 (75%)
		Ig strand G	917..920	CDD:409353	0/2 (0%)
		Ig_3	927..1013	CDD:464046	23/113 (20%)
si:ch211-180f4.1	NP_001373634.1	LRR	51..370	CDD:443914	95/370 (26%)
		leucine-rich repeat	51..70	CDD:275380	8/18 (44%)
		leucine-rich repeat	71..93	CDD:275380	6/22 (27%)
		leucine-rich repeat	94..117	CDD:275380	8/23 (35%)
		leucine-rich repeat	118..141	CDD:275380	7/22 (32%)
		leucine-rich repeat	142..165	CDD:275380	6/22 (27%)
		leucine-rich repeat	166..189	CDD:275380	7/22 (32%)
		leucine-rich repeat	190..213	CDD:275380	8/45 (18%)
		leucine-rich repeat	214..237	CDD:275380	5/22 (23%)
		leucine-rich repeat	238..261	CDD:275380	4/22 (18%)
		leucine-rich repeat	262..285	CDD:275380	7/22 (32%)
		leucine-rich repeat	286..310	CDD:275380	7/46 (15%)
		leucine-rich repeat	311..330	CDD:275380	5/22 (23%)
		leucine-rich repeat	336..359	CDD:275378	7/22 (32%)
		PCC	341..>412	CDD:188093	24/97 (25%)
		leucine-rich repeat	360..372	CDD:275378	5/35 (14%)
		IG_like	434..528	CDD:214653	25/96 (26%)
		Ig strand B	445..449	CDD:409353	1/3 (33%)
		Ig strand C	458..462	CDD:409353	0/3 (0%)
		Ig strand E	494..498	CDD:409353	1/3 (33%)
		Ig strand F	508..513	CDD:409353	3/4 (75%)
		Ig strand G	521..524	CDD:409353	0/2 (0%)