DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CysRS and CRS1

DIOPT Version :9

Sequence 1:	NP_611087.1	Gene:	CysRS / 36784	FlyBaseID:	FBgn0027091	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_014152.1	Gene:	CRS1 / 855474	SGDID:	S000005191	Length:	767	Species:	Saccharomyces cerevisiae

Alignment Length:	782	Identity:	343/782 - (43%)
Similarity:	462/782 - (59%)	Gaps:	93/782 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QPAW-----QAPEAVDRPKLKLFNSLTRQKEDFVPLDGN-NVTWYSCGPTVYDASHMGHARSYIS 64
            ||.|     ||.|.|    |||:|||||.|.:|:|..|| .||||||||||||||||||||:|:|
Yeast    21 QPKWKVPTPQAKETV----LKLYNSLTRSKVEFIPQSGNRGVTWYSCGPTVYDASHMGHARNYVS 81

  Fly    65 FDILRRILSDYFGYNIHYVMNITDIDDKIIRRARQNHLFDEYAAEAQ-----------KLPLDEL 118
            .||.|||:.|||||::.:|.|:||||||||.|||||:|||.:..|..           |..|.:.
Yeast    82 IDINRRIIQDYFGYDVQFVQNVTDIDDKIILRARQNYLFDNFVKENDTKFNATVVDKVKTALFQY 146

  Fly   119 L-------GQQKEVLQRFQDTCAKNTDPDKKIMLDKTLQRMN-----------DAVEALTKAVGK 165
            :       |.:.:.::.| :|...|.|.:       ||:..|           :|:|::||  |.
Yeast   147 INKNFTIQGSEIKTIEEF-ETWLSNADTE-------TLKLENPKFPMHVTAVQNAIESITK--GD 201

  Fly   166 GDEREISEKRLLYLNEAKDPISDWLDSLKGAQINDNAVFEALPRYWEDQFHNDMKSLNILPPDVL 230
            ..:.|::      ..:.||.....||...|:.|::..:|..||.|||.:|::||.|||:|||.|.
Yeast   202 SMDAEVA------FEKVKDVTVPLLDKELGSTISNPEIFRQLPAYWEQKFNDDMLSLNVLPPTVT 260

  Fly   231 TRVSEYVPQIVTFIQKIIDNGLAYA-ANNSVYFDVNGFDKREKHHYAKLVPEAYGDTKSLQEGEG 294
            ||||||||:|:.|:|||||||.||| ::.|||||...|||...|.|||..|...|....:.:|||
Yeast   261 TRVSEYVPEIIDFVQKIIDNGYAYATSDGSVYFDTLKFDKSPNHDYAKCQPWNKGQLDLINDGEG 325

  Fly   295 DLSIAEDRLSEKRSANDFALWKASKAGEPWWDSPWGKGRPGWHIECSAMASDIFGPTFDIHTGGV 359
            .||...|  :.|:|.||||||||||||||.|:|||||||||||||||.|||||.|...|||:||:
Yeast   326 SLSNFAD--NGKKSNNDFALWKASKAGEPEWESPWGKGRPGWHIECSVMASDILGSNIDIHSGGI 388

  Fly   360 DLKFPHHDNELAQSEAAFNESEWVKYFLHTGHLTIAGCKMSKSLKNFVTIQEALKKHSATQLRLA 424
            ||.|||||||||||||.|:..:|:.||||||||.|.|.|||||||||:||||||||.|..|||||
Yeast   389 DLAFPHHDNELAQSEARFDNQQWINYFLHTGHLHIEGQKMSKSLKNFITIQEALKKFSPRQLRLA 453

  Fly   425 FLLHSWKDTLDYSENTMEMATQYEKFLNEFFLNVKDLTR------HVLSEEPRRQFDAWTEVEAA 483
            |....|.:.||:.|:.:.....:|..:|.||..::.|..      |:..:        ::.:|..
Yeast   454 FASVQWNNQLDFKESLIHEVKSFENSMNNFFKTIRALKNDAASAGHISKK--------FSPLEKE 510

  Fly   484 LQKKFSNAQVQVHASLCDNIDTRSALDAIRELVSVSNVYIRDNKTRLNSLLLRNVATYITDLLHV 548
            |...|..::.:||::.|||:.|..||..:.|||:.||.||......|....|..:.:|||.:|.:
Yeast   511 LLADFVESESKVHSAFCDNLSTPVALKTLSELVTKSNTYITTAGAALKIEPLIAICSYITKILRI 575

  Fly   549 FGAISGPRGGIGFPVSGGSGAQAAGADLETTVLPYVQSLAEFRYLVREQA-KTLKAFDILKLCDD 612
            .|..|.| ..:|:....||...:.|: ||.||:|||:.|:.||..||..| |..:..:.|:|.|.
Yeast   576 IGFPSRP-DNLGWAAQAGSNDGSLGS-LEDTVMPYVKCLSTFRDDVRSLAIKKAEPKEFLQLTDK 638

  Fly   613 LRDNVLPNLGVRLEDKDIGKYAVKLVDRDSLL------REREAKLAAEAEKAAEKERKKQAAAEA 671
            :|:..|.||.|.|:|::.....:|.:..|..|      .|:.|...|:.:|..|:::.::
Yeast   639 IRNEDLLNLNVALDDRNGQSALIKFLTNDEKLEIVKLNEEKHANELAKKQKKLEQQKLRE----- 698

  Fly   672 AAAKEAQRR----VNPKEMFLAETEKYSAFDENGLPTHDKEGKEVSKGQIKKLQKLQQQQEQRYN 732
              .||.:|:    :.|::|| .:...|||:||.||||.||:|.:::|...|||:|..:||::.:.
Yeast   699 --QKENERKQKAQIKPQDMF-KDVTLYSAWDEQGLPTKDKDGNDITKSMTKKLKKQWEQQKKLHE 760

  Fly   733 EY 734
            ||
Yeast   761 EY 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CysRS	NP_611087.1	PTZ00399	2..737	CDD:240402	343/782 (44%)
CysRS	NP_611087.1	CysRS_core	21..437	CDD:173899	238/446 (53%)
CRS1	NP_014152.1	PTZ00399	2..762	CDD:240402	341/780 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343586
Domainoid	1	1.000	432	1.000	Domainoid score	I67
eggNOG	1	0.900	-	-		E1_COG0215
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1328
Inparanoid	1	1.050	594	1.000	Inparanoid score	I136
Isobase	1	0.950	-	0	Normalized mean entropy	S696
OMA	1	1.010	-	-		QHG54140
OrthoFinder	1	1.000	-	-		FOG0000992
OrthoInspector	1	1.000	-	-		oto99468
orthoMCL	1	0.900	-	-		OOG6_100332
Panther	1	1.100	-	-	LDO	PTHR10890
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1431
SonicParanoid	1	1.000	-	-		X4186
TreeFam	1	0.960	-	-
	16	15.740