DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CysRS and SPAC29E6.06c

DIOPT Version :9

Sequence 1:	NP_611087.1	Gene:	CysRS / 36784	FlyBaseID:	FBgn0027091	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_594564.1	Gene:	SPAC29E6.06c / 2542721	PomBaseID:	SPAC29E6.06c	Length:	754	Species:	Schizosaccharomyces pombe

Alignment Length:	787	Identity:	343/787 - (43%)
Similarity:	458/787 - (58%)	Gaps:	85/787 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSKR--GQPAWQAPEAVDRPKLKLFNSLTRQKEDFVPLDGNNVTWYSCGPTVYDASHMGHARSYI 63
            ||.|  .|..|..|:. .|.:|.::|:||..|..||. :|:|:|||.|||||||||||||||:|:
pombe     1 MSTRNPAQSHWGVPKG-QRTELYVYNTLTHSKVPFVS-NGSNLTWYCCGPTVYDASHMGHARNYV 63

  Fly    64 SFDILRRILSDYFGYNIHYVMNITDIDDKIIRRARQNHLFDEYAAEAQKLPLDELLGQQKEVLQR 128
            :.|||||||..||||||.:|.|:||||||||.||||.:||:||   .::...::...:.:|.:..
pombe    64 TTDILRRILQSYFGYNITFVQNVTDIDDKIILRARQQYLFEEY---KKQQGTNKSHSEAREKVTE 125

  Fly   129 FQDTCAKNTDPDKKIMLDK-----------TLQRMNDA----VEALTKAVGKGDEREISE-KRLL 177
            .....||...|:....:.:           ||...|..    |:||..|:   |..::|| ..::
pombe   126 AWFAYAKKNLPEPPSSMSEWPQWLASHDIPTLAINNPKLPMHVDALKSAL---DALQVSEASEII 187

  Fly   178 YLN----EAKDPISDWLDSLKGAQINDNAVFEALPRYWEDQFHNDMKSLNILPPDVLTRVSEYVP 238
            .|:    :.:|.:...||:..|:.:.|.|:|..|..||||.|:.||.:||:|||..:||||||||
pombe   188 SLDGFWPKVQDVLVPLLDAELGSTVTDPAIFRKLAAYWEDDFNKDMANLNVLPPTAVTRVSEYVP 252

  Fly   239 QIVTFIQKIIDNGLAY-AANNSVYFDVNGFDKREKHHYAKLVPEAYGDTKSLQEGEGDLSIAEDR 302
            :||.|:|:|||.|.|| ..:.|||||...|:| ..|.||||.|...|:.:.:.||||.|:    .
pombe   253 EIVDFVQRIIDRGYAYPVTDGSVYFDTEAFEK-GGHFYAKLEPWNKGNRELIAEGEGSLA----A 312

  Fly   303 LSEKRSANDFALWKASKAGEPWWDSPWGKGRPGWHIECSAMASDIFGPTFDIHTGGVDLKFPHHD 367
            |:.|:...|||||||||.|||.|||||.|||||||||||.|||.:.|...|||:||:||.|||||
pombe   313 LTGKKRPGDFALWKASKPGEPSWDSPWSKGRPGWHIECSVMASALLGSNIDIHSGGIDLAFPHHD 377

  Fly   368 NELAQSEAAFNESEWVKYFLHTGHLTIAGCKMSKSLKNFVTIQEALKKHSATQLRLAFLLHSWKD 432
            ||||||||.|:..:||.||.|.|||.|.|.|||||||||:||:|.|||.:..||||||||..|..
pombe   378 NELAQSEAYFDCPQWVNYFFHAGHLHIEGQKMSKSLKNFITIKEILKKFTPRQLRLAFLLQQWNT 442

  Fly   433 TLDYSENTMEMATQYEKFLNEFFLNVKDLTR----------HVLSEEPRRQFDAWTEVEAALQKK 487
            .||:.|..:......|:.|..||..|:.|..          ||    |.: ||   ::|..|.:|
pombe   443 QLDFKETLLAYVLNIEQALENFFRTVRALMNETEGVSANGGHV----PEK-FD---KLEIELLEK 499

  Fly   488 FSNAQVQVHASLCDNIDTRSALDAIRELVSVSNVYIRDNKTRLNSLLLRNVATYITDLLHVFGA- 551
            |...|...|.:|||:.:|...:..|..||:.:|:|||:...:..|.||..:|::||.:|.:||.
pombe   500 FQQTQQNTHLALCDSFNTPLVMQHIDNLVTQANIYIREVGQQPCSRLLGQIASWITSMLQIFGLD 564

  Fly   552 ISGPRGGIGFPVSGGSGAQAAGADLETTVLPYVQSLAEFRYLVREQ--AKTLKAFDILKLCDDLR 614
            .:|....:|:..|.||.::      .|..:||:::::.||..|||.  ||. .:.:|||.||..|
pombe   565 ENGHPNAVGWSSSKGSSSE------NTDAMPYIRAVSSFRDRVRELCIAKA-SSQEILKACDIFR 622

  Fly   615 DNVLPNLGVRLEDKDIGKYAVKLVDRDSLLREREAKLAAEAEKAAEKERKKQAAAEAAAAKEAQR 679
            |..:..|||...|:..|...|||||.:.|:..||.||        |:||.|||....|.|::.::
pombe   623 DYDMAALGVSFNDRPQGSALVKLVDAEELIAAREQKL--------EEERAKQAKKAQAKAEQEKK 679

  Fly   680 RV--------NPKEMFLAETEKYSAFDENGLPT--HDKEGKE--VSKGQIKKLQKLQQQQEQRYN 732
            :|        :|.|||....| |.:|||.||||  ..::|.|  |.|.:.|||||...|||:.:.
pombe   680 QVERVMKGKTSPSEMFKMFKE-YLSFDEAGLPTKMRGEDGSEIDVPKSRKKKLQKEYAQQEKLHK 743

  Fly   733 EYLASIE 739
            |||:.||
pombe   744 EYLSYIE 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CysRS	NP_611087.1	PTZ00399	2..737	CDD:240402	340/782 (43%)
CysRS	NP_611087.1	CysRS_core	21..437	CDD:173899	221/436 (51%)
SPAC29E6.06c	NP_594564.1	PTZ00399	1..747	CDD:240402	340/782 (43%)
SPAC29E6.06c	NP_594564.1	CysRS_core	22..446	CDD:173899	220/435 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	404	1.000	Domainoid score	I101
eggNOG	1	0.900	-	-		E1_COG0215
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1328
Inparanoid	1	1.050	555	1.000	Inparanoid score	I190
OMA	1	1.010	-	-		QHG54140
OrthoFinder	1	1.000	-	-		FOG0000992
OrthoInspector	1	1.000	-	-		oto101075
orthoMCL	1	0.900	-	-		OOG6_100332
Panther	1	1.100	-	-	LDO	PTHR10890
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1431
SonicParanoid	1	1.000	-	-		X4186
TreeFam	1	0.960	-	-
	14	13.860