DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Got1 and AAT1

DIOPT Version :9

Sequence 1:	NP_725534.1	Gene:	Got1 / 36782	FlyBaseID:	FBgn0001124	Length:	437	Species:	Drosophila melanogaster
Sequence 2:	NP_012816.1	Gene:	AAT1 / 853755	SGDID:	S000001589	Length:	451	Species:	Saccharomyces cerevisiae

Alignment Length:	455	Identity:	158/455 - (34%)
Similarity:	245/455 - (53%)	Gaps:	57/455 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RLNYPGLLQNFQLSTMSIYADVPKGPAIEVFALTQAFKDDSNPNKVNLSVGAYRTDAGVPWVLPV 71
            ||....|.:.:..|::|   .||:.|..:|..|::.||...|.||::|:||.|:...|.....|.
Yeast     5 RLTNCSLWRPYYTSSLS---RVPRAPPDKVLGLSEHFKKVKNVNKIDLTVGIYKDGWGKVTTFPS 66

  Fly    72 VRKTEISIASDEQVNH--EYLPVTGLETFTNAATELVLGADSPA-----IKENRAFGVQTISGTG 129
            |.|.:..|.|..::|.  .|||:||.:.|.....:.:.....|.     :..:|...|||:||||
Yeast    67 VAKAQKLIESHLELNKNLSYLPITGSKEFQENVMKFLFKESCPQFGPFYLAHDRISFVQTLSGTG 131

  Fly   130 ALRVAADFLHTQLNRNVVYYSNPTWENHHKIFCDAGFTTVKSYRYWDQNKRELD----------F 184
            ||.|||.||...::|: ::..:|:|.||..||.:.||..:..|.|:...:.::|          :
Yeast   132 ALAVAAKFLALFISRD-IWIPDPSWANHKNIFQNNGFENIYRYSYYKDGQIDIDGWIEQLKTFAY 195

  Fly   185 KNMLADLNDAPPGAVIILHACAHNPTGIDPTQEQWTELADLMEKKKLFPLFDSAYQGFASGDPDR 249
            .|. .:.|..||  .||||||.|||||:|||:|||.::.|.:.:.|:.|:.|.||||..||:..:
Yeast   196 NNQ-QENNKNPP--CIILHACCHNPTGLDPTKEQWEKIIDTIYELKMVPIVDMAYQGLESGNLLK 257

  Fly   250 DAWAARYFV--------QRGFELFICQSFAKNFGLYCERTGNLAVV-------------QKNGAT 293
            ||:..|..:        ..|  :|:|||||||.|||.||.|:|:|:             |:..:.
Yeast   258 DAYLLRLCLNVNKYPNWSNG--IFLCQSFAKNMGLYGERVGSLSVITPATANNGKFNPLQQKNSL 320

  Fly   294 KAAVHSQLTLLIRGQYSNPPAYGARIVSKVLNTPELRKEWMASIQAMSSRIREMRTALRDKLVAL 358
            :..:.|||..::||.||:||.||:|:|:.||:..:|:::|...:..|..|:..:|..:.|:|
Yeast   321 QQNIDSQLKKIVRGMYSSPPGYGSRVVNVVLSDFKLKQQWFKDVDFMVQRLHHVRQEMFDRL--- 382

  Fly   359 GTPGTWDHIVN---QIGMFSYTGLNESHVRVLIDQYHIYLLKTGRISMSGLNKGNVEYVAKAIHA 420
                .|..:||   |.|||.||..:...|.:|.:.|.:||...||:|:||:|..||:|:.:::.|
Yeast   383 ----GWPDLVNFAQQHGMFYYTRFSPKQVEILRNNYFVYLTGDGRLSLSGVNDSNVDYLCESLEA 443

Fly 421 420
Yeast 444 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Got1	NP_725534.1	PTZ00376	21..423	CDD:240390	154/441 (35%)
Got1	NP_725534.1	Aminotran_1_2	49..418	CDD:278580	144/409 (35%)
AAT1	NP_012816.1	TyrB	21..445	CDD:224365	154/439 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341994
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1448
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62835
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750